186 | id == 186
186 | category_id == 16
186 | category_order == 13
186 | category_name == Gut Health
186 | category_color == #C47AC0
186 | slug == GNB3-GERD
186 | title == Can This Gene Worsen GERD Pain? (GNB3)
186 | meta_description == The GNB3 gene encodes a protein involved in the gut-brain axis and an overactive variant may worsen GERD symptoms. Learn where y
186 | summary == <p style="text-align:justify"><strong>The GNB3 gene encodes a subunit of G proteins involved in signaling within the gut-brain axis. An overactive variant of this gene has been associated with GERD and the perception of its symptoms. Read below to learn the effects of your GNB3 variant on this condition.</strong></p>
186 | overall_score_text == GERD Score (based on GNB3 gene)
186 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/GNB3--Gut-Inflammation-GERD---all-chips.jpg
186 | author_id == 12
186 | author_name == Carlos Tello
186 | author_title == PhD
186 | author_order == 55
186 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/CarlosTello.webp
186 | author_intro == <p><strong>Carlos received his PhD and MS from the Universidad de Sevilla.</strong></p>    <p>Carlos spent 9 years in the laboratory investigating mineral transport in plants. He then started working as a freelancer, mainly in science writing, editing, and consulting. Carlos is passionate about learning the mechanisms behind biological processes and communicating science to both academic and non-academic audiences. He strongly believes that scientific literacy is crucial to maintain a healthy lifestyle and avoid falling for scams.</p>
186 | author_social_media_name == linkedin
186 | author_social_media_icon == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/social-icon/linkedin.png
186 | author_social_order == 1
186 | author_social_link == https://www.linkedin.com/in/carlos-tello-lacal-b946b4a7/
186 | reviewer == None
186 | medical_reviewer_id == 11
186 | medical_reviewer_name == Puya Yazdi
186 | medical_reviewer_title == MD
186 | publish_date == 2020
186 | publish_date == 5
186 | publish_date == 18
186 | avg_rating == 5.0
186 | tags_id == 437
186 | tags_name == GERD
186 | tags_id == 436
186 | tags_name == GNB3 Gene
186 | tags_id == 438
186 | tags_name == Gut-Brain Axis
186 | tags_id == 308
186 | tags_name == Gut Inflammation
186 | tags_id == 8
186 | tags_name == IBS
186 | tags_id == 407
186 | tags_name == Indigestion
186 | tags_id == 71
186 | tags_name == Pain
186 | permissions_favorite == False
186 | permissions_rate == False
186 | content_article == <p><em><span style="font-weight: 400;">This article is for informational purposes only. None of the information here should be taken as medical advice. If you suspect you may have GERD, seek medical help immediately. </span></em><em><span style="font-weight: 400;">Keep in mind that these results are based on association studies, which are correlative and aren&rsquo;t necessarily causative. In addition, any single genetic variant will typically contribute only a small proportion to the overall risk of the condition, and non-genetic factors play a large role in developing a condition as well. Therefore, just because you have one of these genotypes does not necessarily mean you are at increased risk of developing this condition!</span></em></p> <h2><strong>What Is the <em>GNB3 </em>Gene?</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../gene/gnb3/"><em><span style="font-weight: 400;">GNB3 </span></em><span style="font-weight: 400;">gene</span></a><span style="font-weight: 400;"> encodes the beta 3 subunit of a &lsquo;guanine nucleotide-binding protein&rsquo;, or &lsquo;G protein&rsquo; to abbreviate. G proteins bind to specific receptors on the surface of cells to transmit signals that activate different pathways [</span><a href="https://ghr.nlm.nih.gov/gene/GNB3"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/14671004/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9422713/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The GNB3 subunit is involved in the function of different neurotransmitters such as </span><a href="https://www.selfhacked.com/blog/how-to-increase-serotonin"><span style="font-weight: 400;">serotonin</span></a><span style="font-weight: 400;">. Illustrating the role of this protein in the brain, </span><em><span style="font-weight: 400;">GNB3 </span></em><span style="font-weight: 400;">variants have been associated with major </span><a href="https://selfhacked.com/blog/natural-treatments-depression/"><span style="font-weight: 400;">depression</span></a><span style="font-weight: 400;"> and response to antidepressant treatment in several studies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034069/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321408/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10884039/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/14647404/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25451402/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20826553/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Through other mechanisms, excessive GNB3 activity has been associated with conditions such as high blood pressure, metabolic syndrome, obesity, and type 2 diabetes [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25903425"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716578/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135703/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>GNB3 and Gastroesophageal Reflux Disease</strong></h3> <p><span style="font-weight: 400;">Gastroesophageal reflux disease (GERD) is a condition that causes stomach acid to rise up into the esophagus. This acid reflux can cause heartburn, bad breath, chest </span><a href="https://selfhacked.com/blog/23-ways-to-combat-pain-naturally-by-increasing-your-opioids/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;">, nausea, breathing problems, and even erosion of the teeth [</span><a href="https://www.niddk.nih.gov/health-information/digestive-diseases/acid-reflux-ger-gerd-adults/symptoms-causes"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/books/NBK441938/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">GERD occurs when the lower esophageal sphincter, the passage between the esophagus and the stomach, doesn&rsquo;t close all the way. Risk factors for GERD include pregnancy, diabetes, and certain medications [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140167/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">GNB3 seems to influence GERD pain perception through its involvement in the brain-gut axis. Its overactivation may lower the activation threshold of pain receptors and cause hypersensitivity to acid reflux [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278933/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19174793"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Indeed, G proteins are known to activate several receptors and messenger proteins that may trigger pain in the upper digestive tract (and other body parts) such as </span><a href="https://www.selfdecode.com/gene/trpv1/"><span style="font-weight: 400;">TRPV1</span></a><span style="font-weight: 400;">, CGRP1, </span><a href="https://selfhacked.com/blog/calcitonin-miacalcin/"><span style="font-weight: 400;">calcitonin</span></a><span style="font-weight: 400;">, CRF, cholecystokinin, and neurotensin [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673346/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2066202/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18197882"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18171711"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10963906"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15275763"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">GNB3 </span></em><span style="font-weight: 400;">gene encodes a subunit of messenger G proteins. GNB3 activity seems to contribute to GERD pain by activating receptors and messenger proteins involved in pain perception.</span></span></p> <h2><strong><em>GNB3 </em>Variants and Digestive Issues</strong></h2> <h3><strong>Celiac Disease</strong></h3> <p><span style="font-weight: 400;">The most widely-studied </span><em><span style="font-weight: 400;">GNB3 </span></em><span style="font-weight: 400;">polymorphism is </span><a href="../../snp/rs5443/"><span style="font-weight: 400;">rs5443</span></a><span style="font-weight: 400;">. Its minor allele &lsquo;T&rsquo; causes the production of the normal GNB3 subunit plus a shorter alternative version that increases the activation of the G protein. This alternative version may enhance the response to neurotransmitters [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9425898"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://link.springer.com/article/10.1007/s002109900040"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935284/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The &lsquo;CT&rsquo; genotype was found more frequently than &lsquo;CC&rsquo; among GERD patients in a Dutch study of almost 800 people [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19174793"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People with two copies of this variant felt worse GERD symptoms before a treatment with pantoprazole in a multi-center study on Austrian, German, Dutch, Lithuanian, and South African populations. However, the treatment was similarly effective in all genotypes [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22041889"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">Similarly, this variant and the minor alleles of two barely-investigated polymorphisms (&lsquo;T&rsquo; at </span><a href="../../snp/rs5446/"><span style="font-weight: 400;">rs5446</span></a><span style="font-weight: 400;"> and &lsquo;A&rsquo; at </span><a href="../../snp/rs2301339/"><span style="font-weight: 400;">rs2301339</span></a><span style="font-weight: 400;">) were associated with increased perception of GERD symptoms in a study from the US [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278933/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>Other Digestive Issues</strong></h3> <p><span style="font-weight: 400;">The rs5443 polymorphism has also been investigated regarding its role in indigestion. Depending on the study, the &lsquo;T&rsquo; variant, the major allele &lsquo;C&rsquo;, both, or neither of them have been associated with functional dyspepsia [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27430937"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825227/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17717746/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18331431/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026644/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15057736"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15057736/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16464220/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325307/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">However, one meta-analysis found the evidence insufficient to link any of the </span><em><span style="font-weight: 400;">GNB3 </span></em><span style="font-weight: 400;">genotypes to indigestion and another one only managed to associate the &lsquo;T&rsquo; allele with indigestion characterized by pain in the upper stomach (epigastric pain syndrome) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736015/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501140/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Similarly, the &lsquo;T&rsquo; variant was associated with IBS in a Greek and a Korean study but not in two other studies on Korean populations. A meta-analysis of these and other studies concluded that this </span><em><span style="font-weight: 400;">GNB3 </span></em><span style="font-weight: 400;">polymorphism can&rsquo;t be associated with IBS [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21559741"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20337945"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102162/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325307/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033474/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">A </span><em><span style="font-weight: 400;">GNB3 </span></em><span style="font-weight: 400;">variant with increased activity has been associated with increased GERD incidence and symptom perception. In contrast, research has found little or no connection with indigestion and IBS.</span></span></p> <h2><strong>Your <em>GNB3 </em>Results for GERD</strong></h2> <p>*4638553840211983*</p> <p>&nbsp;</p> <h3><strong>SNP Summary and Table</strong></h3> <p><strong>Primary SNP: </strong><strong><em>GNB3 </em></strong><strong>rs5443</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Normal risk of GERD.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of GERD.</span></li> </ul> <h3><strong>Population Frequency</strong></h3> <p><span style="font-weight: 400;">Almost 36% of the world population carries at least one copy of the minor &lsquo;T&rsquo; allele. Surprisingly, this allele is the major variant in people of African (73% of carriers) and East Asian (52% of carriers) descent. Indeed, the &lsquo;TT&rsquo; genotype is the most common one (56%) in African Americans as opposed to European Americans (only 10%).</span></p> <p>*1590873576823599*</p> <p>&nbsp;</p> <h2><strong>Strategies that May Improve Your GERD</strong></h2> <p>*3709939931920456*</p> <p>&nbsp;</p> <p><em><span style="font-weight: 400;">You may try the complementary approaches listed below if you and your doctor determine that they could be appropriate for you. Discuss the strategies listed here with your doctor. Remember that none of them should ever be done in place of what your doctor recommends or prescribes.</span></em></p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Weight Loss</strong></h4> <p><span style="font-weight: 400;">Obesity is considered a significant risk factor for the development of GERD. Importantly, the &lsquo;T&rsquo; variant of rs5443 is associated with being overweight or obese, and may contribute to GERD through this effect [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920303/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25280441"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870267/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833052/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Being overweight or obese are well-known GERD triggers. The risk variant of </span><em><span style="font-weight: 400;">GNB3</span></em><span style="font-weight: 400;"> may further worsen this condition by promoting weight gain. Losing weight helps reduce GERD symptoms and may be especially recommended in people with this variant.</span></span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Bitters</strong></h4> <p><span style="font-weight: 400;">In one observational study, 50 patients with acid reflux were given an Ayurvedic syrup called Acidinol for 4 weeks. This multi-herbal formula with </span><a href="https://selfhacked.com/blog/bitters-benefits/"><span style="font-weight: 400;">bitters</span></a><span style="font-weight: 400;"> such as </span><a href="https://selfhacked.com/blog/neem-oil-benefits-for-skin-health/"><span style="font-weight: 400;">neem</span></a><span style="font-weight: 400;"> (Azadirachta indica), relieved symptoms of heartburn, stomach pain, bloating, nausea, indigestion, and loss of appetite in over 75% of patients [</span><a href="https://scholar.google.com/scholar?hl=en&amp;as_sdt=0%2C33&amp;q=EFFICACY+STUDY+OF+ACIDINOL+SYRUP+IN+PATIENTS+WITH+ACID+PEPTIC+DISORDERS&amp;btnG="><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Interestingly, the risk variant of </span><em><span style="font-weight: 400;">GNB3 </span></em><span style="font-weight: 400;">promotes the activity of G proteins, including those that activate the receptors for bitter taste. </span><strong>This means that this variant may further enhance the positive effects of bitters on digestive function</strong><span style="font-weight: 400;">. However, more research is needed [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849471/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12764189/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10570481"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><strong>CBD</strong></h4> <p><span style="font-weight: 400;">Activation of cannabinoid </span><a href="https://selfhacked.com/blog/the-lectin-sensitive-gene-cannabanoid-receptor-1-genes-cnr1-rs1049353/"><span style="font-weight: 400;">CB1</span></a><span style="font-weight: 400;"> receptors prevented the relaxation of the lower esophageal sphincter in human and animal studies, and even prevented GERD in dogs. Although </span><a href="https://selfhacked.com/blog/cannabidiol-cbd/"><span style="font-weight: 400;">CBD</span></a><span style="font-weight: 400;"> blocks rather than activating this receptor, it may indirectly contribute to its activation by preventing the breakdown of anandamide [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697772/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2343023/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12360475"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189767/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316151/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Importantly, both CBD and G proteins interact with the pain-involved TRPV1 receptor. While G proteins stimulate it and increase pain perception, CBD makes it less sensitive to stimuli that may trigger pain [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25029033/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673346/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034632/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Supplementing with bitters and CBD may help reduce GERD symptoms, including pain perception.</span></p>
186 | content_snp_table_1590873576823599_key == 1590873576823599
186 | content_snp_table_1590873576823599_blur == True
186 | content_snp_table_1590873576823599_hidden == False
186 | content_learn_more_4638553840211983_key == 4638553840211983
186 | content_learn_more_4638553840211983_blur == True
186 | content_learn_more_4638553840211983_hidden == False
186 | content_learn_more_4638553840211983_text == Based on the variants we looked at, your GNB3 gene variant is somehow associated with an increased risk of GERD and worse symptoms. However, this doesn’t necessarily reflect your potential risk of this condition — just one gene related to it. A healthy diet and lifestyle may help. Keep reading to find out more.
186 | content_recommendation_3709939931920456_key == 3709939931920456
186 | content_recommendation_3709939931920456_blur == True
186 | content_recommendation_3709939931920456_hidden == False
rsIDs = rs5443,rs2301339,rs5446,rs1049353
rsStatus = rs5443,GNB3,chr12,6845711,C,T,,,22,0,Normal
rsStatus = rs2301339,GNB3,chr12,6845460,G,A,C,T,37,0,Normal
rsStatus = rs5446,GNB3,chr12,6847298,C,A,T,,36,0,Normal
rsStatus = rs1049353,CNR1,chr6,88143916,C,A,T,,41,1,HET
