14 | id == 14
14 | category_id == 5
14 | category_order == 3
14 | category_name == Inflammation
14 | category_color == #C47AC0
14 | slug == lectin-sensitive-genes-CNR1
14 | title == How to Tell if You’re Lectin Sensitive Using Your Genetic Data (CNR1)
14 | meta_description == Personalized genetics blog article
14 | summary == <p><strong>Do you have inflammation, digestive problems, brain fog, migraines, or daytime fatigue that your doctor just can&rsquo;t explain? If you have the risk allele&nbsp;in this unexpected gene, lectins may be responsible.</strong></p>
14 | overall_score_text == Lectin Sensitivity (based on CNR1 gene)
14 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/How-to-Know-if-Lectins-Are-Bad-for-You-CNR1_JPG.jpg
14 | author_id == 1
14 | author_name == Jasmine Foster
14 | author_title == BSc, BEd
14 | author_order == 36
14 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
14 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
14 | reviewer_id == 2
14 | reviewer_name == Joe Cohen
14 | reviewer_title == BS
14 | medical_reviewer_id == 11
14 | medical_reviewer_name == Puya Yazdi
14 | medical_reviewer_title == MD
14 | publish_date == 2019
14 | publish_date == 8
14 | publish_date == 19
14 | avg_rating == 5.0
14 | tags_id == 33
14 | tags_name == Autoimmunity
14 | tags_id == 34
14 | tags_name == Brain Fog
14 | tags_id == 35
14 | tags_name == CNR1 Gene
14 | tags_id == 23
14 | tags_name == Food Sensitivity
14 | tags_id == 24
14 | tags_name == Inflammation
14 | tags_id == 32
14 | tags_name == Lectins
14 | permissions_favorite == False
14 | permissions_rate == False
14 | content_article == <p style="text-align: justify;">*9857449440334194*</p> <h3 style="text-align: justify;"><span style="font-weight: 400;">Why is CNR1 Important?</span></h3> <p style="text-align: justify;"><span style="font-weight: 400;">CNR1 codes for cannabinoid receptor 1 (CB1), which binds the cannabinoids in the brain, gut, and other tissues. SNPs in this gene can make you more or less susceptible to inflammatory bowel disease (IBD), and people with risk alleles are likely to have worse IBD than those without. This association suggests a role for CNR1 in maintaining the gut barrier and preventing harmful lectins from entering the bloodstream [</span><a href="https://www.ncbi.nlm.nih.gov/gene/1268"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009453"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">CNR1 rs1049353 is also associated with:</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">Protection from stress [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817535/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Response to antidepressants [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18579347"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Likelihood of becoming dependent on </span><span style="font-weight: 400;">marijuana</span><span style="font-weight: 400;"> or alcohol [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769509/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22085192"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Fat deposition in obese people [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17873324"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827795/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <h2 style="text-align: justify;"><span style="font-weight: 400;">Your Genetic Results for Sensitivity Risk</span></h2> <h3 style="text-align: justify;"><span style="font-weight: 400;">Important SNPs</span></h3> <p style="text-align: justify;"><strong>CNR1 rs1049353:</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Decreased risk of lectin sensitivity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of lectin sensitivity</span></li> </ul> <p style="text-align: justify;">*7069146880430872*</p> <p style="text-align: justify;">*9857449440334194*</p> <h2 style="text-align: justify;"><span style="font-weight: 400;">How Does CNR1 Cause Problems?</span></h2> <h3 style="text-align: justify;"><span style="font-weight: 400;">Gut Inflammation</span></h3> <p style="text-align: justify;"><span style="font-weight: 400;">CNR1 rs1049353 has recently been linked to inflammatory bowel disease, or IBD. More specifically, the T allele at rs1049353 can make a person less susceptible to </span><a href="https://selfhacked.com/blog/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections/"><span style="font-weight: 400;">ulcerative colitis</span></a><span style="font-weight: 400;">; it may also decrease the riks of developing Crohn&rsquo;s disease before 40 years of age. Although this underactive variant protects from IBD, it may worsen the symptoms in people already suffering from this condition. A study in mice found that those lacking <em>CNR1</em> had more severe colitis [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829088/">R</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC385396/">R</a></span><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">People with IBD tend to have increased intestinal permeability; that is, more compounds are able to cross from the intestine into the bloodstream. People with IBD also have immune systems which are more reactive to lectins; their antibodies may bind to lectin antigens that closely resemble human proteins, thereby triggering autoimmunity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366711/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055235/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Meanwhile, a lectin avoidance diet reduced symptoms in 800 people with autoimmune diseases. No single study has connected all of these dots, but Joe&rsquo;s observations of his clients strongly suggest that CNR1, inflammatory disease, and lectins are closely linked [</span><a href="http://circ.ahajournals.org/content/129/Suppl_1/AP354"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400; display: block; border-left: 2px solid #4569fa; padding: 20px; background-color: #e8ebfc;">Variants of CNR1 may increase the severity of inflammatory bowel disease (IBD) and promote other forms of autoimmunity.</span></p> <h3 style="text-align: justify;"><span style="font-weight: 400;">Adiponectin: the Missing Link</span></h3> <p><span style="font-weight: 400;">Animal and clinical studies suggest that cannabinoids (via CB1) impair fat burning and reduce <a href="https://selfhacked.com/blog/adiponectin/">adiponectin</a> levels [<a href="https://www.ncbi.nlm.nih.gov/pubmed/14770190/">R</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/30129173/">R</a>]. In a 305 subjects trial, those with rs1049353-T had higher adiponectin, compared with the "C" allele carriers [<a href="https://pubmed.ncbi.nlm.nih.gov/21892520/">R</a>].</span></p> <p>Adiponectin has beneficial metabolic effects, but according to a recent paper, it may also be a marker of food sensitivity [<a href="https://www.ahajournals.org/doi/abs/10.1161/circ.129.suppl_1.p354" target="_blank" rel="noopener">R</a>]. One possibility is that elevated adiponectin indicates lower CB1 activity, associated with gut inflammation and autoimmunity [<span style="font-weight: 400;"><a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009453">R</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055235/">R</a>].</span></p> <h3 style="text-align: justify;"><span style="font-weight: 400;">Possible Role of the Th1/Th17 response</span></h3> <p><span style="font-weight: 400;">The Th1 and Th17 responses are associated with food sensitivities, as well as with diggestive issues such as <a href="https://selfhacked.com/blog/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections/" target="_blank" rel="noopener">IBD</a> and <a href="https://selfhacked.com/blog/causes-ibs-general-gut-dysfunction/" target="_blank" rel="noopener">IBS</a>. Their excessive activation produces too many cytokines, which cause inflammation in the gut. Moreover, an overactive immune system is more likely to attack not only foreign microbes, but also harmless food-based components [<a href="https://pubmed.ncbi.nlm.nih.gov/12839120/" target="_blank" rel="noopener">R</a>, <a href="https://link.springer.com/chapter/10.1007%2F978-1-4614-0998-4_15">R</a>,<a href="https://www.ncbi.nlm.nih.gov/pubmed/23651166">&nbsp;R</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/24780949">R</a>,<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266036/">&nbsp;R</a>].</span></p> <p><span style="font-weight: 400;">Interestingly, research in animals and cells shows that the <a href="https://selfhacked.com/blog/49-ways-increase-natural-cannabinoids-without-smoking-pot-including-ways-decrease-cannabinoids/" target="_blank" rel="noopener">cannabinoids</a> anandamide (which is naturally produced in the body), <a href="https://selfhacked.com/blog/cannabidiol-cbd/" target="_blank" rel="noopener">CBD</a>, and <a href="https://selfhacked.com/blog/tetrahydrocannabinol-thc/" target="_blank" rel="noopener">THC</a> suppress the Th1 and Th17 responses by activating both CB1 and CB2 receptors. Cannabinoids may be less effective in carriers of the underactive "T" variant at rs1049353 [<a href="https://pubmed.ncbi.nlm.nih.gov/27694494/" target="_blank" rel="noopener">R</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/14741435/" target="_blank" rel="noopener">R</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712515/" target="_blank" rel="noopener">R</a>].</span></p> <h2 style="text-align: justify;"><span style="font-weight: 400;">Recommendations to Prevent or Manage Intolerance</span></h2> <p><span style="font-weight: 400;">Lectin sensitivity shares symptoms with many other conditions, so it's essential that you talk to your doctor about your genetic data&mdash;before making significant changes&mdash;if you think you're intolerant. Together, you can decide whether the diet, supplements, and lifestyle changes here are right for you.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Because so many genes and environmental factors contribute to lectin sensitivity, there is an equally broad spectrum of strategies for preventing its symptoms.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">*2355824061353302*</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">We recommend trying the Lectin Avoidance Diet to see if your symptoms improve; this will confirm whether you&rsquo;re really sensitive to lectins. If you are, try adding some of the other strategies below to your routine to clear up any remaining inflammation. Health is on the horizon!</span></p> <h3 style="text-align: justify;"><span style="font-weight: 400;">Diet</span></h3> <h4 style="text-align: justify;">Lectin Avoidance Diet</h4> <p style="text-align: justify;"><span style="font-weight: 400;">A study of 800 autoimmune patients evaluated a diet with no grains, sprouted grains, pseudo-grains, beans and legumes, soy, peanuts, cashews, nightshades, melons and squashes, non-Southern European cow milk products (Casein A1), and grain/bean-fed animals.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Most of these patients got their </span><a href="http://selfhacked.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">TNF-alpha</span></a><span style="font-weight: 400;"> (an inflammatory molecule) levels reduced to normal after 6 months on this diet [</span><a href="http://circ.ahajournals.org/content/129/Suppl_1/AP354"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Joe has written extensively on his Lectin Avoidance Diet protocol, which he uses to manage his genetic sensitivity. Check out </span><a href="https://selfhacked.com/blog/elimination-diet-safest-foods-people-sensitive-everything/"><span style="font-weight: 400;">this deep dive into the theory behind the diet</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/assigning-inflammation-scores-foods/"><span style="font-weight: 400;">this list of the best and worst foods</span></a><span style="font-weight: 400;"> for sensitive people for more information.</span></p> <h4 style="text-align: justify;">Reduce Gut Permeability &amp; Inflammation</h4> <p style="text-align: justify;"><span style="font-weight: 400;">One of the best things you can do to reduce gut permeability and prevent lectins from entering your bloodstream is to eat </span><a href="https://selfhacked.com/blog/what-is-resistant-starch-sources-how-to-increase-diet/"><span style="font-weight: 400;">resistant starch</span></a><span style="font-weight: 400;"> and other prebiotic foods. These will promote healthy gut flora that produce </span><a href="http://selfhacked.com/blog/health-benefits-butyrate-derivatives-sodium-butyrate-phenylbutyrate-trybutyrine-butyric-acid-butyrate-prodrugs-butyrate-producing-bacteria/"><span style="font-weight: 400;">butyrate</span></a><span style="font-weight: 400;">, which in turn nourishes your intestines [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15139502"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.pnas.org/content/early/2014/01/03/1322269111.abstract"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906513/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4>Avoid Caffeinated Drinks</h4> <p style="text-align: justify;"><span style="font-weight: 400;">CB1 activity stimulates </span><a href="https://selfhacked.com/blog/adenosine-health-effects/"><span style="font-weight: 400;">adenosine receptors</span></a><span style="font-weight: 400;"> and drops cAMP levels. </span><a href="https://selfhacked.com/blog/caffeine-benefits/"><span style="font-weight: 400;">Caffeine</span></a><span style="font-weight: 400;"> can partly reverse this by blocking adenosine receptors [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931547/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.jneurosci.org/content/22/15/6321"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. Coffee &amp; tea consumption is associated with higher adiponectin levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298130/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. </span><span style="font-weight: 400;">In theory, this effect may further suppress your cannabinoid system and worsen food sensitivities.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Caffeine can irritate the digestive system in higher doses. Coffee is among the most common symptom-triggering item in patients with IBS [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019583/" target="_blank" rel="noopener">R</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944381/" target="_blank" rel="noopener">R</a>].</span></p> <h4>Consume More Healthy Fats</h4> <p>Omega-6 fatty acids can stimulate the cannabinoid system via the CB1 receptors [<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340377/" target="_blank" rel="noopener">R</a>]. Try to consume a variety of healthy, whole-food omega-6 sources such as nuts, seeds, eggs, soybean &amp; avocado [<a href="https://www.health.harvard.edu/newsletter_article/no-need-to-avoid-healthy-omega-6-fats" target="_blank" rel="noopener">R</a>].</p> <p>People with lectin and other food sensitivities often struggle to gain weight, so they may benefit from a higher intake of healthy fats. They deliver two times more calories per gram, compared with carbs and protein [<a href="https://www.ncbi.nlm.nih.gov/books/NBK218769/" target="_blank" rel="noopener">R</a>].</p> <h3 style="text-align: justify;"><span style="font-weight: 400;">Lifestyle</span></h3> <p style="text-align: justify;"><span style="font-weight: 400;">Psychological stress decreases CB1 expression and weakens the gut barrier. As such, avoiding stress and taking up stress-busting hobbies like </span><a href="https://selfhacked.com/blog/health-benefits-yoga/"><span style="font-weight: 400;">yoga</span></a><span style="font-weight: 400;"> or </span><a href="https://selfhacked.com/blog/meditation/"><span style="font-weight: 400;">meditation</span></a><span style="font-weight: 400;"> can increase CB1 and help heal a leaky gut [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23305292"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24153250"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843960/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895748/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Moderate </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> increases the sensitivity of the CB1 cannabinoid receptor and strengthens the gut barrier as well [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055381/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19176351"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Likewise, cold exposure stimulates the </span><a href="https://selfhacked.com/blog/the-lectin-sensitive-gene-cannabanoid-receptor-1-genes-cnr1-rs1049353/"><span style="font-weight: 400;">cannabinoid system</span></a><span style="font-weight: 400;"> [</span><a href="http://www.jlr.org/content/57/3/464.short"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.clinicaltrials.gov/ct2/show/NCT02941172"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Finally, </span><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;"> deficiency weakens the gut barrier in mice; make sure you get enough </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">sunlight</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25590952"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3 style="text-align: justify;"><span style="font-weight: 400;">Supplements</span></h3> <p style="text-align: justify;"><span style="font-weight: 400;">DHA (as found in </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">fish oil</span></a><span style="font-weight: 400;">) and </span><a href="https://selfhacked.com/blog/cannabidiol-cbd/"><span style="font-weight: 400;">CBD</span></a><span style="font-weight: 400;"> oil increase </span><a href="https://selfhacked.com/blog/the-lectin-sensitive-gene-cannabanoid-receptor-1-genes-cnr1-rs1049353/"><span style="font-weight: 400;">CB1</span></a><span style="font-weight: 400;"> expression and strengthen the gut barrier [</span><a href="https://docs.lib.purdue.edu/dissertations/AAI3444794/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26104043"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18021759"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423254/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">You can also improve the health of your gut flora (and, thus, your gut barrier) with butyrate, resistant starches, or </span><a href="https://selfhacked.com/blog/probiotics-good-bacteria/"><span style="font-weight: 400;">probiotics</span></a><span style="font-weight: 400;"> (especially </span><em><span style="font-weight: 400;">Lactobacillus</span></em><span style="font-weight: 400;"> species) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688117/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292865/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257727/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p>
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14 | content_learn_more_9857449440334194_text == Based on the variants we looked at, your CNR1 gene makes you somewhat more susceptible to lectin sensitivity. If you suffer from the red-flag symptoms in this post, you’ll need to avoid lectin-rich foods, reduce gut permeability, and prevent inflammation. Keep scrolling to find out how.
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rsIDs = rs1049353
rsStatus = rs1049353,CNR1,chr6,88143916,C,A,T,,41,1,HET
