280 | id == 280
280 | category_id == 16
280 | category_order == 13
280 | category_name == Gut Health
280 | category_color == #C47AC0
280 | slug == IBD5-region-IBD-gut
280 | title == Crucial Genetic Factor for Inflammatory Bowel Disease (IBD5)
280 | meta_description == The IBD5 group of genes has a robust association with IBD. Click to learn the exact variants and get personalized tips.
280 | summary == <p style="text-align:justify"><strong>One group of genes has such a robust association with IBD that scientists named it after this condition: <em>IBD5</em>! Read this post to learn the exact variants behind this association and get tailored tips to lessen their impact!</strong></p>
280 | overall_score_text == Your IBD Score (Based on IBD5)
280 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/IBD5--IBD.jpg
280 | author_id == 9
280 | author_name == Aleksa Ristic
280 | author_title == MS (Pharmacy)
280 | author_order == 45
280 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
280 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
280 | reviewer_id == 14
280 | reviewer_name == Shany Lahan
280 | reviewer_title == MS (Neuroscience)
280 | medical_reviewer_id == 11
280 | medical_reviewer_name == Puya Yazdi
280 | medical_reviewer_title == MD
280 | publish_date == 2020
280 | publish_date == 8
280 | publish_date == 19
280 | avg_rating == 5.0
280 | tags_id == 299
280 | tags_name == Butyrate
280 | tags_id == 627
280 | tags_name == C5ORF56 gene
280 | tags_id == 195
280 | tags_name == Crohn's Disease
280 | tags_id == 298
280 | tags_name == Curcumin
280 | tags_id == 282
280 | tags_name == Dietary fiber
280 | tags_id == 194
280 | tags_name == Gut Health
280 | tags_id == 308
280 | tags_name == Gut Inflammation
280 | tags_id == 73
280 | tags_name == IBD
280 | tags_id == 624
280 | tags_name == IBD5 region
280 | tags_id == 246
280 | tags_name == Probiotics
280 | tags_id == 625
280 | tags_name == SLC22A4 gene
280 | tags_id == 626
280 | tags_name == SLC22A5 gene
280 | permissions_favorite == False
280 | permissions_rate == False
280 | content_article == <p><em><span style="font-weight: 400;">If you have any serious gut health concerns, it is important to discuss them with your doctor. The information in this post is presented for educational purposes only, and should not be used to replace standard medical care.</span></em></p> <h2><strong><em>IBD5</em> Region in Inflammatory Bowel Disease</strong></h2> <p><a href="https://selfhacked.com/blog/crohns-disease/"><span style="font-weight: 400;">Crohn&rsquo;s disease</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/ulcerative-colitis/"><span style="font-weight: 400;">ulcerative colitis</span></a><span style="font-weight: 400;"> (UC) are the two most common subtypes of inflammatory bowel disease or </span><a href="https://selfhacked.com/blog/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections/"><span style="font-weight: 400;">IBD</span></a><span style="font-weight: 400;">. In IBD, inflammation and sores in the gut lining can cause unpleasant digestive symptoms such as diarrhea, abdominal pain, fatigue, rectal bleeding, and more [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980998/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Besides well-known environmental triggers, IBD has a strong genetic component, and different gene variants have been associated with disease incidence and progression [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25732745/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>The Role of <em>IBD5</em></strong></h3> <p><span style="font-weight: 400;">Researchers have identified a group of genes on chromosome 5 that is strongly associated with IBD and named it </span><em><span style="font-weight: 400;">IBD5</span></em><span style="font-weight: 400;">. Besides </span><a href="../../article/nod2-crohns-disease-175/"><em><span style="font-weight: 400;">NOD2</span></em></a><em><span style="font-weight: 400;"> (CARD15)</span></em><span style="font-weight: 400;">, it's the only genetic factor with a proven IBD link. The region contains different genes potentially involved in gut inflammation, including [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629465/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1773608/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><a href="../../../gene/irf1/"><em><span style="font-weight: 400;">IRF1</span></em></a><span style="font-weight: 400;">, which regulates interferons (signaling proteins)</span></li> <li style="font-weight: 400;"><a href="https://www.selfdecode.com/gene/slc22a4/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><em><span style="font-weight: 400;">SLC22A4</span></em></a> <span style="font-weight: 400;">and</span> <a href="../../../gene/slc22a5/"><em><span style="font-weight: 400;">SLC22A5</span></em></a><span style="font-weight: 400;">, which enable carnitine transport</span></li> <li style="font-weight: 400;"><a href="../../../gene/p4ha2/"><em><span style="font-weight: 400;">P4HA2</span></em></a><span style="font-weight: 400;">, which allows </span><a href="https://selfhacked.com/blog/health-benefits-collagen/"><span style="font-weight: 400;">collagen</span></a><span style="font-weight: 400;"> production</span></li> <li style="font-weight: 400;"><a href="../../../gene/c5orf56/"><em><span style="font-weight: 400;">C5ORF56</span></em></a><span style="font-weight: 400;"> (unknown function)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Genes for </span><a href="https://www.selfdecode.com/gene/il4/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">IL-4</span></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/interleukin-1/"><span style="font-weight: 400;">IL-1</span></a><a href="http://www.selfdecode.com/gene/IL13/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">3</span></a><span style="font-weight: 400;"> and other cytokines</span></li> </ul> <p><span style="font-weight: 400;">During the past few decades, scientists have found various SNPs in this region associated with IBD incidence, and they have tried to discover the exact gene responsible for this link. The following chapter summarizes the main results.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><em>IBD5</em> is a region of different genes strongly associated with IBD. Studies have found different variants in this region and tried to discover the ones that play a role in disease development.</span></p> <p>&nbsp;</p> <h2><strong>The Link Between IBD5 Variants and IBD</strong></h2> <p><span style="font-weight: 400;">A large meta-analysis gathered data from over 75,000 subjects to determine the critical IBD genetic factors. One SNP in the </span><em><span style="font-weight: 400;">IBD5</span></em><span style="font-weight: 400;"> region, </span><a href="../../../snp/rs2188962/"><span style="font-weight: 400;">rs2188962</span></a><span style="font-weight: 400;">, correlated with 16% higher disease rates per &ldquo;T&rdquo; allele [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491803/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In another meta-analysis of over 15,000 participants, this variant was associated with 25% higher odds of Crohn&rsquo;s disease [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574810/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. A review including nearly 10,000 people didn&rsquo;t find a significant link between rs2188962-T and ulcerative colitis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087600/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The above variant belongs to a gene called </span><a href="../../../gene/c5orf56/"><em><span style="font-weight: 400;">C5ORF56</span></em></a><span style="font-weight: 400;">. Scientists still don&rsquo;t know the exact role of this gene and whether it plays a role in IBD development. Interestingly, the above study of Crohn&rsquo;s disease patients found that all </span><em><span style="font-weight: 400;">IBD5</span></em><span style="font-weight: 400;"> variants were associated with decreased expression of another gene, </span><a href="../../../gene/slc22a5/"><em><span style="font-weight: 400;">SLC22A5</span></em></a><span style="font-weight: 400;">, making it a candidate gene for IBD [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574810/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A study of 158 families with Crohn's disease-affected members has also suggested </span><em><span style="font-weight: 400;">SLC22A5 </span></em><span style="font-weight: 400;">as a causal genetic factor. More precisely, the authors suggested two SNPs that may play a role in IBD development [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15107849/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><a href="../../../snp/rs1050152/"><span style="font-weight: 400;">rs1050152</span></a><span style="font-weight: 400;">-T in the </span><em><span style="font-weight: 400;">SLC22A4 (OCTN1)</span></em><span style="font-weight: 400;"> gene</span></li> <li style="font-weight: 400;"><a href="../../../snp/rs2631367/"><span style="font-weight: 400;">rs2631367</span></a><span style="font-weight: 400;">-C in the </span><em><span style="font-weight: 400;">SLC22A5 (OCTN2)</span></em><span style="font-weight: 400;"> gene</span></li> </ul> <p><span style="font-weight: 400;">These variants are almost always inherited together, along with other ones from the </span><em><span style="font-weight: 400;">IBD5</span></em><span style="font-weight: 400;"> region. As mentioned, </span><em><span style="font-weight: 400;">SLC22 </span></em><span style="font-weight: 400;">genes enable the uptake of the amino acid </span><a href="http://selfhacked.com/blog/top-18-science-based-health-effects-carnitine/"><span style="font-weight: 400;">carnitine</span></a><span style="font-weight: 400;"> in the gut lining.&nbsp;</span></p> <p><span style="font-weight: 400;">A meta-analysis of 26 studies confirmed the link between the above two variants and IBD. They correlated with 20-23% higher rates of both Crohn's disease and ulcerative colitis. This paper identified another significant </span><em><span style="font-weight: 400;">IBD5</span></em><span style="font-weight: 400;"> SNP, </span><a href="../../../snp/rs12521868/"><span style="font-weight: 400;">rs12521868</span></a><span style="font-weight: 400;">, associated with 36% higher IBD rates [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21279723/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The link between the </span><em><span style="font-weight: 400;">IBD5</span></em><span style="font-weight: 400;"> region and IBD development appears to be significant only in European descendants. Additionally, it may not play a role in ulcerative colitis in children [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21279723/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Four <em>IBD5 </em>variants have shown a robust association with IBD in Caucasians. The SNPs likely involved in IBD development belong to the <em>SLC22A4 </em>and<em> SLC22A5 </em>genes, which enable the transport of carnitine in the gut.</span></p> <h3><strong>How It Works</strong></h3> <p><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">SLC22A4 </span></em><span style="font-weight: 400;">and</span><em><span style="font-weight: 400;"> SLC22A5 </span></em><span style="font-weight: 400;">genes encode transport proteins (OCTN1 and OCTN2) that supply the gut lining with carnitine and other essential components. Mice lacking OCTN2 develop gut inflammation, ulcers, and perforations due to carnitine deficiency [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2170531/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480427/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The gut barrier uses </span><a href="http://selfhacked.com/blog/health-benefits-butyrate-derivatives-sodium-butyrate-phenylbutyrate-trybutyrine-butyric-acid-butyrate-prodrugs-butyrate-producing-bacteria/"><span style="font-weight: 400;">butyrate</span></a><span style="font-weight: 400;"> and other short-chain fatty acids as the primary source of energy and anti-inflammatory protection. Carnitine enables the uptake of fatty acids and their metabolism, making it an essential nutrient for gut health [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231908/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748798/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A study of 944 participants found that people with </span><em><span style="font-weight: 400;">SLC22A4 </span></em><span style="font-weight: 400;">and</span><em><span style="font-weight: 400;"> SLC22A5 </span></em><span style="font-weight: 400;">variants have reduced gene expression in the blood and gut tissue, making them prone to inflammation. This confirms the mentioned link between </span><em><span style="font-weight: 400;">IBD5</span></em><span style="font-weight: 400;"> SNPs and lower </span><em><span style="font-weight: 400;">SLC22A5 </span></em><span style="font-weight: 400;">expression [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21695374/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In reality, the situation is more complex because </span><em><span style="font-weight: 400;">SLC22A5 </span></em><span style="font-weight: 400;">expression can increase in response to gut inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20722056/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. Additionally, the science isn&rsquo;t settled when it comes to the </span><em><span style="font-weight: 400;">IBD5</span></em><span style="font-weight: 400;"> region&mdash;other genes such as </span><em><span style="font-weight: 400;">IRF1</span></em><span style="font-weight: 400;"> and </span><em><span style="font-weight: 400;">P4HA2</span></em><span style="font-weight: 400;"> may also have functional roles [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16835882/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087460/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">People with <em>IBD5</em> variants may have impaired carnitine transport in the gut, which depletes butyrate and paves the way for inflammation and gut damage.</span></p> <p>&nbsp;</p> <h2><strong>Your <em>IBD5</em> Results for IBD</strong></h2> <p>*9942251809775817*</p> <h3><strong>SNP Summary</strong></h3> <p><strong>Primary SNPs:</strong></p> <p><strong><em>C5ORF56</em></strong> <a href="../../../snp/rs2188962/"><strong>rs2188962</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = not associated with IBD</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = associated with higher odds of IBD, especially Crohn&rsquo;s disease</span></li> </ul> <p><strong><em>C5ORF56</em></strong> <a href="../../../snp/rs12521868/"><strong>rs12521868</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = not associated with IBD&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = associated with higher odds of IBD</span></li> </ul> <p><strong><em>SLC22A4</em></strong> <a href="../../../snp/rs1050152/"><strong>rs1050152</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = not associated with IBD&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = associated with higher odds of IBD</span></li> </ul> <p><strong><em>SLC22A5</em></strong> <a href="../../../snp/rs2631367/"><strong>rs2631367</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = not associated with IBD&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = associated with higher odds of IBD</span></li> </ul> <h4><strong>Population Frequency</strong></h4> <p><span style="font-weight: 400;">All SNPs in the </span><em><span style="font-weight: 400;">IBD5 </span></em><span style="font-weight: 400;">region are usually inherited together, which means they act as a single genetic factor. Around 63% of European descendants carry at least one copy of IBD-associated alleles. They are much less common in South Asian (16%) and African (4-7%) populations and nearly non-existent among East Asians.</span></p> <p><span style="font-weight: 400;">There&rsquo;s a notable exception for rs2631367 in African populations, where about 48% of people carry one copy and 19% carry both copies of the &ldquo;C&rdquo; allele.</span></p> <p>*9811876695546722*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Boost Gut Health</strong></h2> <p><em><span style="font-weight: 400;">You may try the complementary approaches listed below if you and your doctor determine that they could be appropriate for you. Remember that none of them should be done in place of what your doctor recommends or prescribes.</span></em></p> <p>*5615861664094646*</p> <h3><strong>Diet</strong></h3> <p><span style="font-weight: 400;">As discussed, people with </span><em><span style="font-weight: 400;">IBD5</span></em><span style="font-weight: 400;"> variants may be prone to gut inflammation due to impaired butyrate supply. Butyrate has produced promising results for IBD, especially ulcerative colitis, in different clinical trials [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12769445"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/8943981"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10795763"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16225487"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A 2020 paper published in &ldquo;</span><em><span style="font-weight: 400;">Gastroenterology</span></em><span style="font-weight: 400;">&rdquo; emphasized the potential of butyrate to improve gut flora and reduce inflammation, making it a promising aid in IBD management [</span><a href="https://www.gastrojournal.org/article/S0016-5085(20)30105-0/fulltext"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">When fed </span><a href="https://selfhacked.com/blog/what-is-resistant-starch-sources-how-to-increase-diet/"><span style="font-weight: 400;">resistant starch</span></a><span style="font-weight: 400;"> and other prebiotics, </span><a href="https://www.selfhacked.com/blog/gut-bacteria-microbiome/"><span style="font-weight: 400;">gut bacteria</span></a><span style="font-weight: 400;"> can produce sufficient amounts of butyrate. The best dietary sources of resistant starch include [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299284/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.eurekalert.org/pub_releases/2013-04/fi-rsc042513.php"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627159/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Oats and other whole grains</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Baked potatoes (cooled)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Legumes</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Green bananas</span></li> </ul> <p><span style="font-weight: 400;">Please note that fiber-rich foods aren't suitable during the active IBD phases or 'flares.'</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">People with <em>IBD5</em> variants should obtain more butyrate by consuming foods rich in resistant starch, such as oats, baked potatoes, and legumes.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Butyrate &amp; Resistant Starch</strong></h4> <p><span style="font-weight: 400;">If you can&rsquo;t get enough resistant starch from food, consider supplementing with butyrate or resistant starch. Butyrate may be a better option if you don&rsquo;t tolerate large amounts of fiber.</span></p> <h4><strong>Probiotics</strong></h4> <p><a href="https://selfhacked.com/blog/probiotics-good-bacteria/"><span style="font-weight: 400;">Probiotic</span></a><span style="font-weight: 400;"> supplementation can boost the production of butyrate and other short-chain fatty acids in the gut and thus lessen the effect of </span><em><span style="font-weight: 400;">IBD5</span></em><span style="font-weight: 400;"> variants [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049320/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230973/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Butyrate-producing probiotics helped heal the gut tissue from Crohn's disease patients in test tubes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597586/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a meta-analysis of 23 studies, a blended</span><a href="https://selfhacked.com/blog/probiotics-gut-health/"> <span style="font-weight: 400;">probiotic</span></a><span style="font-weight: 400;"> containing</span> <a href="https://selfhacked.com/blog/l-plantarum/"><em><span style="font-weight: 400;">Lactobacillus</span></em></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/b-longum/"><em><span style="font-weight: 400;">Bifidobacterium</span></em></a><span style="font-weight: 400;"> strains increased ulcerative colitis remission rates by 1.7 times [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24280877"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. Despite some promising results, the evidence for Crohn&rsquo;s disease is weaker [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1856223/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Probiotic supplementation can boost butyrate production and improve gut inflammation, which is crucial for people with discussed&nbsp;SNPs.</span></p> <h4><strong>L-Carnitine</strong></h4> <p><span style="font-weight: 400;">Impaired </span><a href="http://carnitine"><span style="font-weight: 400;">carnitine</span></a><span style="font-weight: 400;"> transport in the gut is likely the main consequence of </span><em><span style="font-weight: 400;">IBD5</span></em><span style="font-weight: 400;"> variants. Scientists observing this phenomenon suggested L-carnitine supplementation as a possible way to counteract this genetic effect [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21419279/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2170531/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Carnitine was able to improve colon inflammation in animals, but substantial clinical evidence is lacking [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673754/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">L-carnitine supplementation may compensate for the reduced expression of <em>IBD5 </em>genes, but its benefits for IBD lack clinical evidence.</span></p> <h4><strong>Curcumin</strong></h4> <p><span style="font-weight: 400;">In gut cells carrying an </span><em><span style="font-weight: 400;">IBD5</span></em><span style="font-weight: 400;"> SNP (</span><a href="../../../snp/rs1050152/"><span style="font-weight: 400;">rs1050152</span></a><span style="font-weight: 400;">), a turmeric extract restored cell communication and reduced inflammatory cytokines [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210912/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">Curcumin</span></a><span style="font-weight: 400;">, the active ingredient of turmeric, has potent anti-inflammatory effects [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19594223"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. It has produced promising results for IBD in different clinical trials, and further research is currently underway [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29957091"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514688/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153885/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Curcumin may reduce the impact of your SNPs and help improve IBD symptoms.</span></p>
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280 | content_learn_more_9811876695546722_text == Based on the variants we looked at, your IBD5 region is associated with slightly higher rates of IBD. However, this doesn't necessarily reflect your overall risk of IBD, just one genetic factor related to it. Consume more resistant starch and consider supplementing with butyrate and probiotics to boost your gut health. Keep reading to learn more.
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rsIDs = rs1050152,rs12521868,rs2188962,rs2631367
rsStatus = rs1050152,SLC22A4,chr5,132340627,C,T,,,19,19,HET
rsStatus = rs12521868,IRF1-AS1,chr5,132448701,G,T,,,20,6,HET
rsStatus = rs2188962,IRF1-AS1,chr5,132435113,C,T,,,18,9,HET
rsStatus = rs2631367,SLC22A5,chr5,132369766,C,A,G,T,26,0,Normal
