17 | id == 17
17 | category_id == 4
17 | category_order == 1
17 | category_name == Brain
17 | category_color == #C47AC0
17 | slug == Fight-Brain-Fog-with-PARP1
17 | title == Fight Oxidative Stress, Inflammation, and Brain Fog (PARP1)
17 | meta_description == Personalized genetics blog article
17 | summary == <p style="text-align:justify"><strong>Your brain is highly sensitive to the effects of oxidative stress and inflammation &ndash; two of the main factors that cause &ldquo;brain fog&rdquo; and other cognitive problems. The <em>PARP1</em> gene is a key player when it comes to determining how sensitive you are to these factors, and understanding how it works can give you a major advantage when it comes to protecting your brain and optimizing your overall cognitive ability!</strong></p>
17 | overall_score_text == Cognitive score (based on PARP1 gene)
17 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/Fight-Oxidative-Stress-Reduce-Inflammation-and-Avoid-Brain-Fog-with-the-PARP1-Ge.jpg
17 | author_id == 4
17 | author_name == Matt Carland
17 | author_title == PhD
17 | author_order == 10
17 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Matt.jpg
17 | author_intro == <p><strong>Matt received his PhD at the Universit&eacute; de Montr&eacute;al in Neuroscience.</strong></p>    <p>Matt holds multiple degrees in psychology, cognitive science, and neuroscience. He has over a decade of experience in academic research and has published a number of articles in scholarly journals. He currently works as a neuropsychologist in Montreal, where he performs research on the links between personality traits and the development of clinical disorders such as addiction, compulsive gambling, and disordered eating.</p>
17 | reviewer_id == 2
17 | reviewer_name == Joe Cohen
17 | reviewer_title == BS
17 | medical_reviewer_id == 11
17 | medical_reviewer_name == Puya Yazdi
17 | medical_reviewer_title == MD
17 | publish_date == 2019
17 | publish_date == 8
17 | publish_date == 19
17 | avg_rating == 4.555555555555555
17 | tags_id == 34
17 | tags_name == Brain Fog
17 | tags_id == 13
17 | tags_name == Cognition
17 | tags_id == 40
17 | tags_name == DNA Repair
17 | tags_id == 24
17 | tags_name == Inflammation
17 | tags_id == 28
17 | tags_name == Intelligence
17 | tags_id == 39
17 | tags_name == Oxidative Stress
17 | tags_id == 66
17 | tags_name == PARP1 Gene
17 | permissions_favorite == False
17 | permissions_rate == False
17 | content_article == <table style="width: 90%; border-collapse: collapse; margin-left: auto; margin-right: auto;" border="1" cellpadding="10"> <tbody> <tr> <td style="width: 100%; text-align: justify;"><strong>Note:</strong><span style="font-weight: 400;"> The </span><em><span style="font-weight: 400;">PARP1</span></em><span style="font-weight: 400;"> gene is one of the 45 unique intelligence-related genes that we analyze in our comprehensive </span><a href="https://get.selfdecode.com/mind-protocol-nm/"><strong><em>Cognitive Function DNA Wellness Report</em></strong></a><span style="font-weight: 400;">. If you&rsquo;re interested in learning more about the genes that affect your cognitive ability, and the actionable steps that you can take to boost your cognition even further, check it out!</span></td> </tr> </tbody> </table> <p style="text-align: justify;"><span style="font-weight: 400;"><br /><br />Each moment of your life, the cells in your body and brain are continually dividing and making new copies of themselves. And in order to reproduce successfully, cells have to be able to read and copy their DNA as accurately as possible.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Unfortunately, there are many environmental and lifestyle factors that can damage the DNA in your cells, which increases the risk of mutations that can potentially impair your health.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Some of the most common and pervasive causes of DNA damage include:</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><em>Reactive oxygen species (ROS), which build up to cause <a href="https://selfhacked.com/blog/oxidative-stress-101/">oxidative stress</a> that can damage DNA [<a href="https://www.ncbi.nlm.nih.gov/pubmed/16430879">R</a>]</em></li> <li style="font-weight: 400;">Radiation, such as UVA and UVB from excessive <a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/">sun exposure</a> [<a href="https://www.ncbi.nlm.nih.gov/pubmed/31157572">R</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/23873394">R</a>]</li> <li style="font-weight: 400;">Alcohol use, smoking, air pollution, and other environmental toxins [<a href="https://www.ncbi.nlm.nih.gov/pubmed/24313162">R</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/30571815">R</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/28843141">R</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/29177959">R</a>]</li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">The good news is that your body is naturally equipped with a number of mechanisms that it uses to repair its DNA when it gets damaged. One of these defense mechanisms is an enzyme called </span><em><span style="font-weight: 400;">poly-ADP-ribose polymerase 1</span></em><span style="font-weight: 400;"> (PARP1), coded by the </span><a href="../../gene/parp1/"><em><span style="font-weight: 400;">PARP1</span></em><span style="font-weight: 400;"> gene</span></a><span style="font-weight: 400;">.</span></p> <p style="text-align: justify;"><span style="display: block; border-left: 2px solid #4569fa; padding: 20px; background-color: #e8ebfc;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">PARP1</span></em><span style="font-weight: 400;"> gene protects your DNA from being damaged by toxins and other sources of oxidative stress.</span></span></p> <p style="text-align: justify;">&nbsp;</p> <h2 style="text-align: justify;"><strong>The </strong><strong><em>PARP1</em></strong><strong> Gene: Balancing DNA Repair vs. Inflammation</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The PARP1 enzyme is activated whenever your body detects DNA damage in its cells. This enzyme then binds to the damaged DNA to &ldquo;mark&rdquo; it so that other natural repair processes can come in and start fixing the damage [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28676700"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23608917"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23966166"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Although being able to repair your DNA is obviously a good thing, there&rsquo;s a catch: </span><em><span style="font-weight: 400;">PARP1</span></em><span style="font-weight: 400;"> activation also triggers your body&rsquo;s inflammatory response [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24350055"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28576564"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29016792"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">This makes sense because inflammation is a natural side-effect of damage to any part of our body. It is actually caused by our repair mechanisms doing their job &ndash; so inflammation itself isn&rsquo;t necessarily a bad thing on its own! It&rsquo;s only when it becomes excessive or chronic that it should be considered a problem [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26791721"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26459225"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Nonetheless, the trade-off between DNA repair and increased inflammation means that your levels of the PARP1 enzyme have to be held in a delicate balance to ensure optimal health. Too <em>little</em> of it, and your body and brain will be more susceptible to common forms of cellular DNA damage, such as <a href="https://selfhacked.com/blog/oxidative-stress-101/">oxidative stress</a> &ndash; but too <em>much</em> of it, and you will be more likely to experience <a href="https://selfhacked.com/blog/chronic-inflammation-blood-tests/">chronic inflammation</a>!</span></p> <p style="text-align: center;"><img src="https://decodify.s3-us-west-1.amazonaws.com/assets/report/PARP1_figure.png" alt="PARP1_figure" width="2447" height="365" /></p> <p style="text-align: justify;"><span style="font-weight: 400; display: block; border-left: 2px solid #4569fa; padding: 20px; background-color: #e8ebfc;">The PARP1 enzyme helps repair your DNA from damage &ndash; but in the process it also activates inflammatory responses. Therefore, your PARP1 levels need to be held in a delicate balance to ensure optimal health.</span></p> <p style="text-align: justify;">&nbsp;</p> <h2 style="text-align: justify;"><strong><em>PARP1</em></strong><strong> and Cognitive Function</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">Oxidative stress and inflammation are obviously important for many aspects of your overall health. However, your brain is especially sensitive to the negative impact of these factors, which means that one of the earliest symptoms of oxidative stress or chronic inflammation is often impaired cognitive functioning, as well as other psychological symptoms, such as disrupted mood [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26190965"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29016792"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23608917"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In fact, inflammation and oxidative stress are some of the main causes of common, hard-to-treat health conditions, such as &ldquo;</span><a href="https://selfhacked.com/blog/brainfog/"><strong>brain fog</strong></a><strong>&rdquo;</strong><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24457625"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26190965"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The fact that</span> <span style="font-weight: 400;">your brain is particularly sensitive to the actions of </span><em><span style="font-weight: 400;">PARP1</span></em><span style="font-weight: 400;"> is probably why SNPs in this gene have been associated with diverse cognitive functions, such as cognitive flexibility (executive function), learning &amp; memory, general intelligence (IQ), and even the size of certain key brain regions, such as the hippocampus [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27099827"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25712083"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23608917"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400; display: block; border-left: 2px solid #4569fa; padding: 20px; background-color: #e8ebfc;">Your brain is especially sensitive to the effects of <em>PARP1</em> activity, which is why this gene can influence many aspects of your overall cognitive ability, and can even cause chronic &ldquo;brain fog.&rdquo;</span></p> <p style="text-align: justify;">&nbsp;</p> <h2 style="text-align: justify;"><strong>How is Your </strong><strong><em>PARP1</em></strong><strong> Genotype Affecting Your Brain?</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">Below you can see your genotype for the </span><em><span style="font-weight: 400;">PARP1</span></em><span style="font-weight: 400;"> SNP </span><a href="../../snp/rs7515023/"><strong>rs7515023</strong></a><span style="font-weight: 400;">, which plays a significant role in determining how vulnerable your brain is to oxidative stress and inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25712083"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <p style="text-align: justify;">*3013314990042468*</p> <p style="text-align: justify;">*6522861692254558*</p> <p style="text-align: justify;"><span style="font-weight: 400;"><br />The two possible alleles for this SNP are &lsquo;C&rsquo; and &lsquo;T&rsquo; &ndash; and when it comes to optimal cognitive function, it&rsquo;s better to have the minor &lsquo;T&rsquo; allele.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">People who carry this allele tend to have </span><em><span style="font-weight: 400;">PARP1</span></em><span style="font-weight: 400;"> gene levels that are better-regulated, which helps keeps them closer to the &ldquo;sweet spot&rdquo; between having too low or too high levels of the active PARP1 enzyme [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23608917"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25712083"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">This, in turn, reduces their overall risk of experiencing the potential cognitive symptoms of oxidative stress and inflammation, such as brain fog. And because the beneficial effects of the &lsquo;T&rsquo; allele are &ldquo;</span><em><span style="font-weight: 400;">additive</span></em><span style="font-weight: 400;">&rdquo;, two copies are even better than one [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25712083"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]!</span></p> <p style="text-align: justify;"><span style="font-weight: 400; display: block; border-left: 2px solid #4569fa; padding: 20px; background-color: #e8ebfc;">The more &lsquo;T&rsquo; alleles you carry for rs7515023, the less vulnerable you are to oxidative stress and inflammation. This, in turn, reduces your relative risk of experiencing cognitive issues, such as &ldquo;brain fog.&rdquo;</span></p> <p style="text-align: justify;">&nbsp;</p> <h2 style="text-align: justify;"><strong>What Can You Do About Your </strong><strong><em>PARP1</em></strong><strong> Genotype?</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">Because </span><em><span style="font-weight: 400;">PARP1</span></em><span style="font-weight: 400;"> can have undesirable effects when it is too high </span><em><span style="font-weight: 400;">or</span></em><span style="font-weight: 400;"> too low, we don&rsquo;t recommend trying to affect your levels of the </span><em><span style="font-weight: 400;">PARP1</span></em><span style="font-weight: 400;"> gene directly.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">However, you can steps to protect your brain &ndash; and therefore enhance your cognitive functioning &ndash; by addressing the </span><em><span style="font-weight: 400;">root causes</span></em><span style="font-weight: 400;"> of these negative effects: oxidative stress and inflammation.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">*4881386268805607*</span></p> <p style="text-align: justify;"><strong>One great compound that fights against both of these factors at the same time is </strong><a href="https://selfhacked.com/blog/pqq-review/"><strong><em>pyrroloquinoline quinone</em></strong></a><strong> (PQQ).</strong></p> <p style="text-align: justify;"><span style="font-weight: 400;">For example, supplementing with PQQ dramatically decreases levels of inflammatory markers such as </span><em><span style="font-weight: 400;">interleukin-6</span></em><span style="font-weight: 400;"> (IL-6), </span><em><span style="font-weight: 400;">nitric oxide</span></em><span style="font-weight: 400;"> (NOS), and </span><em><span style="font-weight: 400;">C-reactive protein</span></em><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24231099"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19026989"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">PQQ is also a remarkable antioxidant &ndash; for example, it is up to 100 times more effective at breaking down harmful free radicals compared to other common antioxidants, such as </span><a href="https://selfhacked.com/blog/need-know-vitamin-c-32-science-based-health-benefits/"><span style="font-weight: 400;">vitamin C</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/1318959"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/1702437"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/8524146"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">PQQ also </span><a href="https://selfhacked.com/blog/natural-ways-to-improve-mitochondrial-function/"><span style="font-weight: 400;">improves mitochondrial function</span></a><span style="font-weight: 400;">. Abnormal mitochondrial activity is another one of the major factors that can worsen oxidative stress [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24231099"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19861415"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Supplementing with PQQ enhances cognitive function in rats &ndash; most likely because it is protecting their brains from the harmful effects of oxidative stress [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18231627"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19926923"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">You can get PQQ from several common dietary sources, including </span><a href="https://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">green tea</span></a><span style="font-weight: 400;">, leafy green vegetables like spinach, and soybeans or other soy-based products such as tofu and nattō. However, we generally recommend taking a PQQ supplement instead, as dietary sources usually won&rsquo;t usually deliver as much PQQ as direct supplementation can [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/7733865"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17685628"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]!</span></p> <p style="text-align: justify;"><strong>Another great way to tackle oxidative stress and inflammation at their root is to use </strong><a href="https://selfhacked.com/blog/my-review-of-lllt/"><strong><em>low-level laser therapy</em></strong></a><strong> (LLLT).</strong></p> <p style="text-align: justify;"><span style="font-weight: 400;">LLLT involves shining a specially-designed set of lights (usually LEDs) on whatever part of the body you&rsquo;re trying to treat &ndash; in this case, the head. Certain wavelengths of light then pass through your skin and bones to stimulate various biological processes that help reduce inflammation, increase blood flow, and many other major health benefits.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">LLLT is especially effective at treating inflammation. For example, one of the ways that </span><em><span style="font-weight: 400;">PARP1</span></em><span style="font-weight: 400;"> causes inflammation is by activating </span><a href="https://selfhacked.com/blog/nuclear-factor-kappa-b/"><em><span style="font-weight: 400;">nuclear factor kappa-beta</span></em><span style="font-weight: 400;"> (NF-k&beta;)</span></a><span style="font-weight: 400;">, a protein that stimulates the production of </span><em><span style="font-weight: 400;">pro-inflammatory cytokines</span></em><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29016792"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28576564"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. However, one of the main beneficial effects of LLLT is to </span><em><span style="font-weight: 400;">inhibit</span></em><span style="font-weight: 400;"> NF-k&beta;, making it especially ideal when it comes to counteracting the potential negative effects of your </span><em><span style="font-weight: 400;">PARP1</span></em><span style="font-weight: 400;"> genotype [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25207838"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18328453"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21142721"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29116611"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]!</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">LLLT also decreases many other inflammatory markers, such as </span><a href="https://selfhacked.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">TNF-alpha</span></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/cox2-natural-cox2-inhibitors/"><span style="font-weight: 400;">COX-2</span></a><span style="font-weight: 400;">, </span><em><span style="font-weight: 400;">nitric oxide synthase</span></em><span style="font-weight: 400;"> (NOS), and several types of </span><em><span style="font-weight: 400;">interleukins</span></em><span style="font-weight: 400;"> (such as </span><a href="https://selfhacked.com/blog/interleukin-1/"><span style="font-weight: 400;">IL-1</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/interleukin-6/"><span style="font-weight: 400;">IL-6</span></a><span style="font-weight: 400;">) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23003120"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16706694"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23807510"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">LLLT also has other major health benefits that are especially critical for your brain, such as reducing </span><a href="https://selfhacked.com/blog/oxidative-stress-101/"><span style="font-weight: 400;">oxidative stress</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16706694"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23281261"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">] and increasing your production of </span><a href="https://selfhacked.com/blog/a-comprehensive-list-of-natural-ways-to-increase-bdnf/"><span style="font-weight: 400;">BDNF</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/all-about-nerve-growth-factor-and-50-ways-to-increase-it/"><span style="font-weight: 400;">NGF</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23003120"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29116611"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">All together, these many diverse benefits may explain why LLLT has also been associated with significant cognitive benefits, including improved attention, learning, and memory [<a href="https://www.ncbi.nlm.nih.gov/pubmed/29116611">R</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/24672439">R</a>]. It also has other psychological benefits, such as <a href="https://selfhacked.com/blog/natural-treatments-depression/">boosting your mood</a> [<a href="https://www.ncbi.nlm.nih.gov/pubmed/24672439">R</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/19995444">R</a>]!</span></p> <p style="text-align: justify;"><span style="font-weight: 400; display: block; border-left: 2px solid #4569fa; padding: 20px; background-color: #e8ebfc;">If you carry risk-associated (&lsquo;C&rsquo;) alleles in this gene, your best bet is to use supplements and lifestyle hacks that help fight inflammation and oxidative stress at their roots.<br /></span></p>
17 | content_snp_table_3013314990042468_key == 3013314990042468
17 | content_snp_table_3013314990042468_blur == True
17 | content_snp_table_3013314990042468_hidden == False
17 | content_learn_more_6522861692254558_key == 6522861692254558
17 | content_learn_more_6522861692254558_blur == True
17 | content_learn_more_6522861692254558_hidden == False
17 | content_learn_more_6522861692254558_text == Based on your data for this SNP, your PARP1 gene activity is relatively well-regulated, which gives you a roughly average risk of experiencing cognitive disruptions due to oxidative stress and inflammation.
17 | content_recommendation_4881386268805607_key == 4881386268805607
17 | content_recommendation_4881386268805607_blur == True
17 | content_recommendation_4881386268805607_hidden == False
rsIDs = rs7515023
rsStatus = rs7515023,,chr1,226112787,C,T,,,5,32,HET
