102 | id == 102
102 | category_id == 9
102 | category_order == 6
102 | category_name == Longevity
102 | category_color == #C47AC0
102 | slug == IL1B-and-Longevity
102 | title == How Might The IL-1B Gene Impact Longevity?
102 | meta_description == The IL-1B gene codes for interleukin-1-beta, a type of pro-inflammatory cytokine. Read on to learn how it might affect lifespan!
102 | summary == <p style="text-align:justify"><strong>The <em>IL-1B</em> gene codes for a type of pro-inflammatory cytokine called <em>interleukin-1-beta</em> (IL-1&beta;). Although this compound plays a normal role in stimulating the inflammatory response, certain variants in this gene may make some people more prone to chronic inflammation by increasing the production of IL-1&beta;. Chronic inflammation, in turn, may impact lifespan by contributing to the development of autoimmune disorders, cardiovascular issues, and possibly even cancer. Read on to learn more about how this gene works, and what your own genetic variants can tell you about your health!</strong></p>
102 | overall_score_text == Your Longevity Score (Based on IL-1B gene)
102 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/Inflammation_SD_Blog_post_image.jpg
102 | author_id == 4
102 | author_name == Matt Carland
102 | author_title == PhD
102 | author_order == 10
102 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Matt.jpg
102 | author_intro == <p><strong>Matt received his PhD at the Universit&eacute; de Montr&eacute;al in Neuroscience.</strong></p>    <p>Matt holds multiple degrees in psychology, cognitive science, and neuroscience. He has over a decade of experience in academic research and has published a number of articles in scholarly journals. He currently works as a neuropsychologist in Montreal, where he performs research on the links between personality traits and the development of clinical disorders such as addiction, compulsive gambling, and disordered eating.</p>
102 | reviewer == None
102 | medical_reviewer_id == 11
102 | medical_reviewer_name == Puya Yazdi
102 | medical_reviewer_title == MD
102 | publish_date == 2020
102 | publish_date == 2
102 | publish_date == 14
102 | avg_rating == 5.0
102 | tags_id == 179
102 | tags_name == Age-Related Disease
102 | tags_id == 138
102 | tags_name == Atherosclerosis
102 | tags_id == 33
102 | tags_name == Autoimmunity
102 | tags_id == 164
102 | tags_name == Cancer
102 | tags_id == 192
102 | tags_name == Cardiovascular Disease
102 | tags_id == 195
102 | tags_name == Crohn's Disease
102 | tags_id == 96
102 | tags_name == Cytokines
102 | tags_id == 191
102 | tags_name == Heart Health
102 | tags_id == 73
102 | tags_name == IBD
102 | tags_id == 268
102 | tags_name == IL-1B Gene
102 | tags_id == 253
102 | tags_name == IL-6
102 | tags_id == 95
102 | tags_name == Immune System
102 | tags_id == 24
102 | tags_name == Inflammation
102 | tags_id == 101
102 | tags_name == Longevity
102 | tags_id == 39
102 | tags_name == Oxidative Stress
102 | tags_id == 82
102 | tags_name == Rheumatoid Arthritis
102 | tags_id == 196
102 | tags_name == Ulcerative Colitis
102 | permissions_favorite == False
102 | permissions_rate == False
102 | content_article == <table style="width: 90%; border-collapse: collapse; margin-left: auto; margin-right: auto;" border="1" cellpadding="10"> <tbody> <tr> <td style="width: 100%; text-align: justify;"><strong>Note:</strong><span style="font-weight: 400;"> The </span><em><span style="font-weight: 400;">IL1B</span></em><span style="font-weight: 400;"> gene is involved in both inflammation and cardiovascular health. If you&rsquo;re curious to learn more about how your genetics could be impacting each of these aspects of your health, we recommend checking out </span><em><span style="font-weight: 400;">SelfDecode</span></em><span style="font-weight: 400;">&rsquo;s comprehensive </span><a href="https://get.selfdecode.com/gene-reports/inflammation/"><strong><em>Inflammation</em></strong></a><span style="font-weight: 400;"> and </span><a href="https://get.selfdecode.com/gene-reports/cardiovascular/"><strong><em>Cardiovascular</em></strong></a><strong><em> DNA Wellness Reports</em></strong><span style="font-weight: 400;">, which analyze many other important relevant genes!</span></td> </tr> </tbody> </table> <p>&nbsp;</p> <h2><strong style="text-align: justify;">What is the </strong><strong style="text-align: justify;"><em>IL1B</em></strong><strong style="text-align: justify;"> Gene?</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="../../gene/il1b/"><em><span style="font-weight: 400;">IL1B</span></em><span style="font-weight: 400;"> gene</span></a><span style="font-weight: 400;"> is responsible for producing </span><a href="https://selfhack.com/blog/interleukin-1/"><em><span style="font-weight: 400;">interleukin 1-beta</span></em></a><span style="font-weight: 400;"> (IL-1&beta;), one of the major types of pro-inflammatory cytokines [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29584915"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938092/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21304099"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><em><span style="font-weight: 400;">Cytokines</span></em><span style="font-weight: 400;"> are one of the main types of &ldquo;messenger&rdquo; molecules that the immune system uses to regulate the inflammatory response. There are many different kinds of cytokines, each with their own unique functions and roles.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">When it comes to members of the </span><em><span style="font-weight: 400;">interleukin-1</span></em><span style="font-weight: 400;"> family (which includes IL-1&beta;), these compounds act as a sort of &ldquo;alarm&rdquo; signal that are produced (by </span><em><span style="font-weight: 400;">dendritic cells</span></em><span style="font-weight: 400;">, </span><em><span style="font-weight: 400;">macrophages</span></em><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/monocytes/"><em><span style="font-weight: 400;">monocytes</span></em></a><span style="font-weight: 400;">, and </span><a href="https://selfhacked.com/blog/neutrophils/"><em><span style="font-weight: 400;">neutrophils</span></em></a><span style="font-weight: 400;">) in response to cell stress, damage, or death [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24734023"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24332029"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27260388"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24146121"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">These &ldquo;alarm signals&rdquo; then trigger the production and release of many other pro-inflammatory compounds, such as [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27260388"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31676788"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24332029"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24734023"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24146121"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul style="text-align: justify;"> <li><em><span style="font-weight: 400;">Reactive oxygen species</span></em><span style="font-weight: 400;"> (ROS), the main causes of </span><a href="https://selfhacked.com/blog/oxidative-stress-101/"><span style="font-weight: 400;">oxidative stress</span></a></li> <li><span style="font-weight: 400;">Nitric oxide</span></li> <li><a href="https://selfhack.com/blog/nuclear-factor-kappa-b/"><span style="font-weight: 400;">NF-kB</span></a></li> <li><span style="font-weight: 400;">CREB</span></li> <li><a href="../article/stat3-multiple-sclerosis-80"><em><span style="font-weight: 400;">STAT3</span></em></a></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">IL-1&beta; further contributes to the inflammatory response by activating Th9 and </span><a href="https://selfhacked.com/blog/th17/"><span style="font-weight: 400;">Th17 cells</span></a><span style="font-weight: 400;">, as well as stimulating the production of </span><a href="https://selfhack.com/blog/interleukin-6/"><span style="font-weight: 400;">IL-6</span></a><span style="font-weight: 400;">, another major pro-inflammatory cytokine [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27260388"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In other words, nearly all cell types in the immune system either express or are targeted by cytokines in the IL-1 family [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24332029"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. For these reasons, cytokines in the IL-1 family &mdash; such as IL-1&beta; &mdash; are primarily associated with both acute and </span><a href="https://selfhacked.com/blog/chronic-inflammation-blood-tests/"><span style="font-weight: 400;">chronic inflammation</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21304099"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24734023"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The <em>IL1B</em> gene codes for <em>interleukin-1-beta</em> (IL-1&beta;), one of the major types of cytokines that the body uses to trigger many different aspects of the inflammatory response.</span></p> <h2 style="text-align: justify;"><strong>How Does </strong><strong><em>IL1B</em></strong><strong> Influence Lifespan?</strong></h2> <h4 style="text-align: justify;"><strong>Inflammation &amp; Autoimmune Disorders</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Different variants in the </span><em><span style="font-weight: 400;">IL1B</span></em><span style="font-weight: 400;"> gene can influence how much IL-1&beta; a person produces [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12454835"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12528938"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31297985"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17645589"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31297985"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18838388"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31222982"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">These differences, in turn, can influence how susceptible a person is to the effects of inflammation, and thus their likelihood of developing chronic inflammation and other associated health problems [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21304099"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">For example, SNPs in the </span><em><span style="font-weight: 400;">IL1B</span></em><span style="font-weight: 400;"> gene have been associated with a variety of autoimmune and other inflammation-related disorders, such as:</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/rheumatoid-factor/"><span style="font-weight: 400;">Rheumatoid arthritis</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18838388"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22718924"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><em><span style="font-weight: 400;">Pancreatitis</span></em><span style="font-weight: 400;"> (inflammation in the </span><a href="https://selfhacked.com/blog/pancreatic-polypeptide-function/"><span style="font-weight: 400;">pancreas</span></a><span style="font-weight: 400;">) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30634098"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Autoinflammatory disorders, such as </span><a href="https://selfhacked.com/blog/causes-ibs-general-gut-dysfunction/"><span style="font-weight: 400;">inflammatory bowel disease</span></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections/"><span style="font-weight: 400;">Crohn&rsquo;s disease</span></a><span style="font-weight: 400;">, and </span><a href="https://selfhacked.com/blog/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections/"><span style="font-weight: 400;">ulcerative colitis</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21728024"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24751956"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Severe inflammatory reactions due to common infectious diseases (such as the flu) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31196204"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p style="text-align: justify;"><strong>However, the importance of IL-1&beta; isn&rsquo;t just limited to inflammatory disorders </strong><strong><em>per se</em></strong><strong>.</strong><span style="font-weight: 400;"> This is because inflammation also contributes to the development of several other major types of health conditions, each of which can further impact lifespan.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Therefore, there are several additional major ways that genetic variations in </span><em><span style="font-weight: 400;">IL1B</span></em><span style="font-weight: 400;"> may have an affect on overall lifespan, over and beyond the acute and chronic inflammation that IL-1&beta; can contribute to.</span></p> <h4 style="text-align: justify;"><strong>Cardiovascular Health</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Firstly, while </span><em><span style="font-weight: 400;">acute</span></em><span style="font-weight: 400;"> inflammation is a normal part of the immune response, </span><em><span style="font-weight: 400;">chronic</span></em><span style="font-weight: 400;"> inflammation can negatively impact the functioning of other organs and systems throughout the body.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">One of the main systems affected by inflammation are the cardiovascular and circulatory systems. For this reason, chronic inflammation has been associated with the development of a number of significant </span><a href="https://get.selfdecode.com/gene-reports/cardiovascular/"><span style="font-weight: 400;">cardiovascular health</span></a><span style="font-weight: 400;"> issues, including [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24146121"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11877368"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22571369"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21304099"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29584915"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22848083"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><em><span style="font-weight: 400;">Atherosclerosis</span></em><span style="font-weight: 400;"> (hardening of the arteries)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Coronary heart disease</span></li> <li style="font-weight: 400;"><em><span style="font-weight: 400;">Myocardial infarction</span></em><span style="font-weight: 400;"> (commonly known as a &ldquo;heart attack&rdquo;)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Heart failure</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Angina</span></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">Due to the link between elevated inflammation and long-term cardiovascular risk, certain genetic variants in the </span><em><span style="font-weight: 400;">IL1B</span></em><span style="font-weight: 400;"> gene have been associated with the development of heart disease [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11796541"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22848083"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Furthermore, because cardiovascular disorders are a major cause of mortality, the link between chronic inflammation and heart disease forms another major pathway through which variants in the </span><em><span style="font-weight: 400;">IL-1B</span></em><span style="font-weight: 400;"> gene can influence lifespan, over and beyond the &ldquo;direct&rdquo; effects of inflammation by itself.</span></p> <h4 style="text-align: justify;"><strong>Cancer Risk</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Secondly, the other major way that </span><em><span style="font-weight: 400;">IL1B</span></em><span style="font-weight: 400;"> may impact lifespan is by influencing a person&rsquo;s long-term risk of developing cancer.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">This is because &mdash; similar to cardiovascular health &mdash; evidence suggests that increased inflammation may be one potential causal factor in the development and growth of tumorous cells [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20036794"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20303878"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22035839"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Although the link between inflammation and cancer is a general one, cytokines in the IL-1 family in particular have been associated with the early stages of cancer development and tumor growth. By extension, variants in the <em>IL1B</em> gene that increase the expression of IL-1&beta; could increase a person&rsquo;s long-term risk of developing cancer &mdash; which would have obvious negative effects on their likelihood of living long into older age [<a href="https://www.ncbi.nlm.nih.gov/pubmed/24734023">R</a>].</span></p> <p style="text-align: justify;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The effects of <em>IL1B</em> on lifespan are due to its association with chronic inflammation. While this effect is already significant on its own, inflammation can also contribute to the development of autoimmune disorders, cardiovascular issues, and cancer &mdash; all of which can further impact a person&rsquo;s overall lifespan.</span></p> <h2 style="text-align: justify;"><strong>Your </strong><strong><em>IL1B</em></strong><strong> Genotypes</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">You can see your genotypes for several different </span><em><span style="font-weight: 400;">IL1B</span></em><span style="font-weight: 400;"> SNPs in the table below. However, keep in mind that </span><strong>these results are based purely on association studies</strong><span style="font-weight: 400;">, and much more research will be needed to know what role &mdash; if any &mdash; these variants play in actually </span><em><span style="font-weight: 400;">directly</span></em><span style="font-weight: 400;"> impacting a person&rsquo;s overall lifespan.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">By extension, just because a person might have some &ldquo;risk-associated&rdquo; genotypes for some of these SNPs does </span><strong>not</strong><span style="font-weight: 400;"> necessarily mean that they will actually develop the health condition associated with it!</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">This is because there are many different genetic, lifestyle, and environmental factors that can affect overall health and lifespan. </span><strong>In other words, just having a few &ldquo;bad&rdquo; </strong><strong><em>IL1B</em></strong><strong> genotypes does </strong><strong>not</strong><strong> necessarily predict anything specific about a person&rsquo;s lifespan &mdash; rather, these results illustrate just </strong><strong><em>one</em></strong><strong> of the many different genetic factors potentially related to it.</strong></p> <p style="text-align: justify;"><span style="font-weight: 400;">With that in mind, the following table summarizes your results for several different </span><em><span style="font-weight: 400;">IL-1B</span></em><span style="font-weight: 400;"> SNPs that have been potentially linked to longevity:</span></p> <p style="text-align: justify;"><strong>*8219465711313432*</strong></p> <p style="text-align: justify;"><strong>*5973925330328225*</strong></p> <p>&nbsp;</p> <h5><strong>&ldquo;Main&rdquo; </strong><strong><em>IL1B</em></strong><strong> SNP (rs16944):</strong></h5> <p style="text-align: justify;"><span style="font-weight: 400;">One of the more highly-studied SNPs in the </span><em><span style="font-weight: 400;">IL1B</span></em><span style="font-weight: 400;"> gene is </span><a href="../../snp/rs16944/"><strong>rs16944</strong></a><span style="font-weight: 400;">, also often referred to as the &lsquo;</span><em><span style="font-weight: 400;">C-511/T</span></em><span style="font-weight: 400;">&rsquo; polymorphism. </span><strong>When it comes to this SNP, it is probably best to have the &lsquo;GG&rsquo; (</strong><strong><em>homozygous minor</em></strong><strong> genotype), which about 25% of the general world population carries.</strong></p> <p style="text-align: justify;"><span style="font-weight: 400;">However, </span><strong>this genotype is also significantly more common in certain ethnic populations</strong><span style="font-weight: 400;">. For example, up to 40-45% of people of European descent have this genotype. Therefore, the relative chances of you having this genotype may depend on your unique ancestral background.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">According to multiple targeted gene studies in many different ethnic populations, the (non-beneficial) &lsquo;A&rsquo; allele of </span><strong>rs16944</strong><span style="font-weight: 400;"> has been associated with:</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">Rheumatoid arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18838388"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Acute pancreatitis (inflammation in the pancreas) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30634098"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Increased rates of various types of cancer (including cervical, prostate, gastric, bone marrow, and breast cancers) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31297985"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25374200"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://rs16944"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27693669"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12441323"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21160639"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12891537"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Increased risk of mortality from systemic infections, such as septic shock [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27859227"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Increased risk of severe reactions to common infectious illnesses, such as the flu [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31196204"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Reduced rates of survival among elderly patients admitted to geriatric hospital care (males only) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17645589"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">Although the mechanisms of this SNP have not yet been directly confirmed, it is highly likely that these associations are due to elevated levels of IL-1&beta;, for two main reasons:</span></p> <ol style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">Firstly, </span><strong>this SNP is located in the &ldquo;</strong><strong><em>promoter</em></strong><strong>&rdquo; region of the </strong><strong><em>IL1B</em></strong><strong> gene</strong><span style="font-weight: 400;">, which is the section of a gene that generally plays the most direct role in determining how much a gene actually gets expressed throughout the body. Therefore, variants in these SNPs are likely to play a relatively direct role in controlling how much IL-1&beta; the body produces [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18838388"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17645589"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Secondly, many targeted gene studies of </span><em><span style="font-weight: 400;">IL-1B</span></em><span style="font-weight: 400;"> have measured the actual levels of IL-1&beta; in people with different genotypes &mdash; and these studies have consistently reported that </span><strong>carrying more &lsquo;A&rsquo; alleles for this SNP is typically correlated with higher levels of IL-1&beta;</strong><span style="font-weight: 400;"> circulating throughout the body [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12454835"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12528938"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31297985"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17645589"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ol> <p style="text-align: justify;"><span style="font-weight: 400;">Therefore, the effects of this SNP on longevity are highly likely being driven by increased levels of IL-1&beta;, which in turn may raise a person&rsquo;s susceptibility to chronic inflammation (and its secondary effects on other organ systems) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17645589"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h5 style="text-align: justify;"><strong>Other Noteworthy </strong><strong><em>IL1B</em></strong><strong> SNPs:</strong></h5> <p style="text-align: justify;"><strong><em>IL1B</em></strong> <a href="../../snp/rs1143623/"><strong>rs1143623</strong></a><strong>:</strong></p> <ul style="text-align: justify;"> <li><span style="font-weight: 400;">Also known as the &lsquo;</span><em><span style="font-weight: 400;">-1464 C/G</span></em><span style="font-weight: 400;">&rsquo; polymorphism</span></li> <li><span style="font-weight: 400;">SNP located in &ldquo;promoter&rdquo; region of </span><em><span style="font-weight: 400;">IL1B</span></em><span style="font-weight: 400;"> gene [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18838388"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li><span style="font-weight: 400;">The &lsquo;C&rsquo; allele has been associated with </span>rheumatoid arthritis [<a href="https://www.ncbi.nlm.nih.gov/pubmed/18838388">R</a>] and b<span style="font-weight: 400;">reast cancer (in Han Chinese) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31297985"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li><span style="font-weight: 400;">&lsquo;C&rsquo; alleles also directly linked to increased (serum) levels of IL-1&beta; [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31297985"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18838388"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p style="text-align: justify;"><strong><em>IL1B</em></strong> <a href="../../snp/rs1143627/"><strong>rs1143627</strong></a><strong>:</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">Also known as the &lsquo;</span><em><span style="font-weight: 400;">IL-1B-31</span></em><span style="font-weight: 400;">&rsquo; polymorphism</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;AA&rsquo; genotype (</span><em><span style="font-weight: 400;">homozygous minor</span></em><span style="font-weight: 400;">) has been associated with increased rates of several types of cancer [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31222982"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25374200"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19474090"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12500190"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;AA&rsquo; genotype has also been directly linked with increased </span><em><span style="font-weight: 400;">IL1B</span></em><span style="font-weight: 400;"> gene expression (</span><em><span style="font-weight: 400;">IL-1B</span></em><span style="font-weight: 400;"> mRNA levels) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31222982"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p style="text-align: justify;"><strong><em>IL1B</em></strong> <a href="../../snp/rs1143634/"><strong>rs1143634</strong></a><strong>:</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele for this SNP has been associated with increased rates of </span><em><span style="font-weight: 400;">acute pancreatitis</span></em><span style="font-weight: 400;"> (inflammation in the pancreas) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30634098"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p style="text-align: justify;"><strong><em>IL1B</em></strong> <a href="../../snp/rs3136558/"><strong>rs3136558</strong></a><strong>:</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele for this SNP has been associated with </span><em><span style="font-weight: 400;">reduced</span></em><span style="font-weight: 400;"> rates of cervical cancer [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31222982"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p style="text-align: justify;"><strong><em>IL1B</em></strong> <a href="../../snp/rs1143630/"><strong>rs1143630</strong></a><strong>:</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele of this SNP has also been associated with </span><em><span style="font-weight: 400;">reduced</span></em><span style="font-weight: 400;"> rates of cervical cancer [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31222982"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">As you can see from the lists above, the negative health outcomes that have been associated with these </span><em><span style="font-weight: 400;">IL1B</span></em><span style="font-weight: 400;"> gene variants are quite diverse, and cover many of the different potential health conditions associated with chronic inflammation (such as autoimmune disorders, cancer development, etc.). This illustrates the many potential specific pathways that may link certain </span><em><span style="font-weight: 400;">IL1B</span></em><span style="font-weight: 400;"> variants with differences in overall lifespan.</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Several SNPs in the </span><em><span style="font-weight: 400;">IL1B</span></em><span style="font-weight: 400;"> gene have been associated with the long-term development of a variety of health conditions that can impact lifespan, such as chronic inflammation, autoimmune disorders, and cancer risk.</span></span></p> <h2 style="text-align: justify;"><strong>What Can You Do About Your </strong><strong><em>IL1B</em></strong><strong> Genotype?</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">In general, the more &ldquo;non-beneficial&rdquo; genotypes a person carries in the </span><em><span style="font-weight: 400;">IL1B</span></em><span style="font-weight: 400;"> gene, the more likely it is that they will tend to have elevated baseline levels of the pro-inflammatory cytokine IL-1&beta;. This can potentially impact their longevity by increasing their normal &ldquo;baseline&rdquo; level of inflammation, which in turn can also influence their long-term risk of developing a number of inflammation-related health conditions.</span></p> <h3 style="text-align: justify;"><strong>General Lifestyle Tips</strong></h3> <p style="text-align: justify;"><span style="font-weight: 400;">Since many of the long-term effects of elevated IL-1&beta; revolve around its effects on cardiovascular health and cancer risk, there are several very basic, &ldquo;common-sense&rdquo; approaches that a person with </span><em><span style="font-weight: 400;">IL1B</span></em><span style="font-weight: 400;">-related risk factors can take to ensure optimal health.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">First of all, it is important to </span><strong>quit smoking</strong><span style="font-weight: 400;">, if you are a tobacco user. Not only does smoking greatly increase one&rsquo;s cancer risk, but some recent evidence even suggests that cigarette smoke may directly stimulate the production of IL-1&beta;, which could further increase the levels of this pro-inflammatory cytokine &mdash; especially in people that already carry risk-associated alleles in this gene [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25135760"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Secondly, it would also be a good idea to </span><strong>reduce your alcohol consumption</strong><span style="font-weight: 400;"> &mdash; or even eliminate it altogether, if possible! Not only is alcohol associated with many negative long-term effects on health, but &mdash; like smoking &mdash; some recent studies have also reported that alcohol may directly increase the production of IL-1&beta; [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25175869"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Finally, because some of </span><em><span style="font-weight: 400;">IL-1B</span></em><span style="font-weight: 400;">&rsquo;s potential negative effects may stem from the adverse long-term effects of chronic inflammation on the cardiovascular system, it is important to maintain a &ldquo;heart-healthy&rdquo; lifestyle. One key component of this is making sure to </span><strong>get plenty of regular <a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/" target="_blank" rel="noopener">exercise</a></strong><span style="font-weight: 400;">, as exercise is one of the best ways to promote and maintain long-term cardiovascular health [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16534088"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26538582"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Three key general lifestyle factors that can help ensure optimal health and longevity are quitting smoking, cutting back on alcohol consumption, and getting plenty of regular exercise.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In addition to these general lifestyle tips, there are </span><strong>several additional &ldquo;complementary&rdquo; approaches</strong><span style="font-weight: 400;"> that can be taken to potentially counteract some of the potential health risks associated with </span><em><span style="font-weight: 400;">IL1B</span></em><span style="font-weight: 400;"> variants. </span><strong>These recommendations are more &ldquo;targeted,&rdquo;</strong><span style="font-weight: 400;"> in the sense that they deal more directly with the specific mechanisms involved in the </span><em><span style="font-weight: 400;">IL1B</span></em><span style="font-weight: 400;"> gene and its potential effects on health.</span></p> <p style="text-align: justify;"><strong>As always, make sure to speak with your doctor before trying out any of the supplements or dietary changes discussed below</strong><span style="font-weight: 400;">, as these could potentially have negative interactions with any other underlying health conditions you might have, or other key lifestyle and dietary factors. Furthermore, if you think you may be suffering from any inflammation-related or other major health conditions, be sure to consult with your doctor to obtain an official diagnosis and treatment plan &mdash; none of the information below should be used to replace conventional medical care.</span></p> <p style="text-align: justify;"><strong>*8117188001976299*</strong></p> <h3 style="text-align: justify;"><strong>Reducing IL-1&beta; Levels</strong></h3> <p style="text-align: justify;"><strong>Firstly, because higher levels of IL-1&beta; contribute to increased inflammation, one strategy could be to block the expression or production of IL-1&beta; directly.</strong></p> <p style="text-align: justify;"><span style="font-weight: 400;">In fact, blocking or reducing IL-1&beta; production has been proposed as a potential medical strategy for treating a variety of autoinflammatory and cardiovascular diseases [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21304099"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22571369"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22848083"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24146121"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29584915"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">For example, prescription pharmaceutical drugs that block IL-1&beta; activity (by blocking the IL-1 receptor) &mdash; such as </span><em><span style="font-weight: 400;">Anakinra</span></em><span style="font-weight: 400;"> &mdash; have been used to treat inflammation-related conditions such as rheumatoid arthritis, type-2 </span><a href="https://selfhacked.com/blog/glucose/"><span style="font-weight: 400;">diabetes</span></a><span style="font-weight: 400;">, and cardiovascular disease [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12687534"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27175934"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21304099"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15823761"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Similarly, some preliminary animal studies have reported that mice that had their </span><em><span style="font-weight: 400;">IL1B</span></em><span style="font-weight: 400;"> genes &ldquo;deleted&rdquo; (&ldquo;</span><em><span style="font-weight: 400;">knocked out</span></em><span style="font-weight: 400;">&rdquo;) show significantly lower rates of cancer. Based on these findings, drugs that can block the activity of cytokines in the IL-1 family are currently being investigated for their potential to prevent or treat cancer [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31676788"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19181644"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10626139"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24734023"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">However, this research is still in a relatively early phase, and we would never recommend taking pharmaceutical drugs to target </span><em><span style="font-weight: 400;">IL-1B</span></em><span style="font-weight: 400;"> directly.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Furthermore, </span><strong>there is a potential downside to this approach</strong><span style="font-weight: 400;"> &mdash; which is that blocking IL-1 </span><em><span style="font-weight: 400;">too much</span></em><span style="font-weight: 400;"> can potentially suppress the immune response (by interfering with normal, healthy inflammation processes) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24146121"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><strong>Therefore, we only recommend sticking to milder, &ldquo;natural&rdquo; dietary approaches to reducing IL-1&beta; levels. Two good candidates include:</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><strong>Increasing your intake of </strong><strong><em>omega-3 polyunsaturated fatty acids</em></strong><span style="font-weight: 400;">, such as </span><strong><em>docosahexaenoic acid</em></strong><strong> (</strong><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><strong>DHA</strong></a><strong>)</strong><span style="font-weight: 400;">. DHA and other omega-3s have been reported to decrease the activity of many different pro-inflammatory cytokines, including IL-1&beta;. These compounds can be obtained from </span><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><strong>fish oil</strong></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/cod-liver-oil/"><strong>cod liver oil</strong></a><span style="font-weight: 400;">, and </span><a href="https://selfhacked.com/blog/krill-oil-benefits/"><strong>krill oil</strong></a><span style="font-weight: 400;"> supplements, as well as in fish products in general. You could also try adding </span><a href="https://selfhacked.com/blog/ghee-butter/"><strong>ghee butter</strong></a><span style="font-weight: 400;"> to your diet, which is also rich in DHA [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18541548"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p style="text-align: justify;"><strong>Drinking more </strong><a href="https://selfhacked.com/blog/green-tea/"><strong>green tea</strong></a><span style="font-weight: 400;">. Many types of tea &mdash; especially green teas &mdash; are rich in </span><em><span style="font-weight: 400;">polyphenols</span></em><span style="font-weight: 400;"> such as </span><strong><em>epigallocatechin gallate</em></strong><strong> (EGCG)</strong><span style="font-weight: 400;">, which are natural compounds that have been reported to reduce IL-1&beta; levels and activity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/14600251"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21682898"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24630969"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <p style="text-align: justify;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Increasing your intake of DHA and drinking more green tea are two relatively safe and natural dietary approaches to counteracting genetic variants that may be increasing the levels and activity of IL-1&beta;.</span></p> <h3 style="text-align: justify;"><strong>Reducing Oxidative Stress and Inflammation</strong></h3> <p style="text-align: justify;"><span style="font-weight: 400;">Although certain </span><em><span style="font-weight: 400;">IL1B</span></em><span style="font-weight: 400;"> variants can potentially increase a person&rsquo;s overall levels of IL-1&beta;, it is also important to remember that IL-1&beta; itself is primarily activated in response to cellular damage, such as from oxidative stress. It is only once it is activated that it in turn causes acute inflammation.</span></p> <p style="text-align: justify;"><strong>Therefore, another good strategy to counteract </strong><strong><em>IL1B</em></strong><strong> variants would be to fight </strong><a href="https://selfhacked.com/blog/oxidative-stress-101/"><strong>oxidative stress</strong></a><strong> and </strong><a href="https://selfhacked.com/blog/natural-ways-lower-inflammation/"><strong>reduce inflammation</strong></a><strong> at their source</strong><span style="font-weight: 400;">, thereby preventing IL-1&beta; levels from becoming elevated in the first place!</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">There are many supplements that have been reported to do one or other; however, two supplements in particular have shown promise for both reducing oxidative stress and inflammation together:</span></p> <p><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><strong>Curcumin</strong></a><strong>:</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Reduces IL-1&beta; [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23825622"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30569107"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30396035"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">] and other pro-inflammatory cytokines [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20338767"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23425071"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Fights oxidative stress (by scavenging </span><em><span style="font-weight: 400;">reactive oxygen species</span></em><span style="font-weight: 400;"> (ROS)) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15650394"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://doi.org/10.1002/jat.1517"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Alleviates systemic inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15836859"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30584274"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20018257"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20180411"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><a href="https://selfhacked.com/blog/pqq-review/"><strong><em>Pyrroloquinoline quinone</em></strong><strong> (PQQ)</strong></a><strong>:</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Reduces IL-1&beta; [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25314304"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">] and other pro-inflammatory compounds (such as </span><a href="https://selfhack.com/blog/interleukin-6/"><span style="font-weight: 400;">IL-6</span></a><span style="font-weight: 400;"> and CREB) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24231099"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Is a highly-effective anti-oxidant [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/1702437"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/8524146"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Shows significant promise for alleviating systemic inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26319019"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24231099"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28007783"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25687637"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">Therefore, you may want to consider adding these two supplements to your daily regimen.</span></p> <p style="text-align: justify;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">IL-1&beta; causes inflammation when it is activated by cell damage, such as from oxidative stress. Therefore, rather than targeting IL-1&beta; levels directly, another useful approach may be to reduce oxidative stress and alleviate inflammation in general. Curcumin and PQQ are two promising supplements that may accomplish both of these goals at the same time.</span></p> <p style="text-align: justify;">&nbsp;</p>
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102 | content_learn_more_5973925330328225_text == Based on your genotype for these SNPs, you may be slightly more likely than average to have elevated levels of IL-1β. This may also make you somewhat more susceptible to developing certain inflammation-related health conditions, such as cardiovascular and autoimmune disorders — particularly as you age. If you want to find out more about some steps you can take to potentially reduce or minimize your likelihood of developing these conditions, check out some of the recommendations in the sections below!
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rsIDs = rs1143634,rs16944,rs3136558,rs1143630,rs1143627,rs1143623
rsStatus = rs1143634,IL1B,chr2,112832813,G,A,,,33,0,Normal
rsStatus = rs16944,IL1B,chr2,112837290,A,G,,,28,11,HET
rsStatus = rs3136558,IL1B,chr2,112833698,A,G,,,35,0,Normal
rsStatus = rs1143630,IL1B,chr2,112834078,T,A,G,,32,0,Normal
rsStatus = rs1143627,IL1B,chr2,112836810,G,A,,,16,8,HET
rsStatus = rs1143623,IL1B,chr2,112838252,C,A,G,,35,0,Normal
