210 | id == 210
210 | category_id == 18
210 | category_order == 15
210 | category_name == Weight
210 | category_color == #C47AC0
210 | slug == SOCS3-weight
210 | title == A Gene That Connects Sirtuins, Insulin Resistance, and Obesity (SOCS3)
210 | meta_description == SOCS3 is a cytokine suppressor gene that is associated with leptin resistance and weight gain. How can it be counteracted?
210 | summary == <p><strong>SOCS3 is a cytokine suppressor gene that is associated with leptin resistance and weight gain. How does it work, and how can it be counteracted? Read on to find out.</strong></p>
210 | overall_score_text == Weight Gain Score (based on SOCS3)
210 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/SOCS3--Weight.jpg
210 | author_id == 1
210 | author_name == Jasmine Foster
210 | author_title == BSc, BEd
210 | author_order == 36
210 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
210 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
210 | reviewer == None
210 | medical_reviewer_id == 11
210 | medical_reviewer_name == Puya Yazdi
210 | medical_reviewer_title == MD
210 | publish_date == 2020
210 | publish_date == 6
210 | publish_date == 9
210 | avg_rating == 5.0
210 | tags_id == 456
210 | tags_name == Leptin
210 | tags_id == 473
210 | tags_name == Leptin Resistance
210 | tags_id == 165
210 | tags_name == Obesity
210 | tags_id == 145
210 | tags_name == Sirtuins
210 | tags_id == 483
210 | tags_name == SOCS3 Gene
210 | tags_id == 115
210 | tags_name == Weight Gain
210 | tags_id == 184
210 | tags_name == Weight Loss
210 | permissions_favorite == False
210 | permissions_rate == False
210 | content_article == <p><em><span style="font-weight: 400;">This article is for informational purposes only. None of the information here should be taken as medical advice. If you are struggling to maintain a healthy weight, seek medical help. </span></em><em><span style="font-weight: 400;">Keep in mind that these results are based on association studies, which are correlative and aren&rsquo;t necessarily causative. Any single genetic variant will typically contribute only a small proportion to the overall risk of the condition, and non-genetic factors play a large role in developing a condition as well. Therefore, just because you have one of these genotypes does not necessarily mean you are at an increased risk of developing this condition!</span></em></p> <h2><span style="font-weight: 400;">What is SOCS3?</span></h2> <p><em><span style="font-weight: 400;">SOCS3</span></em><span style="font-weight: 400;"> encodes a member of the suppressor of cytokine signalling (SOCS) family of proteins. It is activated by cytokines like IL-6, IL-10, and IFN-gamma, and it in turn suppresses these and other cytokines [</span><a href="https://ghr.nlm.nih.gov/gene/SOCS3"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">SOCS3 specifically regulates cytokines that are activated through the JAK-STAT3 pathway [</span><a href="https://ghr.nlm.nih.gov/gene/SOCS3"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">STAT3 is a transcription factor, meaning that it regulates the expression of other genes. The STAT3 pathway is used by a variety of cytokines, hormones and growth factors to increase blood cell formation, immune cell development, stem cell maintenance, and growth. However, chronic activation of STAT3 underlies various diseases or disorders, such as cancer and </span><a href="https://selfhacked.com/blog/132-biological-mechanisms-for-weight-modulation/"><span style="font-weight: 400;">obesity</span></a><span style="font-weight: 400;"> [</span><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710326/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Chronic activation of SOCS3 has similarly been linked to leptin resistance, increased appetite, and weight gain [</span><a href="https://www.nature.com/articles/nm1071/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">A Connection to the Sirtuins &amp; Leptin Resistance</span></h3> <p><span style="font-weight: 400;">SOCS3 closely communicates with both the sirtuins (</span><em><span style="font-weight: 400;">SIRT</span></em><span style="font-weight: 400;"> family of genes) and with the leptin system, which regulates appetite and prevents overeating [</span><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940852/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/nm1071/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><em><span style="font-weight: 400;">SIRT1</span></em><span style="font-weight: 400;">, a gene well-studied for its relationship with longevity, appears to decrease SOCS3 activity and, in turn, prevent leptin resistance [</span><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940852/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Mice genetically engineered to be deficient in SOCS3 in the brain had more leptin in the hypothalamus and were more sensitive to leptin signalling than normal mice. These SOCS3-deficient mice did not become obese, even when they were offered diets that usually trigger weight gain and obesity in experimental mice [</span><a href="https://www.nature.com/articles/nm1071/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://academic.oup.com/endo/article/157/10/3901/2758363"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The SIRT1-SOCS3 pathway that affects leptin sensitivity is, for this reason, being studied for its potential effects on human obesity [</span><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940852/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/nm1071/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://academic.oup.com/endo/article/157/10/3901/2758363"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">A Note of Caution: SOCS3 &amp; Inflammation</span></h3> <p><span style="font-weight: 400;">The primary beneficial function of SOCS3 is to suppress inflammatory cytokines like IL-6 and IFN-gamma; in fact, SOCS3 is activated during inflammation, as a negative feedback control switch [</span><a href="https://ghr.nlm.nih.gov/gene/SOCS3"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928676/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">As such, low SOCS3 activity may be beneficial for weight management, but it may also allow for increased inflammation through an unregulated </span><a href="https://selfhack.com/blog/natural-stat3-inhibitors/"><span style="font-weight: 400;">JAK-STAT</span></a><span style="font-weight: 400;"> pathway [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928676/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.hindawi.com/journals/mi/2013/650812/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">SOCS3 encodes a cytokine suppressor gene that regulates the JAK-STAT3 pathway and has been associated with leptin resistance and weight gain.</span></p> <h2><span style="font-weight: 400;">SOCS3 Variants &amp; Obesity</span></h2> <p><span style="font-weight: 400;">At least four variants in or near </span><em><span style="font-weight: 400;">SOCS3 </span></em><span style="font-weight: 400;">have been associated with obesity in humans. In each case, the allele associated with increased SOCS3 activity is linked to increased BMI and weight [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002737/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002737/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804661/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/jhg2016145/tables/2"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Perhaps most notably, the uncommon &lsquo;A&rsquo; allele at rs4969168 was associated with increased SOCS3, higher BMI, higher weight, and increased waist circumference measurements in studies of Chinese and Hispanic American people [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002737/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804661/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Other variants associated with increased weight include rs9892622-A (only significant in men in certain Chinese populations), rs4969170-A, and rs614080-A [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002737/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804661/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/jhg2016145/tables/2"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><span style="font-weight: 400;">Your SOCS3 Results for Obesity</span></h2> <p>*5105988051585415*</p> <h3><span style="font-weight: 400;">SNP Summary and Table</span></h3> <p><strong>SOCS3 rs9892622</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with higher BMI or weight</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with higher BMI and weight in certain Chinese populations</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; and &lsquo;A&rsquo; allele are each about as common as the other; about 29% of all people have the &lsquo;GG&rsquo; genotype and about 27% of all people have the &lsquo;AA&rsquo; genotype worldwide.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;AA&rsquo; genotype is more common in people of South Asian descent (36%) and the &lsquo;GG&rsquo; genotype is much more common in people of African descent (54%).</span></li> </ul> <p><strong>SOCS3 rs4969168</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Lower levels of SOCS3 protein; associated with lower BMI, weight, and waist measurements in Chinese and Hispanic populations</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Higher levels of SOCS3 protein; associated with higher BMI, weight, and waist measurements in Chinese and Hispanic populations</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">About 43% of all people worldwide have the &lsquo;GG&rsquo; genotype.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;GG&rsquo; genotype is much more common in people of European descent (73%) and much less common in people of African descent (10%).</span></li> </ul> <p><strong>SOCS3 rs4969170</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Higher levels of SOCS3 protein, possibly associated with weight gain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Lower levels of SOCS3 protein, not associated with weight gain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Only about 21% of all people worldwide have the &lsquo;GG&rsquo; genotype.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;GG&rsquo; genotype is more common in people of European (42%), American (31%), and South Asian (30%) descent and much less common in people of African (8%) and East Asian (2.4%) descent.</span></li> </ul> <p><strong>SOCS3 rs614080</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with morbid obesity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with morbid obesity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">About 40% of all people have the protective &lsquo;GG&rsquo; genotype.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;GG&rsquo; genotype is almost ubiquitous in people of African descent (87%) and very uncommon in people of East Asian (10%), South Asian (12.5%)</span></li> </ul> <p>*8905369434388141*</p> <h2><span style="font-weight: 400;">Recommendations for Weight Control</span></h2> <p><em><span style="font-weight: 400;">You may try the complementary approaches listed below if you and your doctor determine that they could be appropriate for you. Discuss the strategies listed here with your doctor. Remember that none of them should ever be done in place of what your doctor recommends or prescribes.</span></em></p> <p>*6003059462791163*</p> <p><strong>A note</strong><span style="font-weight: 400;">: the strategies below may or may not act on SOCS3 directly. Instead, decreased SOCS3 may simply be an indication that an underlying pathological state has improved, thus reducing SOCS3 activation downstream. If you have potentially detrimental SOCS3 variants and these strategies don&rsquo;t work for you, you may want to look at </span><a href="../article/stat3-obesity-saturated-fat-205"><span style="font-weight: 400;">upstream genes like STAT3</span></a><span style="font-weight: 400;"> for other options.</span></p> <h3><span style="font-weight: 400;">More &amp; Better Sleep</span></h3> <p><span style="font-weight: 400;">Sleep deprivation has been found to increase activity of both SOCS3 and STAT3 in animal studies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621781/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/25451613"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Research over the past few decades has recognized the importance of circadian biology in</span><a href="https://selfhacked.com/blog/132-biological-mechanisms-for-weight-modulation/"><span style="font-weight: 400;"> obesity</span></a><span style="font-weight: 400;">. Scientists think that circadian biology may have a massive influence on energy balance and metabolism [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013188/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In lab settings, mice who ate at the wrong time (when it&rsquo;s dark for humans) gained more weight, despite the absence of any significant differences in calorie intake or activity over the course of the experiment [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013188/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. The authors suspect that their metabolism shifted.</span></p> <p><span style="font-weight: 400;">According to another theory, a disrupted circadian rhythm may be why shift workers seem to be at an increased risk of obesity [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20122305"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Short </span><a href="https://selfhacked.com/blog/health-benefits-sleep/"><span style="font-weight: 400;">sleep </span></a><span style="font-weight: 400;">duration has been associated with weight gain in many studies. A meta-analysis of 30 studies and over 630,000 people associated short sleep duration with a 55% higher incidence of obesity in adults and 89% in children [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18239586"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973603/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2398753/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Poor sleep can increase </span><a href="https://selfhacked.com/blog/top-10-ways-to-curb-your-hunger-and-approaches-that-didnt-work/"><span style="font-weight: 400;">hunger</span></a><span style="font-weight: 400;"> and cravings and disrupt hunger hormones like </span><a href="https://selfhacked.com/blog/ghrelin-role-cognitive-gut-function-weight-inflammation-autoimmunity/"><span style="font-weight: 400;">ghrelin</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/all-about-leptin-its-role-in-chronic-inflammation-cfs-and-weight/"><span style="font-weight: 400;">leptin</span></a><span style="font-weight: 400;"> [</span><a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1547-5069.2009.01262.x/full"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.0010062"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Disrupted sleep schedules may increase both inflammation and SOCS3, leading to increased weight gain.</span></p> <h3><span style="font-weight: 400;">Spicy Food</span></h3> <p><a href="https://selfhacked.com/blog/capsaicin/"><span style="font-weight: 400;">Capsaicin</span></a><span style="font-weight: 400;"> activates </span><a href="../../gene/trpv1/"><span style="font-weight: 400;">TRPV1</span></a><span style="font-weight: 400;">, a heat-sensing receptor that appears to decrease SOCS3 activity in mice; animals without TRPV1 have significantly higher SOCS3 activity than those with the receptor [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511197/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Capsaicin also decreased STAT3 activation in a cell study [</span><a href="http://www.ncbi.nlm.nih.gov/pubmed/17505005"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">TRPV1 activation by capsaicin may also speed up the metabolism, increase energy expenditure, and reduce appetite [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699483/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/13129472"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22378725"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15611784"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">When ingested orally with </span><a href="https://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">green tea</span></a><span style="font-weight: 400;">, capsaicin reduced appetite and food intake in humans. Early research indicates that taking capsaicin as a </span><a href="https://selfhacked.com/blog/a-comprehensive-list-of-effective-ways-to-lose-weight/"><span style="font-weight: 400;">weight loss</span></a><span style="font-weight: 400;"> supplement is safe, but more must be known about its effectiveness [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477151/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426284/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24941669/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">If you like spicy food, you&rsquo;re in luck: capsaicin is found in chili peppers and is responsible for their spicy flavor. The spicier the pepper, the more capsaicin it contains [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/13129472"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22378725"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Spicy food contains capsaicin, which may decrease SOCS3 activity through the activation of TRPV1 heat sensing receptors.</span></p> <h3><span style="font-weight: 400;">Metformin</span></h3> <p><span style="font-weight: 400;">STAT3 and SOCS3 activity were both decreased significantly in mice treated with metformin; this drug has also been found to directly increase SIRT1 activation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22349108/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232372/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/uses-benefits-metformin/"><span style="font-weight: 400;">Metformin</span></a><span style="font-weight: 400;"> decreased food consumption and induced weight loss in a clinical trial on 12 obese women with type 2 diabetes. Metformin may help you lose weight if you have type 2 diabetes and your doctor prescribes you this medication. You may discuss with your doctor if it may be recommended in your case [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9526970"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p>
210 | content_snp_table_5105988051585415_key == 5105988051585415
210 | content_snp_table_5105988051585415_blur == True
210 | content_snp_table_5105988051585415_hidden == False
210 | content_learn_more_8905369434388141_key == 8905369434388141
210 | content_learn_more_8905369434388141_blur == True
210 | content_learn_more_8905369434388141_hidden == False
210 | content_learn_more_8905369434388141_text == Based on the variants we looked at, your SOCS3 gene is moderately associated with leptin resistance and weight gain. However, this doesn't necessarily reflect your overall risk of weight gain, just one gene related to it. More and better sleep and a diet rich in spicy foods may help. Keep scrolling to find out more.
210 | content_recommendation_6003059462791163_key == 6003059462791163
210 | content_recommendation_6003059462791163_blur == True
210 | content_recommendation_6003059462791163_hidden == False
rsIDs = rs614080,rs4969168,rs9892622,rs4969170
rsStatus = rs614080,,chr11,67579816,G,A,,,43,0,Normal
rsStatus = rs4969168,SOCS3,chr17,78357712,A,G,T,,10,27,HET
rsStatus = rs9892622,,chr17,78350041,G,A,C,,12,25,HET
rsStatus = rs4969170,SOCS3-DT,chr17,78364457,A,C,G,,40,0,Normal
