237 | id == 237
237 | category_id == 18
237 | category_order == 15
237 | category_name == Weight
237 | category_color == #C47AC0
237 | slug == FAIM2-weight
237 | title == Is This Gene Linked to Obesity (FAIM2)?
237 | meta_description == FAIM2 encodes a brain protein. Learn about its variants associated with obesity here.
237 | summary == <p style="text-align:justify"><strong>The FAIM2 gene encodes a protein especially found in the brain that blocks programmed cell death. Two variants of this gene have been associated with obesity &mdash; read on to check where your genes stand.</strong></p>
237 | overall_score_text == Your Weight Score (Based on FAIM2 Gene)
237 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/FAIM2--Weight.jpg
237 | author_id == 12
237 | author_name == Carlos Tello
237 | author_title == PhD
237 | author_order == 55
237 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/CarlosTello.webp
237 | author_intro == <p><strong>Carlos received his PhD and MS from the Universidad de Sevilla.</strong></p>    <p>Carlos spent 9 years in the laboratory investigating mineral transport in plants. He then started working as a freelancer, mainly in science writing, editing, and consulting. Carlos is passionate about learning the mechanisms behind biological processes and communicating science to both academic and non-academic audiences. He strongly believes that scientific literacy is crucial to maintain a healthy lifestyle and avoid falling for scams.</p>
237 | author_social_media_name == linkedin
237 | author_social_media_icon == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/social-icon/linkedin.png
237 | author_social_order == 1
237 | author_social_link == https://www.linkedin.com/in/carlos-tello-lacal-b946b4a7/
237 | reviewer == None
237 | medical_reviewer_id == 11
237 | medical_reviewer_name == Puya Yazdi
237 | medical_reviewer_title == MD
237 | publish_date == 2020
237 | publish_date == 7
237 | publish_date == 10
237 | avg_rating == 5.0
237 | tags_id == 216
237 | tags_name == Apoptosis
237 | tags_id == 186
237 | tags_name == BMI
237 | tags_id == 462
237 | tags_name == Body Fat
237 | tags_id == 533
237 | tags_name == Cerebellum
237 | tags_id == 531
237 | tags_name == FAIM2 Gene
237 | tags_id == 532
237 | tags_name == Hippocampus
237 | tags_id == 502
237 | tags_name == Hypothalamus
237 | tags_id == 224
237 | tags_name == Nervous System
237 | tags_id == 165
237 | tags_name == Obesity
237 | permissions_favorite == False
237 | permissions_rate == False
237 | content_article == <p><em><span style="font-weight: 400;">This article is for informational purposes only. None of the information here should be taken as medical advice. If you are struggling to maintain a healthy weight, seek medical help. </span></em><em><span style="font-weight: 400;">Keep in mind that these results are based on association studies, which are correlative and aren&rsquo;t necessarily causative. Any single genetic variant will typically contribute only a small proportion to the overall risk of the condition, and non-genetic factors play a large role in developing a condition as well. Therefore, just because you have one of these genotypes does not necessarily mean you are at an increased risk of developing this condition!</span></em></p> <h2><strong>What Is the <em>FAIM2 </em>Gene?</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../../gene/faim2"><em><span style="font-weight: 400;">FAIM2 </span></em><span style="font-weight: 400;">gene</span></a><span style="font-weight: 400;"> encodes a protein called &lsquo;</span><em><span style="font-weight: 400;">Fas-apoptotic inhibitory molecule 2</span></em><span style="font-weight: 400;">&rsquo; and also known as LFG and NMP35. As its name implies, FAIM2 inhibits a special type of programmed cell death (</span><em><span style="font-weight: 400;">apoptosis</span></em><span style="font-weight: 400;">) induced by a protein called </span><em><span style="font-weight: 400;">Fas</span></em><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC23041/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><em><span style="font-weight: 400;">FAIM2 </span></em><span style="font-weight: 400;">is highly expressed in the membrane of brain cells, especially in certain regions involved in controlling appetite (the hippocampus, </span><a href="https://selfhacked.com/blog/hypothalamus-101/"><span style="font-weight: 400;">hypothalamus</span></a><span style="font-weight: 400;">, and cerebellum). By preventing the death of brain cells and promoting their growth, it plays a key role in the development and maintenance of the nervous system [</span><a href="https://pubmed.ncbi.nlm.nih.gov/9698393/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17635665/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398851/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603513/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6725360/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193209/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Animal studies also showed that it reduces brain damage caused by insufficient blood supply (ischemia), meningitis, and Parkinson&rsquo;s disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6622730/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978830/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27638043/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">FAIM2 is also found in fatty tissues, although at lower levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398851/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The <em>FAIM2 </em>gene encodes a protein mainly found in the brain and involved in the development and maintenance of brain cells.</span></p> <h2><strong><em>FAIM2 </em>Variants in Body Weight</strong></h2> <h3><span style="font-weight: 400;"><strong>Rs7138803</strong>&nbsp;</span></h3> <p><span style="font-weight: 400;">The most widely-investigated polymorphism is </span><a href="../../../snp/rs7138803/"><span style="font-weight: 400;">rs7138803</span></a><span style="font-weight: 400;">. Its minor &lsquo;A&rsquo; variant was first identified as an obesity-related allele in a study on Caucasians (from Iceland, Denmark, the Netherlands, and the US) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19079260/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Since then, the variant has been associated with high obesity rates, BMI, and body fat in multiple studies on Japanese, Chinese, Korean, Spanish, Danish, American (of Hispanic and European ancestry), and Mexican populations [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19851340/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20215397/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22041983/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24948161/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166286/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280302/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014648/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738539/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">The variant was also linked to obesity in Greek adolescents, and American, Mexican, and New Zealander children. However, the association couldn&rsquo;t be replicated in a Mexican study and most studies on Chinese children [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652032/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759132/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941152/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27486100/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28636007/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570414/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634012/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A meta-analysis of 5 studies confirmed its association with increased risk of being overweight or obese [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008255/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The variant has also been associated with diabetes, </span><a href="https://www.selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/"><span style="font-weight: 400;">insulin resistance</span></a><span style="font-weight: 400;">, and metabolic syndrome &mdash; which increase the risk of obesity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21369819/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20215397/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106578/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24269186/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23090577/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Carrying this variant may also predispose to heart disease. In addition to its contribution to excess weight, several studies associated it with increased </span><a href="https://www.selfhacked.com/blog/resting-heart-rate/"><span style="font-weight: 400;">heart rate</span></a><span style="font-weight: 400;">, blood pressure, and risk of heart attack [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922966/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23588626/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;"><strong>Rs7132908</strong>&nbsp;</span></h3> <p><span style="font-weight: 400;">The </span><a href="../../../snp/rs7132908/"><span style="font-weight: 400;">rs7132908</span></a><span style="font-weight: 400;"> polymorphism has been less investigated, but its minor &lsquo;A&rsquo; variant was associated with obesity and high BMI in Caucasian adults of European descent, and Mexican, American, Australian, and European (Danish, Finish, Spanish, German, British, Norwegian, and Dutch) children [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19812171/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973018/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013683/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854022/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A meta-analysis of studies done in children confirmed this association [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31504550/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">As was the case of rs7138803, this variant is also associated with heart disease. Carriers had increased risk of coronary artery disease in Japanese and Chinese studies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020445/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21625854/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>How It Works</strong></h3> <p><span style="font-weight: 400;">The rs7138803 polymorphism is located between this gene and </span><a href="../../../gene/bcdin3d/"><em><span style="font-weight: 400;">BCDIN3D</span></em></a><span style="font-weight: 400;"> and the exact mechanism by which the &lsquo;A&rsquo; variant contributes to obesity remains unknown.&nbsp;</span></p> <p><span style="font-weight: 400;">Owing to its activity in preventing cell death in the fatty tissue and brain regions that control appetite, the </span><em><span style="font-weight: 400;">FAIM2 </span></em><span style="font-weight: 400;">gene may influence body weight by regulating body fat distribution or feeding behavior [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC23041/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106578/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><em><span style="font-weight: 400;">BCDIN3D </span></em><span style="font-weight: 400;">has been barely studied but the research so far has found it blocks the expression of several genes. Interestingly, a study in rats found that its levels in the fatty tissue were reduced when the rats were fed a </span><a href="http://selfhacked.com/blog/low-carb-diet-vs-high-carb-diet/"><span style="font-weight: 400;">high-fat diet</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629726/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21262214/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21779089/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The &lsquo;A&rsquo; variant of rs7132908 shows reduced binding of a molecule that blocks its expression, resulting in higher protein levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028139/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31745258/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Two <em>FAIM2 </em>variants, one of which has been shown to increase <em>FAIM2 </em>expression, are associated with higher obesity rates and risk of heart disease.</span></p> <h2><strong>Your <em>FAIM2 </em>Results for Body Weight</strong></h2> <p>*4244897266689989*</p> <p>&nbsp;</p> <h3><strong>SNP Summary and Table</strong></h3> <p><strong>Primary SNP:</strong></p> <p><strong><em>FAIM2 </em></strong><strong>rs7138803</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = not associated with obesity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = associated with obesity, diabetes, and heart disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">55% of the world population carries two copies of the major &lsquo;G&rsquo; allele</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Carrying one copy of each allele is the most common situation in European descendants</span></li> </ul> <p><strong>Other Important SNPs:</strong></p> <p><strong><em>FAIM2 </em></strong><strong>rs7132908&nbsp;</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = not associated with obesity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = associated with obesity and heart disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The global distribution of the different genotypes resembles that of rs7138803</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele is especially rare in people of African ancestry</span></li> </ul> <p>*6767672060838483*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Improve Weight Control</strong></h2> <p><em><span style="font-weight: 400;">You may try the complementary approaches listed below if you and your doctor determine that they could be appropriate for you. Discuss the strategies listed here with your doctor. Remember that none of them should ever be done in place of what your doctor recommends or prescribes.</span></em></p> <p>*3502565067365319*</p> <p>&nbsp;</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Exercise</strong></h4> <p><span style="font-weight: 400;">In Chinese children, the minor &lsquo;A&rsquo; variant of rs7138803 was only associated with obesity if they were physically inactive. </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">Exercise</span></a><span style="font-weight: 400;"> alters an epigenetic modification of the </span><em><span style="font-weight: 400;">FAIM2 </span></em><span style="font-weight: 400;">gene that could change its expression and has been associated with higher obesity rates and blood fat levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21527513/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420961/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25696115/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">High-intensity exercise is probably the best strategy to lose weight. In addition to promoting fat and calorie burning, it may increase the levels of chemicals that support mental health and suppress appetite such as the neurotransmitters </span><a href="https://selfhacked.com/blog/norepinephrine-stress-hormone/"><span style="font-weight: 400;">norepinephrine</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/endorphins/"><span style="font-weight: 400;">endorphins</span></a><span style="font-weight: 400;">, and the neurotrophin </span><a href="../../article/boost-plasticity-with-the-bdnf-gene-50"><span style="font-weight: 400;">BDNF</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/5124188"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.news-medical.net/news/20120717/Mu-opioid-receptors-put-brakes-on-appetite.aspx"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://journal.frontiersin.org/article/10.3389/neuro.24.005.2010/full"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Aerobic exercise (like walking, running, swimming, etc) has also been shown to cause major reductions in belly fat in multiple studies. Although the reason is not fully understood, </span><a href="https://selfhacked.com/blog/health-benefits-yoga/"><span style="font-weight: 400;">yoga</span></a><span style="font-weight: 400;"> can be a useful tool for </span><a href="http://selfhacked.com/blog/a-comprehensive-list-of-effective-ways-to-lose-weight/"><span style="font-weight: 400;">weight loss</span></a><span style="font-weight: 400;"> too [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17637702"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21951360"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995338/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098025/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198375/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Exercise is an excellent way to lose weight. Certain <em>FAIM2 </em>variants may especially predispose physically inactive people to obesity.</span></p> <h3><strong>Diet</strong></h3> <h4><strong>Low-Saturated Fat Diets</strong></h4> <p><span style="font-weight: 400;">In mice, eating a </span><a href="https://selfhack.com/blog/saturatedfats-low-carb-diet-vs-high-carb-diet/"><span style="font-weight: 400;">high-fat diet</span></a><span style="font-weight: 400;"> increased </span><em><span style="font-weight: 400;">FAIM2 </span></em><span style="font-weight: 400;">expression in the fatty tissue and hypothalamus while reducing it in the rest of the brain [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22627920/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537611/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Several meta-analyses have associated low-fat diets with significant and sustained weight loss, as well as with reduced weight gain. Omega 3's and MUFAs from </span><a href="https://selfhacked.com/blog/olive-oil/"><span style="font-weight: 400;">olive oil</span></a><span style="font-weight: 400;"> are very healthy, so it would be wisest to cut down mainly on </span><em><span style="font-weight: 400;">saturated </span></em><span style="font-weight: 400;">fat [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667723/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516671/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10889789"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Eating a diet low in saturated fats helps lose weight and may alter <em>FAIM2 </em>expression.</span></p>
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237 | content_learn_more_6767672060838483_text == Based on the variants we looked at, your FAIM2 gene is associated with slightly higher obesity rates. However, this doesn't necessarily reflect your overall risk, just one gene related to it. Do more exercise and eat a diet low in saturated fats to maintain a healthy weight. Keep reading to find out more.
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rsIDs = rs7138803,rs7132908
rsStatus = rs7138803,,chr12,49853685,G,A,T,,25,11,HET
rsStatus = rs7132908,FAIM2,chr12,49869365,G,A,C,,22,16,HET
