168 | id == 168
168 | category_id == 16
168 | category_order == 13
168 | category_name == Gut Health
168 | category_color == #C47AC0
168 | slug == IL23R-inflammation-IBD
168 | title == The Gene Involved in Gut Inflammation and IBD (IL23R)
168 | meta_description == IL23R encodes a receptor for IL-23, a pro-inflammatory cytokine. Click to learn how variants in this gene correlate with IBD.
168 | summary == <p style="text-align:justify"><strong>The <em>IL23R</em> gene encodes a receptor for IL-23, a cytokine that plays a role in gut inflammation. Read on to learn about the variants in this gene associated with inflammatory bowel disease&mdash;personalized tips included!</strong></p>
168 | overall_score_text == Your IBD Score (based on IL23R gene)
168 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/IL23R--Gut-Inflammation-IBD-Crohns---all-chips.jpg
168 | author_id == 9
168 | author_name == Aleksa Ristic
168 | author_title == MS (Pharmacy)
168 | author_order == 45
168 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
168 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
168 | reviewer == None
168 | medical_reviewer_id == 11
168 | medical_reviewer_name == Puya Yazdi
168 | medical_reviewer_title == MD
168 | publish_date == 2020
168 | publish_date == 5
168 | publish_date == 2
168 | avg_rating == 5.0
168 | tags_id == 375
168 | tags_name == Andrographis
168 | tags_id == 33
168 | tags_name == Autoimmunity
168 | tags_id == 195
168 | tags_name == Crohn's Disease
168 | tags_id == 298
168 | tags_name == Curcumin
168 | tags_id == 244
168 | tags_name == Fish oil
168 | tags_id == 330
168 | tags_name == Food Intolerance
168 | tags_id == 194
168 | tags_name == Gut Health
168 | tags_id == 73
168 | tags_name == IBD
168 | tags_id == 402
168 | tags_name == IL-23
168 | tags_id == 401
168 | tags_name == IL23R gene
168 | tags_id == 24
168 | tags_name == Inflammation
168 | tags_id == 246
168 | tags_name == Probiotics
168 | tags_id == 50
168 | tags_name == Stress
168 | tags_id == 196
168 | tags_name == Ulcerative Colitis
168 | permissions_favorite == False
168 | permissions_rate == False
168 | content_article == <p><em><span style="font-weight: 400;">This article is for informational purposes only. None of the information here should be taken as medical advice. If you suspect you may have digestive issues, seek medical help. </span></em><em><span style="font-weight: 400;">Keep in mind that these results are based on association studies, which are correlative and aren&rsquo;t necessarily causative. Any single genetic variant will typically contribute only a small proportion to the overall risk of the condition, and non-genetic factors play a large role in developing a condition as well. Therefore, just because you have one of these genotypes does not necessarily mean you are at an increased risk of developing this condition!</span></em></p> <table style="width: 90%; border-collapse: collapse; margin-left: auto; margin-right: auto;" border="1" cellpadding="10"> <tbody> <tr> <td style="width: 100%;"><strong>Note:</strong> <em>IL23R</em> is one of the genes we analyze in our <a href="https://get.selfdecode.com/gene-reports/inflammation/"><em>Inflammation DNA Wellness Report</em></a>, along with many other genes. If you're looking for a comprehensive report on inflammation-related genes, check it out!</td> </tr> </tbody> </table> <p>&nbsp;</p> <h2><strong>IL23R in Gut Inflammation</strong></h2> <h3><strong>What is IL23R?</strong></h3> <p><span style="font-weight: 400;">The </span><a href="http://www.selfdecode.com/gene/il2/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><em><span style="font-weight: 400;">IL2</span></em></a><a href="../../gene/il23r/"><em><span style="font-weight: 400;">3R</span></em><span style="font-weight: 400;"> gene</span></a><span style="font-weight: 400;"> encodes one part of the receptor for interleukin 23, a pro-inflammatory cytokine [</span><a href="https://ghr.nlm.nih.gov/gene/IL23R"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">IL-23</span><span style="font-weight: 400;"> activates </span><a href="http://selfhacked.com/blog/th17/">Th17</a><span style="font-weight: 400;"> cells, enabling them to release cytokines such as </span><span style="font-weight: 400;">IL-1</span><span style="font-weight: 400;">7</span><span style="font-weight: 400;">, </span><span style="font-weight: 400;">IL-21</span><span style="font-weight: 400;">, and IL-22. The primary purpose of this mechanism, known as the </span><strong>IL-23/Th17 axis</strong><span style="font-weight: 400;">, is to combat pathogens such as fungi and bacteria and prevent them from entering the body [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281037/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22044352"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16688182"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Additionally, IL-23 plays a role in the formation of new blood vessels or angiogenesis [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29535706"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">IL23R encodes one part of the receptor for IL-23, a pro-inflammatory cytokine that protects against fungi and bacteria.</span></p> <h3><strong>IBD</strong></h3> <p><a href="https://selfhacked.com/blog/crohns-disease/"><span style="font-weight: 400;">Crohn&rsquo;s disease</span></a><span style="font-weight: 400;"> (CD) and </span><a href="https://selfhacked.com/blog/ulcerative-colitis/"><span style="font-weight: 400;">ulcerative colitis</span></a><span style="font-weight: 400;"> (UC) are two of the most frequently diagnosed subtypes of inflammatory bowel disease (IBD). The cause of IBD lies in a complex interplay of </span><a href="https://selfhacked.com/blog/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections/"><span style="font-weight: 400;">genetic and environmental factors</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106026/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Crohn's mostly affects the small intestine and involves ulcerations of all cell layers of the gut lining. Ulcerative colitis typically affects the colon and rectum, and involves the inflammation of the gut mucosal layer [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622286/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30837080"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>The Role of IL-23</strong></h3> <p><span style="font-weight: 400;">Preclinical research has identified a crucial role of IL-23 in gut inflammation and different autoimmune conditions. Its activity peaks in the small intestine (terminal ileum) and colon, the most common IBD "targets" [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16670770/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12952918/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Animals with increased IL-23 expression have severe widespread inflammation, including the intestines [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11390512/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>IL23R Variants and IBD Susceptibility</strong></h2> <p><span style="font-weight: 400;">Scientists have identified different SNPs in the </span><em><span style="font-weight: 400;">IL23R</span></em><span style="font-weight: 400;"> gene associated with both Crohn&rsquo;s disease and ulcerative colitis. Given their effects vary between populations, we will first outline the results for Europeans (Caucasians) and then mention the key differences in Asians.</span></p> <p><span style="font-weight: 400;">A comprehensive review of 41 studies and over 47,000 participants has found a robust link between two SNPs and IBD [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31728561"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><a href="../../snp/rs11209026/"><span style="font-weight: 400;">rs11209026:</span></a><span style="font-weight: 400;"> the &ldquo;A&rdquo; allele was associated with lower rates of both CD and UC</span></li> <li style="font-weight: 400;"><a href="../../snp/rs10889677/"><span style="font-weight: 400;">rs10889677</span></a><span style="font-weight: 400;">: the &ldquo;A&rdquo; allele was associated with higher rates of both CD and UC</span></li> </ul> <p><span style="font-weight: 400;">Combined, people with rs11209026-A had two times lower rates, and those with rs10889677-A had 37% higher rates of IBD.</span></p> <p><span style="font-weight: 400;">In two meta-analyses of over 38,000 subjects, another IL23R variant correlated with ulcerative colitis. People with the &ldquo;G&rdquo; allele at </span><a href="../../snp/rs7517847/"><span style="font-weight: 400;">rs7517847</span></a><span style="font-weight: 400;"> had significantly lower UC rates. This allele was also protective against Crohn&rsquo;s disease in a meta-analysis of 60 trials and 50K subjects [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25497273"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354875/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26678098"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">When it comes to Asian populations [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31728561"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25497273"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354875/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26678098"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">rs11209026 is protective against CD but not against UC (non-existent in East Asia)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">rs10889677 is weakly associated with higher rates of UC but not CD</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">rs7517847 is associated with neither CD nor UC</span></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">In European populations, people with rs11209026-A and rs7517847-G have lower chances, while those with rs10889677-A have higher chances of getting both Crohn's disease and ulcerative colitis.</span></p> <h3><strong>How It Works</strong></h3> <p><span style="font-weight: 400;">Given the critical role of IL-23 in gut inflammation, it&rsquo;s no wonder that </span><em><span style="font-weight: 400;">IL23R</span></em><span style="font-weight: 400;"> variants correlate with IBD. According to researchers, these SNPs can change the structure of IL-23 receptors, making them more or less responsive to stimulation [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16372191/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Over-stimulation of </span><a href="https://www.selfdecode.com/gene/il23r/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">IL23</span></a><span style="font-weight: 400;">R increases IL-17 and triggers gut inflammation. Both CD and UC patients have elevated IL-17 in the gut lining [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12417590/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16473830/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12477762/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></p> <p><span style="font-weight: 400;">While overactive IL-23 is harmful, the lack of it may also impair the gut microbiome. The exact mechanism behind </span><em><span style="font-weight: 400;">IL23R</span></em><span style="font-weight: 400;"> variants in IBD is likely more complex and has yet to be unraveled [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16920909/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15070757/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16648837/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The above SNPs can change the structure of IL-23 receptors, making them more or less responsive to stimulation. Its over-stimulation can trigger gut inflammation and contribute to IBD.</span></p> <h2><strong>Your IL23R Results for IBD</strong></h2> <p><strong>*6945512845604662*</strong></p> <h3><strong>SNP Summary</strong></h3> <p><strong>Primary SNPs:</strong></p> <p><strong><em>IL23R</em></strong> <a href="../../snp/rs11209026/"><strong>rs11209026</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = not associated with Crohn&rsquo;s disease or ulcerative colitis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = associated with lower rates of Crohn&rsquo;s disease and ulcerative colitis</span></li> </ul> <p><em><span style="font-weight: 400;">Population Frequency</span></em><span style="font-weight: 400;">: Around 12% of European descendants carry the &ldquo;A&rdquo; allele. This allele is nearly non-existent in African and East-Asian populations.</span></p> <p><strong><em>IL23R</em></strong> <a href="../../snp/rs10889677/"><strong>rs10889677</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = associated with higher rates of Crohn&rsquo;s disease and ulcerative colitis&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = not associated with Crohn&rsquo;s disease or ulcerative colitis</span></li> </ul> <p><em><span style="font-weight: 400;">Population Frequency</span></em><span style="font-weight: 400;">: Around 50% of European descendants carry the &ldquo;A&rdquo; allele. It&rsquo;s less common in East-Asian (46%) and African (24%) populations.</span></p> <p><strong><em>IL23R</em></strong> <a href="../../snp/rs7517847/"><strong>rs7517847</strong></a></p> <ul> <li><span style="font-weight: 400;">&lsquo;T&rsquo; = associated with higher rates of Crohn&rsquo;s disease and ulcerative colitis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = associated with lower rates of Crohn&rsquo;s disease and ulcerative colitis&nbsp;</span></li> </ul> <p><em><span style="font-weight: 400;">Population Frequency</span></em><span style="font-weight: 400;">: Around 65% of Europeans and East-Asians carry at least one copy of the &ldquo;G&rdquo; allele. It&rsquo;s less common among African descendants (30%).</span></p> <p>*3179514227822229*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Prevent Gut Inflammation</strong></h2> <p><em><span style="font-weight: 400;">You may try the complementary approaches listed below if you and your doctor determine that they could be appropriate for you. Discuss the strategies listed here with your doctor. Remember that none of them should ever be done in place of what your doctor recommends or prescribes.</span></em></p> <p>*9680035543568162*</p> <h3><strong>Diet</strong></h3> <h4><strong>Low FODMAP Diet</strong></h4> <p><span style="font-weight: 400;">FODMAPs are a group of carbohydrates identified as some of the prime irritants in IBD. FODMAPs is a catchy acronym that stands for Fermentable Oligosaccharides, Disaccharides, Monosaccharides, And Polyols, such as [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28244679"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843040/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388522/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Fructose</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Lactose</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Fructans and galactans</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Galacto-oligosaccharides</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Polyols (sugar alcohols)</span></li> </ul> <p><span style="font-weight: 400;">Specific oligosaccharides can increase the expression of IL-23 in the gut and thus worsen the impact of your variants [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743503/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some experts recommend a low FODMAP diet to help control the symptoms of ulcerative colitis and Crohn&rsquo;s disease. This diet isn&rsquo;t appropriate for everyone&mdash;talk to your doctor or dietician to determine whether it could be right for you.</span></p> <p><span style="font-weight: 400;">For more about the low FODMAP diet, check out</span><a href="https://selfhacked.com/blog/fodmap-diet/"> <span style="font-weight: 400;">this post</span></a><span style="font-weight: 400;"> on how it works and</span><a href="https://selfhacked.com/blog/fodmap-food-list/"> <span style="font-weight: 400;">this post</span></a><span style="font-weight: 400;"> on which foods are included.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The low FODMAP diet eliminates specific foods that may increase IL-23 levels and trigger gut inflammation.</span></p> <h4><strong>Eat More Fish</strong></h4> <p><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">Omega-3</span></a><span style="font-weight: 400;"> fatty acids found in fish, EPA and DHA, may inhibit Th17 cells and lower the levels of IL-17 and IL-23. High intake of fish and omega-3s may be protective against the development of Crohn&rsquo;s disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037798/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055457/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29543869"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153885/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><strong>Increase Potassium Intake</strong></h4> <p><span style="font-weight: 400;">A study of almost 200,000 women found that diets lower in potassium were associated with Crohn&rsquo;s disease. The authors of the study suggested that dietary potassium could affect the Th17 pathway, which means it may counteract your genetic effect [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141241/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Crohn&rsquo;s disease can also increase potassium secretion into the colon, potentially leading to deficiency [</span><a href="https://ods.od.nih.gov/factsheets/Potassium-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Potassium-rich foods to help prevent deficiency include stone fruit (especially apricots and prunes), legumes, bananas, potatoes, and squash [</span><a href="https://ods.od.nih.gov/factsheets/Potassium-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">People with Crohn&rsquo;s disease may be at higher risk of potassium deficiency. Potassium-rich foods may inhibit the Th17 pathway in gut inflammation.</span></p> <h3><strong>Stress Management</strong></h3> <p><span style="font-weight: 400;">Psychological </span><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">stress</span></a><span style="font-weight: 400;"> has well-known detrimental effects on gut health and inflammation. It raises gut permeability and the levels of inflammatory Th17&nbsp; cytokines, including IL-17 [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23470617/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262626/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Many people with IBD develop </span><a href="https://selfhacked.com/blog/natural-treatments-anxiety/"><span style="font-weight: 400;">anxiety</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/natural-treatments-depression/"><span style="font-weight: 400;">depression</span></a><span style="font-weight: 400;"> associated with their debilitating gastrointestinal symptoms. Furthermore, psychological stress may worsen the symptoms of IBD. Because of this potential feedback loop, many doctors emphasize the importance of managing the mental health of IBD patients [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774724/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28245757"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678997/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572298/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Stress raises inflammatory cytokines such as IL-17 and worsens gut inflammation.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Andrographis</strong></h4> <p><a href="http://selfhacked.com/blog/top-12-scientific-benefits-of-andrographis-paniculata-including-dosage-safety-and-side-effects/"><em><span style="font-weight: 400;">Andrographis paniculata</span></em></a><span style="font-weight: 400;">, known as the &ldquo;King of</span><a href="https://selfhacked.com/blog/herbal-bitters/"> <span style="font-weight: 400;">Bitters</span></a><span style="font-weight: 400;">,&rdquo; is traditionally used in Ayurveda and Chinese medicine. It may improve the symptoms of ulcerative colitis [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23292349"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In two clinical trials, andrographolide, the active ingredient in Andrographis, improved UC by suppressing the IL-23/IL-17 axis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835811/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29749556"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Taking 1,200 - 1,800 mg Andrographis daily for 8 weeks reduced the symptoms of mild-to-moderate colitis in adults; the 1,800 mg dose was more effective. However, it did not affect remission rates any more than placebo [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538174/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Andrographis may help with ulcerative colitis by suppressing the IL-23/IL-17 axis.</span></p> <h4><strong>Probiotics</strong></h4> <p><span style="font-weight: 400;">In preclinical research, </span><a href="https://selfhacked.com/blog/l-plantarum/"><em><span style="font-weight: 400;">Lactobacillus</span></em></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/b-longum/"><em><span style="font-weight: 400;">Bifidobacterium</span></em></a><span style="font-weight: 400;"> probiotic strains were able to reduce colon inflammation by blocking the IL-23/Th17 axis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417982/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22730546"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People with IBD often have impaired </span><a href="https://www.selfhacked.com/blog/gut-bacteria-microbiome/"><span style="font-weight: 400;">gut microbiome</span></a><span style="font-weight: 400;">, which may worsen their disease. In a meta-analysis, a blended</span><a href="https://selfhacked.com/blog/probiotics-gut-health/"> <span style="font-weight: 400;">probiotic</span></a><span style="font-weight: 400;"> containing</span> <span style="font-weight: 400;">the above strains increased remission rates 1.7 times in ulcerative colitis patients [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24280877"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">These two strains generally appear to be beneficial in patients with ulcerative colitis [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24280877"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15507864"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15984978"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19174792"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Bifidobacterium and Lactobacillus probiotic strains may soothe colon inflammation by suppressing IL-23. They can be beneficial for ulcerative colitis patients.</span></p> <h4><strong>Curcumin</strong></h4> <p><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">Curcumin</span></a><span style="font-weight: 400;"> is the active ingredient of turmeric with potent anti-inflammatory effects. It can lower the levels of both IL-23 and IL-17 and thus lessen the impact of your IL23R gene [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583902/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23825622"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349589/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Multiple clinical trials have produced promising results for curcumin in IBD, and further research is currently underway [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29957091"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514688/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153885/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><strong>Omega-3/Fish oil</strong></h4> <p><span style="font-weight: 400;">As mentioned, EPA and DHA from fish may lower the levels of IL-17 and IL-23. If you don&rsquo;t eat at least two servings of fatty sea fish weakly, consider taking a fish oil supplement.</span></p> <p><span style="font-weight: 400;">It is unclear whether omega-3 supplementation can help Crohn&rsquo;s disease that has already developed and progressed. However, multiple studies have suggested that omega-3s may help keep it in remission [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153885/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700845/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Curcumin and fish oil inhibit IL-23 and IL-17. They can reduce gut inflammation and help keep IBD in remission.</span></p>
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168 | content_learn_more_3179514227822229_text == Based on the variants we looked at, your IL23R gene is associated with typical IBD rates. However, this doesn't necessarily reflect your overall risk of IBD, just one gene related to it. Avoid stress and FODMAP-rich foods to prevent gut inflammation. Keep reading to learn more.
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rsIDs = rs11209026,rs10889677,rs7517847
rsStatus = rs11209026,IL23R,chr1,67240275,G,A,,,27,0,Normal
rsStatus = rs10889677,IL23R,chr1,67259437,C,A,T,,21,0,Normal
rsStatus = rs7517847,IL23R,chr1,67215986,T,A,C,G,29,0,Normal
