263 | id == 263
263 | category_id == 15
263 | category_order == 11
263 | category_name == Diet
263 | category_color == #C47AC0
263 | slug == HLA-peanut-allergy
263 | title == A Crucial Genetic Factor for Peanut Allergy (HLA)
263 | meta_description == The HLA genes play a key role in allergies and autoimmunity. Learn their link with peanut allergy and check your genetic score.
263 | summary == <p style="text-align:justify"><strong>Still not sure if you&rsquo;re allergic to peanuts? This post reveals a crucial genetic factor for peanut allergy and suggests potential coping strategies - read on to learn more!</strong></p>
263 | overall_score_text == Your Peanut Allergy Score (Based on HLA Genes)
263 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/HLA-DRA--Food-Intolerance-Peanuts-Allergy.jpg
263 | author_id == 9
263 | author_name == Aleksa Ristic
263 | author_title == MS (Pharmacy)
263 | author_order == 45
263 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
263 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
263 | reviewer_id == 14
263 | reviewer_name == Shany Lahan
263 | reviewer_title == MS (Neuroscience)
263 | medical_reviewer_id == 11
263 | medical_reviewer_name == Puya Yazdi
263 | medical_reviewer_title == MD
263 | publish_date == 2020
263 | publish_date == 8
263 | publish_date == 6
263 | avg_rating == 5.0
263 | tags_id == 72
263 | tags_name == HLA Genes
263 | tags_id == 591
263 | tags_name == IgE Antibodies
263 | tags_id == 592
263 | tags_name == Lectin Avoidance Diet
263 | tags_id == 590
263 | tags_name == Peanut Allergy
263 | tags_id == 246
263 | tags_name == Probiotics
263 | permissions_favorite == False
263 | permissions_rate == False
263 | content_article == <p style="text-align: justify;"><strong><em><span style="font-weight: 400;">If you have any serious health concerns related to food allergies, it is important to discuss these concerns with your doctor. The information in this post is presented for educational purposes only, and should not be used to replace standard medical care.</span></em></strong></p> <h2 style="text-align: justify;"><strong>HLA Genes &amp; Food Allergies</strong></h2> <h3 style="text-align: justify;"><strong>The HLA System</strong></h3> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">human leukocyte antigen </span></em><span style="font-weight: 400;">(</span><em><span style="font-weight: 400;">HLA</span></em><span style="font-weight: 400;">) system is a group of human genes encoding HLA proteins. These proteins are also referred to as major histocompatibility complex (MHC) proteins. HLAs are receptors, found on the surface of </span><a href="https://selfhacked.com/blog/how-to-increase-and-decrease-white-blood-cells/"><span style="font-weight: 400;">white blood cells</span></a><span style="font-weight: 400;">. They help flag and remove agents that may harm the body or cause infection. These harmful agents are known as antigens [</span><a href="https://ghr.nlm.nih.gov/gene/HLA-B"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">HLA </span></em><span style="font-weight: 400;">system has three classes; </span><em><span style="font-weight: 400;">HLA-DQ </span></em><span style="font-weight: 400;">and </span><em><span style="font-weight: 400;">-DR</span></em><span style="font-weight: 400;"> belong to class II. HLA-DQ and -DR receptors can present antigens to T-helper cells, which causes these cells to be activated. Upon activation, T-helper cells stimulate B cells. B cells, in turn, make antibodies&nbsp; that target specific antigens for removal [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/2493721"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">For those willing to dive deeper into the immunological background, here&rsquo;s a great chart published by </span><a href="http://emedicine.medscape.com/article/136217-overview"><span style="font-weight: 400;">Medscape</span></a><span style="font-weight: 400;">:&nbsp;</span></p> <p><img style="display: block; margin-left: auto; margin-right: auto;" src="https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/links/nihms730071f1.jpg" alt="An external file that holds a picture, illustration, etc.Object name is nihms730071f1.jpg" width="453" height="527" /></p> <h3 style="text-align: justify;"><strong>Peanut Allergy</strong></h3> <p style="text-align: justify;"><span style="font-weight: 400;">Over the last few decades, the incidence of food allergies has steeply increased, and has become a major public health concern. Food allergies strain healthcare from both medical and financial perspectives [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21134576/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23845860/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Peanut allergy is one of the most common food allergies, affecting 1-3% of infants worldwide. Unlike other types of food allergies, peanut allergy usually lasts for the duration of one&rsquo;s life and often results in severe, life-threatening reactions. The main risk factors for the development of peanut allergy include [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24388012/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27039393/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/books/NBK538526/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul style="text-align: justify;"> <li><strong>Family history of peanut allergy</strong></li> <li><strong>Atopy (allergic tendency)</strong></li> <li><span style="font-weight: 400;">Peanut consumption during pregnancy</span></li> <li><span style="font-weight: 400;">Specific oils used to fry and roast peanuts</span></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">Genes account for up to 80% of susceptibility to peanut allergy [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892276/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Peanut allergy is one of the most common and dangerous food allergies with a strong genetic background.</span></p> <h3 style="text-align: justify;"><strong>The Role of HLA Genes</strong></h3> <p style="text-align: justify;"><em><span style="font-weight: 400;">HLA</span></em><span style="font-weight: 400;"> genes come in many different forms, and there are millions of possible </span><em><span style="font-weight: 400;">HLA </span></em><span style="font-weight: 400;">combinations. Their diversity ensures protection against a wide array of external threats. Still, it can be a double-edged sword, as </span><em><span style="font-weight: 400;">HLA </span></em><span style="font-weight: 400;">variants correlate with different allergies &amp; autoimmune disorders [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748415/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Tiny changes in their structure can make HLA receptors mistakenly flag our own proteins (autoimmunity) or food components (allergies), and trigger an inflammatory reaction [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647156/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC474884/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In particular, HLA-DR and -DQ receptors have well-known roles in allergic reactions. Due to specific gene variants, they may present peanut proteins to T-helper cells, recognizing them as threats. This leads to the production of peanut-specific IgE antibodies [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11918686/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665015/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Genetic variations can cause HLA receptors to mistakenly flag peanut and other food components as dangerous and trigger an inflammatory reaction.</span></p> <h2 style="text-align: justify;"><strong>The Link Between HLA Variants and Peanut Allergy</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">Despite the well-known role of the HLA system in peanut allergy, earlier studies have failed to confirm this link with </span><em><span style="font-weight: 400;">HLA </span></em><span style="font-weight: 400;">gene variants [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16802776"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976616/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A pivotal 2015 study included over 2,000 subjects and identified a robust association between two </span><em><span style="font-weight: 400;">HLA </span></em><span style="font-weight: 400;">variants and peanut allergy [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340086/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><a href="../../../snp/rs7192/"><strong>rs7192</strong></a><span style="font-weight: 400;"> (HLA-DRA): the &ldquo;T&rdquo; allele correlated with 70% higher odds of peanut allergy</span></li> <li style="font-weight: 400;"><a href="../../../snp/rs9275596/"><strong>rs9275596</strong></a><span style="font-weight: 400;"> (HLA-DQ): the &ldquo;C&rdquo; allele correlated with 70% higher odds of peanut allergy</span></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">Accounting for approximately 20% of susceptibility, these SNPs are likely the most significant genetic factors behind peanut allergy. However, their impact may be limited to European descendants [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340086/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A team of Canadian authors conducted a trial of 1,776 people and included it into a meta-analysis, along with six more trials. They confirmed a robust association between the </span><em><span style="font-weight: 400;">HLA </span></em><span style="font-weight: 400;">region and peanut allergy. Most SNPs were inherited together with rs7192 or rs9275596, so rs7192 and rs9275596 likely present with the same genetic risk factor for peanut allergy [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29325868/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><em><span style="font-weight: 400;">HLA-DQ </span></em><span style="font-weight: 400;">and </span><em><span style="font-weight: 400;">-DR </span></em><span style="font-weight: 400;">variants correlate with different autoimmune disorders, confirming the shared genetic background between allergies and autoimmunity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647156/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/2664347/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Two <em>HLA </em>SNPs&mdash;rs7192 and rs9275596&mdash;may present as the primary genetic risk factors of peanut allergy in people of European ancestry.</span></p> <h3 style="text-align: justify;"><strong>How It Works</strong></h3> <p style="text-align: justify;"><span style="font-weight: 400;">The rs7192 variant changes one amino acid in the HLA-DRA receptor and likely increases gene expression. As discussed, altered HLA structures can bind otherwise benign components, such as peanut proteins [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340086/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Both discussed SNPs could change gene expression and receptor binding by influencing DNA methylation, a well-established mechanism in allergies and autoimmunity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340086/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23431366/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23334450/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><a href="../../article/allergies-asthma-methylation-31/"><span style="font-weight: 400;">MTHFR</span></a><span style="font-weight: 400;"> is another gene that connects methylation with allergies and asthma.</span></p> <h2 style="text-align: justify;"><strong>Your HLA Results for Peanut Allergy</strong></h2> <p style="text-align: justify;">*9262377102074018*</p> <h3 style="text-align: justify;"><strong>SNP Summary and Table</strong></h3> <p style="text-align: justify;"><strong>Primary SNPs:</strong></p> <p style="text-align: justify;"><em><strong>HLA-DRA </strong></em><a href="../../../snp/rs7192/"><strong>rs7192</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = not associated with peanut allergy</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = associated with higher rates of peanut allergy</span></li> </ul> <p style="text-align: justify;"><em><span style="font-weight: 400;">Population Frequency:</span></em><span style="font-weight: 400;"> Around 44% of people worldwide carry one copy and 12% carry both copies of the &ldquo;T&rdquo; allele. Its frequency doesn&rsquo;t vary a lot between populations.</span></p> <p style="text-align: justify;"><em><strong>HLA-DQ </strong></em><a href="../../../snp/rs9275596/"><strong>rs9275596</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = not associated with peanut allergy</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = associated with higher rates of peanut allergy</span></li> </ul> <p style="text-align: justify;"><em><span style="font-weight: 400;">Population Frequency:</span></em><span style="font-weight: 400;"> Around 39% of European descendants carry one copy and 12% carry both copies of the &ldquo;C&rdquo; allele. It&rsquo;s less common in East Asian (25%) and South Asian (34%) populations.</span></p> <p style="text-align: justify;">*8288791383936125*</p> <h2 style="text-align: justify;"><strong>Recommendations to Cope With Peanut Allergy</strong></h2> <p style="text-align: justify;"><em><span style="font-weight: 400;">In the following section, we&rsquo;ll outline complementary approaches that may help you cope with peanut allergy. If you have a diagnosed allergy, the below strategies are not meant to replace your standard medical treatment. Make sure to consult with your doctor before making any significant changes to your day-to-day routine.</span></em> <strong><em>Peanut ingestion can cause severe life-threatening reactions in allergic people. Seek medical attention if you experience a rash, swelling, or difficulty breathing after your meal.</em></strong></p> <p style="text-align: justify;">*8659427298603879*</p> <h3 style="text-align: justify;"><strong>Diet</strong></h3> <h4 style="text-align: justify;"><strong>Avoid Peanuts</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">For those with peanut allergy, avoiding all peanut-containing foods is a must.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Keep in mind that the above SNPs don&rsquo;t necessarily mean you are allergic to peanuts. On the other hand, you may lack the genetic risk but still be allergic. Your doctor can order a skin-prick test or IgE blood test, or have you complete an oral food challenge, to confirm the diagnosis [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9186485"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27039393/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">In case you have severe reactions, make sure to read labels carefully, as many packaged foods may contain traces of peanuts.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">When it comes to infant nutrition, some doctors recommend not introducing peanuts or other common allergens in the first year. However, studies have shown that early introduction (at 4-6 months) may actually prevent peanut allergy [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005304/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416404/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">For those with a diagnosed allergy, lifelong avoidance of peanuts is a must. Early introduction of peanuts into an infant's nutrition (at 4-6 months) may prevent an allergy.</span></p> <h4 style="text-align: justify;"><strong>Elimination Diets</strong></h4> <p style="text-align: justify;"><span style="font-weight: 400;">In general, peanut allergy is not associated with other food allergies, but atopy (allergic tendency) is a significant risk factor for development of peanut allergy [</span><a href="https://www.ncbi.nlm.nih.gov/books/NBK538526/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The HLA-DQB1*02 allele plays a role in peanut allergy, and also encodes a receptor responsible for most cases of gluten intolerance (DQ2.5) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778350/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Like all legumes, peanuts are rich in lectins, which may trigger allergic reactions in sensitive people [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20541807/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603809/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. Lectins can increase the expression of HLA class II molecules, potentially worsening your genetic effect [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10884708"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Elimination diets such as the </span><a href="https://selfhacked.com/blog/elimination-diet-safest-foods-people-sensitive-everything/"><span style="font-weight: 400;">Lectin Avoidance Diet</span></a><span style="font-weight: 400;"> can help identify and remove potential food irritants &mdash; such as </span><a href="https://selfhacked.com/blog/lectins-beneficial-harmful/"><span style="font-weight: 400;">lectins</span></a><span style="font-weight: 400;">, gluten, or dairy &mdash; that may worsen allergies &amp; autoimmunity in sensitive individuals [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10884708"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25599185"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647120/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Consider practicing an elimination diet to identify and remove all potential allergens and food irritants.</span></p> <h3 style="text-align: justify;"><strong>Promising Research</strong></h3> <p style="text-align: justify;"><span style="font-weight: 400;">Oral immunotherapy is an experimental treatment approach for allergies, in which a person consumes increasing amounts of an allergen to build up tolerance [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843277/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Peanut oral immunotherapy has shown some promising results, but it can have significant adverse effects, which sometimes require urgent intervention. Due to potentially life-threatening reactions, oral immunotherapy requires strict medical supervision. Health experts are still looking to improve peanut oral immunotherapy and develop other treatment options [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548240/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31761124/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/s41598-019-56961-3"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">A potential solution could lie in combination with probiotics: In a trial of 62 children, peanut oral immunotherapy combined with </span><a href="https://selfhacked.com/blog/l-rhamnosus/"><em><span style="font-weight: 400;">Lactobacillus rhamnosus</span></em></a><span style="font-weight: 400;"> induced peanut tolerance in 82% of cases, compared to 3.6% of those receiving placebo [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25592987/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Oral immunotherapy is a promising but potentially dangerous treatment option for peanut allergy. It requires strict medical supervision.</span></p>
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263 | content_learn_more_8288791383936125_text == Based on the variants we looked at, your HLA genes are associated with slightly higher odds of peanut allergy. However, this doesn't necessarily reflect your overall risk of peanut allergy—it’s just one gene related to it. Don’t eat peanuts if allergic and consider practicing an elimination diet to reduce the impact of your genes. Keep reading to find out more.
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rsIDs = rs7192,rs9275596
rsStatus = rs7192,HLA-DRA,chr6,32443869,T,C,G,,0,0,Unknown
rsStatus = rs9275596,,chr6,32713854,C,A,G,T,7,0,Normal
