177 | id == 177
177 | category_id == 16
177 | category_order == 13
177 | category_name == Gut Health
177 | category_color == #C47AC0
177 | slug == ZNF365-IBD
177 | title == Zinc Fingers, DNA Repair, and Inflammatory Bowel Disease (ZNF365)
177 | meta_description == ZNF365 is a zinc finger protein involved in tagging and repairing damaged DNA. What role does it play in IBD?
177 | summary == <p><strong>ZNF365 is a zinc finger protein involved in tagging and repairing damaged DNA. What role does it play in ulcerative colitis &amp; Crohn&#39;s disease? Read on to find out.</strong></p>
177 | overall_score_text == Gut Inflammation Score (based on ZNF365)
177 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ZNF365--Gut-Inflammation-IBD---all-chips.jpg
177 | author_id == 1
177 | author_name == Jasmine Foster
177 | author_title == BSc, BEd
177 | author_order == 36
177 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
177 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
177 | reviewer == None
177 | medical_reviewer_id == 11
177 | medical_reviewer_name == Puya Yazdi
177 | medical_reviewer_title == MD
177 | publish_date == 2020
177 | publish_date == 5
177 | publish_date == 8
177 | avg_rating == 4.5
177 | tags_id == 195
177 | tags_name == Crohn's Disease
177 | tags_id == 40
177 | tags_name == DNA Repair
177 | tags_id == 194
177 | tags_name == Gut Health
177 | tags_id == 308
177 | tags_name == Gut Inflammation
177 | tags_id == 73
177 | tags_name == IBD
177 | tags_id == 39
177 | tags_name == Oxidative Stress
177 | tags_id == 196
177 | tags_name == Ulcerative Colitis
177 | tags_id == 341
177 | tags_name == Zinc
177 | tags_id == 414
177 | tags_name == Zinc Fingers
177 | tags_id == 413
177 | tags_name == ZNF365 Gene
177 | permissions_favorite == False
177 | permissions_rate == False
177 | content_article == <p><em><span style="font-weight: 400;">This article is for informational purposes only. None of the information here should be taken as medical advice. If you suspect you may have digestive issues, seek medical help. </span></em><em><span style="font-weight: 400;">Keep in mind that these results are based on association studies, which are correlative and aren&rsquo;t necessarily causative. Any single genetic variant will typically contribute only a small proportion to the overall risk of the condition, and non-genetic factors play a large role in developing a condition as well. Therefore, just because you have one of these genotypes does not necessarily mean you are at an increased risk of developing this condition!</span></em></p> <h2><span style="font-weight: 400;">What are Zinc Finger Proteins?</span></h2> <p><span style="font-weight: 400;">ZNF365 (zinc finger protein 365) is believed to play a role in repairing DNA damage and ensuring the stability of the genome. It also participates in </span><a href="https://selfhacked.com/blog/uric-acid-correlated-iq-productivity-lifespan-likely-causal/"><span style="font-weight: 400;">uric acid</span></a><span style="font-weight: 400;"> metabolism and the growth of nerves during fetal development; mutations in the gene are associated with an impressive variety of diseases, including kidney stones, breast cancer, and IBD [</span><a href="https://ghr.nlm.nih.gov/gene/ZNF365"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=ZNF365"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632836/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250380/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><span style="font-weight: 400;">The Role of Zinc Fingers in the Gut</span></h2> <p><span style="font-weight: 400;">ZNF365 mutations have been associated with both Crohn&rsquo;s disease and ulcerative colitis, the two major forms of IBD, as well as IBD risk more broadly [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250380/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574810/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">What is IBD?</span></h3> <p><span style="font-weight: 400;">IBD is a group of autoimmune diseases characterized by inflammation and sores in the gut lining, which can result in diarrhea, abdominal </span><a href="https://selfhacked.com/blog/23-ways-to-combat-pain-naturally-by-increasing-your-opioids/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;">, fatigue, fever, rectal bleeding, nutritional deficiencies, and </span><a href="http://selfhacked.com/blog/a-comprehensive-list-of-effective-ways-to-lose-weight/"><span style="font-weight: 400;">weight loss</span></a><span style="font-weight: 400;">. The definition of IBD includes both ulcerative colitis and Crohn&rsquo;s disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980998/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/crohns-disease/"><span style="font-weight: 400;">Crohn&rsquo;s disease</span></a><span style="font-weight: 400;"> differs from ulcerative colitis in that it is centered higher in the digestive tract (typically in the small intestine, though it can occur anywhere between the mouth and anus) and may damage broader swaths of tissue [</span><a href="https://www.niddk.nih.gov/health-information/digestive-diseases/ulcerative-colitis"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.niddk.nih.gov/health-information/digestive-diseases/crohns-disease/definition-facts"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">By contrast, </span><a href="https://selfhacked.com/blog/ulcerative-colitis/"><span style="font-weight: 400;">ulcerative colitis</span></a><span style="font-weight: 400;"> (UC) produces chronic inflammation and ulceration of the large intestine (the colon) and is also focused on the innermost lining of the colon wall, where Crohn&rsquo;s can damage much broader swaths of tissue [</span><a href="https://www.niddk.nih.gov/health-information/digestive-diseases/ulcerative-colitis"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.niddk.nih.gov/health-information/digestive-diseases/crohns-disease/definition-facts"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/books/NBK459282/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">How Does ZNF365 Contribute to Disease?</span></h3> <p><span style="font-weight: 400;">No studies have specifically investigated how ZNF365 might cause, protect against, or otherwise be connected to IBD. However, there are a few possible options, mostly to do with DNA damage and repair [</span><a href="https://ghr.nlm.nih.gov/gene/ZNF365"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26193347"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">DNA damage, usually from oxidative stress, is a hallmark of IBD. Patients with both Crohn&rsquo;s disease and ulcerative colitis tend to have more </span><a href="https://selfhacked.com/blog/oxidative-stress-101/"><span style="font-weight: 400;">oxidative stress</span></a><span style="font-weight: 400;"> and DNA damage than healthy people; the younger a patient is when ulcerative colitis is diagnosed, the more measurable DNA damage they are likely to have. Unsurprisingly, patients undergoing treatment for their IBD have less DNA damage than those who are untreated [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26193347"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27095753"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://mcr.aacrjournals.org/content/16/4/634"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">ZNF365 stimulates DNA repair by binding to and activating PARP1. PARP1 then binds to damaged DNA, flagging it for other repair mechanisms to move in and get to work. This pathway is obviously important, but must remain in balance; overactivation of PARP1 may trigger inflammation and has also been implicated in IBD [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899195/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782595/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.jbc.org/content/early/2016/02/24/jbc.M116.714386.full.pdf"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">One association study found that </span><strong>ZNF365 expression was higher in people with a protective genotype</strong><span style="font-weight: 400;">, reinforcing the hypothesis that ZNF365 is potentially protective [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250380/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">People with IBD tend to have more DNA damage than healthy people. ZNF365 helps repair DNA by activating PARP1 and may protect against the development of IBD.</span></p> <h3><span style="font-weight: 400;">ZNF365 Variants &amp; IBD</span></h3> <p><span style="font-weight: 400;">At least three ZNF365 variants have been associated with IBD so far: rs10995271, rs7076156, and rs10761659. The &lsquo;G&rsquo; allele of rs10761659 and the &lsquo;C&rsquo; allele of rs10995271 have been identified as potential risk alleles for IBD, while the &lsquo;A&rsquo; allele of rs7076156 may be protective [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574810/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250380/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881818/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719288/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299551/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22936669"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491803/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The protective &lsquo;AA&rsquo; genotype of rs7076156 has been found to increase ZNF365 expression, suggesting that low ZNF365 may reduce capacity for DNA repair and increase susceptibility to disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574810/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250380/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881818/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><span style="font-weight: 400;">Your ZNF365 Results for IBD</span></h2> <p>*8082003439895651*</p> <h3><span style="font-weight: 400;">SNP Summary and Table</span></h3> <p><strong>ZNF365 rs10761659</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with IBD</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with Crohn&rsquo;s disease and ulcerative colitis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Roughly a third of all people worldwide have each of the three possible genotypes (AA, AG, and GG) at this SNP.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The protective AA genotype is far more common in people of African descent (85%) than in any other population; the GG genotype is most common in people of East Asian descent (54%)</span></li> </ul> <p><strong>ZNF365 rs10995271</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with IBD</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with Crohn&rsquo;s disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Just under half (49%) of all people worldwide have the protective GG genotype.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The GG genotype is much more common in people of African descent (74%); the CC genotype is most common in people of East Asian descent (29%).</span></li> </ul> <p><strong>ZNF365 rs7076156</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not protective against Crohn&rsquo;s disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Possibly protective against Crohn&rsquo;s disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">About 77% of all people worldwide have the GG genotype.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The A allele is very rare in people of African descent (3.5%) and very common in people of European descent (48%).</span></li> </ul> <p>*2728064339817633*</p> <h2><span style="font-weight: 400;">Recommendations for Reducing Gut Inflammation</span></h2> <p><em><span style="font-weight: 400;">You may try the complementary approaches listed below if you and your doctor determine that they could be appropriate for you. Discuss the strategies listed here with your doctor. Remember that none of them should ever be done in place of what your doctor recommends or prescribes.</span></em></p> <p>*8925218198332039*</p> <h3><span style="font-weight: 400;">Zinc Sufficiency</span></h3> <p><span style="font-weight: 400;">ZNF365, like other zinc finger proteins, requires atoms of zinc to function. The most important factor for the correct function of ZNF365 is getting enough zinc from dietary sources, including seafood and meat [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250380/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC140525/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Zinc deficiency has been linked to worse outcomes in IBD, and </span><a href="https://selfhacked.com/blog/literally-everything-wanted-know-zinc-backed-science/"><span style="font-weight: 400;">zinc supplementation</span></a><span style="font-weight: 400;"> may improve symptoms. Many researchers strongly recommend monitoring IBD patients for potential zinc deficiency; if you become deficient, your doctor will likely recommend supplements [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177471/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.hindawi.com/journals/bmri/2018/1813047/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://academic.oup.com/ije/article/44/6/1995/2572627"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Zinc is required for any protein with zinc finger domains to work, and zinc deficiency has been linked to worse outcomes in IBD.</span></p> <h3><span style="font-weight: 400;">Yellow, Orange, and Red Fruits &amp; Vegetables</span></h3> <p><span style="font-weight: 400;">Carotenoids are a group of yellow, orange, and red pigments found in many fruits and vegetables. They as a group, but lycopene in particular, have been found to significantly increase markers of DNA repair [</span><a href="https://academic.oup.com/jn/article/135/8/2071S/4664044"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Lycopene sources include any fruits or vegetables that are yellow, orange, or red. Tomatoes are among the richest dietary sources of lycopene; tomato-rich diets have also been associated with beneficial changes to the gut flora in animals [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC521493/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315348/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810255/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some people with IBD may have difficulty digesting certain fruits or vegetables; fortunately, carotenoids are abundant in a wide variety of them. Look for yellow, orange, or red fruits and vegetables to add to your diet and help support DNA repair.</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Fruits and vegetables containing carotenoids generally and lycopene in particular may support DNA repair and improve IBD.</span></p>
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177 | content_learn_more_2728064339817633_text == Based on the variants we looked at, your ZNF365 gene is associated with roughly average rates of IBD. However, this doesn't necessarily reflect your overall risk of IBD, just one gene related to it. Zinc and certain fruits and vegetables may help. Keep scrolling to find out more.
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rsIDs = rs10761659,rs7076156,rs10995271
rsStatus = rs10761659,,chr10,62685804,A,C,G,,40,0,Normal
rsStatus = rs7076156,LOC105378327,chr10,62655424,A,C,G,T,40,0,Normal
rsStatus = rs10995271,,chr10,62678726,G,A,C,,34,0,Normal
