274 | id == 274
274 | category_id == 19
274 | category_order == 16
274 | category_name == Pain
274 | category_color == #C47AC0
274 | slug == BDNF-Migraines-Headaches
274 | title == Can This Gene Influence Your Susceptibility To Headaches And Migraines? (BDNF)
274 | meta_description == BDNF gene variants may make you more susceptible to headaches and migraines. Read on to find out more!
274 | summary == <p style="text-align:justify"><strong>Variants of the BDNF gene may make you more susceptible to headaches and migraines. Read on to find out how these variants may be influencing your own headache and migraine risk, and some steps you can take to potentially reduce their impact!</strong></p>
274 | overall_score_text == Your Headache and Migraine Score (based on BDNF)
274 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/BDNF--Pain-Headaches-Migraine.jpg
274 | author_id == 13
274 | author_name == Lewis Cuthbertson
274 | author_title == PhD
274 | author_order == 12
274 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Lewis_SelfDecode.jpg
274 | author_intro == <p><strong>Lewis completed his PhD in Molecular Microbiology at Northumbria University (UK).</strong></p>    <p>Lewis spent several years researching the biodiversity of bacterial communities in the Arctic and Antarctic, whilst also performing research for a DNA sequencing service, where he was involved in several health based microbiome studies. This gave him an insight into how the highly diverse and invisible to the naked eye portion of human health, can potentially impact an individual&rsquo;s quality of life, driving his desire to help others understand their own complex health needs through the most current scientific research.<br />  &nbsp;</p>
274 | reviewer_id == 10
274 | reviewer_name == Biljana Novkovic
274 | reviewer_title == PhD
274 | medical_reviewer_id == 11
274 | medical_reviewer_name == Puya Yazdi
274 | medical_reviewer_title == MD
274 | publish_date == 2020
274 | publish_date == 8
274 | publish_date == 17
274 | avg_rating == 5.0
274 | tags_id == 159
274 | tags_name == BDNF
274 | tags_id == 160
274 | tags_name == BDNF Gene
274 | tags_id == 69
274 | tags_name == Headache
274 | tags_id == 31
274 | tags_name == Migraine
274 | tags_id == 71
274 | tags_name == Pain
274 | permissions_favorite == False
274 | permissions_rate == False
274 | content_article == <p style="text-align: justify;"><em><span style="font-weight: 400;">If you have persistent or unexplained head pain, it is important to discuss these concerns with your doctor. The information in this post is presented for educational purposes only, and should not be used to replace standard medical care.</span></em></p> <h2 style="text-align: justify;"><span style="font-weight: 400;">What is the </span><em><span style="font-weight: 400;">BDNF </span></em><span style="font-weight: 400;">gene?</span></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="../../../gene/bdnf/"><em><span style="font-weight: 400;">BDNF</span></em></a><span style="font-weight: 400;"> gene encodes the brain-derived neurotrophic factor (BDNF), a crucial growth factor in the brain. BDNF stimulates the creation of new brain cells (</span><a href="https://selfhacked.com/blog/neurogenesis/"><span style="font-weight: 400;">neurogenesis</span></a><span style="font-weight: 400;">), and their development and adaptation (</span><a href="https://selfhacked.com/blog/synaptic-plasticity/"><span style="font-weight: 400;">synaptic plasticity</span></a><span style="font-weight: 400;">) &mdash; vital processes for learning and memory [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29099059"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27167299"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">BDNF is abundant in brain areas involved in [</span><a href="https://ghr.nlm.nih.gov/gene/BDNF"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835061/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/health-benefits-sleep/"><span style="font-weight: 400;">Sleep</span></a></li> <li style="font-weight: 400;"><a href="https://selfhack.com/blog/61-biological-mechanisms-that-influence-weight/"><span style="font-weight: 400;">Weight control</span></a></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Appetite</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">Stress response</span></a></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">Changes in BDNF expression and blood levels have a significant health impact and correlate with a range of mental and metabolic disorders [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21924328"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29217485"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">BDNF proteins also play a role in regulating pain response [</span><a href="https://www.pnas.org/content/96/14/7714"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The <em>BDNF</em> gene encodes for BDNF protein. One function of BDNF is balancing pain response.</span></p> <h2 style="text-align: justify;"><span style="font-weight: 400;">The link between BDNF, and Migraine and Headache Pain</span></h2> <h3 style="text-align: justify;"><span style="font-weight: 400;">Headaches and Migraines</span></h3> <p style="text-align: justify;"><span style="font-weight: 400;">Headaches are unpleasant pains in your head associated with aching and pressure, and may be caused by malfunctions of the nervous system. Persistent headaches are the primary symptom of </span><a href="https://selfhacked.com/blog/migraines-and-headaches-causes-and-solutions/"><span style="font-weight: 400;">migraines</span></a><span style="font-weight: 400;">, alongside symptoms such as [</span><a href="https://ghr.nlm.nih.gov/condition/migraine"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">Nausea</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Sickness</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Seeing flashing lights or spots</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Light and sound sensitivity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Loss of sight</span></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The factors which lead to headaches and migraines are complex. One factor is thought to be increased sensitivity to pain in the nervous system.</span></p> <h2 style="text-align: justify;"><span style="font-weight: 400;">BDNF and Head Pain</span></h2> <h3 style="text-align: justify;"><em><span style="font-weight: 400;">BDNF </span></em><span style="font-weight: 400;">variants</span></h3> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">BDNF</span></em><span style="font-weight: 400;"> variant rs6265 has been associated with variations in BDNF protein production and transport. This is thought to negatively impact the body's ability to maintain a balanced response to pain. However, the mechanism behind this is still not clear [</span><a href="https://pubmed.ncbi.nlm.nih.gov/12553913/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22901763/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Two recent meta-analyses investigated the association between </span><em><span style="font-weight: 400;">BDNF </span></em><span style="font-weight: 400;">gene variants and migraine risk. The first consisted of 4 studies with a total of 3183 participants. The second involved 3322 participants and over 5 studies.</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">The authors of the first meta study reported that carrying a &lsquo;T&rsquo; allele at the rs6265 SNP was associated with an increased risk of migraine. This observation was confirmed by the second meta study [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289130/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28507530/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">An association between the &lsquo;T&rsquo; allele at rs2049046 and increased migraine risk was also identified by the researchers. Several other studies have also confirmed this link, although the mechanism behind this is not yet fully clear [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28150221/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24708359/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Whilst there is evidence that these SNPs are linked to migraines, some studies have failed to find a link. Further studies are required to investigate this relationship, particularly in non-white populations [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24708359/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289130/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28507530/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em>BDNF </em>variants may play a role in determining BDNF protein levels and activity, as well as susceptibility to headaches and migraines.</span></p> <h2 style="text-align: justify;"><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">BDNF</span></em><span style="font-weight: 400;"> Results for Headaches and Migraines</span></h2> <p style="text-align: justify;"><strong>*6882977651215445*</strong></p> <h3 style="text-align: justify;"><span style="font-weight: 400;">SNP Summary and Table</span></h3> <p style="text-align: justify;"><strong><em>BDNF</em></strong><strong> rs6265</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;TT&rsquo; = Associated with an increased risk of migraine [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289130/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12553913/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25649076/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;CT&rsquo; = Associated with an increased risk of migraine [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289130/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12553913/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25649076/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;CC&rsquo; =&nbsp; Associated with a normal risk of migraine</span></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">33% of people carry a copy of the risk &lsquo;T&rsquo; allele. The &lsquo;T&rsquo; allele is particularly prominent in East Asian populations, with 73% of individuals carrying at least one copy [</span><a href="https://useast.ensembl.org/Homo_sapiens/Variation/Population?db=core;r=11:27657869-27658869;v=rs6265;vdb=variation;vf=83312598"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><strong><em>BDNF</em></strong><strong> rs2049046</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;TT&rsquo; = Associated with an increased risk of migraine [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289130/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;AT&rsquo; = Associated with an increased risk of migraine [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289130/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;AA&rsquo; = Associated with a normal risk of migraine</span></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">81% of people carry at least one copy of the &lsquo;T&rsquo; allele [</span><a href="https://useast.ensembl.org/Homo_sapiens/Variation/Population?db=core;r=11:27701728-27702728;v=rs2049046;vdb=variation;vf=84182929"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><strong>*9813464469023467*</strong></p> <h2 style="text-align: justify;"><span style="font-weight: 400;">Recommendations to Reduce your Risk of Headaches and Migraines</span></h2> <p style="text-align: justify;"><strong>*8652446710988415*</strong></p> <h3 style="text-align: justify;"><span style="font-weight: 400;">Lifestyle</span></h3> <h4 style="text-align: justify;"><span style="font-weight: 400;">Exercise</span></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Getting plenty of regular </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> is one of the best ways to promote overall health. Among its many well-known benefits, exercise can directly promote healthy production and release of BDNF in the brain and throughout the body. Exercising regularly may reduce overall pain, and migraine frequency [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27253067"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11991541"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/31386821"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30203180/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132632/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4 style="text-align: justify;"><span style="font-weight: 400;">Stress</span></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/stress-bad-uncovering-hidden-effects-stress/"><span style="font-weight: 400;">Stress</span></a><span style="font-weight: 400;"> is another key lifestyle factor that can significantly alter the amount of BDNF you produce [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25584253"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16024125"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15341606"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/9220467"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Therefore, it would be a good idea to cultivate some stress-busting hobbies, such as </span><a href="https://selfhacked.com/blog/health-benefits-yoga/"><span style="font-weight: 400;">yoga</span></a><span style="font-weight: 400;"> or </span><a href="https://selfhacked.com/blog/meditation/"><span style="font-weight: 400;">meditation</span></a><span style="font-weight: 400;">. Yoga has been associated with a reduction in the intensity, frequency, and duration of migraine attacks [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24049209"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25558129"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22891145"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23440614"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24395196"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22377965"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23541163"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746941/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3 style="text-align: justify;"><span style="font-weight: 400;">Supplements &amp; Diet</span></h3> <p style="text-align: justify;"><span style="font-weight: 400;">Several supplements can also help counteract any risk alleles you carry by directly stimulating healthy BDNF production.</span></p> <h4 style="text-align: justify;"><span style="font-weight: 400;">Butyrate &amp; Resistant Starch</span></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Histone deacetylase (HDAC) inhibitors, such as </span><a href="https://selfhacked.com/blog/butyrate-health-benefits-butyrate-derivatives-sodium-butyrate-phenylbutyrate-trybutyrine-butyric-acid-butyrate-prodrugs-butyrate-producing-bacteria/"><span style="font-weight: 400;">sodium butyrate</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/resistant2-resistant-starch-metabolism-autoimmunity-cancer-weight-loss-digestion/"><span style="font-weight: 400;">resistant starches</span></a><span style="font-weight: 400;">, have been shown to boost healthy BDNF production in the brain [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19549282"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23615664"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343644/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">They boost neurogenesis and synaptic plasticity &mdash; benefits which may be linked to healthy BDNF levels and reduced brain inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19549282"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23615664"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26868600"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/25284351"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-020-1078-9"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Butyrate can be obtained from dairy sources such as milk or butter, or it can be supplemented directly [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10386321"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27346602"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Alternatively, you could also try increasing your consumption of resistant starches, common dietary compounds that your gut flora naturally convert into active butyrate [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21831780"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27357127"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28166818"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Foods that are rich in resistant starch include corn, rice, green bananas, and potatoes [</span><a href="http://r/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4 style="text-align: justify;"><span style="font-weight: 400;">Fish Oil / Docosahexaenoic Acid (DHA)&nbsp;</span></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Another potential supplement for carriers of rs6265 risk alleles is </span><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">fish oil</span></a><span style="font-weight: 400;">. Fish oil contains polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA), which promote neurogenesis and synaptic plasticity by boosting BDNF levels [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15672635"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24860731"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26901223"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17284765"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Supplementing with fish oil / DHA has also been associated with reduced migraine attack durations [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28665211/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4 style="text-align: justify;"><span style="font-weight: 400;">Curcumin</span></h4> <p style="text-align: justify;"><span style="font-weight: 400;">Finally, curcumin supplementation has been associated with healthy BDNF levels in the brain of rodent models. Curcumin has also been associated with decreased frequency of migraine attacks. Also consider cooking with turmeric, as this contains curcumin&nbsp; [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28167853/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29237386/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p>
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274 | content_learn_more_9813464469023467_text == Based on the variants we looked at, your BDNF gene may be associated with non-optimal BDNF levels and an increased risk of developing headaches and migraines. However, this doesn't necessarily reflect your overall headache and migraine risk — just one gene related to it. Read on to find out more.
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rsIDs = rs2049046,rs6265
rsStatus = rs2049046,BDNF,chr11,27702228,T,A,,,17,16,HET
rsStatus = rs6265,BDNF,chr11,27658369,C,T,,,38,0,Normal
