15 | id == 15
15 | category_id == 5
15 | category_order == 3
15 | category_name == Inflammation
15 | category_color == #C47AC0
15 | slug == lectin-sensitive-genes-MTHFR
15 | title == Are You Sensitive to Lectins? (MTHFR)
15 | meta_description == Personalized genetics blog article
15 | summary == <p><strong>Do you have inflammation, digestive problems, brain fog, migraines, or daytime fatigue that your doctor just can&rsquo;t explain? If you have risk alleles in these two unexpected genes, lectins may be responsible.</strong></p>
15 | overall_score_text == Lectin Sensitivity (based on MTHFR gene)
15 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/How-to-Know-if-Lectins-Are-Bad-for-You-MTHFR_JPG.jpg
15 | author_id == 1
15 | author_name == Jasmine Foster
15 | author_title == BSc, BEd
15 | author_order == 36
15 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
15 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
15 | reviewer_id == 2
15 | reviewer_name == Joe Cohen
15 | reviewer_title == BS
15 | medical_reviewer_id == 11
15 | medical_reviewer_name == Puya Yazdi
15 | medical_reviewer_title == MD
15 | publish_date == 2019
15 | publish_date == 8
15 | publish_date == 19
15 | avg_rating == 4.875
15 | tags_id == 33
15 | tags_name == Autoimmunity
15 | tags_id == 34
15 | tags_name == Brain Fog
15 | tags_id == 23
15 | tags_name == Food Sensitivity
15 | tags_id == 24
15 | tags_name == Inflammation
15 | tags_id == 32
15 | tags_name == Lectins
15 | tags_id == 37
15 | tags_name == Methylation
15 | tags_id == 36
15 | tags_name == MTHFR Gene
15 | permissions_favorite == False
15 | permissions_rate == False
15 | content_article == <h2><span style="font-weight: 400;">What are Lectins?</span></h2> <p><a href="https://selfhacked.com/blog/lectins-beneficial-harmful/"><span style="font-weight: 400;">Lectins</span></a><span style="font-weight: 400;"> are a type of protein found in especially high amounts in legumes and whole grains (especially wheat). You can read Joe&rsquo;s SelfHacked articles on </span><a href="http://selfhacked.com/blog/are-you-lectin-sensitive-using-genes-symptoms-and-blood-tests/"><span style="font-weight: 400;">lectin sensitivity</span></a><span style="font-weight: 400;"> for a detailed explanation of this poorly understood food intolerance [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359455/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705319/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In brief, however, lectins can cause troublesome illness if they cross the gut barrier, enter the bloodstream, and trigger inflammation throughout the body [</span><a href="https://www.ahajournals.org/doi/abs/10.1161/circ.129.suppl_1.p354"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some people are more genetically susceptible to lectin sensitivity than others. If you have the rare &lsquo;T&rsquo; allele at CNR1 rs1049353 and reduced MTHFR enzyme activity, you are at the greatest risk.</span></p> <h3><span style="font-weight: 400;">Symptoms of Lectin Sensitivity</span></h3> <p><span style="font-weight: 400;">Lectin sensitivity is a type of food sensitivity, and as such it may present with many of the same symptoms as other types of non-allergic or autoimmune-triggering intolerance. These include:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Digestive problems: the most common symptoms of food sensitivity, these can present as bloating, nausea, diarrhea, and flatulence [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570116/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28592442"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Brain fog, which reduces mental sharpness and clarity, learning, memory, and concentration [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490655/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/natural-treatments-anxiety/"><span style="font-weight: 400;">Anxiety</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/natural-treatments-depression/"><span style="font-weight: 400;">depression</span></a><span style="font-weight: 400;">: chronic inflammation decreases feelings of reward and </span><a href="http://selfhacked.com/blog/21-drugs-increase-motivation/"><span style="font-weight: 400;">motivation</span></a><span style="font-weight: 400;"> and increases sensitivity to perceived threats. In this way, inflammation can also worsen the symptoms of </span><a href="https://selfhacked.com/blog/ptsd-causes-treatments/"><span style="font-weight: 400;">PTSD</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907532/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997866/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143487/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26952745"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Insomnia: people (and especially teenagers) with insomnia have more inflammation than people who get a healthy amount of </span><a href="https://selfhacked.com/blog/health-benefits-sleep/"><span style="font-weight: 400;">sleep</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629050/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927381/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316336/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Skin conditions: atopic dermatitis (eczema), rashes, and other symptoms of skin inflammation are common in food allergy and intolerance [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122280/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21575008"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><span style="font-weight: 400;">For more on the symptoms of lectin sensitivity, including Joe&rsquo;s experience with his clients, <a href="../article/lectin-sensitive-genes-cnr1-14">check out this post</a>.</span></p> <p><span style="font-weight: 400; display: block; border-left: 2px solid #4569fa; padding: 20px; background-color: #e8ebfc;">The most common symptom of lectin sensitivity include gut problems, brain fog, anxiety, depression, insomnia, skin conditions, and fatigue.</span></p> <h3><span style="font-weight: 400;">How Can You Tell If You&rsquo;re Sensitive?</span></h3> <p><span style="font-weight: 400;">Even if you experience all of the above symptoms, you may not be lectin sensitive; each one can result from a whole bunch of different triggers that might not even have to do with what you eat. Nevertheless, they&rsquo;re a good jumping off point for you to start investigating the possibility of lectin sensitivity.</span></p> <p><span style="font-weight: 400;">If you suffer from some or all of these symptoms, the next steps are:</span></p> <ol> <li style="font-weight: 400;"><span style="font-weight: 400;">Check your genes for markers of sensitivity and</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Try a </span><a href="https://selfhacked.com/blog/elimination-diet-safest-foods-people-sensitive-everything/"><span style="font-weight: 400;">lectin avoidance diet</span></a><span style="font-weight: 400;">.</span></li> </ol> <p>*5515547706700505*</p> <h3><span style="font-weight: 400;">Why is MTHFR Important?</span></h3> <p><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">MTHFR </span></em><span style="font-weight: 400;">gene codes for an enzyme known as methylenetetrahydrofolate reductase or MTHFR. This enzyme is central to </span><a href="https://selfhacked.com/blog/16-proven-benefits-vitamin-b9-folate-folic-acid/"><span style="font-weight: 400;">folate</span></a><span style="font-weight: 400;"> metabolism, DNA production, and methylation pathways that are essential for all bodily functions [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25449138"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Low MTHFR activity can lead to increased </span><a href="https://selfhacked.com/blog/optimal-homocysteine-levels-increase-decrease/"><span style="font-weight: 400;">homocysteine</span></a><span style="font-weight: 400;">, an inflammatory amino acid. Elevated homocysteine can wreak havoc on your health; it has been linked to cardiovascular disease, reduced brain function, and autoimmunity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25449138"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25802182"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19224340"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15131313"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; display: block; border-left: 2px solid #4569fa; padding: 20px; background-color: #e8ebfc;">CNR1 may protect the gut barrier, while MTHFR is essential for cellular growth and division. Together, they may create a risky environment for lectin sensitivity to develop.</span></p> <h2><span style="font-weight: 400;">Your Genetic Results for Sensitivity Risk</span></h2> <h3><span style="font-weight: 400;">Important SNPs</span></h3> <p><strong>MTHFR rs1801133:</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Decreased risk of lectin sensitivity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increased homocysteine, increased risk of lectin sensitivity</span></li> </ul> <p><strong>MTHFR rs1801131:</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Decreased risk of lectin sensitivity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Increased homocysteine, increased risk of lectin sensitivity</span></li> </ul> <p>*5524935320259325*</p> <h2><span style="font-weight: 400;">How Do These Genes Cause Problems?</span></h2> <p>*5515547706700505*</p> <h3><span style="font-weight: 400;">MTHFR and Folate Metabolism</span></h3> <p><span style="font-weight: 400;">MTHFR has gotten a lot of attention in the last few years, and largely for good reason: this enzyme is absolutely necessary for cell growth and division, which implicates it in just about every process in the body [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17572411"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Homocysteine is a toxic and inflammatory amino acid which builds up in people with low MTHFR activity (and, thus, low levels of methylfolate). High homocysteine can lead to </span><a href="https://selfhacked.com/blog/oxidative-stress-101/"><span style="font-weight: 400;">oxidative stress</span></a><span style="font-weight: 400;"> and increased rates of cell death (apoptosis), which leads to tissue damage and immune dysfunction [</span><a href="https://academic.oup.com/humupd/article/13/3/225/2458410"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">MTHFR and Autoimmunity</span></h3> <p><span style="font-weight: 400;">Of particular interest here is the connection between MTHFR and autoimmunity. A handful of studies have directly linked polymorphisms in this gene to autoimmune disorders like Graves&rsquo; disease and </span><a href="https://selfhacked.com/blog/causes-symptoms-diagnosis-risk-factors-of-multiple-sclerosis/"><span style="font-weight: 400;">multiple sclerosis</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20941748"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499570/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Risk alleles that reduce MTHFR activity cause an increase in homocysteine in the body. This inflammatory amino acid may be the reason why MTHFR is linked to autoimmunity: people with high homocysteine are&nbsp; more likely to produce antibodies against their own proteins (autoantibodies), thereby triggering an autoimmune response [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15131313"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741875/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; display: block; border-left: 2px solid #4569fa; padding: 20px; background-color: #e8ebfc;">MTHFR is also linked to autoimmune disease; increased homocysteine may encourage the formation of antibodies against &ldquo;self&rdquo; proteins.</span></p> <h2><span style="font-weight: 400;">Recommendations to Prevent or Manage Intolerance</span></h2> <p><span style="font-weight: 400;">Lectin sensitivity shares symptoms with many other conditions, so it's essential that you talk to your doctor about your genetic data&mdash;before making significant changes&mdash;if you think you're intolerant. Together, you can decide whether the diet, supplements, and lifestyle changes here are right for you.</span></p> <p><span style="font-weight: 400;">Because so many genes and environmental factors contribute to lectin sensitivity, there is an equally broad spectrum of strategies for preventing its symptoms.</span></p> <p><span style="font-weight: 400;">*1051554414765916*</span></p> <p><span style="font-weight: 400;">One of the safest things is trying the Lectin Avoidance Diet to see if your symptoms improve; this will confirm whether you&rsquo;re really sensitive to lectins. If you are, try adding some of the other strategies below to your routine to clear up any remaining inflammation. Health is on the horizon!&nbsp;</span></p> <h3><span style="font-weight: 400;">Diet</span></h3> <h4><span style="font-weight: 400;">Lectin Avoidance Diet</span></h4> <p><span style="font-weight: 400;">A study of 800 autoimmune patients evaluated a diet with no grains, sprouted grains, pseudo-grains, beans and legumes, soy, peanuts, cashews, nightshades, melons and squashes, non-Southern European cow milk products (Casein A1), and grain/bean-fed animals.</span></p> <p><span style="font-weight: 400;">Most of these patients got their </span><a href="http://selfhacked.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">TNF-alpha</span></a><span style="font-weight: 400;"> (an inflammatory molecule) levels reduced to normal after 6 months on this diet [</span><a href="http://circ.ahajournals.org/content/129/Suppl_1/AP354"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Joe has written extensively on his Lectin Avoidance Diet protocol, which he uses to manage his genetic sensitivity. Check out </span><a href="https://selfhacked.com/blog/elimination-diet-safest-foods-people-sensitive-everything/"><span style="font-weight: 400;">this deep dive into the theory behind the diet</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/assigning-inflammation-scores-foods/"><span style="font-weight: 400;">this list of the best and worst foods</span></a><span style="font-weight: 400;"> for sensitive people for more information.</span></p> <h4><span style="font-weight: 400;">Avoid Synthetic </span><a href="https://selfhacked.com/blog/16-proven-benefits-vitamin-b9-folate-folic-acid/"><span style="font-weight: 400;">Folic Acid</span></a></h4> <p><span style="font-weight: 400;">Most folate supplements come in the form of folic acid; meanwhile, many fortified foods have folic acid added to them. Unfortunately, if you have reduced MTHFR activity, you cannot properly metabolize folic acid, and it may accumulate in your bloodstream [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745533/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://ods.od.nih.gov/factsheets/Folate-Consumer/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059208/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><span style="font-weight: 400;">Reduce Gut Permeability &amp; Inflammation</span></h4> <p><span style="font-weight: 400;">One of the best things you can do to reduce gut permeability and prevent lectins from entering your bloodstream is to eat </span><a href="https://selfhacked.com/blog/what-is-resistant-starch-sources-how-to-increase-diet/"><span style="font-weight: 400;">resistant starch</span></a><span style="font-weight: 400;"> and other prebiotic foods. These will promote healthy gut flora that produce </span><a href="http://selfhacked.com/blog/health-benefits-butyrate-derivatives-sodium-butyrate-phenylbutyrate-trybutyrine-butyric-acid-butyrate-prodrugs-butyrate-producing-bacteria/"><span style="font-weight: 400;">butyrate</span></a><span style="font-weight: 400;">, which in turn nourishes your intestines [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15139502"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.pnas.org/content/early/2014/01/03/1322269111.abstract"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906513/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Because </span><a href="http://selfhacked.com/blog/treg/"><span style="font-weight: 400;">regulatory T cells</span></a><span style="font-weight: 400;"> (</span><a href="http://selfhacked.com/blog/treg/"><span style="font-weight: 400;">Tregs</span></a><span style="font-weight: 400;">) are reduced in autoimmune diseases (and because lectins promote autoimmunity), lectin sensitive people can benefit a great deal from diet choices that increase Tregs [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24410782"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">Diet and Lifestyle</span></h3> <p><span style="font-weight: 400;">Lifestyle choices that increase Tregs and, therefore, might help prevent autoimmunity include:</span></p> <ul> <li><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">Sun</span></a><span style="font-weight: 400;"> exposure: ultraviolet light appears to restore Tregs to normal levels in some circumstances, suppressing an overactive immune system [</span><a href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0054895"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626364/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">Exercise</span></a><span style="font-weight: 400;">: repeated aerobic exercise increases Tregs in mice. Try going for multiple walks or jogs per week to maximize this benefit [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787986/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li><a href="http://selfhacked.com/blog/reasons-sweating-far-often/"><span style="font-weight: 400;">Sauna</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21951023"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">DHA</span></a><span style="font-weight: 400;"> in the form of seafood [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24410782"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <h3><span style="font-weight: 400;">Supplements</span></h3> <p><span style="font-weight: 400;">If you have any of the risk alleles in </span><em><span style="font-weight: 400;">MTHFR</span></em><span style="font-weight: 400;"> SNPs, your body might need some help metabolizing folate. The best supplement choice is probably methylfolate, which doesn&rsquo;t require the MTHFR enzyme to be active and beneficial; avoid synthetic folic acid [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28597528"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Supplements that increase Tregs and, therefore, could help prevent autoimmunity include:</span></p> <ul> <li style="font-weight: 400;"><em><span style="font-weight: 400;">Lactobacillus</span> <a href="https://selfhacked.com/blog/probiotics-good-bacteria/"><span style="font-weight: 400;">probiotics</span></a><span style="font-weight: 400;"> [</span><a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047244"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></em></li> <li style="font-weight: 400;"><span style="font-weight: 400;">DHA [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24410782"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Butyrate [</span><a href="https://www.nature.com/articles/nature12721"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Methylfolate</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">Curcumin</span></a><span style="font-weight: 400;">, many polyphenols [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125122/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688629/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738975/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/cannabidiol-cbd/"><span style="font-weight: 400;">CBD</span></a><span style="font-weight: 400;"> Oil [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327652/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul>
15 | content_snp_table_5524935320259325_key == 5524935320259325
15 | content_snp_table_5524935320259325_blur == True
15 | content_snp_table_5524935320259325_hidden == False
15 | content_learn_more_5515547706700505_key == 5515547706700505
15 | content_learn_more_5515547706700505_blur == True
15 | content_learn_more_5515547706700505_hidden == False
15 | content_learn_more_5515547706700505_text == Based on the variants we looked at, your CNR1 and MTHFR genes make you somewhat more susceptible to lectin sensitivity. If you suffer from the red-flag symptoms in this post, you’ll need to avoid lectin-rich foods, reduce gut permeability, and prevent inflammation. Keep scrolling to find out how.
15 | content_recommendation_1051554414765916_key == 1051554414765916
15 | content_recommendation_1051554414765916_blur == True
15 | content_recommendation_1051554414765916_hidden == False
rsIDs = rs1801133,rs1801131,rs1049353
rsStatus = rs1801133,MTHFR,chr1,11796321,G,A,C,,40,0,Normal
rsStatus = rs1801131,MTHFR,chr1,11794419,T,G,,,24,15,HET
rsStatus = rs1049353,CNR1,chr6,88143916,C,A,T,,41,1,HET
