256 | id == 256
256 | category_id == 15
256 | category_order == 11
256 | category_name == Diet
256 | category_color == #C47AC0
256 | slug == ADH1B-Alcohol-Consumption
256 | title == Can This Alcohol Metabolizing Gene Influence Your Alcohol Consumption? (ADH1B)
256 | meta_description == ADH1B variants impact your ability to break down alcohol. Read on to find out how this may be influencing your overall drinking!
256 | summary == <p><strong>Variants of the ADH1B gene influence the rate at which alcohol is converted to acetaldehyde. Acetaldehyde can be toxic and may lead to adverse side effects, potentially influencing your desire to consume alcohol. Read on to find out how these variants may be influencing your own alcohol consumption, and some steps you can take to potentially reduce their impact.</strong></p>
256 | overall_score_text == Your Alcohol Consumption Score (based on ADH1B)
256 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ADH1B--Restrictions-Alcohol.jpg
256 | author_id == 13
256 | author_name == Lewis Cuthbertson
256 | author_title == PhD
256 | author_order == 12
256 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Lewis_SelfDecode.jpg
256 | author_intro == <p><strong>Lewis completed his PhD in Molecular Microbiology at Northumbria University (UK).</strong></p>    <p>Lewis spent several years researching the biodiversity of bacterial communities in the Arctic and Antarctic, whilst also performing research for a DNA sequencing service, where he was involved in several health based microbiome studies. This gave him an insight into how the highly diverse and invisible to the naked eye portion of human health, can potentially impact an individual&rsquo;s quality of life, driving his desire to help others understand their own complex health needs through the most current scientific research.<br />  &nbsp;</p>
256 | reviewer_id == 10
256 | reviewer_name == Biljana Novkovic
256 | reviewer_title == PhD
256 | medical_reviewer_id == 11
256 | medical_reviewer_name == Puya Yazdi
256 | medical_reviewer_title == MD
256 | publish_date == 2020
256 | publish_date == 8
256 | publish_date == 5
256 | avg_rating == 5.0
256 | tags_id == 572
256 | tags_name == ADH
256 | tags_id == 571
256 | tags_name == ADH1B
256 | tags_id == 567
256 | tags_name == Alcohol
256 | tags_id == 573
256 | tags_name == Hangover
256 | permissions_favorite == False
256 | permissions_rate == False
256 | content_article == <p><span style="font-weight: 400;"><em>If you have any serious health concerns related to alcohol consumption or other dietary issues, it is important to discuss these concerns with your doctor. The information in this post is presented for educational purposes only, and should not be used to replace standard medical care.</em></span></p> <h2><span style="font-weight: 400;">What Is </span><em><span style="font-weight: 400;">ADH1B</span></em><span style="font-weight: 400;">?</span></h2> <p><span style="font-weight: 400;">The </span><a href="../../../gene/adh1b/"><em><span style="font-weight: 400;">ADH1B</span></em></a><em><span style="font-weight: 400;"> gene </span></em><span style="font-weight: 400;">encodes for part of an enzyme named Alcohol Dehydrogenase (ADH), which is involved in the breakdown of alcohol in the liver.</span></p> <p><span style="font-weight: 400;">ADH is responsible for the first step in this breakdown, where drinking alcohol is changed into potentially toxic acetaldehyde.</span></p> <p><span style="background-color: #e8ebfc; border-left-width: 2px; border-left-style: solid; border-left-color: #4569fa; display: block; padding: 20px;">The <em>ADH1B</em> gene encodes an enzyme involved in the conversion of alcohol into potentially toxic acetaldehyde.</span></p> <h2><span style="font-weight: 400;">Role In Alcohol Consumption</span></h2> <p><em><span style="font-weight: 400;">ADH1B</span></em><span style="font-weight: 400;"> variants are thought to influence alcohol consumption and alcohol dependence. Each variant produces an ADH enzyme that is capable of breaking down alcohol at a different rate.</span></p> <p><span style="font-weight: 400;">Certain </span><em><span style="font-weight: 400;">ADH1B</span></em><span style="font-weight: 400;"> variants produce a more active ADH, and more active ADH increases the rate at which alcohol is converted to acetaldehyde. This can lead to a build-up of toxic acetaldehyde following alcohol consumption, which can have negative effects such as [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860432/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860434/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span><span style="font-weight: 400;">&nbsp;</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Flushing</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Sweating</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Nausea</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Accelerated </span><a href="https://www.selfhacked.com/blog/resting-heart-rate/"><span style="font-weight: 400;">heart rate</span></a><span style="font-weight: 400;">&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Vomiting</span></li> </ul> <p><span style="font-weight: 400;">These negative &lsquo;hangover&rsquo; effects may discourage </span><em><span style="font-weight: 400;">ADH1B</span></em><span style="font-weight: 400;"> variant carriers from drinking alcohol. This is in comparison to non-variant carriers, who can drink alcohol without experiencing these symptoms [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252425/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860432/"><span style="font-weight: 400;"> R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left-width: 2px; border-left-style: solid; border-left-color: #4569fa; display: block; padding: 20px;"><em>ADH1B</em> variants impact the activity of ADH enzymes, which may lead to negative effects that influence overall alcohol consumption.</span></p> <h2><em><span style="font-weight: 400;">ADH1B</span></em><span style="font-weight: 400;"> Variants</span></h2> <h3><span style="font-weight: 400;">rs1229984</span></h3> <p><span style="font-weight: 400;">Carrying a &lsquo;T&rsquo; allele of rs1229984, a SNP in the </span><em><span style="font-weight: 400;">ADH1B</span></em><span style="font-weight: 400;"> gene, can result in a 70- to 80-fold increase in the rate of conversion of alcohol to acetaldehyde following alcohol consumption. The&nbsp; &lsquo;T&rsquo; allele of rs1229984 can also cause side effects, including </span><a href="http://selfhacked.com/blog/natural-treatment-migraines/"><span style="font-weight: 400;">migraines</span></a><span style="font-weight: 400;">, flushing, and breathlessness [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17718394/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19486361/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://pubmed.ncbi.nlm.nih.gov/20205700/"><span style="font-weight: 400;"> R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The &lsquo;T&rsquo; variant of rs1229984 is particularly common in East Asians, where it is also associated with lower alcohol consumption and negative reactions to drinking alcohol, such as flushing [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252425/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://pubmed.ncbi.nlm.nih.gov/20205700/"><span style="font-weight: 400;"> R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24588059/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">On the other hand, several studies have associated carrying a &lsquo;C&rsquo; allele of rs1229984, a SNP in the </span><em><span style="font-weight: 400;">ADH1B</span></em><span style="font-weight: 400;"> gene, with an overall increase in </span><a href="../../../trait/alcohol-drinking/"><span style="font-weight: 400;">alcohol drinking</span></a><span style="font-weight: 400;">. This is relative to carriers of the &lsquo;T&rsquo; allele, which has been linked to a reduced risk of </span><a href="../../../diseasetrait/alcohol-dependence/"><span style="font-weight: 400;">alcohol dependence</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252425/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://pubmed.ncbi.nlm.nih.gov/18996923/"><span style="font-weight: 400;"> R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28485404/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">rs2066702</span></h3> <p><span style="font-weight: 400;">A study found that carriers of the &lsquo;A&rsquo; allele of this variant felt more tired and had an accelerated heart rate after drinking alcohol [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20477764/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Two genome-wide studies, of more than 69,000 people combined, found a significant protective effect for carrying an &lsquo;A&rsquo; allele of the SNP rs2066702 on alcohol dependence in African-Americans. There are additional studies also confirming the link [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165335/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://pubmed.ncbi.nlm.nih.gov/30482948/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://academic.oup.com/hmg/article/15/9/1539/628136"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">rs1042026</span></h3> <p><span style="font-weight: 400;">Two studies, one of almost 3000 people in China and another of around 4600 Australian twins, found a significant relationship between carrying a &lsquo;C&rsquo; allele of rs1042026 and reduced alcohol consumption [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30639619/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18996923/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left-width: 2px; border-left-style: solid; border-left-color: #4569fa; display: block; padding: 20px;">Carriers of <em>ADH1B </em>variants are more likely to experience adverse effects when drinking, and as a result are less likely to consume alcohol than non-carriers.</span></p> <h2><span style="font-weight: 400;">Limitations</span></h2> <p><span style="font-weight: 400;">It's important to mention that there are also conflicting studies which have found no association between </span><em><span style="font-weight: 400;">ADH1B</span></em><span style="font-weight: 400;"> variant carriers and alcohol dependence or breakdown [</span><a href="https://academic.oup.com/hmg/article/15/9/1539/628136"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664151/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">There are several reasons for these discrepancies.</span></p> <p><span style="font-weight: 400;">First, there are many variants in different ADH genes that affect ADH enzyme activity and </span><em><span style="font-weight: 400;">ADH1B</span></em><span style="font-weight: 400;"> is only one of them.&nbsp;</span></p> <p><span style="font-weight: 400;">Next, studies have found that the environment often plays a greater role in drinking habits than genetics, for example peer pressure and social drinking [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10857249/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/3307505/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;&nbsp;</span></p> <p><span style="font-weight: 400;">For example, several environmental factors are known to interact with </span><em><span style="font-weight: 400;">ADH1B</span></em><span style="font-weight: 400;"> genetic risk factors and in some instances, they oppose the prospective effects of the genotype [</span><a href="https://pubmed.ncbi.nlm.nih.gov/2927121/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://pubmed.ncbi.nlm.nih.gov/10857249/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://pubmed.ncbi.nlm.nih.gov/17949469/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11707634/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Marital status</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Religion</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Parental strictness</span></li> </ul> <p><span style="background-color: #e8ebfc; border-left-width: 2px; border-left-style: solid; border-left-color: #4569fa; display: block; padding: 20px;"><em>ADH1B</em> gene variants are only a part of the equation when it comes to alcohol consumption. Other genes and environmental factors also play a role.</span></p> <h2><em><span style="font-weight: 400;">ADH1B</span></em><span style="font-weight: 400;"> Variants, Alcohol Consumption, &amp; Cancer</span></h2> <p><span style="font-weight: 400;">Certain </span><em><span style="font-weight: 400;">ADH1B</span></em><span style="font-weight: 400;"> variants have been linked to throat cancer [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443950/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957421/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. This is because acetaldehyde has a direct negative impact on DNA.&nbsp;</span></p> <p><span style="font-weight: 400;">People with </span><em><span style="font-weight: 400;">ADH1B</span></em><span style="font-weight: 400;"> variants ('T' allele for rs1229984, &lsquo;C&rsquo; allele for rs1042026) may have a lower risk of throat cancer because they tend to drink less alcohol [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23060937/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://pubmed.ncbi.nlm.nih.gov/21437268/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30639619/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The drug Antabuse (Disulfiram) was developed to imitate the hangover effects of </span><em><span style="font-weight: 400;">ADH1B</span></em><span style="font-weight: 400;"> variants as a treatment for alcohol dependence, and has since been associated with a lower risk of cancer [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29065820/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">On the other hand, heavy drinkers carrying </span><em><span style="font-weight: 400;">ADH1B</span></em><span style="font-weight: 400;"> variants may be more likely to develop throat cancer than heavy drinkers without those variants. There is evidence that variants in other genes that increase acetaldehyde levels (</span><em><span style="font-weight: 400;">ADH1C</span></em><span style="font-weight: 400;">) increase the risk of throat cancer in heavy drinkers [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860434/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left-width: 2px; border-left-style: solid; border-left-color: #4569fa; display: block; padding: 20px;"><em>ADH1B</em> variants may provide relative protective effects on risk of cancer due to reduced alcohol consumption. However, heavy drinking may result in an increased risk of cancer for variant carriers.</span></p> <h2><span style="font-weight: 400;">Your <em>ADH1B</em> Results for Alcohol Consumption</span></h2> <p><strong>*8885617220810322*</strong></p> <h3><span style="font-weight: 400;">SNP Summary and Table</span></h3> <p><strong><em>ADH1B</em></strong> <a href="../../../snp/rs1229984/"><strong>rs1229984</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;TT&rsquo; = Associated with an accelerated conversion of alcohol into acetaldehyde. May be associated with flushing, nausea, and worse hangovers when drinking, often resulting in lower alcohol consumption [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17718394/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28485404/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;CT&rsquo; = Associated with an accelerated conversion of alcohol into acetaldehyde. May be associated with flushing, nausea, and worse hangovers when drinking, often resulting in lower alcohol consumption&nbsp; [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17718394/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28485404/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;CC&rsquo; = Associated with normal conversion of alcohol into acetaldehyde. May be associated with increased risk of alcoholism [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28485404/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400;">91% of East Asians carry a copy of the &lsquo;T&rsquo; allele. The 'T' allele is much less common in the rest of the world, where less than 10% are carriers [</span><a href="https://useast.ensembl.org/Homo_sapiens/Variation/Population?db=core;r=4:99317662-99318662;v=rs1229984;vdb=variation;vf=65055042"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><strong><em>ADH1B</em></strong> <a href="../../../snp/rs2066702/"><strong>rs2066702</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;AA&rsquo; = Associated with accelerated conversion of alcohol into acetaldehyde. May be associated with flushing, nausea, and worse hangovers when drinking, often resulting in lower alcohol consumption [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165335/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;AG&rsquo; = Associated with accelerated conversion of alcohol into acetaldehyde. May be associated with flushing, nausea, and worse hangovers when drinking, often resulting in lower alcohol consumption&nbsp; [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165335/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;GG&rsquo; = Associated with normal conversion of ethanol to acetaldehyde. May be associated with an increased risk of alcoholism [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165335/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400;">The 'A' allele is mainly in Africans and African Americans, where 34% of individuals carry the &lsquo;A&rsquo; allele. 4% of Native Americans also carry the &lsquo;A&rsquo; allele. The &lsquo;A&rsquo; allele is not typically present outside of these groups [</span><a href="https://useast.ensembl.org/Homo_sapiens/Variation/Explore?db=core;r=4:99307360-99308360;v=rs2066702;vdb=variation;vf=65515393"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><strong><em>ADH1B</em></strong> <a href="../../../snp/rs1042026/"><strong>rs1042026</strong></a><strong>&nbsp;</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;CC&rsquo; = Associated with lower alcohol consumption </span><span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/30639619/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722191/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;CT&rsquo; = </span><span style="font-weight: 400;">Associated with lower alcohol consumption</span><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30639619/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722191/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;TT&rsquo; = Associated with normal alcohol consumption </span><span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/30639619/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722191/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400;">Roughly 53% of individuals carry a copy of the &lsquo;C&rsquo; allele. This allele is more common in East Asians, where 97% of people have it, and South Asians, where 79% are carriers [</span><a href="https://useast.ensembl.org/Homo_sapiens/Variation/Population?db=core;r=4:99306809-99307809;v=rs1042026;vdb=variation;vf=65010574"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><strong>*2995639702691742*</strong></p> <h2><span style="font-weight: 400;">Recommendations To Reduce The Impact Of Risk-Associated </span><em><span style="font-weight: 400;">ADH1B</span></em><span style="font-weight: 400;"> Variants&nbsp;</span></h2> <p><span style="font-weight: 400;">In the following section, we&rsquo;ll describe some complementary approaches that may potentially help counteract some of the negative health implications associated with </span><em><span style="font-weight: 400;">ADH1B</span></em><span style="font-weight: 400;"> variants. Nonetheless, keep in mind that the strategies below should not be used to replace standard medical treatment.</span></p> <p><span style="font-weight: 400;">Always make sure to consult with your doctor before making any lifestyle, dietary, or other significant changes to your day-to-day routine, in order to minimize the risk of adverse interactions, side-effects, or other potentially negative outcomes.</span></p> <p><strong>*9723761988242783*</strong></p> <h3><span style="font-weight: 400;">Lifestyle</span></h3> <p><span style="font-weight: 400;">Whilst carrying an </span><em><span style="font-weight: 400;">ADH1B</span></em><span style="font-weight: 400;"> variant tends to reduce a person's overall alcohol consumption, this one gene may not reflect your overall alcohol consumption habits.&nbsp;</span></p> <p><span style="font-weight: 400;">If you typically have worse hangover symptoms as a result of carrying an </span><em><span style="font-weight: 400;">ADH1B </span></em><span style="font-weight: 400;">variant, consider not drinking, drinking less, or drinking slower to reduce the negative effects associated with increased acetaldehyde buildup [</span><a href="https://medlineplus.gov/ency/article/002041.htm"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Keep in mind that heavy drinking whilst carrying one of these variants may potentially increase your risk of throat cancer and should be avoided [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860434/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">Drugs</span></h3> <p><span style="font-weight: 400;">Avoid taking </span><span style="font-weight: 400;">acetaminophen (Tylenol/Paracetamol) after consuming alcohol to reduce hangover side effects, as this may result in liver or kidney damage </span><span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/30377576/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/10649673/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p>
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256 | content_learn_more_9723761988242783_key == 9723761988242783
256 | content_learn_more_9723761988242783_blur == True
256 | content_learn_more_9723761988242783_hidden == False
256 | content_learn_more_9723761988242783_text == Based on the variants we looked at, your ADH1B genotype may be associated with slightly increased rates of alcohol to acetaldehyde breakdown and increased hangover severity which may reduce your overall alcohol consumption. However, this doesn't necessarily reflect your overall alcohol consumption — just one gene related to it. Read on to find out more.
256 | content_recommendation_2995639702691742_key == 2995639702691742
256 | content_recommendation_2995639702691742_blur == True
256 | content_recommendation_2995639702691742_hidden == False
rsIDs = rs1229984,rs1042026,rs2066702
rsStatus = rs1229984,ADH1B,chr4,99318162,T,C,G,,6,28,HET
rsStatus = rs1042026,ADH1B,chr4,99307309,T,A,C,G,17,0,Normal
rsStatus = rs2066702,ADH1B,chr4,99307860,G,A,,,24,0,Normal
