187 | id == 187
187 | category_id == 16
187 | category_order == 13
187 | category_name == Gut Health
187 | category_color == #C47AC0
187 | slug == IL12A-Celiac-Disease
187 | title == Can This Gene Worsen Celiac Disease? (IL12A)
187 | meta_description == he IL12A gene controls the production of cytokines and some variants are associated with celiac disease. Learn where your varian
187 | summary == <p style="text-align:justify"><strong>The IL12A gene encodes a protein that is combined with others to produce the cytokines IL-12, IL-23, and IL-35. Variants of this gene can contribute to celiac disease. Read on to learn if your variants are associated with this condition.</strong></p>
187 | overall_score_text == Celiac Disease Score (based on IL12A gene)
187 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/IL12A-AS1--Gut-Inflammation-Celiac-disease---all-chips.jpg
187 | author_id == 12
187 | author_name == Carlos Tello
187 | author_title == PhD
187 | author_order == 55
187 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/CarlosTello.webp
187 | author_intro == <p><strong>Carlos received his PhD and MS from the Universidad de Sevilla.</strong></p>    <p>Carlos spent 9 years in the laboratory investigating mineral transport in plants. He then started working as a freelancer, mainly in science writing, editing, and consulting. Carlos is passionate about learning the mechanisms behind biological processes and communicating science to both academic and non-academic audiences. He strongly believes that scientific literacy is crucial to maintain a healthy lifestyle and avoid falling for scams.</p>
187 | author_social_media_name == linkedin
187 | author_social_media_icon == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/social-icon/linkedin.png
187 | author_social_order == 1
187 | author_social_link == https://www.linkedin.com/in/carlos-tello-lacal-b946b4a7/
187 | reviewer == None
187 | medical_reviewer_id == 11
187 | medical_reviewer_name == Puya Yazdi
187 | medical_reviewer_title == MD
187 | publish_date == 2020
187 | publish_date == 5
187 | publish_date == 18
187 | avg_rating == 5.0
187 | tags_id == 213
187 | tags_name == Celiac Disease
187 | tags_id == 96
187 | tags_name == Cytokines
187 | tags_id == 308
187 | tags_name == Gut Inflammation
187 | tags_id == 426
187 | tags_name == IL-12
187 | tags_id == 425
187 | tags_name == IL12A Gene
187 | tags_id == 402
187 | tags_name == IL-23
187 | tags_id == 427
187 | tags_name == IL-35
187 | permissions_favorite == False
187 | permissions_rate == False
187 | content_article == <p><em><span style="font-weight: 400;">This article is for informational purposes only. None of the information here should be taken as medical advice. If you suspect you may have celiac disease, seek medical help immediately. </span></em><em><span style="font-weight: 400;">Keep in mind that these results are based on association studies, which are correlative and aren&rsquo;t necessarily causative. In addition, any single genetic variant will typically contribute only a small proportion to the overall risk of the condition, and non-genetic factors play a large role in developing a condition as well. Therefore, just because you have one of these genotypes does not necessarily mean you are at increased risk of developing this condition!</span></em></p> <h2><strong>What Is the <em>IL12A </em>Gene?</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../gene/IL12a/"><em><span style="font-weight: 400;">IL12A </span></em><span style="font-weight: 400;">gene</span></a><span style="font-weight: 400;"> encodes IL12-p35, required to form the pro-inflammatory cytokine </span><a href="http://selfhacked.com/blog/interleukin-1/"><span style="font-weight: 400;">IL-1</span></a><a href="https://www.selfdecode.com/gene/IL12a/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">2</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC313992/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22819329/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">IL-12 is produced by various immune cells (dendritic cells, macrophages, and B cells) in response to infections. It plays multiple roles in the immune system, including [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22819329/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Favoring the development of </span><a href="https://selfhacked.com/blog/supplements-people-th1-dominant/"><span style="font-weight: 400;">Th1 </span></a><span style="font-weight: 400;">over </span><a href="http://selfhacked.com/blog/supplements-people-th2-dominant/"><span style="font-weight: 400;">Th2</span></a><span style="font-weight: 400;"> cells [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12563297/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16476011/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC98681/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Promoting the development and activity of </span><a href="http://selfhacked.com/blog/homing-fundamenal-cause-epstein-barr-reactivation/#Top_Supplements_to_Increase_CD8_T_Cells"><span style="font-weight: 400;">CD8+ T cells</span></a><span style="font-weight: 400;"> and </span><a href="http://selfhacked.com/blog/intro-natural-killer-cells-increase-decrease/"><span style="font-weight: 400;">natural killer cells</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC54627/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189443/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Stimulating </span><a href="https://www.selfhacked.com/blog/interferon-gamma-how-to-increase-decrease-high-low-levels/"><span style="font-weight: 400;">IFN-&gamma;</span></a><span style="font-weight: 400;"> secretion [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191131/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400;">This cytokine helps fight off infections in normal conditions, but its excessive production may cause autoimmune and inflammatory diseases such as:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Rheumatoid arthritis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367096/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/causes-symptoms-diagnosis-risk-factors-of-multiple-sclerosis/"><span style="font-weight: 400;">Multiple sclerosis</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647371/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Autoimmune hyperthyroidism (Grave&rsquo;s disease) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21044109/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Sj&ouml;gren&rsquo;s syndrome [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867192/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Asthma [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21513752/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Primary biliary cirrhosis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902537/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400;">In addition, IL12-p35 can bind to other proteins and form cytokines other than IL-12 (such as IL-23 and IL-35) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22819329/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17433650"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25697137"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18033300"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">IL12A </span></em><span style="font-weight: 400;">gene encodes a protein that can bind to others to form the cytokines IL-12, IL-23, or IL-35, all of which are involved in the immune response.</span></span></p> <h3><strong><em>IL12A </em>and Celiac Disease</strong></h3> <p><span style="font-weight: 400;">Celiac disease is an immune disorder triggered in response to gluten, a protein found in grains such as wheat, barley, and rye. The immune cells recognize gluten as a threat and mount an aggressive inflammatory response that damages the small intestine and causes digestive issues and </span><a href="https://www.selfhacked.com/blog/nutrient-deficiencies/"><span style="font-weight: 400;">nutrient deficiencies</span></a><span style="font-weight: 400;"> due to poor absorption [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437500/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.mayoclinic.org/diseases-conditions/celiac-disease/symptoms-causes/syc-20352220"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">More specifically, the activation of immature CD4+ T cells by gluten causes their development into Th1 cells and the release of inflammatory cytokines such as </span><a href="https://www.selfhacked.com/blog/interferon-gamma-how-to-increase-decrease-high-low-levels/"><span style="font-weight: 400;">IFN-&gamma;</span></a><span style="font-weight: 400;"> and </span><a href="https://www.selfdecode.com/gene/il21/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">IL-21</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481430/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988122/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1382937/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20571486/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Although the inflamed gut lining of celiac patients has increased IL12-p35 levels, it lacks the other protein needed to produce IL-12. This suggests that the IL-12 cytokine doesn&rsquo;t play a key role in celiac disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1810422/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9721152"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/14675396"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The role of IL-23 in celiac disease is unclear: a variant at the gene that encodes its receptor (</span><a href="../../gene/il23r/"><em><span style="font-weight: 400;">IL23R</span></em></a><span style="font-weight: 400;">) increased susceptibility to celiac disease in Spaniards but not in Dutch [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18368064"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18047540"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some scientists believe that </span><em><span style="font-weight: 400;">IL12A </span></em><span style="font-weight: 400;">may contribute to celiac disease mainly through the production of IL-35 [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22819329/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31726085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Celiac disease is a disorder in which the immune system causes inflammation and damages the small intestine in response to gluten, a protein found in most grains. The </span><em><span style="font-weight: 400;">IL12A </span></em><span style="font-weight: 400;">gene is believed to contribute to celiac disease through the production of IL-35.</span></span></p> <h2><strong><em>IL12A </em>Variants and Celiac Disease</strong></h2> <p><span style="font-weight: 400;">The most widely-studied </span><em><span style="font-weight: 400;">IL12A </span></em><span style="font-weight: 400;">polymorphism is </span><a href="../../snp/rs17810546/"><span style="font-weight: 400;">rs17810546</span></a><span style="font-weight: 400;">, located in a region of the gene that can be bound by certain proteins to activate its expression (an </span><em><span style="font-weight: 400;">enhancer</span></em><span style="font-weight: 400;">). Its rare variant &lsquo;G&rsquo; increases the expression of this protein [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31726085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">This variant was linked to celiac disease in 5 studies on British, Italian, Dutch, Finnish, Saharawi, Irish, and Swedish-Norwegian populations, and the association was confirmed in a meta-analysis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673512/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210127/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032060/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840835/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19693089"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848913/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">This polymorphism has also been associated with Beh&ccedil;et&rsquo;s disease and juvenile arthritis, further illustrating the role of IL12-p35 in inflammatory and immune conditions [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810947/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370488/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26097239"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002762/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The rs17810546 polymorphism is strongly linked to the minor &lsquo;C&rsquo; variant of </span><a href="../../snp/rs9811792/"><span style="font-weight: 400;">rs9811792</span></a><span style="font-weight: 400;">, which was also associated with celiac disease in the same studies.</span></p> <p><span style="font-weight: 400;">A less widely-investigated polymorphism is </span><a href="../../snp/rs2561288/"><span style="font-weight: 400;">rs2561288</span></a><span style="font-weight: 400;">, whose major allele &lsquo;T&rsquo; was associated with a slightly increased incidence of celiac disease in a north Indian population [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666579/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Several </span><em><span style="font-weight: 400;">IL12A </span></em><span style="font-weight: 400;">variants have been associated with celiac disease. The most widely-studied one increases the expression of the gene.</span></span></p> <h2><strong>Your <em>IL12A </em>Results for Celiac Disease</strong></h2> <p>*3108554114609125*</p> <p>&nbsp;</p> <h3><span style="font-weight: 400;">SNP Summary and Table</span></h3> <p><strong>Primary SNP: </strong><strong><em>IL12A </em></strong><strong>rs17810546</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Normal risk of celiac disease.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Increased risk of celiac disease.</span></li> </ul> <p><strong>Other Important SNPs:&nbsp;</strong></p> <p><strong><em>IL12A </em></strong><strong>rs9811792&nbsp;</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Normal risk of celiac disease.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Increased risk of celiac disease.</span></li> </ul> <p><strong><em>IL12A </em></strong><strong>rs2561288</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased risk of celiac disease.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Lower risk of celiac disease.</span></li> </ul> <h3><strong>Population Frequency</strong></h3> <p><span style="font-weight: 400;">The &lsquo;G&rsquo; variant at rs17810546 is very rare and 92% of the world population doesn&rsquo;t carry any copies of this allele. In European and American descendants, this variant is slightly more common (~18% of carriers).</span></p> <p><span style="font-weight: 400;">In both rs9811792 and rs2561288, the minor variant is only slightly less frequent. The most common scenario is to carry one copy of each allele, as is the case for ~44% of the world population.</span></p> <p>*6793920365639008*</p> <p>&nbsp;</p> <h2><strong>Strategies that May Improve Your Celiac Disease</strong></h2> <p>*9572605097539908*</p> <p>&nbsp;</p> <p><em><span style="font-weight: 400;">You may try the complementary approaches listed below if you and your doctor determine that they could be appropriate for you. Discuss the strategies listed here with your doctor. Remember that none of them should ever be done in place of what your doctor recommends or prescribes.</span></em></p> <h3><strong>Diet</strong></h3> <h4><strong>Gluten-free Diet</strong></h4> <p><span style="font-weight: 400;">The only effective treatment for celiac disease is a strict gluten-free diet, which allows the management of the symptoms in most cases. Gluten is found in the following grains and their products [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267495/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Wheat</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Rye</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Spelt</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Barley</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Triticale</span></li> </ul> <p><span style="font-weight: 400;">Although gluten seems to have no effect on IL-12 levels, it has been shown to stimulate the production of IL-23 and IL-35 [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9721152"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18802048"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31726085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><span style="font-weight: 400;">Avoidance of Lectin/Other Potential Irritants</span></h4> <p><span style="font-weight: 400;">Dietary </span><a href="https://selfhacked.com/blog/lectins-beneficial-harmful/"><span style="font-weight: 400;">lectins</span></a><span style="font-weight: 400;"> may worsen inflammation in people sensitive to them. For example, lectins contributed to autoimmunity in one study with rheumatoid arthritis patients [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1115436/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10884708"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Preliminary research suggests that avoiding lectins may reduce the symptoms of autoimmune conditions in sensitive individuals [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25599185"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A lectin from buckwheat stimulated dendritic cells to produce IL-12 and other pro-inflammatory cytokines in test tubes [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25867364"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Gut damage and inflammation in celiac disease may cause temporary lactose intolerance. Such patients may need to avoid dairy until their gut lining recovers [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15775678"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Elimination diets such as the </span><a href="https://selfhacked.com/blog/elimination-diet-safest-foods-people-sensitive-everything/"><span style="font-weight: 400;">Lectin Avoidance Diet</span></a><span style="font-weight: 400;"> may help identify and remove common food irritants &mdash; such as </span><a href="https://selfhacked.com/blog/lectins-beneficial-harmful/"><span style="font-weight: 400;">lectins</span></a><span style="font-weight: 400;">, gluten, and dairy &mdash; that may be worsening autoimmunity in sensitive individuals [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10884708"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25599185"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647120/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The most effective way to treat celiac disease is to go gluten-free. Other potential irritants such as lectins and lactose may worsen autoimmunity in some people.</span></p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Moderate Sun Exposure</strong></h4> <p><span style="font-weight: 400;">Moderate </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">sun exposure</span></a><span style="font-weight: 400;"> is the best way to get natural </span><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">UV</span></a><span style="font-weight: 400;"> light and </span><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;">, which both help suppress inflammation. Because vitamin D inhibits the development of Th1 cells, it may be beneficial in the specific case of celiac disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566188/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20635942"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30300262"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Vitamin D deficiency and subsequent bone issues are common in celiac disease patients, so it&rsquo;s crucial to get enough of this nutrient [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640651/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21210250"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Vitamin D supplementation lowered IL-12 levels in some human studies but not in others. In a study on 57 people with lupus, vitamin D deficiency was associated with increased IL-23 levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797739/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22028071"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23184900"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27927883"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">People with celiac disease may have vitamin D deficiency. A moderate exposure to </span><span style="font-weight: 400;">sunlight is a good way to produce this vitamin and may reduce some cytokines associated with </span><em><span style="font-weight: 400;">IL12A</span></em><span style="font-weight: 400;">.</span></span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Probiotics</strong></h4> <p><span style="font-weight: 400;">Bacterial overgrowth in the small intestine may worsen celiac disease and hinder gut recovery [</span><a href="https://www.mayoclinic.org/diseases-conditions/celiac-disease/symptoms-causes/syc-20352220"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/probiotics-good-bacteria/"><span style="font-weight: 400;">Probiotic</span></a><span style="font-weight: 400;"> (</span><em><span style="font-weight: 400;">Bifidobacterium spp.</span></em><span style="font-weight: 400;">) supplementation in patients with celiac disease has yielded mixed results. In one trial, it improved the symptoms but not immunological markers. In another one, it only improved lab markers of inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23314670"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24774670"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In 109 patients with celiac disease and IBS, a mixture of probiotic strains significantly improved IBS symptoms [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382041/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A few studies in mice with colitis showed that supplementation with </span><em><span style="font-weight: 400;">Lactobacillus </span></em><span style="font-weight: 400;">or </span><em><span style="font-weight: 400;">Bifidobacterium </span></em><a href="https://selfhacked.com/blog/probiotics-good-bacteria/"><span style="font-weight: 400;">probiotics</span></a><span style="font-weight: 400;"> can reduce gut inflammation by blocking the </span><a href="https://www.selfdecode.com/gene/il23r/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">IL23</span></a><span style="font-weight: 400;">/Th17 axis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417982/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27718511"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277968/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Preliminary research suggests that some probiotics may help people with celiac disease reduce gut inflammation and damage.</span></p>
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187 | content_learn_more_3108554114609125_text == Based on the variants we looked at, your IL12A gene variants are somehow associated with an increased risk of celiac disease. However, this doesn’t necessarily reflect your potential risk of this condition — just one gene related to it. A healthy diet and lifestyle may help. Keep reading to find out more.
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rsIDs = rs9811792,rs17810546,rs2561288
rsStatus = rs9811792,IL12A-AS1,chr3,159979210,C,T,,,6,9,HET
rsStatus = rs17810546,IL12A-AS1,chr3,159947262,A,G,,,31,0,Normal
rsStatus = rs2561288,IL12A-AS1,chr3,159957140,T,C,,,25,13,HET
