185 | id == 185
185 | category_id == 16
185 | category_order == 13
185 | category_name == Gut Health
185 | category_color == #C47AC0
185 | slug == BACH2-Gut-Inflammation
185 | title == Can This Gene Cause Gut Inflammation? (BACH2)
185 | meta_description == The BACH2 gene controls the immune response and some variants are associated with conditions such as celiac disease and IBD. Lea
185 | summary == <p style="text-align:justify"><strong>The BACH2 gene encodes a protein that controls the development of immune cells. Variants of this gene can contribute to inflammatory and immune conditions such as celiac disease and IBD. Read on to learn if your variants are associated with this condition.</strong></p>
185 | overall_score_text == Your overall score
185 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/BACH2--Gut-Inflammation-Celiac---all-chips.jpg
185 | author_id == 12
185 | author_name == Carlos Tello
185 | author_title == PhD
185 | author_order == 55
185 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/CarlosTello.webp
185 | author_intro == <p><strong>Carlos received his PhD and MS from the Universidad de Sevilla.</strong></p>    <p>Carlos spent 9 years in the laboratory investigating mineral transport in plants. He then started working as a freelancer, mainly in science writing, editing, and consulting. Carlos is passionate about learning the mechanisms behind biological processes and communicating science to both academic and non-academic audiences. He strongly believes that scientific literacy is crucial to maintain a healthy lifestyle and avoid falling for scams.</p>
185 | author_social_media_name == linkedin
185 | author_social_media_icon == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/social-icon/linkedin.png
185 | author_social_order == 1
185 | author_social_link == https://www.linkedin.com/in/carlos-tello-lacal-b946b4a7/
185 | reviewer == None
185 | medical_reviewer_id == 11
185 | medical_reviewer_name == Puya Yazdi
185 | medical_reviewer_title == MD
185 | publish_date == 2020
185 | publish_date == 5
185 | publish_date == 14
185 | avg_rating == 5.0
185 | tags_id == 434
185 | tags_name == BACH2 Gene
185 | tags_id == 213
185 | tags_name == Celiac Disease
185 | tags_id == 195
185 | tags_name == Crohn's Disease
185 | tags_id == 308
185 | tags_name == Gut Inflammation
185 | tags_id == 435
185 | tags_name == Th1 Cells
185 | permissions_favorite == False
185 | permissions_rate == False
185 | content_article == <p><em><span style="font-weight: 400;">This article is for informational purposes only. None of the information here should be taken as medical advice. If you suspect you may have celiac disease, seek medical help immediately. </span></em><em><span style="font-weight: 400;">Keep in mind that these results are based on association studies, which are correlative and aren&rsquo;t necessarily causative. In addition, any single genetic variant will typically contribute only a small proportion to the overall risk of the condition, and non-genetic factors play a large role in developing a condition as well. Therefore, just because you have one of these genotypes does not necessarily mean you are at increased risk of developing this condition!</span></em></p> <h2><strong>What Is the <em>BACH2 </em>Gene?</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../gene/bach2/"><span style="font-weight: 400;">BACH2 gene</span></a><span style="font-weight: 400;"> encodes one of the two members of the BACH (&lsquo;</span><span style="font-weight: 400;">B</span><span style="font-weight: 400;">ric-a-brac, tramtrack </span><span style="font-weight: 400;">a</span><span style="font-weight: 400;">nd broad complex and </span><span style="font-weight: 400;">c</span><span style="font-weight: 400;">ap n&prime; collar </span><span style="font-weight: 400;">h</span><span style="font-weight: 400;">omology&rsquo;) family. BACH proteins bind to DNA to turn &lsquo;off&rsquo; the expression of specific genes [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27052415/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><em><span style="font-weight: 400;">BACH2 </span></em><span style="font-weight: 400;">is mainly expressed in B cells and T cells and is involved in the development of these cell types [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170901/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18769450/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804940/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12204112"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In B cells, BACH2 delays their development and increases their time window to produce high-affinity antibodies (IgG) against viruses and bacteria [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170901/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23850379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020649/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15152264/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">Depending on the T cell subtype, BACH2 can [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012215/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Finetune </span><a href="http://selfhacked.com/blog/supplements-people-th1-dominant/"><span style="font-weight: 400;">Th1</span></a><span style="font-weight: 400;"> development through a complex network of genes that stimulate and inhibit it [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978142/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946995/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710737/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Block the development and inflammatory responses of </span><a href="http://selfhacked.com/blog/supplements-people-th2-dominant/"><span style="font-weight: 400;">Th2</span></a><span style="font-weight: 400;"> cells [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696756/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025763/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Stimulate the production of anti-inflammatory cytokines (IL-9 and </span><a href="http://selfhacked.com/blog/il-10/"><span style="font-weight: 400;">IL-10</span></a><span style="font-weight: 400;">) by Th9 cells [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31451674/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Block the development and inflammatory response of </span><a href="http://selfhacked.com/blog/th17/"><span style="font-weight: 400;">Th17</span></a><span style="font-weight: 400;"> cells [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710737/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833222/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Promote the development, activity, and survival of anti-inflammatory </span><a href="http://selfhacked.com/blog/treg/"><span style="font-weight: 400;">Tregs</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710737/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946995/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><span style="font-weight: 400;">All in all, BACH2 helps control the correct functioning of the immune system, mainly by reducing inflammatory responses. Variants that alter its activity have been associated with different immune and inflammatory conditions such as:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Celiac disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">IBD (especially Crohn&rsquo;s) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299551/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29452228"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686259/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Autoimmune thyroid disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490518/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24346624"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937134/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Rheumatoid arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26939566"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034583/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/causes-symptoms-diagnosis-risk-factors-of-multiple-sclerosis/"><span style="font-weight: 400;">Multiple sclerosis</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25670004"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829620/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Addison&rsquo;s disease [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27807919"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095240/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Lupus [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542470/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Vitiligo [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366044/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Asthma [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517659/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Type 1 diabetes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825945/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764829/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566280/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25661663"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400;">Similarly, reduced </span><em><span style="font-weight: 400;">BACH2 </span></em><span style="font-weight: 400;">expression has been observed in the blood of people with multiple sclerosis, lupus, and chronic pancreatitis while </span><a href="https://selfhacked.com/blog/ulcerative-colitis/"><span style="font-weight: 400;">ulcerative colitis</span></a><span style="font-weight: 400;"> was associated with higher BACH2 levels [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25670004"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31808546"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833222/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30402962"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">BACH2 </span></em><span style="font-weight: 400;">gene encodes a protein that regulates the development of immune cells by turning &lsquo;off&rsquo; certain genes. Alterations in its activity have been associated with different immune and inflammatory conditions, including celiac disease.</span></span></p> <h3><strong>BACH2 and Celiac Disease</strong></h3> <p><span style="font-weight: 400;">Celiac disease is an immune disorder triggered in response to gluten, a protein found in grains such as wheat, barley, and rye. The immune cells recognize gluten as a threat and mount an aggressive inflammatory response that damages the small intestine and causes digestive issues and </span><a href="https://www.selfhacked.com/blog/nutrient-deficiencies/"><span style="font-weight: 400;">nutrient deficiencies</span></a><span style="font-weight: 400;"> due to poor absorption [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437500/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.mayoclinic.org/diseases-conditions/celiac-disease/symptoms-causes/syc-20352220"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">More specifically, the activation of immature CD4+ T cells by gluten causes their development into Th1 cells and the release of inflammatory cytokines such as </span><a href="https://www.selfhacked.com/blog/interferon-gamma-how-to-increase-decrease-high-low-levels/"><span style="font-weight: 400;">IFN-&gamma;</span></a><span style="font-weight: 400;"> and </span><a href="https://www.selfdecode.com/gene/il21/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">IL-21</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481430/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988122/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1382937/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20571486/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The role of BACH2 in regulating the development of Th1 cells may explain the abundance of polymorphisms at this gene associated with celiac disease, as will be discussed below. In line with this, a transcriptomic analysis found reduced </span><em><span style="font-weight: 400;">BACH2 </span></em><span style="font-weight: 400;">expression in T cells from celiac patients [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596691/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Celiac disease is a disorder in which the immune system causes inflammation and damages the small intestine in response to gluten, a protein found in most grains. The BACH2 protein may protect from it by preventing the development of Th1 cells.</span></p> <h2><strong><em>BACH2 </em>Variants and Gut Inflammation</strong></h2> <h3><strong>Celiac Disease</strong></h3> <p><span style="font-weight: 400;">Several variants of the </span><em><span style="font-weight: 400;">BACH2 </span></em><span style="font-weight: 400;">gene involved in celiac disease have been identified, although none of them has been extensively investigated.</span></p> <p><span style="font-weight: 400;">The minor allele &lsquo;G&rsquo; at </span><a href="../../snp/rs11755527/"><span style="font-weight: 400;">rs11755527</span></a><span style="font-weight: 400;"> was associated with celiac disease in a British and Dutch study. This variant has also been associated with type 1 diabetes in Pakistani but not in Brazilian populations [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840835/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712654/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25661663"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25904084"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/32236312"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">The minor variant &lsquo;A&rsquo; at another polymorphism, </span><a href="../../snp/rs10806425/"><span style="font-weight: 400;">rs10806425</span></a><span style="font-weight: 400;">, was associated with celiac disease in 5 European (British, Finnish, Dutch, and Italian) populations [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847618/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Another minor variant (&lsquo;C&rsquo; at </span><a href="../../snp/rs7753008/"><span style="font-weight: 400;">rs7753008</span></a><span style="font-weight: 400;">) was associated with this condition in a study on population samples from Spain, Poland, Italy, UK, Netherlands, and India [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242065/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In contrast, the minor allele &lsquo;C&rsquo; of </span><a href="../../snp/rs2474619/"><span style="font-weight: 400;">rs2474619</span></a><span style="font-weight: 400;"> was protective against celiac disease in the same study. Interestingly, its major variant has been linked to autoimmune hyperthyroidism (Grave&rsquo;s disease) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084811/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24346624"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Although these studies didn&rsquo;t measure </span><em><span style="font-weight: 400;">BACH2 </span></em><span style="font-weight: 400;">activity, we can speculate that most of these variants reduce it based on the association of low BACH2 levels with celiac disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596691/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <h3><strong>Inflammatory Bowel Disease</strong></h3> <p><span style="font-weight: 400;">The role of BACH2 in IBD has been less widely researched.</span></p> <p><span style="font-weight: 400;">A large meta-analysis of 6 studies (with populations from Germany, Belgium, UK, and US) identified the major allele &lsquo;C&rsquo; at the </span><a href="../../snp/rs1847472/"><span style="font-weight: 400;">rs1847472</span></a><span style="font-weight: 400;"> polymorphism as a susceptibility variant for Crohn&rsquo;s disease. This variant also increased the risk of recurrence after the surgical removal of affected bowel regions in a Canadian study [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299551"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29452228"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The authors of the second study speculated that this variant may cause an inappropriate immune response against beneficial gut bacteria, thus preventing the restoration of the </span><a href="https://selfhacked.com/blog/gut-bacteria-microbiome/"><span style="font-weight: 400;">gut flora</span></a><span style="font-weight: 400;">, by altering the production of antibodies by B cells [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29452228"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Anecdotally, a study of British children with IBD identified two rare </span><em><span style="font-weight: 400;">BACH2 </span></em><span style="font-weight: 400;">variants in two children with ulcerative colitis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686259/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Several </span><em><span style="font-weight: 400;">BACH2 </span></em><span style="font-weight: 400;">variants that possibly reduce its activity have been associated with celiac disease and, in some cases, other immune conditions. Another variant was associated with Crohn&rsquo;s disease incidence and recurrence.</span></span></p> <h2><strong>Your <em>BACH2 </em>Results for Celiac Disease</strong></h2> <p>*7947746346895557*</p> <p>&nbsp;</p> <h3><strong>SNP Summary and Table</strong></h3> <p><strong>Primary SNP: </strong><strong><em>BACH2 </em></strong><strong>rs11755527&nbsp;</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Normal risk of celiac disease.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Increased risk of celiac disease.</span></li> </ul> <p><span style="font-weight: 400;">Population frequency: 85% of the world population carries the &lsquo;C&rsquo; allele. The minor variant is especially rare in African descendants (only 3.5% of &lsquo;GG&rsquo;).</span></p> <p><strong>Other Important SNPs:&nbsp;</strong></p> <p><strong><em>BACH2 </em></strong><strong>rs10806425</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Normal risk of celiac disease.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increased risk of celiac disease.</span></li> </ul> <p><span style="font-weight: 400;">Population frequency: 90% of the world population carries the &lsquo;C&rsquo; allele. &lsquo;A&rsquo; is most common among European descendants and rarest in people with an African background.</span></p> <p><strong><em>BACH2 </em></strong><strong>rs7753008</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Normal risk of celiac disease.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Increased risk of celiac disease.</span></li> </ul> <p><span style="font-weight: 400;">Population frequency: Almost 67% of the world population carries two copies of the major allele &lsquo;T&rsquo; The &lsquo;C&rsquo; allele is almost non-existent in people of East Asian ancestry, while 62% of European descendants carry at least one copy.</span></p> <p><strong><em>BACH2 </em></strong><strong>rs2474619&nbsp;</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Normal risk of celiac disease.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Reduced risk of celiac disease.</span></li> </ul> <p><span style="font-weight: 400;">Population frequency: Less than 8% of the world population carries two copies of the &lsquo;C&rsquo; allele. This variant is almost non-existent in people of African descent but more common in East Asian and European descendants.</span></p> <p>*1128729083589710*</p> <p>&nbsp;</p> <h2><strong>Strategies that May Improve Your Celiac Disease</strong></h2> <p>*9663449267437365*</p> <p><em><span style="font-weight: 400;">You may try the complementary approaches listed below if you and your doctor determine that they could be appropriate for you. Discuss the strategies listed here with your doctor. Remember that none of them should ever be done in place of what your doctor recommends or prescribes.</span></em></p> <h3><strong>Diet</strong></h3> <h4><strong>Gluten-free Diet</strong></h4> <p><span style="font-weight: 400;">The only effective treatment for celiac disease is a strict gluten-free diet, which allows the management of the symptoms in most cases. Gluten is found in the following grains and their products [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267495/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Wheat</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Rye</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Spelt</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Barley</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Triticale</span></li> </ul> <p><span style="font-weight: 400;">T-cells lacking BACH2 increase their expression of several genes needed for the development of Th1 cells, including those that encode the cytokines </span><a href="https://www.selfhacked.com/blog/interferon-gamma-how-to-increase-decrease-high-low-levels/"><span style="font-weight: 400;">IFN-&gamma;</span></a><span style="font-weight: 400;"> and </span><a href="https://www.selfdecode.com/gene/IL12a/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">IL-12</span></a><span style="font-weight: 400;">. A gluten-free diet may thus help reduce Th1 overproduction in people with underactive </span><em><span style="font-weight: 400;">BACH2 </span></em><span style="font-weight: 400;">variants [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946995/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710737/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><strong>Avoidance of Lectins/Other Potential Irritants</strong></h4> <p><span style="font-weight: 400;">Dietary </span><a href="https://selfhacked.com/blog/lectins-beneficial-harmful/"><span style="font-weight: 400;">lectins</span></a><span style="font-weight: 400;"> may worsen inflammation in people sensitive to them. For example, lectins contributed to autoimmunity in one study with rheumatoid arthritis patients [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1115436/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10884708"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Preliminary research suggests that avoiding lectins may reduce the symptoms of autoimmune conditions in sensitive individuals [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25599185"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Lectins stimulate the production of several pro-inflammatory cytokines, including BACH2-related IFN-&gamma;. Still, more research is needed to clarify the possible connection between lectins and celiac disease [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10884708"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Gut damage and inflammation in celiac disease may cause temporary lactose intolerance. Such patients may need to avoid dairy until their gut lining recovers [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15775678"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A cell-based study found that lactose prevents Tregs from inhibiting Th1 and Th17 responses, possibly increasing inflammation. This effect may be increased in people with underactive </span><em><span style="font-weight: 400;">BACH2 </span></em><span style="font-weight: 400;">variants [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239808/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Elimination diets such as the </span><a href="https://selfhacked.com/blog/elimination-diet-safest-foods-people-sensitive-everything/"><span style="font-weight: 400;">Lectin Avoidance Diet</span></a><span style="font-weight: 400;"> may help identify and remove common food irritants &mdash; such as </span><a href="https://selfhacked.com/blog/lectins-beneficial-harmful/"><span style="font-weight: 400;">lectins</span></a><span style="font-weight: 400;">, gluten, and dairy &mdash; that may be worsening autoimmunity in sensitive individuals [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10884708"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25599185"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647120/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The most effective way to treat celiac disease is to go gluten-free. Other potential irritants such as lectins and lactose may worsen autoimmunity in some people.</span></p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Moderate Sun Exposure</strong></h4> <p><span style="font-weight: 400;">Moderate </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">sun exposure</span></a><span style="font-weight: 400;"> is the best way to get natural </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">UV</span></a><span style="font-weight: 400;"> light and </span><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;">, which both help suppress inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566188/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20635942"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Vitamin D deficiency and subsequent bone issues are common in celiac disease patients, so it&rsquo;s crucial to get enough of this nutrient [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640651/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21210250"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Additionally, vitamin D may help overcome the negative effects of certain </span><em><span style="font-weight: 400;">BACH2 </span></em><span style="font-weight: 400;">variants on celiac disease by inhibiting the development of Th1 cells [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11673504"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">People with celiac disease may have vitamin D deficiency. A moderate exposure to </span><span style="font-weight: 400;">sunlight is a good way to produce this vitamin and reduce inflammation and Th1 cell development.</span></span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Black Cumin</strong></h4> <p><a href="https://selfhacked.com/blog/black-cumin-seed-nigella-sativa-top-scientific-benefits/"><span style="font-weight: 400;">Black cumin</span></a><span style="font-weight: 400;">, also known as </span><a href="http://selfhacked.com/blog/top-28-scientific-benefits-of-the-panacea-black-cumin-seed-nigella-sativa/"><span style="font-weight: 400;">black seed</span></a><span style="font-weight: 400;">, has well-known anti-inflammatory properties.</span></p> <p><span style="font-weight: 400;">In one clinical trial, adding 900 mg of black seed oil daily to a gluten-free diet helped restore </span><a href="https://selfhacked.com/blog/iron-balance-blood-test-iron-deficiency-anemia-overload/"><span style="font-weight: 400;">iron</span></a><span style="font-weight: 400;"> levels and reduce inflammation and gut damage. The same authors found that </span><a href="http://selfhacked.com/blog/top-28-scientific-benefits-of-the-panacea-black-cumin-seed-nigella-sativa/"><span style="font-weight: 400;">black cumin oil</span></a><span style="font-weight: 400;"> may help with dermatitis herpetiformis, a skin condition caused by celiac disease [</span><a href="https://scholar.google.com/scholar_lookup?journal=Res+J+Pharm+Biol+Chem+Sci&amp;title=Immunomodulatory+effect+of+Nigella+sativa+oil+treatment+in+iron+deficiency+anemia+caused+by+refractory+coeliac+disease&amp;author=MT+Osman&amp;author=BI+Taha&amp;author=G+Al-Duboni&amp;author=LA+Muhamed&amp;volume=3&amp;publication_year=2012&amp;pages=887-95&amp;"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633670/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Preliminary research in cells suggests that black cumin may reduce </span><a href="http://selfhacked.com/blog/supplements-foods-exercise-right-type-th1-vs-th2-dominance/"><span style="font-weight: 400;">Th1 dominance</span></a><span style="font-weight: 400;"> and IFN-&gamma; release, which are associated with both </span><em><span style="font-weight: 400;">BACH2 </span></em><span style="font-weight: 400;">and celiac disease [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20600757"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Preliminary research suggests that black seed oil may help people with celiac disease reduce gut inflammation and damage, and restore nutrient deficiencies.</span></p>
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185 | content_learn_more_7947746346895557_text == Based on the variants we looked at, your BACH2 gene variants are somehow associated with an increased risk of celiac disease. However, this doesn’t necessarily reflect your potential risk of this condition — just one gene related to it. A healthy diet and lifestyle may help. Keep reading to find out more.
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rsIDs = rs1847472,rs11755527,rs7753008,rs10806425,rs2474619
rsStatus = rs1847472,BACH2,chr6,90263440,C,A,,,6,25,HET
rsStatus = rs11755527,BACH2,chr6,90248512,C,G,,,8,19,HET
rsStatus = rs7753008,BACH2,chr6,90099920,T,A,C,,23,0,Normal
rsStatus = rs10806425,BACH2,chr6,90216893,C,A,,,5,16,HET
rsStatus = rs2474619,BACH2,chr6,90170316,C,A,,,3,22,HET
