243 | id == 243
243 | category_id == 18
243 | category_order == 15
243 | category_name == Weight
243 | category_color == #C47AC0
243 | slug == LPL-weight
243 | title == The Connection Between Fat Metabolism, Weight, and Genetics (LPL)
243 | meta_description == Lipase breaks fats into smaller molecules so they can be absorbed into the bloodstream. Can genetic variation affect weight?
243 | summary == <p><strong>Lipase breaks dietary fats into smaller molecules so they can be absorbed into the bloodstream. Can genetic variation in this crucial digestive enzyme affect weight?</strong></p>
243 | overall_score_text == Weight Gain Score (based on LPL)
243 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/LPL--Weight.jpg
243 | author_id == 1
243 | author_name == Jasmine Foster
243 | author_title == BSc, BEd
243 | author_order == 36
243 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
243 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
243 | reviewer == None
243 | medical_reviewer_id == 11
243 | medical_reviewer_name == Puya Yazdi
243 | medical_reviewer_title == MD
243 | publish_date == 2020
243 | publish_date == 7
243 | publish_date == 13
243 | avg_rating == 5.0
243 | tags_id == 305
243 | tags_name == Fat burning
243 | tags_id == 541
243 | tags_name == Lipase
243 | tags_id == 542
243 | tags_name == LPL Gene
243 | tags_id == 141
243 | tags_name == Metabolic Health
243 | tags_id == 289
243 | tags_name == Metabolic syndrome
243 | tags_id == 165
243 | tags_name == Obesity
243 | tags_id == 115
243 | tags_name == Weight Gain
243 | tags_id == 184
243 | tags_name == Weight Loss
243 | permissions_favorite == False
243 | permissions_rate == False
243 | content_article == <p><em><span style="font-weight: 400;">This article is for informational purposes only. None of the information here should be taken as medical advice. If you are struggling to maintain a healthy weight, seek medical help. </span></em><em><span style="font-weight: 400;">Keep in mind that these results are based on association studies, which are correlative and aren&rsquo;t necessarily causative. Any single genetic variant will typically contribute only a small proportion to the overall risk of the condition, and non-genetic factors play a large role in developing a condition as well. Therefore, just because you have one of these genotypes does not necessarily mean you are at an increased risk of developing this condition!</span></em></p> <h2><span style="font-weight: 400;">What is Lipase?</span></h2> <p><span style="font-weight: 400;">Lipase is an enzyme that breaks down dietary fats and oils so that they can be absorbed from the intestine into the bloodstream [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299384/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://www.selfhacked.com/blog/lipase-test/"><span style="font-weight: 400;">Pancreatic lipase</span></a><span style="font-weight: 400;"> is the most important type of lipase and the main form of lipase in the gut, produced and released by the pancreas, the same gland that makes </span><a href="https://selfhacked.com/blog/insulin-101/"><span style="font-weight: 400;">insulin</span></a><span style="font-weight: 400;">. After a meal, your pancreas releases lipase into your digestive tract, where it breaks down fatty </span><a href="https://www.selfhacked.com/blog/triglycerides/"><span style="font-weight: 400;">triglycerides</span></a><span style="font-weight: 400;"> into smaller molecules that are easier to absorb (monoglycerides and fatty acids) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657100/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In addition to the pancreas, lipases are also produced in the liver (hepatic lipase), blood vessel lining (endothelial lipase), and other tissues such as the muscles, heart, brain, and even fat tissues themselves (</span><a href="https://www.selfdecode.com/gene/LPL/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">lipoprotein lipase</span></a><span style="font-weight: 400;">) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078429/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780840/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12483461"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">How Does Lipase Affect Weight?</span></h3> <p><span style="font-weight: 400;">As we&rsquo;ve already mentioned, lipase breaks down fats to make them easier to absorb from the intestine into the bloodstream [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299384/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Researchers have found that blocking the pancreatic lipase aids in weight loss by preventing the absorption of fats [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657100/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People with lower lipase activity may be able to eat more dietary fats without gaining as much weight; by the same token, those with higher lipase activity may be more susceptible to weight gain from relatively less dietary fat [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657100/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Indeed, there are a few weight loss drugs that block pancreatic lipase and have been found to cause weight loss - orlistat (Xenical, Alli) and cetilistat (in clinical trials). Orlistat reduces fat absorption by about 30% [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19220279"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23950589"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/14667178"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Lipase is a digestive enzyme that breaks dietary fats into smaller molecules so that they can be absorbed into the bloodstream. Excess lipase activity has been linked to weight gain and obesity.</span></p> <h2><span style="font-weight: 400;">Lipase Variants &amp; Measurements of Weight Gain</span></h2> <p><span style="font-weight: 400;">A number of </span><em><span style="font-weight: 400;">LPL</span></em><span style="font-weight: 400;"> variants have been associated with obesity and measures of weight gain. One of these, rs250, is an insertion mutation; people with this variant have a slightly longer </span><em><span style="font-weight: 400;">LPL </span></em><span style="font-weight: 400;">gene than those who don&rsquo;t. The insertion mutation may increase the expression of lipase, thereby increasing fat absorption and likelihood of obesity. Unfortunately, though its link to obesity is significant, this variant is not reported on any major commercial DNA chip [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17299379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Five more variants of </span><em><span style="font-weight: 400;">LPL</span></em><span style="font-weight: 400;"> have been associated with weight and metabolic health outcomes. Generally speaking, variants that increase lipase allow for increased fat absorption, which potentially increases blood fats and fat tissue [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299384/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657100/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">One interesting study found that the &lsquo;TT&rsquo; genotype of </span><a href="../../../snp/rs320/"><span style="font-weight: 400;">rs320</span></a><span style="font-weight: 400;"> was associated with reduced BMI and waist circumference in women who ate a lot of polyunsaturated fatty acids (PUFAs). The &lsquo;G&rsquo; allele at this SNP is presumed to cause increased lipase activity and increased potential weight gain [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356006/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The &lsquo;G&rsquo; allele of </span><a href="../../../snp/rs1800590/"><span style="font-weight: 400;">rs1800590</span></a><span style="font-weight: 400;"> has been associated with increased BMI and more abdominal fat. Meanwhile, the &lsquo;A&rsquo; allele of </span><a href="../../../snp/rs264/"><span style="font-weight: 400;">rs264</span></a><span style="font-weight: 400;"> has been associated with increased weight regain after a weight loss program [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813926/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22492381/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Finally, two SNPs have been associated with increased blood fats and metabolic syndrome, though they have not been studied in the context of weight gain specifically. At </span><a href="../../../snp/rs7841189/"><span style="font-weight: 400;">rs7841189</span></a><span style="font-weight: 400;">, the uncommon &lsquo;T&rsquo; allele appears to be linked to reduced lipase activity (possibly protective against metabolic syndrome); at </span><a href="../../../snp/rs2083637/"><span style="font-weight: 400;">rs2083637</span></a><span style="font-weight: 400;">, the uncommon &lsquo;G&rsquo; allele may increase lipase activity and promote fat absorption [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378651/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915922/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Genetic variants that increase lipase expression have been associated with weight gain and metabolic dysfunction.</span></p> <h2><span style="font-weight: 400;">Your LPL Results for Weight Gain</span></h2> <p>*4970721037018908*</p> <h3><span style="font-weight: 400;">SNP Summary and Table</span></h3> <p><strong>LPL rs320</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with lower BMI in women who consume more polyunsaturated fats</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with higher BMI in women who consume more polyunsaturated fats</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">About 55% of all people worldwide have the &lsquo;TT&rsquo; genotype.</span></li> </ul> <p><strong>LPL rs1800590</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with BMI or abdominal fat</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with increased BMI and abdominal fat</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Only about 22% of all people worldwide have at least one copy of the &lsquo;G&rsquo; allele.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele is much more common in people of African descent (70%) and almost nonexistent in people of East Asian descent (0.2%).</span></li> </ul> <p><strong>LPL rs264</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with weight regain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with more weight regained after a weight loss program</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">About 29% of all people worldwide have at least one copy of the &lsquo;A&rsquo; allele.</span></li> </ul> <p><strong>LPL rs7841189</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with metabolic syndrome</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Possibly protective against metabolic syndrome</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">About 73% of all people worldwide have the &lsquo;CC&rsquo; genotype.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;CC&rsquo; genotype is less common in people of African descent (60%) and somewhat more common in people of South Asian and American descent (each 82%).</span></li> </ul> <p><strong>LPL rs2083637</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with metabolic syndrome</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with metabolic syndrome &amp; increased blood fats</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">About 42% of all people worldwide have at least one copy of the &lsquo;G&rsquo; allele.</span></li> </ul> <p>*6852057850825022*</p> <h2><span style="font-weight: 400;">Recommendations for Blocking Fat Absorption</span></h2> <p><em><span style="font-weight: 400;">You may try the complementary approaches listed below if you and your doctor determine that they could be appropriate for you. Discuss the strategies listed here with your doctor. Remember that none of them should ever be done in place of what your doctor recommends or prescribes.</span></em></p> <p>*5195753801257934*</p> <h3><span style="font-weight: 400;">Lifestyle</span></h3> <h4><span style="font-weight: 400;">Hydration</span></h4> <p><span style="font-weight: 400;">Dehydration can </span><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">stress</span></a><span style="font-weight: 400;"> the pancreas and cause it to produce more lipase. There are many good reasons to drink plenty of water during the day, and this is one of them; staying hydrated can help keep lipase production within a normal range. This is recommended regardless of your genotype, but especially important if you have a tendency to produce excess lipase [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28266591/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277949/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Researchers have estimated that drinking 500 ml (17 oz) of water </span><a href="https://authoritynutrition.com/how-much-water-should-you-drink-per-day/"><span style="font-weight: 400;">per day</span></a><span style="font-weight: 400;"> can boost metabolism by 24-30% over a period of 1-1.5 hours, while 2 liters (68 oz) of water can make you burn an additional 96 calories [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/14671205"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="http://selfhacked.com/blog/hydrogen-water/"><span style="font-weight: 400;">Molecular hydrogen water</span></a><span style="font-weight: 400;"> is often claimed to be better for weight loss. In the only study carried out so far (in mice) it induced </span><a href="http://www.selfdecode.com/gene/fgf2/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">FGF2</span></a><a href="https://www.selfdecode.com/gene/fgf21/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">1</span></a><span style="font-weight: 400;">, which resulted in the burning of brown fat. Whether hydrogen water has the same effects in humans remains unknown [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21293445"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Proper hydration supports pancreatic health and prevents the overproduction of lipase.</span></p> <h3><span style="font-weight: 400;">Diet</span></h3> <h4><span style="font-weight: 400;">Green Tea</span></h4> <p><a href="http://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">Green tea</span></a><span style="font-weight: 400;"> and its extracts have been found to block the action of lipase in animals and humans [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21412692"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11924761"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19271168"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">EGCG</span></a><span style="font-weight: 400;">, the major active compound in green tea, caused between 0.2 and 3.5 kg of weight loss in limited human studies. Green tea, meanwhile, is hypothesized to make us burn more calories, even at rest. In most studies, this amounts to a modest 3-4% increase in energy, though some studies have shown an increase as high as 8%. For a 2,000 calorie diet, 3-4% amounts to an additional 60-80 calories per day [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19597519"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025876/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://link.springer.com/article/10.1007%2FBF00403623"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19390166"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16176615"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17299107"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In one study of 60 obese individuals, the group taking green tea extract lost 7.3lbs and burned 183 more calories per day (on average) after 3 months [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18006026"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17882140"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">According to a review of 11 studies, green tea extract or EGCG can slightly improve weight loss and maintenance. However, a Cochrane database review of 14 studies regarded the change in weight as nonsignificant in most studies, so the evidence is inconclusive [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19597519/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23235664/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The majority of weight loss trials used special extracts with higher concentrations of active ingredients (catechins and </span><a href="https://selfhacked.com/blog/caffeine-benefits/"><span style="font-weight: 400;">caffeine</span></a><span style="font-weight: 400;">), compared with regular tea. Hence, it may be necessary to take an EGCG-rich green tea extract for beneficial effects [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025876/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Green tea contains active compounds that block lipase and have been used successfully as tools for weight loss.</span></p> <h4><span style="font-weight: 400;">Apples</span></h4> <p><span style="font-weight: 400;">Researchers are looking for naturally-occurring compounds that block pancreatic lipase and potentially reduce fat absorption. One food that is surprisingly rich in such compounds is the apple; </span><a href="https://selfhacked.com/blog/apple-polyphenols/"><span style="font-weight: 400;">apple polyphenols</span></a><span style="font-weight: 400;"> called procyanidins have been found to effectively block the action of lipase and reduce the absorption of triglyceride fats in mice and humans [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21412692"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17458979"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Polyphenols from various fruits (including </span><a href="https://selfhacked.com/blog/blueberries-health-benefits/"><span style="font-weight: 400;">blueberries</span></a><span style="font-weight: 400;"> and apples) led to lower weight in animal studies [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23936120"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23529981"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><span style="font-weight: 400;">Foods Containing Phytic Acid</span></h4> <p><a href="https://selfhacked.com/blog/phytic-acid-the-ultimate-anti-aging-compound/"><span style="font-weight: 400;">Phytic acid</span></a><span style="font-weight: 400;"> is a compound found in whole grains, legumes, potatoes, nuts, and seeds. It has a bad reputation as an &ldquo;anti-nutrient&rdquo; among the followers of popular diets like the paleo diet. This is because phytic acid tends to bind to nutrients like </span><a href="https://selfhacked.com/blog/literally-everything-wanted-know-zinc-backed-science/"><span style="font-weight: 400;">zinc</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/iron-balance-blood-test-iron-deficiency-anemia-overload/"><span style="font-weight: 400;">iron</span></a><span style="font-weight: 400;"> and make them less available for absorption [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325021/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21412692"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Phytic acid also happens to block the action of lipase, potentially reducing absorption of fats [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21412692"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">For reasons presumed to be unrelated to phytic acid, a diet rich in grains, legumes, nuts, and seeds is often recommended as part of a weight loss program. People who eat this kind of diet are less likely to develop heart disease and diabetes, for example: two conditions which are often comorbid with obesity [</span><a href="https://www.niddk.nih.gov/health-information/weight-management/adult-overweight-obesity/eating-physical-activity"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608274/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><span style="font-weight: 400;">Cooking Spices</span></h4> <p><span style="font-weight: 400;">One study found that a blend of common cooking spices, when added to a fatty meal, blocked lipase and reduced fat absorption. The spices in this blend were </span><a href="https://selfhacked.com/blog/black-pepper-piperine/"><span style="font-weight: 400;">black pepper</span></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/top-15-proven-scientific-reasons-spice-life-cinnamon-references/"><span style="font-weight: 400;">cinnamon</span></a><span style="font-weight: 400;">, cloves, </span><a href="https://selfhacked.com/blog/garlic-health-benefits/"><span style="font-weight: 400;">garlic</span></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/scientifically-proven-health-benefits-of-ginger/"><span style="font-weight: 400;">ginger</span></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/oregano/"><span style="font-weight: 400;">oregano</span></a><span style="font-weight: 400;">, paprika, </span><a href="https://selfhacked.com/blog/benefits-rosemary/"><span style="font-weight: 400;">rosemary</span></a><span style="font-weight: 400;">, and turmeric [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322464/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The authors of this study suggested that cooking with these spices in large amounts (14.5g in a meal) could be a helpful tool to manage the health of overweight and obese patients [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322464/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Cooking spices contain many active compounds that have been studied for their potential to promote weight loss. It is possible that consuming many of these compounds in combination could improve their effectiveness [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144156/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Many compounds found in edible plants (from apples to whole grains to cooking spices) block the action of lipase and may reduce the absorption of dietary fats.</span></p> <h3><span style="font-weight: 400;">Supplements</span></h3> <h4><span style="font-weight: 400;">Ginseng</span></h4> <p><span style="font-weight: 400;">Korean red </span><a href="https://selfhacked.com/blog/ginseng/"><span style="font-weight: 400;">ginseng</span></a><span style="font-weight: 400;"> contains active compounds that can block lipase activity in animals and humans [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21412692"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12967598"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Ginseng has also been studied as a potential weight loss tool in animals and humans. In a study of obese middle-aged Korean women, those who took a ginseng supplement alongside other weight loss strategies experienced slightly more weight loss and a slight beneficial modification of their gut flora [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766689/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986624/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><span style="font-weight: 400;">Curcumin</span></h4> <p><span style="font-weight: 400;">Turmeric, the significant active compound of which is </span><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">curcumin</span></a><span style="font-weight: 400;">, is one of a blend of spices that blocked lipase in one study of 20 overweight adults [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25592751"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A meta-analysis of 21 studies found that curcumin supplementation was associated with significant improvements to weight loss outcomes in patients with metabolic syndrome and similar disorders. In these studies, curcumin decreased BMI, weight, waist circumference, and </span><a href="http://selfhacked.com/blog/all-about-leptin-its-role-in-chronic-inflammation-cfs-and-weight/"><span style="font-weight: 400;">leptin</span></a><span style="font-weight: 400;"> (suggesting a possible improvement to leptin sensitivity) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582779/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Ginseng and curcumin have each been found to block lipase and possibly help with weight loss outcomes.</span></p>
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243 | content_learn_more_6852057850825022_text == Based on the variants we looked at, your LPL gene is moderately associated with weight gain and metabolic disruption. However, this doesn't necessarily reflect your overall risk of obesity, just one gene related to it. Drinking lots of water and eating a healthy diet full of fruit, whole grains, nuts, legumes, and spices may help; read on to learn more.
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rsStatus = rs1800590,LPL,chr8,19939160,T,G,,,28,0,Normal
rsStatus = rs2083637,,chr8,20007664,A,G,,,26,0,Normal
rsStatus = rs7841189,,chr8,19987865,C,T,,,31,0,Normal
rsStatus = rs264,LPL,chr8,19955669,G,A,,,12,11,HET
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