112 | id == 112
112 | category_id == 15
112 | category_order == 11
112 | category_name == Diet
112 | category_color == #C47AC0
112 | slug == FGF21-fat-keto-diet
112 | title == Do Your Genes Favor Dietary Fat? (FGF21)
112 | meta_description == FGF21 codes for a hormone with complex metabolic roles. Click to learn how its variants may impact dietary fat metabolism.
112 | summary == <p style="text-align:justify"><strong>The FGF21 gene codes for a hormone with complex roles in fat &amp; glucose metabolism. Specific FGF21 variants may correlate with a reduced preference for dietary fat and a poor response to the keto diet. Read on to get gene-based tips for fat burning!</strong></p>
112 | overall_score_text == Your Fat Preference and Metabolism Score (based on FGF21 score)
112 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/FGF21--Diet-ketogenic-diet.jpg
112 | author_id == 9
112 | author_name == Aleksa Ristic
112 | author_title == MS (Pharmacy)
112 | author_order == 45
112 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
112 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
112 | reviewer == None
112 | medical_reviewer_id == 11
112 | medical_reviewer_name == Puya Yazdi
112 | medical_reviewer_title == MD
112 | publish_date == 2020
112 | publish_date == 3
112 | publish_date == 10
112 | avg_rating == 4.75
112 | tags_id == 299
112 | tags_name == Butyrate
112 | tags_id == 303
112 | tags_name == Cold exposure
112 | tags_id == 298
112 | tags_name == Curcumin
112 | tags_id == 297
112 | tags_name == Dietary fat
112 | tags_id == 302
112 | tags_name == FGF21 gene
112 | tags_id == 244
112 | tags_name == Fish oil
112 | tags_id == 301
112 | tags_name == Keto diet
112 | tags_id == 142
112 | tags_name == Liver
112 | tags_id == 141
112 | tags_name == Metabolic Health
112 | tags_id == 140
112 | tags_name == Metabolism
112 | tags_id == 300
112 | tags_name == PPAR-alpha
112 | permissions_favorite == False
112 | permissions_rate == False
112 | content_article == <h2><strong>What is FGF21?</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../gene/fgf21/"><em><span style="font-weight: 400;">FGF21</span></em></a><span style="font-weight: 400;"> (Fibroblast growth factor 21) gene codes for a hormone with complex roles in metabolism, thermoregulation, and food preferences. The liver is the primary source of FGF21, where it regulates fat and glucose metabolism, response to </span><a href="http://selfhacked.com/blog/intermittent-fasting/"><span style="font-weight: 400;">fasting</span></a><span style="font-weight: 400;">, and more [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964258/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30198244"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665770/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">More precisely, it increases </span><a href="http://selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;">insulin sensitivity</span></a><span style="font-weight: 400;"> and promotes fatty acid oxidation. Brown fat tissue is another significant source of FGF21, which stimulates energy production and helps the body adapt to cold temperatures [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057552/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585322/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431415/figure/f1-br-0-0-890/&nbsp;%20" target="_blank" rel="noopener"><span style="font-weight: 400;"><img src="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431415/bin/br-06-05-0495-g00.jpg" alt="FGF21 glucose fat lipids metabolism" width="574" height="407" /></span></a></p> <p><span style="font-weight: 400;">Reduced activity of this hormone may play a role in obesity and other metabolic disorders. In preliminary research, FGF21 analogs have shown the potential to improve weight control, blood lipid profile, liver fat content, and </span><a href="https://selfhacked.com/blog/glucose/"><span style="font-weight: 400;">glucose</span></a><span style="font-weight: 400;"> metabolism [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912948/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431415/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079612/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18687777/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Variations in the FGF21 gene have been associated with different metabolic parameters, food preference, and response to macronutrients. In this post, we explore the impact of your variants on dietary fat preference and metabolism.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">FGF21 is a hormone with complex roles in fat and glucose metabolism, energy balance, and temperature control. Variants in the FGF21 gene correlate with different metabolic traits and food preferences.</span></p> <h2><strong>How FGF21 Variants Impact Fat Preference and Metabolism</strong></h2> <h3><strong>Dietary Preference: Fat vs. Carbs</strong></h3> <p><span style="font-weight: 400;">A 2018 study analyzed the data from over 450,000 people and found a significant association between one FGF21 SNP and macronutrient preference.</span></p> <p><span style="font-weight: 400;">Carriers of the minor &ldquo;A&rdquo; allele at </span><a href="../../snp/rs838133/"><span style="font-weight: 400;">rs838133</span></a><span style="font-weight: 400;"> consumed less fat and more carbohydrates. Additionally, these subjects had lower body fat but higher waist-hip ratio and blood pressure [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912948/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Another trial of 38,000 participants confirmed the link between rs838133 and lower fat/higher carb preference [</span><a href="https://academic.oup.com/hmg/article/22/9/1895/620909"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">One more SNP in this gene showed a similar trend in a study of 33,500 subjects. People with the minor &ldquo;G&rdquo; allele at </span><a href="../../snp/rs838145/"><span style="font-weight: 400;">rs838145</span></a><span style="font-weight: 400;"> consumed less fat and more carbs [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652928/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">FGF21 variants have shown a robust link with increased preference for sweets and alcohol consumption, and we'll cover this topic in detail in another post [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912948/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28467924/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">People with the FGF21 variants, such as rs838133-A and rs838145-G, tend to eat less fat and more carbs. They may also have higher blood pressure and waist-hip ratio.</span></p> <h3><strong>Fat Metabolism and the Keto Diet</strong></h3> <p><span style="font-weight: 400;">As mentioned, FGF21 plays crucial roles in fat metabolism and fasting response. In studies on mice, it boosted fatty acid oxidation and the production of </span><a href="https://www.selfhacked.com/blog/ketone-bodies/"><span style="font-weight: 400;">ketone bodies</span></a><span style="font-weight: 400;">, helping them adapt to the </span><a href="https://selfhacked.com/blog/ketogenic-diet-ketosis-health-benefits-physiology-genetics/"><span style="font-weight: 400;">ketogenic diet</span></a><span style="font-weight: 400;"> or starvation [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18687777/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17550778/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705613/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">When placed on the keto diet, mice with removed FGF21 gained weight and suffered from fatty liver and glucose intolerance. They weren't able to produce enough ketone bodies. The researchers suggested that FGF21 is essential for the metabolic adaptation to the keto diet and extended periods of fasting [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17550778/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057552/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Since the above variants likely reduce FGF21 function and hinder fat burning, they may not go well with high-fat diets, especially the keto diet [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749404/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756759/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, human studies have been less consistent: some of them found that FGF21 doesn't drive the production of ketone bodies and may not be among the critical factors for the keto diet metabolic effects [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665770/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18680716/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25133427/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Additionally, lower FGF21 function may not have the same effects as a complete lack of this hormone, which caused an inadequate response to the keto diet in mice.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">According to animal research, the lack of FGF21 causes a poor metabolic response to the keto diet. People with the above variants might face the same issue, but there's no clinical evidence to support this.</span></p> <h3><strong>FGF21 and PPAR-alpha</strong></h3> <p><span style="font-weight: 400;">Peroxisome proliferator-activated receptor (PPAR)-alpha is a transcription factor that activates FGF21 and increases its production. These two work hand in hand to boost fat metabolism and insulin sensitivity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19531592/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964258/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The interaction between </span><a href="https://selfhacked.com/blog/about-ppar-alpha-and-natural-ways-to-activate-it/"><span style="font-weight: 400;">PPAR-a</span></a><span style="font-weight: 400;"> and FGF21 may be essential for metabolic adaptation to fasting and ketosis, but once again, the research in humans is limited [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964258/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057552/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><em><span style="font-weight: 400;">Did you know?</span></em><span style="font-weight: 400;"> The lipids from breast milk stimulate the interaction between PPAR-a and FGF21 in infants. According to a group of Japanese researchers, this effect helps create &ldquo;epigenetic memory that persists into adulthood&rdquo; with lasting metabolic benefits [</span><a href="https://www.nature.com/articles/s41467-018-03038-w/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your FGF21 Results for Fat Preference and Metabolism</strong></h2> <p><strong>*7347361430423727*</strong></p> <h3><strong>SNP Summary and Table</strong></h3> <p><strong><em>FGF21</em></strong> <a href="../../snp/rs838133/"><strong>rs838133</strong></a><span style="font-weight: 400;">:</span></p> <ul> <li><span style="font-weight: 400;">&ldquo;G&rdquo; = doesn&rsquo;t correlate with dietary fat preference and metabolism</span></li> <li><span style="font-weight: 400;">&ldquo;A&rdquo; = correlates with lower dietary fat preference and potentially with impaired metabolism</span></li> </ul> <p><strong><em>FGF21</em></strong> <a href="../../snp/rs838145/"><strong>rs838145</strong></a>:</p> <ul> <li><span style="font-weight: 400;">&ldquo;A&rdquo; = doesn&rsquo;t correlate with dietary fat preference and metabolism</span></li> <li><span style="font-weight: 400;">&ldquo;G&rdquo; = correlates with lower dietary fat preference and potentially with impaired metabolism</span></li> </ul> <h3><strong>Population Frequency</strong></h3> <p><span style="font-weight: 400;">These two variants are almost always inherited together, meaning they act as a single genetic factor. Among European descendants, 47-48% of the population carry one and 17-18% carry both copies of the &ldquo;problematic&rdquo; minor alleles.</span></p> <p><span style="font-weight: 400;">Interestingly, their frequencies in African populations don&rsquo;t match at all: around 46% of people carry a minor allele at rs838133 and only around 3% at rs838145.</span></p> <p><strong>*3517871056127419*</strong></p> <h2><strong>Recommendations to Improve Fat Metabolism</strong></h2> <p><em><span style="font-weight: 400;">In the following section, we&rsquo;ll outline complementary approaches that may help improve fat metabolism. If you have a diagnosed metabolic disorder, the below strategies are not meant to replace your standard medical treatment.</span></em></p> <p><em><span style="font-weight: 400;">Make sure to consult with your doctor before making any significant changes to your day-to-day routine.</span></em></p> <p><strong>*5907824791479401*</strong></p> <h3><strong>Diet</strong></h3> <p><span style="font-weight: 400;">Clinical research is yet to elucidate the link between FGF21 and the response to the keto diet in humans. Until then, people with the discussed variants may want to avoid keto and other high-fat diets due to impaired FGF21 activity.</span></p> <p><span style="font-weight: 400;">That doesn't mean your body prefers high-carb diets either. Stick with a balanced, diverse diet and try to get your nutrients from whole, unprocessed foods.</span></p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Cold Exposure</strong></h4> <p><span style="font-weight: 400;">FGF21 partakes in body temperature control. In response to cold, the fat tissue releases higher amounts of this hormone. A study on human volunteers confirmed that </span><a href="https://selfhacked.com/blog/12-reasons-embrace-cold/"><span style="font-weight: 400;">cold exposure</span></a><span style="font-weight: 400;"> boosts FGF21. It may also help indirectly by stimulating PPAR-a [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22302939/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21373720/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.sciencedirect.com/science/article/pii/S1550413114000060"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553052/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Indeed, studies show that cold exposure &ldquo;activates&rdquo; the fat tissue and increases calorie expenditure. It boosts </span><a href="https://selfhacked.com/blog/adiponectin/"><span style="font-weight: 400;">adiponectin</span></a><span style="font-weight: 400;">, a protein that increases fat burning and blood sugar control. Low levels of adiponectin are associated with obesity and </span><a href="https://www.selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;">insulin resistance</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16936205"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19303978"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12436346"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726172/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><strong>Exercise</strong></h4> <p><span style="font-weight: 400;">FGF21 blood levels increased significantly after a treadmill run in healthy volunteers. Higher-intensity aerobic </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> may be particularly effective for boosting FGF21 and, in turn, burning more fat [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646740/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">According to animal research, exercise also boosts PPAR-alpha and reduces the negative metabolic impact of aging [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21618160"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12384451"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785847/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Regular physical activity is one of your best tools for improving metabolic health and weight control, and it&rsquo;s essential if you carry the FGF21 variants.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Curcumin</strong></h4> <p><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">Curcumin</span></a><span style="font-weight: 400;"> is a potent anti-inflammatory component of turmeric. In mice on a high-fat diet, it boosted FGF21 production in the liver and increased sensitivity to its effects [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27967217"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Clinical trials suggest that curcumin can reduce markers of liver injury and liver fat buildup in people non-alcoholic fatty liver disease (NAFLD) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27270872?dopt=Abstract"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30653773?dopt=Abstract"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><strong>Butyrate</strong></h4> <p><a href="http://selfhacked.com/blog/health-benefits-butyrate-derivatives-sodium-butyrate-phenylbutyrate-trybutyrine-butyric-acid-butyrate-prodrugs-butyrate-producing-bacteria/"><span style="font-weight: 400;">Butyrate</span></a><span style="font-weight: 400;"> is a short-chain fatty acid (SCFA) produced by the </span><a href="https://selfhacked.com/blog/probiotics-good-bacteria/"><span style="font-weight: 400;">probiotics</span></a><span style="font-weight: 400;"> in our gut. According to preliminary research, it can increase FGF21 and thus improve fat oxidation&nbsp; [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644874/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/srep37589"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314370/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A small clinical trial confirmed that SCFAs support fat burning and energy production [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28539646"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><strong>Fish Oil/Omega3</strong></h4> <p><span style="font-weight: 400;">Omega-3 fatty acids found in </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">fish oil</span></a><span style="font-weight: 400;">, EPA and DHA, are natural PPAR-a activators, meaning they may boost FGF21 activity [</span><a href="https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-13-17"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A solid body of clinical evidence voices their metabolic benefits, such as reducing </span><a href="https://www.selfhacked.com/blog/triglycerides/"><span style="font-weight: 400;">triglycerides</span></a><span style="font-weight: 400;"> and high blood pressure [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21975919"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9129504"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054797/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>FGF21 in Drug Development</strong></h3> <p><span style="font-weight: 400;">This hormone is a hot topic in drug development, and many FGF21 analogs are being researched for their potential to help with obesity, insulin resistance, fatty liver, and more [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431415/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079612/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Scientists are developing gene therapy developed to increase FGF21 expression in the long run. Their tests on animals showed promising metabolic and anti-aging benefits, but the research is still young [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079533/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p>
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112 | content_learn_more_3517871056127419_text == Your FGF21 variants are associated with a slightly reduced preference for dietary fat. According to preliminary research, you might not handle high-fat diets well. Avoid practicing the keto diet and consider our gene-based suggestions to improve fat metabolism. Keep reading for more details.
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rsIDs = rs838133,rs838145
rsStatus = rs838133,FUT1,chr19,48756272,A,C,G,T,40,1,HET
rsStatus = rs838145,IZUMO1,chr19,48745473,G,A,C,,17,11,HET
