190 | id == 190
190 | category_id == 16
190 | category_order == 13
190 | category_name == Gut Health
190 | category_color == #C47AC0
190 | slug == ITLN1-Crohn-inflammation
190 | title == Inflammation, Metabolic Health & Crohn’s Disease (ITLN1)
190 | meta_description == ITLN1 encodes a protein that controls the immune response and inflammation. Learn about its link with Crohn’s disease.
190 | summary == <p style="text-align:justify"><strong>The <em>ITLN1</em> gene encodes a protein with versatile roles in immunity, inflammation, and metabolic health. Read on to learn about a variant in this gene associated with Crohn&rsquo;s disease.</strong></p>
190 | overall_score_text == Your Crohn’s Disease Score (Based on ITLN1 Gene)
190 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ITLN1--Gut-Inflammation-IBD---all-chips.jpg
190 | author_id == 9
190 | author_name == Aleksa Ristic
190 | author_title == MS (Pharmacy)
190 | author_order == 45
190 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
190 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
190 | reviewer == None
190 | medical_reviewer_id == 11
190 | medical_reviewer_name == Puya Yazdi
190 | medical_reviewer_title == MD
190 | publish_date == 2020
190 | publish_date == 5
190 | publish_date == 18
190 | avg_rating == 5.0
190 | tags_id == 33
190 | tags_name == Autoimmunity
190 | tags_id == 195
190 | tags_name == Crohn's Disease
190 | tags_id == 207
190 | tags_name == Exercise
190 | tags_id == 73
190 | tags_name == IBD
190 | tags_id == 24
190 | tags_name == Inflammation
190 | tags_id == 445
190 | tags_name == Intelectin-1
190 | tags_id == 444
190 | tags_name == ITLN1 gene
190 | tags_id == 443
190 | tags_name == Lactoferrin
190 | tags_id == 290
190 | tags_name == Mediterranean diet
190 | tags_id == 75
190 | tags_name == Microbiome
190 | tags_id == 115
190 | tags_name == Weight Gain
190 | permissions_favorite == False
190 | permissions_rate == False
190 | content_article == <p><em><span style="font-weight: 400;">This article is for informational purposes only. None of the information here should be taken as medical advice. If you suspect you may have digestive issues, seek medical help. </span></em><em><span style="font-weight: 400;">Keep in mind that these results are based on association studies, which are correlative and aren&rsquo;t necessarily causative. Any single genetic variant will typically contribute only a small proportion to the overall risk of the condition, and non-genetic factors play a large role in developing a condition as well. Therefore, just because you have one of these genotypes does not necessarily mean you are at an increased risk of developing this condition!</span></em></p> <h2><strong>The <em>ITLN1 </em>Gene: 3 in 1</strong></h2> <p><span style="font-weight: 400;">The </span><a href="https://www.selfdecode.com/gene/itln1/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><em><span style="font-weight: 400;">ITLN1</span></em></a><span style="font-weight: 400;"> gene encodes intelectin-1, also known as omentin-1, a protein with versatile roles in immunity and inflammation. Intelectin-1 is a lectin (carb-binding protein) that can recognize cell walls of different pathogens and activate the immune response against them [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11313366/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">It also serves as a receptor for </span><a href="http://selfhacked.com/blog/lactoferrin/"><span style="font-weight: 400;">lactoferrin</span></a><span style="font-weight: 400;">, a protein with powerful anti-microbial and immune-boosting properties [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16866365/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">Intelectin-1 plays its third crucial role as an adipokine, a cytokine released from the adipose tissue. It reduces inflammation and boosts metabolism, </span><a href="http://selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;">insulin sensitivity</span></a><span style="font-weight: 400;">, heart health, and more. Low intelectin-1 levels correlate with a range of conditions, including Crohn&rsquo;s disease, diabetes, obesity, and viral infections [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412447/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28640441"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30641171/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680436/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">ITLN1 encodes intelectin-1 (omentin-1), a protein that reduces inflammation, detects different pathogens, and maintains metabolic health.</span></p> <h3><strong>Intelectin-1 in Crohn&rsquo;s Disease</strong></h3> <p><a href="https://selfhacked.com/blog/crohns-disease/"><span style="font-weight: 400;">Crohn&rsquo;s disease</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/ulcerative-colitis/"><span style="font-weight: 400;">ulcerative colitis</span></a><span style="font-weight: 400;"> are two of the most frequently diagnosed subtypes of inflammatory bowel disease (IBD). The cause of IBD lies in a complex interplay of </span><a href="https://selfhacked.com/blog/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections/"><span style="font-weight: 400;">genetic and environmental factors</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106026/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Crohn's mostly affects the small intestine and involves ulcerations of all cell layers of the gut lining. Impaired microbiome and bacterial overgrowth play crucial roles in disease development [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622286/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28134633"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167487/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Intelectin-1 binds pathogens in the intestines and enables their removal. At the same time, it strengthens the gut lining and supports digestion [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11313366/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16866365/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">By enabling the uptake of lactoferrin, ITLN-1 provides additional anti-microbial and anti-inflammatory support, crucial for Crohn&rsquo;s disease prevention [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357271/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Intelectin-1 may also be a target for autoimmune reactions in Crohn&rsquo;s disease, but the research is still young [</span><a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081662"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Intelectin-1 helps prevent Crohn&rsquo;s disease by detecting bacteria, reducing inflammation, and enabling the uptake of lactoferrin.</span></p> <h2><strong>The Link Between One ITLN1 Variant and Crohn&rsquo;s Disease</strong></h2> <p><span style="font-weight: 400;">A meta-analysis of over 12,000 subjects (European ancestry) found a connection between one ITLN1 SNP and Crohn&rsquo;s. People with the &ldquo;C&rdquo; allele at </span><a href="../../snp/rs2274910/"><span style="font-weight: 400;">rs2274910</span></a><span style="font-weight: 400;"> had 14% disease rates [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574810/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a Portuguese trial of 1,137 subjects, those carrying the &ldquo;C&rdquo; allele had 55% higher chances of being diagnosed with Crohn&rsquo;s [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22573572"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The same variant correlated with 84% higher rates of IBD-associated colorectal cancer among 2,287 patients [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28243990"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>How It Works</strong></h3> <p><span style="font-weight: 400;">As mentioned, intelectin-1 protects the gut from pathogens and inflammation. More precisely, it suppresses the pro-inflammatory cytokines </span><a href="../article/tnf-longevity-86"><span style="font-weight: 400;">TNF</span></a><a href="http://selfhacked.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">-alpha</span></a><span style="font-weight: 400;"> and </span><a href="http://selfhacked.com/blog/interleukin-6/"><span style="font-weight: 400;">IL-6</span></a><span style="font-weight: 400;"> [</span><a href="https://content.sciendo.com/view/journals/cipms/28/3/article-p176.xml?language=en"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27331575"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876344/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Intelectin-1 levels are significantly lower in Crohn&rsquo;s disease patients, compared with healthy controls [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28640441"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Although the scientists are still figuring out the exact role of rs2274910 in Crohn&rsquo;s, the above evidence suggests this variant may reduce ITLN-1 expression. Another possible explanation is a change in the protein structure caused by this SNP, which might trigger an autoimmune response [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864798/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Intelectin-1 suppresses TNF-a and IL-6 in the gut and prevents microbial infections. The &ldquo;C&rdquo; allele at rs2274910 likely reduces ITLN-1 expression and thus contributes to Crohn&rsquo;s disease.</span></p> <h2><strong>Your ITLN1 Results for Crohn&rsquo;s Disease</strong></h2> <p>*3669383965924628*</p> <h3><strong>SNP Summary</strong></h3> <p><strong>Primary SNP:</strong></p> <p><strong><em>ITLN1</em></strong> <a href="../../snp/rs2274910/"><strong>rs2274910</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = associated with higher rates of Crohn&rsquo;s disease and complications</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = not associated with Crohn&rsquo;s disease</span></li> </ul> <p><em><span style="font-weight: 400;">Population Frequency</span></em><span style="font-weight: 400;">: Around 49% of European descendants carry one copy and 8% carry both copies of the &ldquo;C&rdquo; allele. This allele is much more common in African populations, where 38% of people have one and 54% have both copies.</span></p> <p>*2092681436611172*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Reduce Gut Inflammation</strong></h2> <p><em><span style="font-weight: 400;">You may try the complementary approaches listed below if you and your doctor determine that they could be appropriate for you. Discuss the strategies listed here with your doctor. Remember that none of them should ever be done in place of what your doctor recommends or prescribes.</span></em></p> <p>*7599230751554609*</p> <h3><strong>Lifestyle&nbsp;</strong></h3> <h4><strong>Weight Control</strong></h4> <p><span style="font-weight: 400;">Low intelectin-1 is associated with obesity. In two clinical trials with obese children and adults, dietary and lifestyle interventions successfully reduced weight and thus boosted intelectin-1 [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29198435"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28833541"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Obesity is associated with more severe IBD forms and more frequent complications. The negative impact of excess weight partly stems from the impaired secretion of intelectin-1 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442902/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30352258"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Getting rid of extra pounds may boost your intelectin-1 levels, reduce IBD severity, and improve your overall health.</span></p> <h4><strong>Moderate Exercise</strong></h4> <p><span style="font-weight: 400;">In 13 women, a 6-week endurance training program increased intelectin-1 by 10%. A mixture of aerobic and resistance training boosted its levels by 45% in 32 obese children [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25789872"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27737602"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Moderate </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> is among the best remedies for overall and gut health. Physical activity changes the composition of the gut flora by increasing beneficial species [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667627/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">While exercise helps prevent Crohn's, some people with active disease may not be able to adjust their physical activity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743119/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660805/"><span style="font-weight: 400;"> R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022156/"><span style="font-weight: 400;"> R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">If you have IBD, we recommend talking to your doctor about how much physical activity would be beneficial in your case.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">In case your condition allows for it, moderate exercise is a great way to increase intelectin levels and improve gut health.</span></p> <h3><strong>Diet</strong></h3> <h4><strong>Mediterranean Diet</strong></h4> <p><span style="font-weight: 400;">In 67 obese subjects, a low-calorie Mediterranean diet significantly reduced weight and boosted intelectin-1. The consumption of </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;"> may also increase intelectin, while </span><a href="http://selfhacked.com/blog/low-carb-diet-vs-high-carb-diet/"><span style="font-weight: 400;">saturated fat</span></a><span style="font-weight: 400;"> may suppress it [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29198435"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27931137"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27331575"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The antioxidant and anti-inflammatory olive components can reduce gut inflammation and help prevent IBD [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471980/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413052/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The Mediterranean diet is rich in olive oil, fruits, vegetables, nuts, and whole grains. It implies a moderate intake of fish while cutting back on saturated fat and refined sugar.</span></p> <p><span style="font-weight: 400;">Some experts recommend the Mediterranean diet as a complementary approach to digestive disorders such as IBD. The incidence of IBD is lower in the Mediterranean regions, compared with northern Europe [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24979151/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502201/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">.</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372922/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Due to high fiber content, IBD patients may want to avoid this kind of diet during the active phases or &ldquo;flares&rdquo; [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27059169/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The Mediterranean diet can improve weight control and increase omentin-1. It may be the right choice for Crohn&rsquo;s if you're not in the active phase of the disease.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Lactoferrin</strong></h4> <p><span style="font-weight: 400;">As mentioned, intelectin-1 enables the uptake of lactoferrin, so people with reduced ITLN-1 expression may lack anti-microbial and anti-inflammatory protection. Lactoferrin is crucial for immunity in infants but continues to maintain different immune functions in adulthood [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16866365/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1793702/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Lactoferrin helps increase </span><a href="https://selfhacked.com/blog/iron-balance-blood-test-iron-deficiency-anemia-overload/"><span style="font-weight: 400;">iron</span></a><span style="font-weight: 400;"> absorption and cell delivery. That is essential for Crohn's disease patients, who are iron-deficient in 60-80% and anemic in up to 74% of cases [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959949/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946590/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">According to a meta-analysis of four clinical trials with 600 pregnant women, lactoferrin is just as efficient as iron supplements in improving anemia. What&rsquo;s more, it caused fewer gastrointestinal side effects and better </span><a href="https://selfhacked.com/blog/hemoglobin-good-bad-lab-tests-normal-values-reference-ranges/"><span style="font-weight: 400;">hemoglobin</span></a><span style="font-weight: 400;"> improvement [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29059584"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Since iron supplements can irritate the gut in Crohn's disease patients, lactoferrin might be a great alternative, especially for those with the ITLN-1 variant [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181268/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Lactoferrin may compensate for lower intelectin-1 levels, improve the immune response, and help prevent iron deficiency in Crohn&rsquo;s disease.</span></p> <h4><strong>Fish oil</strong></h4> <p><span style="font-weight: 400;">Omega-3 fatty acids from </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">fish oil</span></a><span style="font-weight: 400;"> (EPA and DHA) may lessen the negative impact of your variant by suppressing TNF-alpha and IL-6 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257651/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/2783477/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22765297"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">High intake of fish oil omega-3s may be protective against the development of Crohn&rsquo;s disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153885/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">It is unclear whether omega-3 supplementation can help Crohn&rsquo;s disease that has already developed and progressed. However, multiple studies have suggested that omega-3s may help keep it in remission [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153885/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700845/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Fish oil can counteract your variant by suppressing TNF-a and IL-6. It may help prevent Crohn&rsquo;s disease and keep it in remission.</span></p>
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190 | content_learn_more_2092681436611172_text == Based on the variant we looked at, your ITLN1 gene is associated with slightly higher rates of Crohn’s disease. However, this doesn't necessarily reflect your overall risk of Crohn’s, just one gene related to it. Exercise in moderation and practice the Mediterranean diet to prevent gut inflammation. Keep reading to learn more.
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rsIDs = rs2274910
rsStatus = rs2274910,ITLN1,chr1,160882256,T,A,C,,28,0,Normal
