181 | id == 181
181 | category_id == 16
181 | category_order == 13
181 | category_name == Gut Health
181 | category_color == #C47AC0
181 | slug == AGT-Crohn-inflammation
181 | title == Surprising Genetic Factor for Crohn’s Disease (AGT)
181 | meta_description == AGT encodes angiotensinogen, a protein that controls blood pressure and inflammation. Learn its link with Crohn’s disease.
181 | summary == <p style="text-align:justify"><strong>The <em>AGT</em> gene encodes angiotensinogen, a protein that helps control blood pressure and inflammation. Scientists have found a surprising link between one AGT variant and Crohn&rsquo;s disease &mdash; read on to learn the details and get tailored tips!</strong></p>
181 | overall_score_text == Your Crohn’s Disease Score (Based on AGT Gene)
181 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/AGT--Gut-Inflammation-Crohns---all-chips.jpg
181 | author_id == 9
181 | author_name == Aleksa Ristic
181 | author_title == MS (Pharmacy)
181 | author_order == 45
181 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
181 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
181 | reviewer == None
181 | medical_reviewer_id == 11
181 | medical_reviewer_name == Puya Yazdi
181 | medical_reviewer_title == MD
181 | publish_date == 2020
181 | publish_date == 5
181 | publish_date == 11
181 | avg_rating == 4.5
181 | tags_id == 424
181 | tags_name == AGT gene
181 | tags_id == 33
181 | tags_name == Autoimmunity
181 | tags_id == 195
181 | tags_name == Crohn's Disease
181 | tags_id == 73
181 | tags_name == IBD
181 | tags_id == 290
181 | tags_name == Mediterranean diet
181 | tags_id == 252
181 | tags_name == Olive oil
181 | tags_id == 246
181 | tags_name == Probiotics
181 | tags_id == 423
181 | tags_name == RAS system
181 | permissions_favorite == False
181 | permissions_rate == False
181 | content_article == <p><em><span style="font-weight: 400;">This article is for informational purposes only. None of the information here should be taken as medical advice. If you suspect you may have digestive issues, seek medical help. </span></em><em><span style="font-weight: 400;">Keep in mind that these results are based on association studies, which are correlative and aren&rsquo;t necessarily causative. Any single genetic variant will typically contribute only a small proportion to the overall risk of the condition, and non-genetic factors play a large role in developing a condition as well. Therefore, just because you have one of these genotypes does not necessarily mean you are at an increased risk of developing this condition!</span></em></p> <h2><strong>What is AGT?</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../gene/agt/"><em><span style="font-weight: 400;">AGT</span></em></a><span style="font-weight: 400;"> gene encodes angiotensinogen, a liver-made protein at the basis of the renin-angiotensin system (RAS). The primary RAS function is to control blood pressure and fluid balance in the body [</span><a href="https://ghr.nlm.nih.gov/gene/AGT"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/low-higher-renin-how-to-increase-decrease-renin/"><span style="font-weight: 400;">Renin</span></a><span style="font-weight: 400;"> from kidneys converts angiotensinogen into angiotensin I. Next, the ACE enzyme converts angiotensin I to angiotensin II (AII), the bioactive form that narrows blood vessels. Besides this well-studied role, RAS and AII also contribute to wound healing, inflammation, and more [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16816138"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22283774"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">AGT encodes angiotensinogen, a part of the RAS system with crucial roles in blood pressure control and inflammation.</span></p> <h3><strong>The Role of Angiotensin in Crohn&rsquo;s Disease</strong></h3> <p><a href="https://selfhacked.com/blog/crohns-disease/"><span style="font-weight: 400;">Crohn&rsquo;s disease</span></a><span style="font-weight: 400;"> (CD) is a subtype of inflammatory bowel disease (IBD), an autoimmune condition caused by a mixture of </span><a href="https://selfhacked.com/blog/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections/"><span style="font-weight: 400;">genetic and environmental factors</span></a><span style="font-weight: 400;">. It mostly affects the small intestine and involves ulcerations of all cell layers of the gut lining [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106026/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622286/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30837080"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Angiotensin II and other RAS components function as gut cytokines and control inflammation, scarring, and wound healing. Crohn&rsquo;s disease patients have increased levels of AII in the gut lining, compared with healthy controls or patients with </span><a href="https://selfhacked.com/blog/ulcerative-colitis/"><span style="font-weight: 400;">ulcerative colitis</span></a><span style="font-weight: 400;"> (UC) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/3013940/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/2159930/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">AII contributes to granulomatous inflammation, which is common in the gut of CD but not UC patients. It may enhance gut scarring via </span><a href="http://selfhacked.com/blog/tgf/"><span style="font-weight: 400;">TGF-beta1</span></a><span style="font-weight: 400;"> and increase inflammatory cytokines such as </span><a href="../article/tnf-longevity-86"><span style="font-weight: 400;">TNF</span></a><a href="http://selfhacked.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">-alpha</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/8812683/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11345594/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12410849/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Crohn&rsquo;s disease is a subtype of IBD that usually affects the small intestine. AGT-derived peptides control inflammation, wound healing, and scarring in the gut.</span></p> <h2><strong>AGT Variant &amp; Crohn&rsquo;s Disease Rates</strong></h2> <p><span style="font-weight: 400;">Considering the role of angiotensin in gut inflammation and scarring, researchers set out to determine the impact of AGT gene variants on Crohn&rsquo;s disease.</span></p> <p><span style="font-weight: 400;">An Australian study of 235 CD patients and 185 controls found a robust link with </span><a href="../../snp/rs5051/"><span style="font-weight: 400;">rs5051</span></a><span style="font-weight: 400;">. The &ldquo;T&rdquo; allele was more common among CD patients, and those with the &ldquo;TT&rdquo; genotype had 2.4 times higher CD rates [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2563170/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The authors failed to replicate the association in a group of 112 CD patients, but the sample was too small [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2563170/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">A variation of the AGT gene may correlate with higher CD rates. These preliminary results require confirmation in larger clinical trials.</span></p> <h3><strong>How It Works</strong></h3> <p><span style="font-weight: 400;">This variant is a change of one nucleotide in the AGT promoter, which increases gene expression and results in higher levels of angiotensinogen. Since the RAS chain reaction starts with angiotensinogen, this AGT variant can indirectly boost angiotensin II (AII) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9120024/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The same SNP correlates with high blood pressure and liver scarring, which confirms its potential to raise AII levels [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/1394429/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10733535/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605175/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your AGT Results for Crohn&rsquo;s Disease</strong></h2> <p>*2101473345560736*</p> <h3><strong>SNP Summary</strong></h3> <p><strong>Primary SNP:</strong></p> <p><strong><em>AGT</em></strong> <a href="../../snp/rs5051/"><strong>rs5051</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = not associated with Crohn&rsquo;s disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = associated with higher rates of Crohn&rsquo;s disease</span></li> </ul> <p><em><span style="font-weight: 400;">Population Frequency</span></em><span style="font-weight: 400;">: Around 47% of European descendants carry one copy and 18% carry both copies of the &ldquo;T&rdquo; allele. It&rsquo;s much more common in East Asian and African populations, where 72% and 85% of people carry both copies, respectively.</span></p> <p>*7474179870929111*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Reduce Gut Inflammation</strong></h2> <p><em><span style="font-weight: 400;">You may try the complementary approaches listed below if you and your doctor determine that they could be appropriate for you. Discuss the strategies listed here with your doctor. Remember that none of them should ever be done in place of what your doctor recommends or prescribes.</span></em></p> <p>*5751349309445779*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Avoid Stress</strong></h4> <p><span style="font-weight: 400;">Psychological </span><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">stress</span></a><span style="font-weight: 400;"> activates the RAS system and thus negatively impacts heart health and inflammation. This system has a well-known role in </span><a href="https://selfhacked.com/blog/natural-treatments-depression/"><span style="font-weight: 400;">depression</span></a><span style="font-weight: 400;"> and other stress-related conditions [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034950/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22290200"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Stress can have detrimental effects on gut health. It raises gut permeability and the levels of different inflammatory cytokines [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23470617/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262626/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Many people with IBD develop </span><a href="https://selfhacked.com/blog/natural-treatments-anxiety/"><span style="font-weight: 400;">anxiety</span></a><span style="font-weight: 400;"> and depression associated with their digestive symptoms. In turn, psychological stress may worsen IBD symptoms. Because of this potential feedback loop, many doctors emphasize the importance of managing the mental health of IBD patients [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774724/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28245757"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678997/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572298/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Psychological stress can activate the RAS system, impair gut health, and contribute to IBD.</span></p> <h3><strong>Diet</strong></h3> <h4><strong>Mediterranean Diet</strong></h4> <p><span style="font-weight: 400;">Many natural compounds from fish and cereals can inhibit ACE, a key enzyme in the RAS system that makes angiotensin II. On the other hand, high sugar levels activate this system and increase AII [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383949/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15677497"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">High intake of </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">omega-3 fatty acids</span></a><span style="font-weight: 400;"> from fish (EPA and DHA) may be protective against the development of Crohn&rsquo;s disease [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29543869"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153885/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">A recommended dietary pattern to keep IBD in remission also includes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372922/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Increased intake of fiber, especially from fruits and vegetables</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Avoiding processed vegetable oils</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Cutting back on red meat</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Reduced intake of sweets and refined carbs</span></li> </ul> <p><span style="font-weight: 400;">The Mediterranean diet generally follows the above pattern. It's rich in fruits, vegetables, nuts, whole grains, and </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;">. It implies a moderate intake of fish while cutting back on red meat and sweets.</span></p> <p><span style="font-weight: 400;">Some experts recommend the Mediterranean diet as a complementary approach to digestive disorders such as IBD. The incidence of IBD is lower in the Mediterranean regions, compared with northern Europe [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24979151/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502201/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">. </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372922/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Due to high fiber content, IBD patients may want to avoid this kind of diet during the active phases of &ldquo;flares&rdquo; [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27059169/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Mediterranean diet can reduce the RAS system activity and help prevent gut inflammation. However, it may not be suitable during the active phases of IBD.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Probiotics</strong></h4> <p><a href="https://selfhacked.com/blog/probiotics-good-bacteria/"><span style="font-weight: 400;">Probiotic</span></a><span style="font-weight: 400;"> strains from the </span><em><span style="font-weight: 400;">Lactobacillus</span></em><span style="font-weight: 400;"> and </span><em><span style="font-weight: 400;">Bifidobacterium</span></em><span style="font-weight: 400;"> groups can produce ACE-inhibiting peptides. Yogurt with probiotic bacteria can inhibit ACE more potently, compared with non-probiotic strains [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769158/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15030202/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375191/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People with Crohn&rsquo;s disease often have impaired </span><a href="https://www.selfhacked.com/blog/gut-bacteria-microbiome/"><span style="font-weight: 400;">gut microbiome</span></a><span style="font-weight: 400;">, which may worsen their condition. Different</span> <em><span style="font-weight: 400;">Lactobacillus</span></em><span style="font-weight: 400;"> and </span><em><span style="font-weight: 400;">Bifidobacterium</span></em><span style="font-weight: 400;"> probiotics have been studied in CD patients. The following strains have shown the best results [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155344/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/l-rhamnosus/"><em><span style="font-weight: 400;">Lactobacillus rhamnosus</span></em></a></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/l-casei/"><em><span style="font-weight: 400;">Lactobacillus casei</span></em></a></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/b-breve/"><em><span style="font-weight: 400;">Bifidobacterium breve</span></em></a></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/b-longum/"><em><span style="font-weight: 400;">Bifidobacterium longum</span></em></a></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Different probiotic strains can produce ACE-inhibiting peptides and help reduce gut inflammation in Crohn&rsquo;s disease patients.</span></p> <h4><strong>Whey Protein</strong></h4> <p><span style="font-weight: 400;">Various peptides from <a href="https://selfhacked.com/blog/whey-protein-health-benefits/" target="_blank" rel="noopener">whey protein</a> have demonstrated ACE-inhibiting properties [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24662785"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10399349"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28053783"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A meta-analysis revealed that high doses of whey protein (around 45 g) might reduce inflammation, as measured by </span><a href="http://selfhacked.com/blog/c-reactive-protein/"><span style="font-weight: 400;">CRP</span></a><span style="font-weight: 400;"> levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344580/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Whey protein reduced gut inflammation and damage to the intestinal lining by increasing both antioxidant defenses and good bacteria in 30 patients with Crohn&rsquo;s disease [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22038507"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Whey protein contains multiple ACE-inhibiting peptides. It may protect the gut lining and reduce inflammation due to Crohn&rsquo;s disease, but the available research is limited.</span></p> <h4><strong>Pycnogenol</strong></h4> <p><a href="https://selfhacked.com/blog/pycnogenol-pine-bark-extract-health-benefits/"><span style="font-weight: 400;">Pycnogenol</span></a><span style="font-weight: 400;"> is a supplement made from extracts of the French maritime pine bark. It's rich in procyanidins, compounds with potent anti-inflammatory, antioxidant, and ACE-inhibiting effects [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11996210/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077626/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a clinical trial with 30 children, pycnogenol improved the symptoms of Crohn&rsquo;s disease. Researchers suggest this benefit may be due to an increase in </span><a href="http://selfhacked.com/blog/30-scientifically-proven-health-benefits-glutathione/"><span style="font-weight: 400;">glutathione</span></a><span style="font-weight: 400;"> and </span><a href="http://selfhacked.com/blog/the-brain-fog-gene-rs4880-or-sod2/"><span style="font-weight: 400;">SOD</span></a><span style="font-weight: 400;">, two crucial antioxidants [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23710677"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Pycnogenol is rich in anti-inflammatory compounds that can reduce RAS activity. According to limited clinical evidence, it may improve the symptoms of Crohn&rsquo;s disease.</span></p>
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181 | content_learn_more_7474179870929111_text == Based on the variant we looked at, your AGT gene is associated with slightly higher rates of Crohn’s disease. However, this doesn't necessarily reflect your overall risk of Crohn’s, just one gene related to it. Avoid stress and practice the Mediterranean diet to prevent gut inflammation. Keep reading to learn more.
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rsIDs = rs4880,rs5051
rsStatus = rs4880,SOD2,chr6,159692840,A,G,,,17,16,HET
rsStatus = rs5051,AGT,chr1,230714126,C,A,G,T,24,0,Normal
