191 | id == 191
191 | category_id == 16
191 | category_order == 13
191 | category_name == Gut Health
191 | category_color == #C47AC0
191 | slug == FCGR2A-ulcerative-colitis
191 | title == The Role of One Receptor in Ulcerative Colitis (FCGR2A)
191 | meta_description == FCGR2A encodes a receptor that activates the antimicrobial response. Click to learn about its link with ulcerative colitis.
191 | summary == <p style="text-align:justify"><strong>The <em>FCGR2A</em> gene encodes a receptor that activates the antimicrobial response. One variant in this gene is associated with ulcerative colitis&mdash;read on to learn the details and get tailored tips.</strong></p>
191 | overall_score_text == Your ulcerative colitis score (based on FCGR2A gene)
191 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/FCGR2A--Gut-Inflammation-IBD---all-chips.jpg
191 | author_id == 9
191 | author_name == Aleksa Ristic
191 | author_title == MS (Pharmacy)
191 | author_order == 45
191 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
191 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
191 | reviewer == None
191 | medical_reviewer_id == 11
191 | medical_reviewer_name == Puya Yazdi
191 | medical_reviewer_title == MD
191 | publish_date == 2020
191 | publish_date == 5
191 | publish_date == 18
191 | avg_rating == 5.0
191 | tags_id == 298
191 | tags_name == Curcumin
191 | tags_id == 383
191 | tags_name == FCGR2A
191 | tags_id == 73
191 | tags_name == IBD
191 | tags_id == 446
191 | tags_name == IgG antibodies
191 | tags_id == 24
191 | tags_name == Inflammation
191 | tags_id == 50
191 | tags_name == Stress
191 | tags_id == 245
191 | tags_name == Sunlight
191 | tags_id == 196
191 | tags_name == Ulcerative Colitis
191 | tags_id == 232
191 | tags_name == Vitamin D
191 | permissions_favorite == False
191 | permissions_rate == False
191 | content_article == <p><em><span style="font-weight: 400;">This article is for informational purposes only. None of the information here should be taken as medical advice. If you suspect you may have digestive issues, seek medical help. </span></em><em><span style="font-weight: 400;">Keep in mind that these results are based on association studies, which are correlative and aren&rsquo;t necessarily causative. Any single genetic variant will typically contribute only a small proportion to the overall risk of the condition, and non-genetic factors play a large role in developing a condition as well. Therefore, just because you have one of these genotypes does not necessarily mean you are at an increased risk of developing this condition!</span></em></p> <table style="width: 90%; border-collapse: collapse; margin-left: auto; margin-right: auto;" border="1" cellpadding="10"> <tbody> <tr> <td style="width: 100%;"><strong>Note:</strong> The <em>FCGR2A</em>&nbsp;gene is mentioned in SelfDecode&rsquo;s <a href="https://get.selfdecode.com/gene-reports/inflammation/" target="_blank" rel="noopener"><strong><em>Inflammation DNA Wellness Report</em></strong></a>, along with many other important genes. If you're looking for a comprehensive, personalized resource that can help you combat inflammation, check it out!</td> </tr> </tbody> </table> <p>&nbsp;</p> <h2><strong><em>FCGR2A</em> in Immunity and Inflammation</strong></h2> <p><a href="https://commons.wikimedia.org/w/index.php?curid=18176688" target="_blank" rel="noopener"><strong><img src="https://upload.wikimedia.org/wikipedia/commons/thumb/4/4f/Fc_receptor_schematic.svg/600px-Fc_receptor_schematic.svg.png" alt="File:Fc receptor schematic.svg" width="450" height="418" /></strong></a></p> <p><sub><span style="font-weight: 400;">By Fc_receptor_schematic_big.png: en:User: Ciar from w: enderivative work: Rehua (talk)</span><span style="font-weight: 400;">&nbsp;</span></sub></p> <p><span style="font-weight: 400;">The </span><a href="../../gene/fcgr2a/"><em><span style="font-weight: 400;">FCGR2A</span></em></a><span style="font-weight: 400;"> gene encodes a specific type of Fc receptor: Fc&gamma;RIIA or CD32. Immune cells such as </span><a href="https://selfhacked.com/blog/monocytes/"><span style="font-weight: 400;">monocytes</span></a><span style="font-weight: 400;"> and macrophages express Fc receptors, which recognize antibodies attached to pathogens or infected cells [</span><a href="https://ghr.nlm.nih.gov/gene/FCGR2A"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Fc&gamma;(gamma) receptors recognize IgG antibodies. While they all bind IgG1 and IgG3 antibodies, only Fc&gamma;RIIA can effectively bind IgG2. Once activated, this receptor sets off different mechanisms that promote inflammation and pathogen removal [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26497525"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://onlinelibrary.wiley.com/doi/full/10.1046/j.1365-2362.2001.00881.x"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://onlinelibrary.wiley.com/doi/full/10.1111/jth.12905"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">Over-active CD32 can contribute to autoimmunity, while its suppression leads to poor antimicrobial response [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17981207"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em>FCGR2A</em> encodes a receptor that binds IgG antibodies and signals the immune response against pathogens. An over-active receptor can contribute to inflammation and autoimmunity.</span></p> <h3><strong>The Role in Ulcerative Colitis</strong></h3> <p><a href="https://selfhacked.com/blog/ulcerative-colitis/"><span style="font-weight: 400;">Ulcerative colitis</span></a><span style="font-weight: 400;"> (UC) and </span><a href="https://selfhacked.com/blog/crohns-disease/"><span style="font-weight: 400;">Crohn&rsquo;s disease</span></a><span style="font-weight: 400;"> (CD) are the most frequent subtypes of inflammatory bowel disease (IBD). The cause of IBD lies in a complex interplay of </span><a href="https://selfhacked.com/blog/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections/"><span style="font-weight: 400;">genetic and environmental factors</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106026/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Ulcerative colitis typically affects the colon and rectum, and involves inflammation of the surface (mucosal) layer [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622286/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30837080"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Although IBD is considered a T cell-mediated condition, recent evidence implies a dysfunction in B cells and Fc&gamma;R signaling in IBD development. In patients with IBD, and especially ulcerative colitis, IgG antibodies can flag healthy gut components and trigger an autoimmune reaction [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473071/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/1082398/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477154/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Ulcerative colitis is a form of autoimmune colon inflammation. Self-destructive IgG antibodies can play a role in this condition via impaired Fc&gamma;R signaling.</span></p> <h2><strong>FCGR2A Variant and Ulcerative Colitis Susceptibility</strong></h2> <p><span style="font-weight: 400;">Robust evidence suggests a link between one FCGR2A variant and ulcerative colitis. In a meta-analysis of six trials and over 26,000 participants, the "A" allele at </span><a href="../../snp/rs1801274/"><span style="font-weight: 400;">rs1801274</span></a><span style="font-weight: 400;"> was associated with 21% higher UC rates. All subjects were of European ancestry [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084597/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A study of over 41,000 European subjects confirmed the association between this variant and IBD. However, some studies haven&rsquo;t found a significant link with Crohn&rsquo;s disease, suggesting its primary role in ulcerative colitis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491803/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574810/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The same SNP is associated with ulcerative colitis in Korean and Japanese populations, too [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26398853"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19915573"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The &ldquo;A&rdquo; allele at rs1801274 is associated with higher rates of ulcerative colitis across different populations.</span></p> <h3><strong>IBD Complications and Dietary Factors</strong></h3> <p><span style="font-weight: 400;">A meta-analysis that included 2,287 IBD patients associated this variant with 65% higher chances of IBD-associated colorectal cancer. However, when corrected for other contributing factors, the effect became non-significant [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28243990"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A study of over 165,000 women identified one dietary factor that greatly impacts the link between rs1801274 and ulcerative colitis. In women with the &ldquo;AA&rdquo; genotype, </span><a href="https://selfhacked.com/blog/iron-balance-blood-test-iron-deficiency-anemia-overload/"><span style="font-weight: 400;">iron</span></a><span style="font-weight: 400;"> from animal sources was associated with higher UC rates (3-fold increase for each 1 g of added iron) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549140/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">On the other hand, iron from animal sources was protective in women with the &ldquo;GG&rdquo; genotype [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549140/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">People with rs1801274-A may be more prone to IBD-associated colon cancer. Iron from animal sources could amplify the effects of this variant.</span></p> <h3><strong>How It Works</strong></h3> <p><span style="font-weight: 400;">The G&gt;A switch at rs1801274 changes one amino acid in the Fc&gamma;RIIA structure. The &ldquo;A&rdquo; allele codes for </span><a href="https://www.selfhacked.com/blog/histidine/"><span style="font-weight: 400;">histidine</span></a><span style="font-weight: 400;">, which increases the receptor affinity for IgG antibodies, especially IgG2. This change improves pathogen removal but also contributes to autoimmune conditions such as ulcerative colitis [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10675363/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/1532589/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The activation of Fc&gamma;RIIA receptors on the gut immune cells triggers </span><a href="http://selfhacked.com/blog/interleukin-1/"><span style="font-weight: 400;">IL-1b</span></a><span style="font-weight: 400;"> production, which in turn drives </span><a href="http://selfhacked.com/blog/supplements-people-th1-dominant/"><span style="font-weight: 400;">Th1</span></a><a href="http://selfhacked.com/blog/th17/"><span style="font-weight: 400;">7</span></a><span style="font-weight: 400;"> immunity and inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473071/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477154/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>Other Conditions</strong></h3> <p><span style="font-weight: 400;">This variant has a well-known role in autoimmune conditions, such as:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Lupus [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17606457"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]&nbsp;&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Graves&rsquo; disease [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20148910"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Kawasaki disease [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22081228"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400;">Changes in the Fc&gamma;RIIA structure and function can also affect the immune response to HIV, bacterial infections, lymphomas, and more [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20041166"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9683667/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19066394"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><strong>Your FCGR2A Results for Ulcerative Colitis</strong></h2> <p>*1332231460016670*</p> <h3><strong>SNP Summary</strong></h3> <p><strong>Primary SNP:</strong></p> <p><strong><em>FCGR2A</em></strong> <a href="../../snp/rs1801274/"><strong>rs1801274</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = not associated with ulcerative colitis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = associated with higher rates of ulcerative colitis and complications</span></li> </ul> <p><em><span style="font-weight: 400;">Population Frequency</span></em><span style="font-weight: 400;">: Around 47% of European descendants carry one copy, and 26% carry both copies of the &ldquo;A&rdquo; allele. This allele is even more common in East Asian populations, where 43% of people have one and 51% have both copies.</span></p> <p>*1938953253872866*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Reduce Gut Inflammation</strong></h2> <p><em><span style="font-weight: 400;">You may try the complementary approaches listed below if you and your doctor determine that they could be appropriate for you. Discuss the strategies listed here with your doctor. Remember that none of them should ever be done in place of what your doctor recommends or prescribes.</span></em></p> <p>*5480544928759643*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Avoid Stress</strong></h4> <p><span style="font-weight: 400;">Clinical and animal studies have shown the potential of psychological </span><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">stress</span></a><span style="font-weight: 400;"> to raise IgG antibodies, especially IgG2. Stress can also mimic your gene variant by increasing IL-1b levels and activating Th17 cells [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9364619"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12608916"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19773812"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797502/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Psychological stress has well-known detrimental effects on gut health and inflammation. It raises gut permeability and the levels of different inflammatory cytokines [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23470617/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262626/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Many ulcerative colitis patients develop </span><a href="https://selfhacked.com/blog/natural-treatments-anxiety/"><span style="font-weight: 400;">anxiety</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/natural-treatments-depression/"><span style="font-weight: 400;">depression</span></a><span style="font-weight: 400;"> associated with their debilitating digestive symptoms. In turn, stress may worsen the symptoms of UC. Because of this potential feedback loop, many doctors emphasize the importance of managing the mental health of UC patients [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774724/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28245757"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678997/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572298/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Psychological stress can worsen the impact of your gene variant and play a significant role in ulcerative colitis development. Try to avoid stress and practice relaxation techniques.</span></p> <h4><strong>Moderate Sun Exposure</strong></h4> <p><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">Sunlight</span></a><span style="font-weight: 400;"> is the best natural source of </span><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;">, which helps combat Th17-associated inflammation. In a trial of 1,470 older people, vitamin D deficiency was associated with higher levels of IgG2 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998156/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883018/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Additionally, UV light may counteract your FCGR2A variant by suppressing Th17 cells [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289959/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289959/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/calcium-101/"><span style="font-weight: 400;">Calcium</span></a><span style="font-weight: 400;"> and vitamin D deficiencies are common in ulcerative colitis patients, leading to osteoporosis and joint disorders. The lack of vitamin D is also associated with increased UC severity and duration. Moderate sun exposure will help you get enough of this crucial nutrient [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202340/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257592/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30864011"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Moderate sun exposure may lessen the impact of your variant. It supplies vitamin D, which is crucial for ulcerative colitis patients.</span></p> <h3><strong>Diet</strong></h3> <h4><strong>IgG-Based Elimination Diet</strong></h4> <p><span style="font-weight: 400;">Unlike acute allergic reactions, which are IgE-mediated, most delayed food reactions (sensitivities) are IgG-mediated. Based on this feature, doctors have developed special elimination diets, excluding foods that raise IgG levels in sensitive patients [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314037/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721378/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774223/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a study of 97 ulcerative colitis patients, an IgG-based elimination diet significantly reduced the symptoms and improved the quality of life. This approach may be particularly useful for people with the discussed SNP, given its effect on IgG activity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29788288"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">A special elimination diet can remove the foods that increase IgG levels and thus potentially improve ulcerative colitis.</span></p> <h4><strong>Limit the Intake of Iron From Animal Sources</strong></h4> <p><span style="font-weight: 400;">As mentioned, </span><a href="https://selfhacked.com/blog/iron-balance-blood-test-iron-deficiency-anemia-overload/"><span style="font-weight: 400;">iron</span></a><span style="font-weight: 400;"> from animal sources can amplify the impact of rs1801274-A on ulcerative colitis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549140/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Red meat is the most concentrated animal source of iron. Increased intake of red or processed meat is associated with higher ulcerative colitis relapses (re-activation) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774255/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774231/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Consider limiting the intake of pork, lamb, and beef. You can replace them with fish, chicken, and plant sources of iron. Of course, measure your </span><a href="https://selfhacked.com/blog/ferritin/"><span style="font-weight: 400;">ferritin</span></a><span style="font-weight: 400;"> and iron levels to make sure you are still getting enough iron.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">To reduce the impact of your variant, limit the intake of red meat and replace it with fish, chicken, and plant sources of iron.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Boswellia</strong></h4> <p><a href="http://selfhacked.com/blog/boswellia/"><span style="font-weight: 400;">Boswellia</span></a><span style="font-weight: 400;"> resin or frankincense is a natural remedy with powerful anti-inflammatory properties. It may counteract the Fc&gamma;RIIA receptors by reducing IL-1b levels and Th17 activity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24469975"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17321470"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309643/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Boswellia extract also has antioxidant activity and protects the intestinal barrier from inflammatory damage [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425476/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">It was effective in the treatment of 30 patients with chronic colitis with minimal side effects. In another trial, Boswellia resin improved ulcerative colitis with 80-82% remission [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11488449"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9049593"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Boswellia resin or frankincense is a powerful anti-inflammatory. It may counteract the Fc&gamma;RIIA receptors and improve the symptoms of ulcerative colitis.</span></p> <h4><strong>Curcumin</strong></h4> <p><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">Curcumin</span></a><span style="font-weight: 400;"> is the active principle of turmeric. It can suppress Th17 cells and lower IL-1b levels [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19594223"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29549176"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29852475"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Multiple clinical trials have produced promising results for curcumin in IBD, and further research is currently underway [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29957091"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514688/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153885/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><strong>Vitamin D</strong></h4> <p><span style="font-weight: 400;">As mentioned, </span><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">vitamin D</span></a><span style="font-weight: 400;"> deficiency is associated with higher Th17 activity and IgG levels&nbsp; [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998156/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883018/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">If you can&rsquo;t get enough vitamin D from sun exposure, consider taking a supplement. In a meta-analysis of 18 trials and 908 patients, vitamin D supplementation corrected a deficiency and helped prevent IBD relapse [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257592/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Curcumin and vitamin D may reduce the impact of your FCGR2A variant and help with ulcerative colitis.</span></p>
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191 | content_learn_more_1938953253872866_text == Based on the variant we looked at, your FCGR2A gene is associated with slightly higher rates of ulcerative colitis. However, this doesn't necessarily reflect your overall risk of UC, just one gene related to it. Avoid stress and limit the intake of red meat to prevent gut inflammation. Keep reading to learn more.
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rsIDs = rs1801274
rsStatus = rs1801274,FCGR2A,chr1,161509955,A,C,G,,22,0,Normal
