249 | id == 249
249 | category_id == 15
249 | category_order == 11
249 | category_name == Diet
249 | category_color == #C47AC0
249 | slug == NOS3-diet
249 | title == Can This Gene Influence Your Response to Unsaturated Fats (NOS3)?
249 | meta_description == NOS3 produces NO and influences the metabolic response to unsaturated fatty acids. Learn more here.
249 | summary == <p style="text-align:justify"><strong>The NOS3 gene produces nitric oxide &nbsp;(NO), a key messenger molecule that protects blood vessel function. A variant of this gene increases the risk of heart disease but improves the metabolic response to unsaturated fatty acids. Read on to learn where your NOS3 gene stands.</strong></p>
249 | overall_score_text == Your Diet Score (based on NOS3 Gene)
249 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/NOS3--Diet-Fats---Omega-3.jpg
249 | author_id == 12
249 | author_name == Carlos Tello
249 | author_title == PhD
249 | author_order == 55
249 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/CarlosTello.webp
249 | author_intro == <p><strong>Carlos received his PhD and MS from the Universidad de Sevilla.</strong></p>    <p>Carlos spent 9 years in the laboratory investigating mineral transport in plants. He then started working as a freelancer, mainly in science writing, editing, and consulting. Carlos is passionate about learning the mechanisms behind biological processes and communicating science to both academic and non-academic audiences. He strongly believes that scientific literacy is crucial to maintain a healthy lifestyle and avoid falling for scams.</p>
249 | author_social_media_name == linkedin
249 | author_social_media_icon == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/social-icon/linkedin.png
249 | author_social_order == 1
249 | author_social_link == https://www.linkedin.com/in/carlos-tello-lacal-b946b4a7/
249 | reviewer_id == 14
249 | reviewer_name == Shany Lahan
249 | reviewer_title == MS (Neuroscience)
249 | medical_reviewer_id == 11
249 | medical_reviewer_name == Puya Yazdi
249 | medical_reviewer_title == MD
249 | publish_date == 2020
249 | publish_date == 7
249 | publish_date == 29
249 | avg_rating == 5.0
249 | tags_id == 134
249 | tags_name == Heart Disease
249 | tags_id == 556
249 | tags_name == Nitric Oxide
249 | tags_id == 173
249 | tags_name == NO
249 | tags_id == 174
249 | tags_name == NOS3 Gene
249 | tags_id == 252
249 | tags_name == Olive oil
249 | tags_id == 557
249 | tags_name == Omega-3 Fatty Acids
249 | permissions_favorite == False
249 | permissions_rate == False
249 | content_article == <h2><strong>What Is the <em>NOS3 </em>Gene?</strong></h2> <p><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">NOS3 </span></em><span style="font-weight: 400;">gene codes for a protein called NOS3, short for </span><a href="https://www.selfdecode.com/gene/nos3/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><em><span style="font-weight: 400;">nitric oxide synthase 3</span></em></a><span style="font-weight: 400;">. NOS3 is most abundant in the inner lining of the blood vessels, where it produces nitric oxide (NO) from the amino acid arginine [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16585403"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16416260"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">NO is a molecule with multiple functions in the immune and nervous systems. Importantly, NOS3-derived NO lowers the risk of heart disease by increasing blood flow [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728140/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21196271"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;&nbsp;&nbsp;</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The <em>NOS3 </em>gene is responsible for producing NO. This molecule acts as a messenger in several processes and reduces the risk of heart disease.</span></p> <h3><strong>Dietary Fats and NOS3 Activity</strong></h3> <p><span style="font-weight: 400;">In addition to improving blood fat profile, unsaturated fats may reduce the risk of heart disease through their interaction with NOS3.</span></p> <p><span style="font-weight: 400;">Studies in rats showed that </span><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">omega-3</span></a><span style="font-weight: 400;"> fatty acids (</span><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">DHA</span></a><span style="font-weight: 400;"> &amp; </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">EPA</span></a><span style="font-weight: 400;">) activate NOS3 and increase NO availability in the blood vessels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579688/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25870973/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23159066/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A study in mice found that dietary monounsaturated fatty acid (MUFA), found in olive oil, increases NOS3 activity in </span><a href="https://selfhacked.com/blog/increase-decrease-red-blood-cells/"><span style="font-weight: 400;">red blood cells</span></a><span style="font-weight: 400;">, &mdash; and saturated fats reduce it [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030221/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20450877/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Unsaturated fats with omega-3 and MUFAs prevent heart disease by improving blood fat profile and increasing NOS3 activity.</span></p> <h2><strong>Your NOS3 Results for Diet</strong></h2> <p>*3414713779431841*</p> <p>&nbsp;</p> <h3><strong>SNP Summary and Table</strong></h3> <p><strong>Primary SNP: </strong><strong><em>NOS3 </em></strong><strong>rs1799983</strong></p> <ul> <li><span style="font-weight: 400;">&lsquo;G&rsquo; = Normal response to unsaturated fats</span></li> <li><span style="font-weight: 400;">&lsquo;T&rsquo; = Increased improvement in blood fat profile and vessel function in response to unsaturated fats</span></li> <li><span style="font-weight: 400;">Almost 70% of the world population has &lsquo;GG&rsquo;</span></li> <li><span style="font-weight: 400;">In people with European ancestry, the frequency of the &lsquo;T&rsquo; allele is increased to 34%&nbsp;</span></li> </ul> <p>*2765834798255933*</p> <p>&nbsp;</p> <h2><strong>Interaction of <em>NOS3 </em>Variants with Dietary Fats</strong></h2> <p><span style="font-weight: 400;">Among the different </span><em><span style="font-weight: 400;">NOS3 </span></em><span style="font-weight: 400;">polymorphisms, </span><a href="../../../snp/rs1799983/"><span style="font-weight: 400;">rs179983</span></a><span style="font-weight: 400;"> has been most widely studied. Its minor &lsquo;T&rsquo; variant produces a protein that can&rsquo;t reach activation sites in cell membranes, ultimately </span><strong>decreasing NO production</strong><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17449720"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">This variant has been associated with a higher risk of different heart conditions, possibly because it increases blood pressure, vessel stiffness, and cholesterol [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30789045"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856856/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28865601"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30140993"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166328/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17404185/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31138610/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The silver lining is that it provides more room for improvement. For instance, </span><strong>the positive effects of heart-healthy unsaturated fatty acids are generally stronger in carriers of the &lsquo;T&rsquo; allele</strong><span style="font-weight: 400;">.</span></p> <h4><strong>Response to Omega-3 Fatty Acids</strong></h4> <p><span style="font-weight: 400;">In an Irish trial of metabolic syndrome patients, carriers of the &lsquo;T&rsquo; variant had higher baseline blood triglyceride levels but could lower them more effectively by taking omega-3 supplements [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20409549/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Similarly, supplementation with omega-3 fatty acids (from both fish and </span><a href="https://selfhacked.com/blog/flaxseed-oil-benefits/"><span style="font-weight: 400;">flaxseed oil</span></a><span style="font-weight: 400;">) was more effective at lowering blood triglycerides and cholesterol in Chinese diabetics with the &lsquo;T&rsquo; variant [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013782/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a British study, high blood levels of omega-3 fatty acids from </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">fish oil</span></a><span style="font-weight: 400;"> were associated with improved blood vessel function in carriers of the risk &lsquo;T&rsquo; variant. A clinical trial replicated this result, but only in women [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12065317/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435553/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">However, two British trials on people with moderate risk of heart disease found fish oil beneficial in terms of blood vessel function and blood pressure regardless of the </span><em><span style="font-weight: 400;">NOS3 </span></em><span style="font-weight: 400;">genotype [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25332321/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26817716/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><strong>Response to MUFA</strong></h4> <p><span style="font-weight: 400;">In a Spanish study, people with two copies of the &lsquo;T&rsquo; variant had the highest baseline blood pressure. Possibly because the &lsquo;T&rsquo; allele results in an underactive NOS3 protein, this genotype was insensitive to the effects of both olive oil &mdash; which lowered blood pressure in carriers of the &lsquo;G&rsquo; variant &mdash; and saturated fats &mdash; which increased it [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26994605/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">However, carriers of this genotype saw the highest benefits from dietary virgin olive oil in terms of increased NO levels and improved blood vessel function in another Spanish study. The authors believed that the antioxidant polyphenols found in the oil were responsible for this effect [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21816783/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">A <em>NOS3 </em>variant resulting in reduced NO production is associated with heart disease but carriers especially benefit from dietary omega-3 fatty acids and virgin olive oil.</span></p> <h2><strong>Recommendations to Increase NOS3 Activity</strong></h2> <p>*3787955244325485*</p> <p>&nbsp;</p> <h3><strong>Diet</strong></h3> <h4><strong>Unsaturated Fats</strong></h4> <p><span style="font-weight: 400;">As has been previously discussed, carriers of the risk &lsquo;T&rsquo; variant may especially benefit from omega-3 fatty acids to not only improve their blood fat profile but also reduce their risk of heart disease [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12065317/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435553/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20409549/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013782/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In the case of olive oil, only polyphenol-rich virgin oil seems to improve blood vessel function in people with this variant [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26994605/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21816783/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Given the well-known health benefits of these fats, we recommend that you include them in your diet and replace saturated fats with them as much as possible &mdash; even if you carry the &lsquo;G&rsquo; variant!</span></p> <h4><strong>Foods Rich in NO Precursors</strong></h4> <p><span style="font-weight: 400;">Watermelon is very rich in the non-essential amino acid </span><a href="https://www.selfhacked.com/blog/health-benefits-of-l-citrulline/"><strong><em>citrulline</em></strong></a><span style="font-weight: 400;">, which the body can use to make NO&rsquo;s precursor arginine. Other citrulline sources include melons, pumpkins, and cucumbers. More directly, </span><strong>arginine-rich foods</strong><span style="font-weight: 400;"> include chickpeas, peanuts, soybeans, lentils, turkey, and pork loin [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27749691"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/20386132"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23075551"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Similarly, foods that contain </span><strong>nitrates </strong><span style="font-weight: 400;">can potentially increase NO. Vegetables are rich in nitrates and roughly supply 80% of these compounds [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19439460"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">Beetroot is the most famous nitrate-rich food. Some other foods rich in nitrates include [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412236/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Leafy greens</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Celery</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Broccoli</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Chinese cabbage</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Turnips</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Cucumbers</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Carrots</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Cauliflower</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/pomegranate/"><span style="font-weight: 400;">Pomegranate</span></a><span style="font-weight: 400;"> juice</span></li> </ul> <h4><strong>Plant Antioxidants</strong></h4> <p><span style="font-weight: 400;">One of the mechanisms by which antioxidants reduce the generation of free radicals is by increasing NOS3 production. People with underactive </span><em><span style="font-weight: 400;">NOS3 </span></em><span style="font-weight: 400;">variants may benefit from including the following antioxidants in their diets [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12512693"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913633/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:&nbsp;</span></p> <ul> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/top-15-scientific-health-benefits-of-resveratrol-with-references/"><span style="font-weight: 400;">Resveratrol</span></a><span style="font-weight: 400;"> (found in grapes, </span><a href="https://selfhacked.com/blog/blueberries-health-benefits/"><span style="font-weight: 400;">blueberries</span></a><span style="font-weight: 400;">, peanuts, pistachios, and dark chocolate)</span></li> <li style="font-weight: 400;"><a href="https://www.selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">Epigallocatechin</span></a><span style="font-weight: 400;"> gallate (mainly in </span><a href="http://selfhacked.com/blog/green-tea/"><span style="font-weight: 400;">green tea</span></a><span style="font-weight: 400;">)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Genistein (in soybeans, broad beans, and lupins)</span></li> <li style="font-weight: 400;"><a href="https://www.selfhacked.com/blog/chlorogenic-acid/"><span style="font-weight: 400;">Chlorogenic acid</span></a><span style="font-weight: 400;"> (in coffee and tea)</span></li> <li style="font-weight: 400;"><a href="https://www.selfhacked.com/blog/quercetin-22-scientifically-proven-benefits-quercetin/"><span style="font-weight: 400;">Quercetin</span></a><span style="font-weight: 400;"> (in leafy vegetables, broccoli, apples, peppers, tea, and fruit juices)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Kaempferol (in apples, grapes, tomatoes, green tea, and potatoes)</span></li> <li style="font-weight: 400;"><a href="https://www.selfhacked.com/blog/rutin/"><span style="font-weight: 400;">Rutin</span></a><span style="font-weight: 400;"> (in oranges, buckwheat, apricots, cherries, grapes, and plums)</span></li> </ul> <h4><strong>Vitamin C</strong></h4> <p><a href="https://selfhacked.com/blog/need-know-vitamin-c-32-science-based-health-benefits/"><span style="font-weight: 400;">Vitamin C</span></a><span style="font-weight: 400;"> reduces oxidative damage to the tissues (including the blood vessels) by breaking down free radicals. Importantly, it activates the production of NOS3-derived NO [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12551864"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11243424"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12396668"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">You can increase your daily intake of this vitamin by including natural sources such as bell peppers, kiwis, strawberries, oranges, broccoli, and tomatoes in your diet or by taking supplements.</span></p> <h4><strong>Iron</strong></h4> <p><span style="font-weight: 400;">Iron is required for NOS3 to function. Because excessive doses may increase the risk of coronary artery disease, it&rsquo;s preferable to obtain it from iron-rich foods such as shellfish, liver, sardines, lentils, and spinaches than from supplements [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23276910"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927548/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Foods rich in omega-3, monounsaturated fatty acids, antioxidants, vitamin C, and iron can increase NOS3 activity.</span></p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Quitting Smoking</strong></h4> <p><strong>Cigarette smoke reduces </strong><span style="font-weight: 400;"><strong>arginine</strong> <strong>availability</strong>, which is needed for NOS3 to produce nitric oxide [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391310/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">In carriers of the &lsquo;T&rsquo; variant at rs1799983, smoking further reduces NO production and dramatically increases the risk of heart disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978174/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25304051"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><strong>Avoiding Pollution</strong></h4> <p><span style="font-weight: 400;">Environmental pollutants reduce both NOS3 production and NO release. People with the &lsquo;T&rsquo; variant of rs1799983 should be especially cautious with their exposure to pollution, since they have an increased risk of developing ischemic heart disease from it [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/8890937/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161281/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><strong>Exercise</strong></h4> <p><span style="font-weight: 400;">Moderate </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise </span></a><span style="font-weight: 400;">has multiple health benefits. Interestingly, it lowers blood pressure by stimulating NOS3. Exercise is effective even in people who carry underactive </span><em><span style="font-weight: 400;">NOS3 </span></em><span style="font-weight: 400;">variants such as the &lsquo;T&rsquo; allele of rs1799983 [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24748593"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25129643"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Research shows that giving up smoking, reducing exposure to pollution, and engaging in moderate exercise can significantly improve NOS3 function.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Methylfolate</strong></h4> <p><a href="http://selfhacked.com/blog/tetrahydrobiopterin-bh4-role-body-buy/"><em><span style="font-weight: 400;">Tetrahydrobiopterin</span></em></a><a href="https://selfhacked.com/blog/tetrahydrobiopterin-bh4-role-body-buy/"><span style="font-weight: 400;"> (</span></a><a href="http://selfhacked.com/blog/tetrahydrobiopterin-bh4-role-body-buy/"><span style="font-weight: 400;">BH4</span></a><a href="https://selfhacked.com/blog/tetrahydrobiopterin-bh4-role-body-buy/"><span style="font-weight: 400;">)</span></a><span style="font-weight: 400;"> is essential for NOS3 function. In a few studies, middle-aged and elderly people who took BH4 supplements had improved vasodilation and circulation, which the authors attributed to NOS3-derived NO. Supplements increasing BH4 availability, such as </span><a href="https://selfhacked.com/blog/l-methylfolate-health-benefits/"><em><span style="font-weight: 400;">methylfolate</span></em></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/need-know-vitamin-c-32-science-based-health-benefits/"><span style="font-weight: 400;">vitamin C</span></a><span style="font-weight: 400;">, are promising subjects for additional research [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16585403"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625172/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11243424"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Supplements increasing the levels or availability of the molecules required by NOS3 to function, such as methylfolate, may increase NOS3 activity.</span></p>
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249 | content_learn_more_3414713779431841_text == Based on the variants we looked at, your NOS3 gene is associated with heart disease but also with a slightly better response to unsaturated fatty acids. In addition to including them in your diet, other dietary and lifestyle interventions can help you increase your NOS3 activity. Keep scrolling to find out more.
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rsIDs = rs179983,rs1799983
rsStatus = rs179983,ATXN1,chr6,16349913,A,G,,,30,0,Normal
rsStatus = rs1799983,NOS3,chr7,150999023,T,A,G,,31,0,Normal
