106 | id == 106
106 | category_id == 15
106 | category_order == 11
106 | category_name == Diet
106 | category_color == #C47AC0
106 | slug == TCF7L2-diabetes-carbs
106 | title == The Link Between Diabetes and High-Carb Foods (TCF7L2)
106 | meta_description == TCF7L2 is strongly associated with diabetes and may determine your response to carbs. Click to get gene-based diet tips.
106 | summary == <p style="text-align:justify"><strong>The <em>TCF7L2</em> gene has the strongest known association with diabetes. Variants in this gene may determine how well you respond to high-carb foods &mdash; read on to get gene-based diet tips for improved blood sugar control.</strong></p>
106 | overall_score_text == Your Response to High-Carb Foods (Based on TCF7L2)
106 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/TCF7L2--Diet.jpg
106 | author_id == 9
106 | author_name == Aleksa Ristic
106 | author_title == MS (Pharmacy)
106 | author_order == 45
106 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
106 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
106 | reviewer == None
106 | medical_reviewer_id == 11
106 | medical_reviewer_name == Puya Yazdi
106 | medical_reviewer_title == MD
106 | publish_date == 2020
106 | publish_date == 2
106 | publish_date == 28
106 | avg_rating == 5.0
106 | tags_id == 285
106 | tags_name == Carbohydrates
106 | tags_id == 127
106 | tags_name == Diabetes Type 2
106 | tags_id == 183
106 | tags_name == Diet
106 | tags_id == 282
106 | tags_name == Dietary fiber
106 | tags_id == 281
106 | tags_name == GLP-1
106 | tags_id == 283
106 | tags_name == Glycemic index
106 | tags_id == 139
106 | tags_name == Insulin
106 | tags_id == 252
106 | tags_name == Olive oil
106 | tags_id == 280
106 | tags_name == TCF7L2 gene
106 | tags_id == 284
106 | tags_name == Whole grains
106 | permissions_favorite == False
106 | permissions_rate == False
106 | content_article == <h2><strong>TCF7L2 and Glucose Metabolism</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../gene/tcf7l2/"><em><span style="font-weight: 400;">TCF7L2</span></em></a><span style="font-weight: 400;"> (transcription factor 7 like 2) gene, previously known as TCF4, codes for a vital transcription factor. It controls the expression of other genes in digestive organs such as the gut and pancreas, with a particular role in </span><a href="https://selfhacked.com/blog/glucose/"><span style="font-weight: 400;">glucose metabolism</span></a><span style="font-weight: 400;"> and insulin secretion [</span><a href="https://ghr.nlm.nih.gov/gene/TCF7L2"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16772326/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">This gene has the strongest association with type 2 diabetes observed so far. Specific variants in this gene, such as </span><a href="../../snp/rs7903146/"><span style="font-weight: 400;">rs7903146</span></a><span style="font-weight: 400;">, correlate with increased diabetes rates among all major populations [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16415884/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17563454/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22872755"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">As you are about to learn in this post, the impact of this gene on diabetes can be reduced&mdash;or worsened&mdash;by the type of food we eat.</span></p> <h3><strong>How Does TCF7L2 Affect Blood Sugar?</strong></h3> <p><span style="font-weight: 400;">From what we currently know, TCF7L2 variants can impair insulin secretion but not </span><a href="http://selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;">insulin sensitivity</span></a><span style="font-weight: 400;">. This gene controls the activity of </span><a href="https://selfhacked.com/blog/glp-1-a-hormone-that-causes-weight-loss-and-good-cognitive-effects/"><span style="font-weight: 400;">GLP-1</span></a><span style="font-weight: 400;">, an intestinal peptide that stimulates insulin secretion in response to food [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063563/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17671651/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809956/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">During and after each meal, the body signals an enhanced secretion of insulin to balance blood sugar levels. GLP-1 is one of the crucial mediators of this response, known as incretins [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17928588"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">TCF7L2 variants&mdash;such as the &ldquo;T&rdquo; allele at rs7903146&mdash;likely prevent GLP-1 from stimulating the pancreas, raising insulin levels, and reducing blood sugar after meals [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17437080/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18445358"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Foods high in sugar and quickly digestible carbs have a high glycemic index (GI) and glycemic load (GL). They drastically increase blood glucose and insulin demand, thus magnifying the impact of TCF7L2 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667467/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;"><img src="https://www.glycemicindex.com/cmsAdmin/uploads/gi_graph.gif" alt="Image result for glycemic index" width="423" height="423" /></span></p> <p><sub><span style="font-weight: 400;">Source: <a href="https://www.glycemicindex.com/about.php">https://www.glycemicindex.com</a></span></sub></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Specific TCF7L2 variants hinder GLP-stimulated insulin secretion in response to food. This effect comes to light after meals high in sugar and quickly digestible carbs.</span></p> <h3><strong>Evolutive Perspective</strong></h3> <p><span style="font-weight: 400;">The diabetes-associated "T" allele at rs7903146 is ancestral, while the other (C) evolved more recently. As we were transitioning from hunter-gatherers to agriculture-based societies, TCF7L2 adapted to carbohydrate-rich diets [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17206141"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People with the variant allele metabolized high-starch foods such as grains more efficiently, which brought them an evolutionary advantage. The ancestral "T" allele is now much less common as it doesn't "handle" modern diets well.</span></p> <h2><strong>Dietary Factors That Impact the TCF7L2-Diabetes Link</strong></h2> <p><span style="font-weight: 400;">In two studies of 4,000 participants, tailored nutritional and lifestyle interventions were able to lower or even remove the negative impact of TCF7L2 variants (rs12255372 and rs7903146) on diabetes risk. Patients were educated and motivated to reduce weight, </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> more, and improve their diets [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762036/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17437080/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Dietary advice was general: it included a reduction in calories and </span><a href="http://selfhacked.com/blog/low-carb-diet-vs-high-carb-diet/"><span style="font-weight: 400;">saturated fat</span></a><span style="font-weight: 400;"> while increasing the consumption of vegetables and other fiber-rich foods. Given the study designs, it's hard to estimate the impact of specific dietary changes on TCF7L2-associated diabetes risk.</span></p> <h3><strong>Glycemic Index and Glycemic Load</strong></h3> <p><span style="font-weight: 400;">A clinical trial of over 3,000 women took this further and examined the effect of food glycemic index (GI) and glycemic load (GL) on TCF7L2 variants:</span></p> <p><span style="font-weight: 400;">Women with the &ldquo;TT&rdquo; genotype at </span><a href="../../snp/rs12255372/"><span style="font-weight: 400;">rs12255372</span></a><span style="font-weight: 400;"> who consumed foods with the highest GI and GL had 2.7 higher diabetes rates, compared with the "GG" carriers. On the other hand, those with the lowest GI and GL had only 1.66 and 1.82 higher incidence, respectively [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667467/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The authors concluded that carbohydrate quality and quantity might modify the association between TCF7L2 variants and diabetes in women. The same likely goes for men, but studies are yet to confirm that [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667467/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">People with the &ldquo;T&rdquo; alleles at rs12255372 and rs7903146 have increased diabetes rates. The consumption of foods with high GI and GL may worsen the effects of TCF7L2 variations.</span></p> <h3><strong>Whole Grains and Dietary Fiber</strong></h3> <p><span style="font-weight: 400;">Increased consumption of whole grains and dietary fiber generally reduces the risk of diabetes, but the same may not hold for people with TCF7L2 risk alleles [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15277155/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9096978/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Namely, in a study of over 3,000 people, the intake of whole grains was inversely associated with diabetes rates only among the "CC" carriers at </span><a href="../../snp/rs7903146/"><span style="font-weight: 400;">rs7903146</span></a><span style="font-weight: 400;">. The authors concluded that "</span><em><span style="font-weight: 400;">the "T" allele negated the protective effect of whole-grain intake</span></em><span style="font-weight: 400;">" [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19149908/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A large Sweedish study followed 24,800 participants for 12 years and examined the impact of dietary fiber intake on the TCF7L2-diabetes link.</span></p> <p><span style="font-weight: 400;">People with the &ldquo;T&rdquo; allele at rs7903146 who ate less fiber had 24% higher diabetes rates, compared with the &ldquo;CC&rdquo; genotype. High fiber intake more than doubled their diabetes rates (from 24 to 56%) while having a protective effect among the &ldquo;CC&rdquo; carriers [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433658/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">According to the authors, the &ldquo;T&rdquo; allele may prevent dietary fiber from increasing GLP-1 and stimulating insulin secretion.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Increased intake of whole grains and dietary fiber reduces the risk of diabetes in general, but it may have the opposite effect among the &ldquo;T&rdquo; allele carriers at rs7903146.</span></p> <h2><strong>Your TCF7L2 Results for Response to High-Carb Foods</strong></h2> <p><strong>*5732030326866111*</strong></p> <h3><strong>SNP Summary and Table</strong></h3> <p><strong>Primary SNP:</strong></p> <p><strong><em>TCF7L2</em></strong> <a href="../../snp/rs7903146/"><strong>rs7903146</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = no association with diabetes; good response to whole grains and fiber</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = associated with diabetes; poor response to whole grains and fiber</span></li> </ul> <p><strong>Other Important SNP:</strong></p> <p><strong><em>TCF7L2</em></strong> <a href="../../snp/rs12255372/"><strong>rs12255372</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = no association with diabetes; typical response to moderate- and high-GI foods</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = associated with diabetes; poor response to moderate- and high-GI foods</span></li> </ul> <h3><strong>Population Frequency</strong></h3> <p><span style="font-weight: 400;">These two variants are almost always inherited together, which means they act as a single genetic factor.</span></p> <p><span style="font-weight: 400;">About 40% of European descendants carry one copy of the problematic &ldquo;T&rdquo; allele while 10-12% carry both copies. In East-Asian populations, this allele is much less common (2-4%).</span></p> <p><strong>*3377026932119038*</strong></p> <h2><strong>Recommendations to Balance Blood Sugar</strong></h2> <p><em><span style="font-weight: 400;">In the following section, we&rsquo;ll outline complementary approaches that may help balance blood sugar levels. If you have diabetes or any other metabolic disorder, the below strategies are not meant to replace your standard medical treatment.</span></em></p> <p><em><span style="font-weight: 400;">Make sure to consult with your doctor before making any significant changes to your day-to-day routine.</span></em></p> <p><strong>*7919177884661894*</strong></p> <h3><strong>Diet</strong></h3> <p><span style="font-weight: 400;">In general, diets rich in low-GI foods may protect against type 2 diabetes and improve insulin secretion. They may be particularly beneficial for people with TCF7L2 risk variants such as rs7903146-T [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15277155/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9096978/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">More precisely, suitable food items for the &ldquo;T&rdquo; allele carriers include [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584181/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Fish and seafood</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Eggs</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Meat and organs</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Olives and </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Non-starchy vegetables</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Nuts and seeds</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Fruits (in moderation)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Grass-fed dairy (in moderation, if tolerant)</span></li> </ul> <p><span style="font-weight: 400;">On the other hand, people with the &ldquo;C&rdquo; allele may want to cut back on animal products and increase the intake of whole grains, legumes, fruits, and vegetables.&nbsp;</span></p> <p><span style="font-weight: 400;">Everyone looking to improve blood sugar control, especially those with TCF7L2 risk variants, should avoid or minimize the intake of [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584181/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.diabetes.org/nutrition"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Sweets</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Juices and sodas with added sugar</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">White rice</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Instant breakfast cereals</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">White flour bread and pastry</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">White four and instant pasta</span></li> </ul> <h4><strong>GLP-1 Stimulants</strong></h4> <p><span style="font-weight: 400;">Olive oil, nuts, avocados, and eggs are particularly beneficial as they stimulate GLP-1 secretion and may thus lower the impact of TCF7L2 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148911/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Folks praise </span><a href="http://selfhacked.com/blog/top-15-proven-scientific-reasons-spice-life-cinnamon-references/"><span style="font-weight: 400;">cinnamon</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/9-proven-health-benefits-momordica-charantia-bitter-melon-including-risks/"><span style="font-weight: 400;">bitter melon</span></a><span style="font-weight: 400;"> as age-old remedies that may reduce blood sugar, and preliminary clinical research has confirmed their effectiveness. What&rsquo;s more, they partly work by boosting GLP-1 [</span><a href="http://ajl.sagepub.com/content/early/2012/10/09/1559827612462960.full.pdf"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901047/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.hindawi.com/journals/ecam/2013/625892/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29339109"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">People with TCF7L2 risk variants should increase the intake of low-GI foods and cut back on refined carbs and starches. Olive oil, nuts, avocados, eggs, and cinnamon may help by boosting GLP-1.</span></p> <h3><strong>Lifestyle</strong></h3> <p><span style="font-weight: 400;">Specific lifestyle adjustments may work in synergy with diet to beat the negative effect of TCF7L2. In the studies described above, weight reduction and moderate physical activity likely contributed to positive results [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370926/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17437080/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The American Diabetes Association recommends the combination of moderate aerobic and resistance training, at least 150 min/week. Also, it's crucial to avoid a sedentary lifestyle and interrupt longer periods of sitting every 30 min [</span><a href="https://care.diabetesjournals.org/content/39/11/2065"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>Supplements</strong></h3> <p><em><span style="font-weight: 400;">Keep in mind that the FDA hasn&rsquo;t approved the below supplements for the prevention or treatment of diabetes. Consult with your doctor before supplementing.</span></em></p> <p><span style="font-weight: 400;">The following supplements may lessen the effect of TCF7L2 variations by boosting GLP-1:</span></p> <ul> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/olive-leaf-extract-10-unexpected-health-benefits/"><span style="font-weight: 400;">Olive leaf extract</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163370/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/19-health-benefits-of-berberine-with-references/"><span style="font-weight: 400;">Berberine</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19945441"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/american-ginseng/"><span style="font-weight: 400;">American </span></a><a href="https://selfhacked.com/blog/ginseng/"><span style="font-weight: 400;">ginseng</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25060691"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/9-proven-health-benefits-momordica-charantia-bitter-melon-including-risks/"><span style="font-weight: 400;">Bitter melon extract</span></a><span style="font-weight: 400;"> [</span><a href="http://www.hindawi.com/journals/ecam/2013/625892/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]&nbsp;</span></li> </ul> <p><span style="font-weight: 400;">They have shown beneficial effects on blood sugar control in clinical trials. Still, the research behind them is limited and warrants further investigation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596374/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23118793"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180277/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11194526/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29339109"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p>
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106 | content_learn_more_3377026932119038_text == Your TCF7L2 variants are associated with slightly higher diabetes rates. You may not respond well to large amounts of carbohydrates, so try focusing on foods with a moderate or low glycemic index. Follow our gene-based diet tips to improve blood sugar control.
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rsIDs = rs7903146,rs12255372
rsStatus = rs7903146,TCF7L2,chr10,112998590,C,G,T,,29,0,Normal
rsStatus = rs12255372,TCF7L2,chr10,113049143,G,A,T,,41,0,Normal
