178 | id == 178
178 | category_id == 16
178 | category_order == 13
178 | category_name == Gut Health
178 | category_color == #C47AC0
178 | slug == CRHR1-IBS-anxiety
178 | title == The Hidden Link Between IBS and Anxiety (CRHR1)
178 | meta_description == CRHR1 encodes a receptor for CRH, a crucial hormone for stress response. Variants in this gene correlate with IBS and anxiety.
178 | summary == <p style="text-align:justify"><strong>The <em>CRHR1</em> gene encodes a receptor for CRH, a crucial hormone in the gut-brain connection and stress response. Read this post to learn about the variants in this gene associated with IBS and related anxiety.</strong></p>
178 | overall_score_text == Your IBS Score (based on CRHR1 gene)
178 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CRHR1--IBS---all-chips.jpg
178 | author_id == 9
178 | author_name == Aleksa Ristic
178 | author_title == MS (Pharmacy)
178 | author_order == 45
178 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
178 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
178 | reviewer == None
178 | medical_reviewer_id == 11
178 | medical_reviewer_name == Puya Yazdi
178 | medical_reviewer_title == MD
178 | publish_date == 2020
178 | publish_date == 5
178 | publish_date == 9
178 | avg_rating == 5.0
178 | tags_id == 112
178 | tags_name == Anxiety
178 | tags_id == 416
178 | tags_name == Cortisol
178 | tags_id == 417
178 | tags_name == CRH
178 | tags_id == 418
178 | tags_name == CRHR1 gene
178 | tags_id == 194
178 | tags_name == Gut Health
178 | tags_id == 415
178 | tags_name == HPA axis
178 | tags_id == 8
178 | tags_name == IBS
178 | tags_id == 246
178 | tags_name == Probiotics
178 | tags_id == 50
178 | tags_name == Stress
178 | permissions_favorite == False
178 | permissions_rate == False
178 | content_article == <p><em><span style="font-weight: 400;">This article is for informational purposes only. None of the information here should be taken as medical advice. If you suspect you may have digestive issues, seek medical help. </span></em><em><span style="font-weight: 400;">Keep in mind that these results are based on association studies, which are correlative and aren&rsquo;t necessarily causative. Any single genetic variant will typically contribute only a small proportion to the overall risk of the condition, and non-genetic factors play a large role in developing a condition as well. Therefore, just because you have one of these genotypes does not necessarily mean you are at an increased risk of developing this condition!</span></em></p> <h2><strong>CRHR1 and the HPA Axis</strong></h2> <p><a href="https://commons.wikimedia.org/w/index.php?curid=53298307" target="_blank" rel="noopener"><span style="font-weight: 400;"><img src="https://upload.wikimedia.org/wikipedia/commons/thumb/e/ee/HPA_Axis_Diagram_%28Brian_M_Sweis_2012%29.svg/654px-HPA_Axis_Diagram_%28Brian_M_Sweis_2012%29.svg.png" alt="HPA axis CRH ACTH cortisol" width="469" height="430" /></span></a></p> <p><sub><span style="font-weight: 400;">By Shelley Adams: HPA Axis Diagram (Brian M Sweis 2012).png, CC BY-SA 3.0</span></sub></p> <p><span style="font-weight: 400;">The </span><a href="../../gene/crhr1/"><em><span style="font-weight: 400;">CRHR1</span></em></a><span style="font-weight: 400;"> gene encodes the first type of the CRH receptor (CRH-R1). The release of CRH sets off the hypothalamic-pituitary-adrenal (HPA) axis, resulting in the secretion of cortisol, the stress hormone [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057754/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In response to stress, the HPA axis stimulates the nervous system, cardiovascular system, and bowel movements. Excess CRH levels play a role in a range of physical and mental disorders [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/7830793/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/1980834/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17238026/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>The Role of CRH in IBS</strong></h3> <p><span style="font-weight: 400;">Irritable bowel syndrome (IBS) is a gut condition that causes abdominal pain, bloating, and impaired bowel movements. The NIH estimates that as many as 20% of Americans may experience IBS symptoms, but doctors still don&rsquo;t know the exact causes behind it [</span><a href="https://en.wikipedia.org/wiki/Linaclotide"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Recent IBS research has focused on the gut-brain connection and the impact of psychosocial factors such as stress and anxiety [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23991913/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17238026/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15309899/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">As mentioned, CRH mediates stress response and impacts bowel movements, which makes it a key player in IBS. Administration of CRH can cause or worsen IBS symptoms in humans and lab animals [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434156/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9691924"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9691924/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Excess CRH may also increase pain sensitivity in the gut, potentially worsening the symptoms of IBS and other digestive disorders [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17238026"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">IBS is a bowel movement disorder with a strong mental component. By controlling stress response and gut sensitivity, CRH plays a crucial role in IBS development.</span></p> <h2><strong><em>CRHR1</em> Variants and IBS Susceptibility</strong></h2> <p><span style="font-weight: 400;">A study of 500 subjects found a link between </span><em><span style="font-weight: 400;">CRHR1</span></em><span style="font-weight: 400;"> variants and IBS: the condition was more common in people with the &ldquo;G&rdquo; alleles at </span><a href="../../snp/rs110402/"><span style="font-weight: 400;">rs110402</span></a><span style="font-weight: 400;"> and </span><a href="../../snp/rs242924/"><span style="font-weight: 400;">rs242924</span></a><span style="font-weight: 400;">. These SNPs were also associated with higher IBS-related anxiety [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048544/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The above trial excluded Asian subjects because they have drastically different allele frequencies for these variants. In a Japanese study, the opposite alleles correlated with higher IBS rates [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434156/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Previous research has associated the same SNPs with depression and anxiety, confirming the central role of CRH in the gut-brain connection [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443704/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21438878/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430712/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The &ldquo;G&rdquo; alleles at rs110402 and rs242924 correlate with higher rates of IBS and related anxiety. These variants have the opposite effect in Asian populations.</span></p> <h3><strong>How It Works</strong></h3> <p><span style="font-weight: 400;">Unlike CRH-R2, the stimulation of CRH-R1 receptors stimulates bowel movements and increases gut sensitivity. CRH may also cause inflammation via CRH-R1. These receptors are a crucial link between stress response and IBS symptoms [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17238026/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The studied SNPs are in the intron region of CRHR1; they may impact gene expression and the structure of the final product (receptor). In simple terms, </span><strong>the &ldquo;G&rdquo; alleles may enhance the activation of CRH-R1 receptors and thus contribute to IBS</strong><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11606483/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21883143/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16484629/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your CRHR1 Results for IBS</strong></h2> <p>*2199587662616013*</p> <h3><strong>SNP Summary</strong></h3> <p><strong>Primary SNPs:</strong></p> <p><strong><em>CRHR1</em></strong> <a href="../../snp/rs110402/"><strong>rs110402</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = associated with higher rates of IBS and related anxiety</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = not associated with IBS</span></li> </ul> <p><strong><em>CRHR1</em></strong> <a href="../../snp/rs242924/"><strong>rs242924</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = associated with higher rates of IBS and related anxiety&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = not associated with IBS</span></li> </ul> <h4><strong>Population Frequency</strong></h4> <p><span style="font-weight: 400;">These two variants are almost always inherited together, which means they act as a single genetic factor. Around 50% of European descendants carry one copy, and 30% carry both copies of the &ldquo;G&rdquo; allele. This allele is much less common in East Asian populations (15%).</span></p> <p>*1204232844075934*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Improve Gut Health</strong></h2> <p><em><span style="font-weight: 400;">You may try the complementary approaches listed below if you and your doctor determine that they could be appropriate for you. Discuss the strategies listed here with your doctor. Remember that none of them should ever be done in place of what your doctor recommends or prescribes.</span></em></p> <p>*8002644229161979*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Avoid Stress</strong></h4> <p><span style="font-weight: 400;">Psychosocial stress is the primary HPA axis activator. Excessive CRH-R1 stimulation mediates various adverse effects of stress, both mental and physical [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15196881"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10629757"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Stress can trigger or worsen IBS symptoms. Some researchers refer to both &ldquo;irritable bowel&rdquo; and &ldquo;irritable brain&rdquo; as equal factors in the development of IBS. Many experts recommend stress management as part of a holistic strategy to treat this condition [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202343/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692018/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28061975"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In two studies of 232 participants, different relaxation strategies significantly reduced IBS symptoms, in some cases even better than conventional treatment [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/14572570"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/3313684"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Stress can stimulate CRH-R1 receptors, activate the HPA axis, and trigger IBS symptoms. Different relaxation techniques may provide relief from this condition.</span></p> <h3><strong>Diet</strong></h3> <h4><strong>Fermented Foods</strong></h4> <p><span style="font-weight: 400;">Probiotic-rich foods may reduce HPA axis activity and keep the stress hormones under control. Imbalances in the gut microbiota can trigger gut inflammation and activate the HPA axis, while probiotics may lessen this effect [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511921/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794709/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Most IBS patients have impaired gut microbiota, featured by low diversity and numbers of beneficial probiotic strains [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039952/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Fermented foods are a great way to increase your intake of probiotics and control IBS symptoms. The following foods have shown promising results in clinical trials [</span><a href="https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2036.2008.03818.x"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2036.2007.03362.x"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30256365"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723656/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Buttermilk</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Yogurt</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Kefir</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Sauerkraut (fermented cabbage)</span></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Probiotics may prevent over-stimulation of the HPA axis. Fermented foods help restore your gut microbiota, which is essential for IBS prevention and control.</span></p> <h4><strong>Zinc-Rich Foods</strong></h4> <p><span style="font-weight: 400;">Zinc deficiency activates the HPA axis and increases cortisol secretion. In a trial of 27 volunteers, i.v. zinc administration suppressed cortisol levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964522/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986464/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/1702662"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">IBS patients often have a zinc deficiency. Zinc supplementation can be effective against diarrhea, especially in malnourished children [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/2247262"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933690/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11101480"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9651405"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">That said, over-supplementation with zinc may also cause digestive issues. Most people can get enough of this mineral from dietary sources, such as [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231515/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231515/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Meat</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Seafood (especially oysters)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Dairy products</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Nuts and seeds</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Legumes</span></li> </ul> <p><span style="font-weight: 400;">However, people with gut inflammation might have impaired zinc absorption and require higher levels of zinc, in which case supplements can help.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Zinc deficiency can activate the HPA axis and worsen IBS symptoms, especially diarrhea.&nbsp;</span></p> <h4><strong>Limit Caffeine Intake</strong></h4> <p><span style="font-weight: 400;">Caffeine is a psychostimulant that spikes cortisol and increases alertness. This effect is more pronounced in people who don&rsquo;t regularly consume caffeinated beverages [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2257922/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/8951977"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a trial of 330 IBS patients, coffee was one of the top ten food items associated with symptoms such as indigestion, pain, and loose stools. Most dietary guidelines for IBS patients recommend limiting caffeine intake [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23644955/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nice.org.uk/guidance/cg61"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://gastro.org/patient-care/conditions-diseases/irritable-bowel-syndrome"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In sensitive people, higher doses of caffeine may provoke anxiety, which is closely related to IBS [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/2727208"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Caffeine may spike cortisol and contribute to unpleasant digestive symptoms in some IBS patients.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Peppermint Oil</strong></h4> <p><span style="font-weight: 400;">Peppermint is an age-old traditional remedy for stress and digestive issues. Its relaxing properties partly stem from the ability to suppress CRH, leading to lower cortisol levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132346/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/peppermint-oil-benefits-uses-side-effects/"><span style="font-weight: 400;">Peppermint oil</span></a><span style="font-weight: 400;"> is a well-known natural remedy for IBS with a significant chunk of evidence to back up its use. In a meta-analysis of 12 studies and 835 patients, it reduced abdominal pain and other symptoms of IBS without adverse effects [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337770/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Up to 80% of IBS patients may have small intestinal bacterial overgrowth or </span><a href="https://selfhacked.com/blog/sibo-causes-and-treatment/"><span style="font-weight: 400;">SIBO</span></a><span style="font-weight: 400;">. Peppermint oil reduced intestinal gas production and IBS symptoms in patients with bacterial overgrowth [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17420159"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Peppermint oil may suppress CRH, improve the gut flora, and reduce IBS symptoms.</span></p> <h4><strong>Probiotics</strong></h4> <p><span style="font-weight: 400;">As mentioned, probiotics can prevent over-stimulation of the HPA axis. The following strains showed promising clinical results in IBS patients:</span></p> <ul> <li style="font-weight: 400;"><em><span style="font-weight: 400;">Bifidobacterium infantis </span></em><span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15765388"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><em><span style="font-weight: 400;">Bifidobacterium lactis </span></em><span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27782892"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><em><span style="font-weight: 400;">Saccharomyces cerevisiae</span></em><span style="font-weight: 400;"> (Brewer&rsquo;s yeast) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5236513/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400;">According to a review of 10 studies, probiotics may reduce anxiety and improve mood and cognition in depressed patients. Given the robust gut-brain connection, this effect is crucial for people struggling with IBS [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319175/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Probiotics may balance the gut-brain connection and improve IBS symptoms.</span></p>
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178 | content_learn_more_1204232844075934_text == Based on the variants we looked at, your CRHR1 gene is associated with slightly higher IBS rates and related anxiety. However, this doesn't necessarily reflect your overall risk of IBS, just one gene related to it. Avoid stress, consume fermented foods, and limit caffeine intake to improve gut health. Keep reading to learn more.
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rsIDs = rs110402,rs242924
rsStatus = rs110402,CRHR1,chr17,45802681,G,A,C,,8,4,HET
rsStatus = rs242924,CRHR1,chr17,45808001,G,C,T,,12,0,Normal
