171 | id == 171
171 | category_id == 16
171 | category_order == 13
171 | category_name == Gut Health
171 | category_color == #C47AC0
171 | slug == HNF4A-gut-inflammation
171 | title == Does This Liver Gene Affect Gut Inflammation? (HNF4A)
171 | meta_description == HNF4A is vital for proper liver function, but certain variants of this gene are linked to gut inflammation. Find out more here!
171 | summary == <p style="text-align:justify"><strong>The HNF4A gene has several different functions in the body, most of which are related to the liver. Research suggests that certain variants of HNF4A may be associated with disorders that cause gut inflammation. Find out who may be affected and what strategies may help.</strong></p>
171 | overall_score_text == Gut Inflammation Score (Based On HNF4A Gene)
171 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/HNF4A--Gut-Inflammation-IBD---all-chips.jpg
171 | author_id == 8
171 | author_name == Mathew Eng
171 | author_title == PharmD
171 | author_order == 40
171 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Mathew.jpg
171 | author_intro == <p><strong>Mathew received his PharmD from the University of Hawaii and an undergraduate degree in Biology from the University of Washington.</strong></p>    <p>Mathew is a licensed pharmacist with clinical experience in oncology, infectious disease, and diabetes management. He has a passion for personalized patient care and believes that education is essential to living a healthy life. His goal is to motivate individuals to find ways to manage their chronic conditions.</p>
171 | reviewer == None
171 | medical_reviewer_id == 11
171 | medical_reviewer_name == Puya Yazdi
171 | medical_reviewer_title == MD
171 | publish_date == 2020
171 | publish_date == 5
171 | publish_date == 3
171 | avg_rating == 5.0
171 | tags_id == 195
171 | tags_name == Crohn's Disease
171 | tags_id == 194
171 | tags_name == Gut Health
171 | tags_id == 308
171 | tags_name == Gut Inflammation
171 | tags_id == 405
171 | tags_name == HNF4A Gene
171 | tags_id == 73
171 | tags_name == IBD
171 | tags_id == 196
171 | tags_name == Ulcerative Colitis
171 | permissions_favorite == False
171 | permissions_rate == False
171 | content_article == <p><em><span style="font-weight: 400;">This article is for informational purposes only. None of the information here should be taken as medical advice. If you suspect you may have any kind of infection, seek medical help immediately. Keep in mind that these results are based on association studies, which are correlative and aren&rsquo;t necessarily causative. In addition, any single genetic variant will typically contribute only a small proportion to the overall risk of the condition, and non-genetic factors play a large role in developing a condition as well. Therefore, just because you have one of these genotypes does not necessarily mean you are at increased risk of developing this condition!</span></em></p> <h2><strong>What Is The <em>HNF4A</em> Gene?</strong></h2> <p><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">HNF4A</span></em><span style="font-weight: 400;"> gene is responsible for creating a protein called </span><strong>HNF4A</strong><span style="font-weight: 400;"> (also referred to as NR2A1).</span></p> <p><span style="font-weight: 400;">The HNF4A protein is a transcription factor, meaning that it regulates the expression of other genes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841246/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">HNF4A primarily acts on genes related to the liver, ultimately leading to several effects, including [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841246/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12514743"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Development of the liver, kidneys, and intestines</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Activation of </span><a href="https://selfhacked.com/blog/cyp-enzymes-interact-supplements-related-genes/"><span style="font-weight: 400;">CYP enzymes</span></a><span style="font-weight: 400;">, which help detox the body</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Production of </span><a href="https://selfhacked.com/blog/sex-hormone-binding-globulin-shbg/"><span style="font-weight: 400;">SHBG</span></a><span style="font-weight: 400;">, a protein that regulates sex hormones</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Regulation of </span><a href="https://selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;">insulin resistance</span></a></li> </ul> <p><span style="font-weight: 400;">Research has found that variations in the </span><em><span style="font-weight: 400;">HNF4A</span></em><span style="font-weight: 400;"> gene may increase the risk of certain health conditions, such as diabetes, metabolic syndrome, and </span><a href="https://selfhacked.com/blog/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections/"><span style="font-weight: 400;">inflammatory bowel disease (IBD)</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19748811"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325000/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435391/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">This article will focus on the association between </span><em><span style="font-weight: 400;">HNF4A</span></em><span style="font-weight: 400;"> and IBD, including who may be affected and strategies that may help with the condition.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The HNF4A gene is responsible for regulating the expression of other genes involved in liver function. Certain variants of HNF4A may increase the risk of developing inflammatory bowel disease.</span></p> <h2><strong><em>HNF4A</em> &amp; Inflammatory Bowel Disease</strong></h2> <h3><strong>What Is Inflammatory Bowel Disease (IBD)?</strong></h3> <p><span style="font-weight: 400;">Inflammatory bowel disease (IBD) is a broad term used to describe conditions that cause chronic inflammation in the digestive tract, including the esophagus, stomach, and intestines [</span><a href="https://www.cdc.gov/ibd/what-is-IBD.htm"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">IBD is a complex disorder that can be caused by multiple factors, including genetics, diet, </span><a href="https://www.selfhacked.com/blog/gut-bacteria-microbiome/"><span style="font-weight: 400;">gut microbiome</span></a><span style="font-weight: 400;">, and environmental factors [</span><a href="https://www.cdc.gov/ibd/what-is-IBD.htm"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">There are two main types of IBD:</span></p> <p><a href="https://selfhacked.com/blog/ulcerative-colitis/"><strong>Ulcerative colitis</strong></a><span style="font-weight: 400;"> typically affects the large intestine (colon) and the rectum [</span><a href="https://www.cdc.gov/ibd/what-is-IBD.htm"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/crohns-disease/"><strong>Crohn&rsquo;s disease</strong></a><span style="font-weight: 400;"> can affect any part of the digestive tract (from the mouth to the anus), but it most commonly affects portions of the small intestine [</span><a href="https://www.cdc.gov/ibd/what-is-IBD.htm"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Both conditions can cause diarrhea, cramps, fatigue, abdominal pain, weight loss, and rectal bleeding [</span><a href="https://www.cdc.gov/ibd/what-is-IBD.htm"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Inflammatory bowel disease describes conditions that cause inflammation in the digestive tract. The two main types of IBD are ulcerative colitis and Crohn&rsquo;s disease.</span></p> <h3><strong>How Do Variants Of <em>HNF4A</em> Affect IBD?</strong></h3> <h4><strong>Ulcerative Colitis</strong></h4> <p><span style="font-weight: 400;">Several studies suggest that certain genetic variants of </span><em><span style="font-weight: 400;">HNF4A</span></em><span style="font-weight: 400;"> may increase the risk of developing ulcerative colitis (UC) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812019/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21744425"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21831733"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A genome study including over 7,000 people with European ancestry found that </span><strong>the &lsquo;C&rsquo; allele in rs6017342 is associated with greater rates of UC</strong><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812019/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Likewise, a study of over 2,000 Dutch patients also found that those carrying a &lsquo;C&rsquo; allele were significantly more likely to have UC [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21744425"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">On the other hand, a Korean study of about 1,900 patients concluded that the other allele in rs6017342 (the &lsquo;A&rsquo; allele) may have a protective effect against UC [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21831733"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Why do certain variants affect the risk of UC?</span></p> <p><span style="font-weight: 400;">The HNF4A protein helps maintain the </span><a href="https://selfhacked.com/blog/leaky-gut-syndrome-signs-symptoms-treatments/"><span style="font-weight: 400;">mucosal barrier in the intestines</span></a><span style="font-weight: 400;">. This barrier is responsible for protecting the lining of the intestines while allowing nutrients to be absorbed [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19855405"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">According to researchers, </span><strong>certain variants in </strong><strong><em>HNF4A</em></strong><strong> (like the &lsquo;C&rsquo; allele in rs6017342) may reduce expression of the HNF4A protein, which can disrupt the mucosal barrier in the intestines</strong><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812019/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Certain variants of the HNF4A gene can disrupt the mucosal barrier that protects the intestines, which may increase the risk of developing ulcerative colitis.</span></p> <h4><strong>Crohn&rsquo;s Disease</strong></h4> <p><span style="font-weight: 400;">Fewer studies have linked the </span><em><span style="font-weight: 400;">HNF4A </span></em><span style="font-weight: 400;">gene to Crohn&rsquo;s disease, but there is still some evidence.</span></p> <p><span style="font-weight: 400;">According to a study of over 1,600 Canadian children, </span><strong>the &lsquo;G&rsquo; allele in rs1884613 may be associated with childhood-onset Crohn&rsquo;s disease</strong><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931920/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Similar to the mechanism for ulcerative colitis, researchers theorize that the &lsquo;G&rsquo; allele may lower the expression of HNF4A, leading to impairment of the mucosal barrier in the intestines [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931920/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Variants of HNF4A have also been linked to increased risk of childhood-onset Crohn&rsquo;s disease.</span></p> <h2><strong>Your <em>HNF4A</em> Results for IBD</strong></h2> <p>*6726030900221933*</p> <p><strong>Primary SNPs:&nbsp;</strong></p> <p><strong>HNF4A rs6017342</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with lower risk of ulcerative colitis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with higher risk of ulcerative colitis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">These associations were found in European and Korean populations</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">About 25% of European populations carry the &lsquo;CC&rsquo; genotype (highest risk)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">About 80% of East Asian populations carry the &lsquo;CC&rsquo; genotype (highest risk)</span></li> </ul> <p><strong>HNF4A rs1884613</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with Crohn&rsquo;s disease&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with higher risk of childhood-onset Crohn&rsquo;s disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">This association was found in a French Canadian population</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">About 2% of European populations carry the &lsquo;GG&rsquo; genotype (highest risk)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">About 17% of East Asian populations carry the &lsquo;GG&rsquo; genotype (highest risk)</span></li> </ul> <p>*1739354538522113*</p> <h2><strong>Recommendations to Improve Gut Inflammation</strong></h2> <p><em><span style="font-weight: 400;">You may try the complementary approaches listed below if you and your doctor determine that they could be appropriate for you. Discuss the strategies listed here with your doctor. Remember that none of them should ever be done in place of what your doctor recommends or prescribes.</span></em></p> <p>*8373414708026239*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Maintain a Circadian Rhythm</strong></h4> <p><span style="font-weight: 400;">There is evidence that the </span><em><span style="font-weight: 400;">HNF4A</span></em><span style="font-weight: 400;"> gene has a close relationship with the body&rsquo;s internal clock. According to cellular studies, HNF4A activity is directly associated with </span><a href="https://selfhacked.com/blog/what-it-means-to-keep-to-a-circadian-rhythm/"><span style="font-weight: 400;">circadian rhythm</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310821/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Keeping a consistent sleep-wake cycle is likely important for the optimal function of HNF4A [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310821/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Research also shows that </span><a href="https://selfhack.com/blog/methods-to-fall-asleep-insomniac/"><span style="font-weight: 400;">poor sleep quality</span></a><span style="font-weight: 400;"> and circadian disturbances can promote inflammation and worsen the progression of IBD [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29173529"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25732745"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/what-it-means-to-keep-to-a-circadian-rhythm/"><span style="font-weight: 400;">Check out our circadian rhythm article for more information</span></a><span style="font-weight: 400;">.</span></p> <h3><strong>Diet</strong></h3> <h4><strong>Calorie Restriction</strong></h4> <p><span style="font-weight: 400;">There are several proteins in the body that are coactivators of </span><em><span style="font-weight: 400;">HNF4A</span></em><span style="font-weight: 400;">. One example is </span><a href="http://selfhacked.com/blog/about-pgc-1alpha-and-natural-ways-to-increase-it/"><span style="font-weight: 400;">PGC-1alpha</span></a><span style="font-weight: 400;">, a protein that promotes the activity of HNF4A [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12651943/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Animal and cell studies show that </span><a href="http://selfhacked.com/blog/intermittent-fasting/"><span style="font-weight: 400;">fasting</span></a><span style="font-weight: 400;"> can activate PGC-1alpha, which in turn activates HNF4A [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12651943/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Fasting and calorie restriction may also be beneficial for those suffering from IBD [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528490/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099178/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Research in animals suggests that </span><a href="http://selfhacked.com/blog/intermittent-fasting/"><span style="font-weight: 400;">intermittent fasting</span></a><span style="font-weight: 400;"> and calorie-restricted diets can reduce intestinal inflammation, promote protective </span><a href="https://selfhacked.com/blog/how-your-gut-microbiota-can-make-you-fat-or-thin/"><span style="font-weight: 400;">gut microbiota</span></a><span style="font-weight: 400;">, and help reverse intestinal damage [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528490/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099178/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, clinical research has not been conclusive.&nbsp;</span></p> <p><span style="font-weight: 400;">A study of 60 patients with IBD who fasted for Ramadan found that disease activity of ulcerative colitis decreased in men after fasting, but overall quality of life did not improve [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19405258"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In another study of 222 hospitalized patients with IBD, fasting had no effect on disease activity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31308352"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Intermittent fasting and calorie restriction promotes HNF4A activity and improves gut inflammation, according to animal studies. However, research in humans has produced mixed results.</span></p> <h4><strong>Avoid High-Fat Diets</strong></h4> <p><span style="font-weight: 400;">High-fat diets may reduce expression and activity of HNF4A by up to 30%, according to animal and cell studies [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29150932"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28442500"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A number of studies also show that diets high in fat (especially </span><a href="https://selfhack.com/blog/saturatedfats-low-carb-diet-vs-high-carb-diet/"><span style="font-weight: 400;">saturated and trans fats</span></a><span style="font-weight: 400;">) can increase intestinal inflammation, disturb the gut microbiome, and exacerbate IBD symptoms [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23761644"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23977107"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843040/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27793606"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Those worried about gut inflammation may benefit from limiting the intake of fats and switching to healthier fats [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843040/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153885/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Berberine</strong></h4> <p><span style="font-weight: 400;">In studies using rat and mouse cells, </span><a href="https://selfhacked.com/blog/berberine-19-health-benefits-of-berberine-with-references/"><span style="font-weight: 400;">berberine</span></a><span style="font-weight: 400;"> increased the expression of </span><em><span style="font-weight: 400;">HNF4A </span></em><span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18932278"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19160796"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Research has also found that supplementation with berberine may help those with IBD by improving the gut mucosal barrier, as well as through its antioxidant and anti-inflammatory effects [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27697643"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, no strong studies in humans have been conducted yet. More clinical trials are needed to fully evaluate the effectiveness of this supplement.</span></p>
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171 | content_learn_more_1739354538522113_text == Based on the variants we looked at, your HNF4A gene is somewhat associated with a higher risk of IBD. However, this doesn't necessarily reflect your overall gut health — just one gene related to it. Certain lifestyle, diet, and supplement choices can help. Keep scrolling to find out more.
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rsIDs = rs6017342,rs1884613
rsStatus = rs6017342,,chr20,44436388,A,C,G,T,7,34,HET
rsStatus = rs1884613,LOC105372629,chr20,44351775,C,A,G,T,33,0,Normal
