127 | id == 127
127 | category_id == 15
127 | category_order == 11
127 | category_name == Diet
127 | category_color == #C47AC0
127 | slug == STAT3-diet
127 | title == The Link Between Weight Gain, Saturated Fats, & Genetics (STAT3)
127 | meta_description == STAT3 plays many important roles in the body. Genetic variants may even affect how the body responds to certain fats.
127 | summary == <p style="text-align:justify"><strong>The STAT3 gene has many important functions in the body, including roles in the immune system and inflammatory response. Interestingly, certain variants of this gene are associated with increased weight gain from eating specific types of fat. Find out how STAT3 may affect your diet and who may be affected.</strong></p>
127 | overall_score_text == Your Diet Score (Based On STAT3 Gene)
127 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/STAT3--Fats.jpg
127 | author_id == 8
127 | author_name == Mathew Eng
127 | author_title == PharmD
127 | author_order == 40
127 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Mathew.jpg
127 | author_intro == <p><strong>Mathew received his PharmD from the University of Hawaii and an undergraduate degree in Biology from the University of Washington.</strong></p>    <p>Mathew is a licensed pharmacist with clinical experience in oncology, infectious disease, and diabetes management. He has a passion for personalized patient care and believes that education is essential to living a healthy life. His goal is to motivate individuals to find ways to manage their chronic conditions.</p>
127 | reviewer == None
127 | medical_reviewer_id == 11
127 | medical_reviewer_name == Puya Yazdi
127 | medical_reviewer_title == MD
127 | publish_date == 2020
127 | publish_date == 3
127 | publish_date == 21
127 | avg_rating == 5.0
127 | tags_id == 183
127 | tags_name == Diet
127 | tags_id == 116
127 | tags_name == Insulin Resistance
127 | tags_id == 140
127 | tags_name == Metabolism
127 | tags_id == 165
127 | tags_name == Obesity
127 | tags_id == 306
127 | tags_name == Saturated fat
127 | tags_id == 210
127 | tags_name == STAT3 Gene
127 | permissions_favorite == False
127 | permissions_rate == False
127 | content_article == <table style="width: 90%; border-collapse: collapse; margin-left: auto; margin-right: auto;" border="1" cellpadding="10"> <tbody> <tr> <td style="width: 100%; text-align: justify;"><strong>Note:</strong><span style="font-weight: 400;"> The </span><em><span style="font-weight: 400;">STAT3</span></em><span style="font-weight: 400;"> gene is mentioned in the <em>SelfDecode</em>&rsquo;s <em><strong><a href="https://get.selfdecode.com/gene-reports/nm/thyroid/" target="_blank" rel="noopener">Thyroid DNA Wellness Report</a></strong></em>. If you&rsquo;re curious to learn more about how your genetics could be impacting thyroid health, we recommend checking the report out</span><span style="font-weight: 400;">!</span></td> </tr> </tbody> </table> <p>&nbsp;</p> <h2><strong>The <em>STAT3 </em>Gene</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../gene/stat3/"><em><span style="font-weight: 400;">STAT3</span></em><span style="font-weight: 400;"> gene</span></a><span style="font-weight: 400;"> is responsible for producing a protein with the same name, STAT3.</span></p> <p><span style="font-weight: 400;">The STAT3 protein is a </span><a href="https://selfhacked.com/category/transcription-factors/"><span style="font-weight: 400;">transcription factor</span></a><span style="font-weight: 400;">, which are a group of proteins that play a key role in regulating the expression of other genes, especially ones involved in the immune system [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050093/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Certain variations in the </span><em><span style="font-weight: 400;">STAT3</span></em><span style="font-weight: 400;"> gene can increase or decrease the activity of the STAT3 protein, potentially leading to several negative health effects [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17881745"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29873274"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">For example, research has identified </span><em><span style="font-weight: 400;">STAT3</span></em><span style="font-weight: 400;"> variants that are associated with cancer, </span><a href="../article/stat3-autoimmune-thyroid-disorders-71"><span style="font-weight: 400;">autoimmune thyroid disorders</span></a><span style="font-weight: 400;">, and </span><a href="../article/stat3-inflammatory-bowel-disease-70"><span style="font-weight: 400;">inflammatory bowel disease</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29873274"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824579/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574810/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Another interesting association is the link between </span><em><span style="font-weight: 400;">STAT3</span></em><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/what-are-fatty-acids/"><span style="font-weight: 400;">dietary fats</span></a><span style="font-weight: 400;">, which will be the focus of this article.&nbsp;</span></p> <p><span style="font-weight: 400;">There is some evidence that certain </span><em><span style="font-weight: 400;">STAT3</span></em><span style="font-weight: 400;"> variants may alter how the body processes dietary fats, potentially increasing the risk of obesity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19776189"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhack.com/blog/natural-stat3-inhibitors/"><span style="font-weight: 400;">Read more about STAT3</span></a><span style="font-weight: 400;">.</span></p> <h2><strong><em>STAT3</em> and Dietary Fats</strong></h2> <p><span style="font-weight: 400;">There is evidence that the STAT3 protein also plays an important part in </span><a href="http://selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;">insulin sensitivity</span></a><span style="font-weight: 400;"> and body weight regulation, likely due to interactions with </span><a href="https://www.selfdecode.com/gene/tlr4/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">TLR4</span></a><span style="font-weight: 400;"> and </span><a href="http://selfhacked.com/blog/all-about-leptin-its-role-in-chronic-inflammation-cfs-and-weight/"><span style="font-weight: 400;">leptin</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19776189"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">This may help explain why certain variants of the </span><em><span style="font-weight: 400;">STAT3</span></em><span style="font-weight: 400;"> gene are associated with obesity and insulin sensitivity, according to some studies [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19776189"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139842/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">More specifically, these genetic variants may disrupt or lower the activity of </span><em><span style="font-weight: 400;">STAT3</span></em><span style="font-weight: 400;">, which can increase the risk of insulin resistance or abdominal obesity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19776189"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139842/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>Who Is Affected?</strong></h3> <h4><strong>Obesity</strong></h4> <p><span style="font-weight: 400;">A study looked at the genetic data of 1,754 French adults who were followed for 7.5 years [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19776189"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Researchers found that the following variants were associated with an increased risk of abdominal obesity, but only in men [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19776189"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><a href="../../snp/rs8069645/"><span style="font-weight: 400;">rs8069645</span></a><span style="font-weight: 400;"> (&ldquo;G&rdquo; allele)&nbsp;</span></li> <li style="font-weight: 400;"><a href="../../snp/rs744166/"><span style="font-weight: 400;">rs744166</span></a><span style="font-weight: 400;"> (&ldquo;G&rdquo; allele)&nbsp;</span></li> <li style="font-weight: 400;"><a href="../../snp/rs1053005/"><span style="font-weight: 400;">rs1053005</span></a><span style="font-weight: 400;"> (&ldquo;C&rdquo; allele)</span></li> <li style="font-weight: 400;"><a href="../../snp/rs2293152/"><span style="font-weight: 400;">rs2293152</span></a><span style="font-weight: 400;"> (&ldquo;CC&rdquo; genotype)</span></li> </ul> <p><span style="font-weight: 400;">According to the study, men carrying two risk alleles have about double the risk of abdominal obesity compared to those carrying only one risk allele or less [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19776189"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">On top of that, researchers found that eating a diet high in </span><a href="https://selfhack.com/blog/saturatedfats-low-carb-diet-vs-high-carb-diet/"><span style="font-weight: 400;">saturated fats</span></a><span style="font-weight: 400;"> may further increase the risk of abdominal obesity by as much as 32%, but only for those carrying multiple risk alleles [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19776189"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Interestingly enough, other types of fats, such as </span><a href="https://selfhacked.com/blog/mufas-health-benefits-monounsaturated-fats/"><span style="font-weight: 400;">monounsaturated</span></a><span style="font-weight: 400;"> and polyunsaturated fats, do not appear to have this same effect that saturated fats do [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19776189"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Four different STAT3 variants are associated with abdominal obesity in men, according to a study of French people.</span> In addition, a diet high in saturated fats may further increase the risk of obesity in those carrying risk alleles.</span></p> <h4><strong>Insulin Resistance</strong></h4> <p><span style="font-weight: 400;">The same previously mentioned French study also looked at the effects of </span><em><span style="font-weight: 400;">STAT3</span></em><span style="font-weight: 400;"> variants on </span><a href="https://selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;">insulin resistance</span></a><span style="font-weight: 400;">.</span></p> <p><span style="font-weight: 400;">Researchers found that the &lsquo;G&rsquo; allele of </span><strong>rs744166</strong><span style="font-weight: 400;"> along with the &lsquo;C&rsquo; alleles of </span><strong>rs1053005 </strong><span style="font-weight: 400;">and</span><strong> rs2293152 </strong><span style="font-weight: 400;">were associated with insulin resistance, but this time only in females [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19776189"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">For example, women who have the &lsquo;CC&rsquo; genotype in </span><strong>rs2293152 </strong><span style="font-weight: 400;">may have up to 3 times higher risk of developing insulin resistance compared to other genotypes, according to the study [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19776189"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The above variants are also linked to insulin resistance, but only in women.</span></p> <p>&nbsp;</p> <h2><strong>Your <em>STAT3</em> Results for Dietary Fats</strong></h2> <p><em><span style="font-weight: 400;">You can see your genotypes for STAT3 in the table below. However, keep in mind that these associations are based on studies from certain ethnic populations &mdash; so you should interpret your results with caution if you are not descended from one of these specific groups!</span></em></p> <p>*8205547116999321*</p> <h3><span style="font-weight: 400;">SNP Summary and Table</span></h3> <p><strong>Primary SNPs:</strong></p> <p><strong>STAT3 rs8069645</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = No association with dietary fats</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with abdominal obesity and increased weight gain from saturated fats</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">This association was only found in men from a French population</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">About 12% of people worldwide have the &lsquo;GG&rsquo; genotype (highest risk)</span></li> </ul> <p><strong>STAT3 rs744166</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = No association with dietary fats</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with abdominal obesity and increased weight gain from saturated fats</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">This association was only found in men from a French population</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">About 28% of people worldwide have the &lsquo;GG&rsquo; genotype (highest risk)</span></li> </ul> <p><strong>STAT3 rs1053005</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = No association with dietary fats</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with abdominal obesity and increased weight gain from saturated fats</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">This association was only found in men from a French population</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">About 10% of people worldwide have the &lsquo;CC&rsquo; genotype (highest risk)</span></li> </ul> <p><strong>STAT3 rs2293152</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with abdominal obesity and increased weight gain from saturated fats</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = No association with dietary fats</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">This association was only found in men from a French population</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">About 45% of people worldwide have the &lsquo;CC&rsquo; genotype (highest risk)</span></li> </ul> <p>*1192981116213034*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Improve Weight Control</strong></h2> <p><em><span style="font-weight: 400;">Talk to your doctor before implementing any of the following strategies. There may be unexpected interactions with your current medications or health conditions.&nbsp;</span></em></p> <p><em><span style="font-weight: 400;">None of these recommendations should ever be used to replace any of the treatments or medications that your doctor gives you.</span></em></p> <p>*8572408412777557*</p> <p><span style="font-weight: 400;">Research suggests that </span><em><span style="font-weight: 400;">STAT3</span></em><span style="font-weight: 400;"> variants that impair or reduce the activity of the STAT3 protein may be connected to obesity and poor response to dietary fats.</span></p> <p><span style="font-weight: 400;">However, imbalances in STAT3 have been linked to a number of health conditions. For example, high STAT3 activity is linked to autoimmune disorders and cancer, while low activity is associated with immune deficiencies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824579/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710320/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Regular Exercise</strong></h4> <p><span style="font-weight: 400;">Among the many health benefits of </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">physical exercise</span></a><span style="font-weight: 400;"> is an increase in fat metabolism (fat burning) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872299/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008806/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">There is also evidence that exercise may be a healthy way to increase the expression of </span><em><span style="font-weight: 400;">STAT3</span></em><span style="font-weight: 400;">, especially in older adults [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18729804"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">While any exercise is better than nothing, certain forms of exercise may be better than others at burning fat, according to research [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008806/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">For example, there&rsquo;s some evidence that aerobic exercise in a fasted state burns significantly more fat than in a fed state [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27609363"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Research also suggests that high-intensity interval training may increase fat metabolism and reduce abdominal fat better than other types of aerobic exercise [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991639/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Nonetheless, any kind of regular moderate to vigorous exercise will provide a multitude of health benefits, such as reducing the risk of heart disease, improving mental health, and improving overall well being [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172294/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19521110"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26524568"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>Diet</strong></h3> <h4><strong>Choosing The Right Fats</strong></h4> <p><span style="font-weight: 400;">As discussed, certain </span><em><span style="font-weight: 400;">STAT3</span></em><span style="font-weight: 400;"> variants may predispose some individuals to gaining more weight from consuming </span><a href="https://selfhack.com/blog/saturatedfats-low-carb-diet-vs-high-carb-diet/"><span style="font-weight: 400;">saturated fats</span></a><span style="font-weight: 400;"> compared to others [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19776189"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Those carrying these risk alleles would likely benefit from avoiding foods high in saturated fats, such as [</span><a href="https://www.hsph.harvard.edu/nutritionsource/what-should-you-eat/fats-and-cholesterol/types-of-fat/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Pork, bacon, and sausage</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Coconut oil, butter, ghee, cheese, and other dairy products made from whole or reduced-fat milk</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Many types of fast food</span></li> </ul> <p><span style="font-weight: 400;">Instead of saturated fats, moderate amounts of </span><a href="https://selfhacked.com/blog/mufas-health-benefits-monounsaturated-fats/"><span style="font-weight: 400;">monounsaturated</span></a><span style="font-weight: 400;"> or polyunsaturated fats may be a healthier choice [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577766/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some foods rich in unsaturated fats include [</span><a href="https://medlineplus.gov/ency/patientinstructions/000747.htm"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.heart.org/en/healthy-living/healthy-eating/eat-smart/fats/polyunsaturated-fats"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Fish, including salmon, trout, and mackerel</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Sunflower seeds</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Walnuts</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Flax seeds or flax oil</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Soybean oil</span></li> <li style="font-weight: 400;"><a href="https://www.selfhacked.com/blog/safflower-oil/"><span style="font-weight: 400;">Safflower oil</span></a></li> </ul>
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127 | content_learn_more_1192981116213034_text == Based on the variants we looked at, your STAT3 genotype is somewhat associated with obesity and increased weight gain from saturated fats. However, this doesn't necessarily reflect your overall response to dietary fats — just one gene related to it. Lifestyle and diet changes may help. Keep scrolling to find out more.
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rsIDs = rs2293152,rs1053005,rs744166,rs8069645
rsStatus = rs2293152,STAT3,chr17,42329511,G,A,C,T,45,0,Normal
rsStatus = rs1053005,STAT3,chr17,42313892,T,C,,,23,19,HET
rsStatus = rs744166,STAT3,chr17,42362183,A,C,G,,21,0,Normal
rsStatus = rs8069645,STAT3,chr17,42342884,A,C,G,T,26,1,HET
