26 | id == 26
26 | category_id == 5
26 | category_order == 3
26 | category_name == Inflammation
26 | category_color == #C47AC0
26 | slug == hla-b27-autoimmunity
26 | title == A Key Genetic Player in Autoimmunity (HLA-B)
26 | meta_description == HLA-B27 is strongly associated with certain autoimmune conditions. Click to check how this relates to your health.
26 | summary == <p><strong>HLA-B27 variant has a strong correlation with certain&nbsp;autoimmune disorders. Still, you can carry this variant and maintain flawless health. Knowing your genes and taking care of them makes all the difference&mdash;read on to learn more about this &quot;autoimmunity gene.&quot;</strong></p>
26 | overall_score_text == Autoimmunity Score (based on HLA-B27 Gene)
26 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/Do-You-Have-This-Critical-Gene-for-Autommunity-HLA-B27_JPG.jpg
26 | author_id == 9
26 | author_name == Aleksa Ristic
26 | author_title == MS (Pharmacy)
26 | author_order == 45
26 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
26 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
26 | reviewer_id == 1
26 | reviewer_name == Jasmine Foster
26 | reviewer_title == BSc, BEd
26 | medical_reviewer_id == 11
26 | medical_reviewer_name == Puya Yazdi
26 | medical_reviewer_title == MD
26 | publish_date == 2019
26 | publish_date == 8
26 | publish_date == 26
26 | avg_rating == 5.0
26 | tags_id == 33
26 | tags_name == Autoimmunity
26 | tags_id == 72
26 | tags_name == HLA Genes
26 | tags_id == 73
26 | tags_name == IBD
26 | tags_id == 76
26 | tags_name == Infections
26 | tags_id == 74
26 | tags_name == Joint Disorders
26 | tags_id == 75
26 | tags_name == Microbiome
26 | permissions_favorite == False
26 | permissions_rate == False
26 | content_article == <h2><span style="font-weight: 400;">What is the HLA System?</span></h2> <p><span style="font-weight: 400;">The human leukocyte antigen (HLA) system is a group of human genes encoding the major histocompatibility complex (MHC) proteins, or HLAs. This system has three groups or classes; HLA-A, </span><a href="../../gene/hla-b/"><span style="font-weight: 400;">HLA-B</span></a><span style="font-weight: 400;">, and HLA-C genes belong to class I [</span><a href="https://ghr.nlm.nih.gov/gene/HLA-B"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">HLAs are proteins or antigens on the surface of </span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"><span style="font-weight: 400;">white blood cells</span></a><span style="font-weight: 400;">. They help flag and remove external agents that may cause infection. HLA-B antigens bring bacterial or viral proteins from the inside to the cell surface so T-lymphocytes can detect and kill infected or foreign cells [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1079257/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">They also have anti-cancer effects and play a role in immune rejection or acceptance of organ transplants [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333229/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://ghr.nlm.nih.gov/gene/HLA-B"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">HLA genes come in many different forms, and there are millions of their possible combinations. Their diversity ensures that humans are protected against a huge array of disease agents, but it can be a double-edged sword: some types of HLAs are associated with autoimmune disorders [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628004/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The HLA genes encode proteins that present external components on the surface of white blood cells, enabling your immune system to detect and destroy them.</span></p> <h3><span style="font-weight: 400;">HLA-B27 Antigen</span></h3> <p><span style="font-weight: 400;">The HLA-B27 antigen is one of the hundreds of possible forms of HLA-B. It supports the antiviral immune response by &ldquo;flagging&rdquo; peptides from viruses&mdash;such as influenza, HIV, and Epstein-Barr&mdash;and presenting them to T-killer cells. These cells then recognize viral peptides as dangerous and use them as a beacon to find and destroy other viruses [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240147/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">HLA-B27 has over 100 sub-variations. Despite its beneficial roles, HLA-B27 is also strongly associated with a group of autoimmune joint disorders known as spondyloarthritis (SpA) [</span><a href="https://www.ncbi.nlm.nih.gov/gene/3106"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364987/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">HLA-B27 enables an antiviral immune response, but it's strongly associated with certain autoimmune disorders.</span></p> <h4><span style="font-weight: 400;">Prevalence</span></h4> <p><span style="font-weight: 400;">The prevalence of HLA-B27 varies from 50% in some Indian populations to almost zero in Australian Aborigines. About </span><strong>6% of the US population</strong><span style="font-weight: 400;"> carries this gene, which is most common among white people [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038331/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><span style="font-weight: 400;">HLA-B27 and Autoimmune Diseases</span></h2> <p><span style="font-weight: 400;">*8786977045203572*</span></p> <h3><span style="font-weight: 400;">Ankylosing Spondylitis &amp; Other Conditions</span></h3> <p><span style="font-weight: 400;">HLA-B27 strongly correlates with certain autoimmune diseases, such as [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/4604133/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Psoriasis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Ankylosing spondylitis (spine deformation)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">IBD (inflammatory bowel disease), in combination with spondylitis</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Reactive arthritis (Reiter&rsquo;s syndrome)&mdash;inflammation of the joints, urethra, and eyes</span></li> </ul> <p><span style="font-weight: 400;">These conditions fall under the umbrella of spondyloarthritis, with the most common form being ankylosing spondylitis (AS). In AS, inflammation gradually fuses the vertebrae in the spine, causing back </span><a href="https://selfhacked.com/blog/23-ways-to-combat-pain-naturally-by-increasing-your-opioids/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> and limited movement. It usually affects young men [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25447326"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/books/NBK470173/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">HLA-B27 is associated with autoimmune disorders known as spondyloarthritis. The main one is ankylosing spondylitis, which causes spine inflammation and chronic back pain.</span></p> <h3><span style="font-weight: 400;">How Strong is This Connection?</span></h3> <p><span style="font-weight: 400;">The connection between HLA-B27 and ankylosing spondylitis (AS) is extremely strong: 90&ndash;95% of all AS patients have this gene. For other autoimmune conditions, the prevalence of HLA-B27 ranges between 50-90% [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1079257/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Does this mean almost everyone with HLA-B27 will get AS or another autoimmune disease? Not at all!</span></p> <p><span style="font-weight: 400;">Approximately 1.3% European HLA-B27 carriers have AS, though Caucasian (white) ethnicity and the presence of a family member with AS increase the odds 16-20 times. These statistics suggest that HLA-B27 is just one of several risk factors [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/6608352/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9433870/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Similarly, over 50% of people with anterior uveitis (eye inflammation) have this variant, but only 1% of all HLA-B27 carriers develop uveitis [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/1869411/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In other words, HLA-B27 correlates with the above disorders, but many more factors contribute and decide which carriers develop autoimmunity. Below you can learn more about these factors and whether you can influence some of them.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">HLA-B27 variant strongly correlates with spondyloarthritis and other forms of autoimmunity, but only a fraction of HLA-B27 carriers develop a disease. It depends on many more factors discussed below.</span></p> <h2><span style="font-weight: 400;">How It Works</span></h2> <p><span style="font-weight: 400;">Despite the well-known link, the exact mechanisms of HLA-B27-related autoimmunity are still not clear. According to the main theories, an error probably occurs in one of two processes [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12154202/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12468816/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25861975"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240147/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ol> <li style="font-weight: 400;"><strong>The way it presents peptides to T-killer cells</strong><span style="font-weight: 400;">: upon activation, T-killer cells are supposed to only flag the foreign peptide and not HLA-B27 itself. However, T-cells may mistakenly flag HLA-B27 fragments or other peptides as foreign and attack them.</span></li> <li style="font-weight: 400;"><strong>The biochemical properties (structure) of HLA-B27 itself</strong><span style="font-weight: 400;">: the protein may misfold in such a way that causes inflammation within the cell and triggers an immune response.&nbsp;</span></li> </ol> <p><span style="font-weight: 400;">Whatever the root cause, one thing is for sure: inflammation lurks behind all autoimmune disorders associated with HLA-B27 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421792/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">The Microbiome Connection</span></h3> <p><span style="font-weight: 400;">A solid body of evidence also implicates the role of microbes in autoimmune disorders associated with HLA-B27 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139385/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791354/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939298/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Microbial infections such as </span><em><span style="font-weight: 400;">Salmonella, Yersinia, Klebsiella, </span></em><span style="font-weight: 400;">and</span><em><span style="font-weight: 400;"> Chlamydia</span></em><span style="font-weight: 400;"> can contribute to autoimmune disorders in HLA-B27 carriers because [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314700/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068055/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/2879176/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29438717"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16941202"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240147/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ol> <li style="font-weight: 400;"><span style="font-weight: 400;">They increase the expression of HLA-B27 on the surface of infected cells.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Some parts of the HLA-B27 antigen are similar to peptides from these bacteria, so the immune system attacks them.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">This antigen weakens the anti-bacterial immune response, leading to persistent infections that trigger autoimmunity.</span></li> </ol> <h3><span style="font-weight: 400;">Other Genes</span></h3> <p><span style="font-weight: 400;">The interaction of the </span><a href="../../gene/erap1/"><em><span style="font-weight: 400;">ERAP1</span></em></a><span style="font-weight: 400;"> gene with HLA-B27 seems to play an important role, so you may want to check your data for that gene, too.</span></p> <p><span style="font-weight: 400;">Specifically, the &lsquo;T&rsquo; allele at </span><a href="../../snp/rs30187/"><span style="font-weight: 400;">rs30187</span></a><span style="font-weight: 400;"> and the &lsquo;A&rsquo; allele at </span><a href="../../snp/rs27434/"><span style="font-weight: 400;">rs27434</span></a><span style="font-weight: 400;"> correlate with ankylosing spondylitis when combined with HLA-B27 [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640413/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">HLA-B27 can partake in an autoimmune response by misfolding, &ldquo;confusing&rdquo; T-killers and other immune cells, or weakening the anti-bacterial immune response.</span></p> <h2><span style="font-weight: 400;">Your HLA-B27 Results for Autoimmunity</span></h2> <p>*8786977045203572*</p> <p><strong>Primary SNPs</strong><span style="font-weight: 400;">:&nbsp;</span></p> <p><a href="../../gene/hla-b/"><strong>HLA-B</strong></a> <a href="../../snp/rs4349859/"><strong>rs4349859</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640413/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335985/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26200952"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978685/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;A&rdquo; allele correlates with the HLA-B27 variant</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;G&rdquo; allele doesn&rsquo;t correlate with the HLA-B27 variant</span></li> </ul> <p><a href="../../gene/hla-b/"><strong>HLA-B</strong></a> <a href="../../snp/rs13202464/"><strong>rs13202464</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;G&rdquo; allele correlates with the HLA-B27 variant</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;A&rdquo; allele doesn&rsquo;t correlate with the HLA-B27 variant</span></li> </ul> <p><a href="../../snp/rs116488202/"><strong>rs116488202</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;T&rdquo; allele correlates with the HLA-B27 variant</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&ldquo;C&rdquo; allele doesn&rsquo;t correlate with the HLA-B27 variant</span></li> </ul> <p>*2084205808851882*</p> <p><span style="font-weight: 400;">HLA-B27 is inherited in a dominant model; that is, both one or two copies of the associated allele imply the same correlation with&nbsp;autoimmune diseases [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/6608352/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><strong>Please note</strong><span style="font-weight: 400;">: To confirm the presence of this gene and detect the exact subtype, you may want to do the HLA-B27 blood test in a healthcare institution.</span></p> <h2><span style="font-weight: 400;">Recommendations to Support the Immune System</span></h2> <p><span style="font-weight: 400;">Do you belong to the fraction of people with the HLA-B27 variant? Instead of simply concluding that autoimmunity "runs in your family," there are many things you can do to support your immune system.</span></p> <p><span style="font-weight: 400;">Bring your genetic data along to your next doctor's appointment, and ask them if the recommendations below could be right for you. This post is for informational purposes only.</span></p> <p><span style="font-weight: 400;">*3838147832370051*</span></p> <h3><span style="font-weight: 400;">Diet</span></h3> <p><span style="font-weight: 400;">Given the role of the microbiome and bacterial infections in HLA-B27 autoimmunity, you may want to boost your gut health and ward off pathogens by:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Consuming fermented and other </span><a href="https://selfhacked.com/blog/probiotics-good-bacteria/"><span style="font-weight: 400;">probiotic</span></a><span style="font-weight: 400;">-rich foods</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Feeding the good bacteria in your gut with prebiotics</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Including </span><a href="https://www.selfhacked.com/blog/natural-antibiotics/"><span style="font-weight: 400;">natural antibiotics</span></a><span style="font-weight: 400;"> in your diet</span></li> </ul> <p><em><span style="font-weight: 400;">Klebsiella </span></em><span style="font-weight: 400;">can trigger autoimmunity in HLA-B27 carriers, and it thrives on sugar and starch. A reduced intake of sweets and refined carbs may help prevent the infection [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/8835506"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678459/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC215235/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">TNF-alpha causes inflammation in HLA-B27-related autoimmunity. According to limited clinical evidence, the following may lower TNF-alpha [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/30171593"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ol> <li style="font-weight: 400;"><span style="font-weight: 400;">Practicing the ketogenic diet [</span><a href="http://www.ncbi.nlm.nih.gov/pubmed/21939657"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981249/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Fasting [</span><a href="http://www.ncbi.nlm.nih.gov/pubmed/21235381"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828461/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Consuming olive oil, fish, and cruciferous veggies [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29165098"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/16497254"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/16226132"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/17849266"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17569223"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ol> <p><span style="font-weight: 400;">Lectins can also increase TNF-alpha and contribute to HLA-B27-related autoimmunity, especially in </span><a href="https://selfhacked.com/blog/are-you-lectin-sensitive-using-genes-symptoms-and-blood-tests/"><span style="font-weight: 400;">lectin-sensitive</span></a><span style="font-weight: 400;"> people [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10884708"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/2044082"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><a href="https://selfhacked.com/blog/elimination-diet-safest-foods-people-sensitive-everything/"><span style="font-weight: 400;">The Lectin Avoidance Diet</span></a><span style="font-weight: 400;"> has a powerful program to help you detect and eliminate pro-inflammatory foods (hint: it&rsquo;s not just about </span><a href="https://selfhacked.com/blog/lectins-beneficial-harmful/"><span style="font-weight: 400;">lectins</span></a><span style="font-weight: 400;">).</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cut back on sugar and starch; take care of your gut health; increase your intake of olive oil and fish; try the ketogenic diet, fasting, and the Lectin Avoidance Diet.</span></p> <h3><span style="font-weight: 400;">Lifestyle</span></h3> <p><span style="font-weight: 400;">Practicing <a href="https://selfhacked.com/blog/health-benefits-yoga/">yoga</a> has lowered TNF-alpha in a couple of small clinical trials</span><span style="font-weight: 400;">&nbsp;[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820143/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/24703167"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">Supplements</span></h3> <p><span style="font-weight: 400;">The following supplements may help by reducing TNF-alpha and other inflammatory markers:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Probiotics [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213508/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Curcumin [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17569223"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/21911894"><span style="font-weight: 400;">R,</span></a> <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753829/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/cannabidiol-cbd/"><span style="font-weight: 400;">CBD</span></a><span style="font-weight: 400;"> oil [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085542/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17712814"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458548/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">Omega-3</span></a><span style="font-weight: 400;">/fish oil [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17062435"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/2783477"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><span style="font-weight: 400;">In mice with HLA-B27, a probiotic strain called </span><em><span style="font-weight: 400;">Lactobacillus GG</span></em><span style="font-weight: 400;"> restored the gut microbiome and prevented recurrence of colitis (colon inflammation) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1773552/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p>Please note there's insufficient evidence to recommend nutritional supplements for prevention or treatment of autoimmune conditions.</p>
26 | content_snp_table_2084205808851882_key == 2084205808851882
26 | content_snp_table_2084205808851882_blur == True
26 | content_snp_table_2084205808851882_hidden == False
26 | content_learn_more_8786977045203572_key == 8786977045203572
26 | content_learn_more_8786977045203572_blur == True
26 | content_learn_more_8786977045203572_hidden == False
26 | content_learn_more_8786977045203572_text == There is a medium possibility that you carry the HLA-B27 variant, which correlates with autoimmune disorders such as spondyloarthritis.. You may want to address inflammation and support your microbiome—keep reading for more details.
26 | content_recommendation_3838147832370051_key == 3838147832370051
26 | content_recommendation_3838147832370051_blur == True
26 | content_recommendation_3838147832370051_hidden == False
rsIDs = rs30187,rs13202464,rs116488202,rs4349859,rs27434
rsStatus = rs30187,ERAP1,chr5,96788627,T,A,C,,42,0,Normal
rsStatus = rs13202464,,chr6,31376806,A,G,,,13,0,Normal
rsStatus = rs116488202,,chr6,31377139,C,A,T,,11,0,Normal
rsStatus = rs4349859,MICA-AS1,chr6,31398010,G,A,C,,6,0,Normal
rsStatus = rs27434,ERAP1,chr5,96793809,A,G,T,,17,16,HET
