284 | id == 284
284 | category_id == 19
284 | category_order == 16
284 | category_name == Pain
284 | category_color == #C47AC0
284 | slug == PRDM16-migraine-obesity
284 | title == A Surprising Genetic Factor for Migraines (PRDM16)
284 | meta_description == The PRDM16 gene is involved in weight management and antioxidant defense. Click to learn about its role in migraines.
284 | summary == <p style="text-align:justify"><strong>Have scientists discovered a genetic link between oxidative stress, obesity and migraines? Read this post to learn about the role of <em>PRDM16</em> variants in migraine development!</strong></p>
284 | overall_score_text == Your Migraine Score (Based on PRDM16 Gene)
284 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/PRDM16--Pain-Headaches-Migraine.jpg
284 | author_id == 9
284 | author_name == Aleksa Ristic
284 | author_title == MS (Pharmacy)
284 | author_order == 45
284 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
284 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
284 | reviewer == None
284 | medical_reviewer_id == 11
284 | medical_reviewer_name == Puya Yazdi
284 | medical_reviewer_title == MD
284 | publish_date == 2020
284 | publish_date == 8
284 | publish_date == 24
284 | avg_rating == 5.0
284 | tags_id == 635
284 | tags_name == Coenzyme Q10
284 | tags_id == 298
284 | tags_name == Curcumin
284 | tags_id == 207
284 | tags_name == Exercise
284 | tags_id == 570
284 | tags_name == Fat Metabolism
284 | tags_id == 31
284 | tags_name == Migraine
284 | tags_id == 165
284 | tags_name == Obesity
284 | tags_id == 39
284 | tags_name == Oxidative Stress
284 | tags_id == 71
284 | tags_name == Pain
284 | tags_id == 634
284 | tags_name == PRDM16
284 | permissions_favorite == False
284 | permissions_rate == False
284 | content_article == <p><em><span style="font-weight: 400;">If you have persistent or unexplained pain, it is important to discuss these concerns with your doctor. The information in this post is presented for educational purposes only, and should not be used to replace standard medical care.</span></em></p> <h2><strong>The <em>PRDM16 </em>Gene in Migraine Development</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../../gene/prdm16/"><em><span style="font-weight: 400;">PRDM16</span></em></a><span style="font-weight: 400;"> gene encodes a protein involved in brown fat tissue metabolism, which has crucial roles in weight control. Studies have associated obesity with migraines, and some authors consider </span><em><span style="font-weight: 400;">PRDM16</span></em><span style="font-weight: 400;"> to be the genetic link between these conditions [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19339685/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3007155"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29890628/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">&nbsp; </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/18796271/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Additionally, </span><em><span style="font-weight: 400;">PRDM16 </span></em><span style="font-weight: 400;">partakes in </span><a href="https://selfhacked.com/blog/oxidative-stress-101/"><span style="font-weight: 400;">oxidative stress</span></a><span style="font-weight: 400;"> response, another critical mechanism in migraine development [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20835244/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755953/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The <em>PRDM16</em> gene may be involved in migraine development via its roles in weight control and oxidative stress response.</span></p> <h3><strong>The Link Between PRDM16 Variants and Migraine</strong></h3> <p><span style="font-weight: 400;">One </span><em><span style="font-weight: 400;">PRDM16</span></em><span style="font-weight: 400;"> variant, </span><a href="../../../snp/rs2651899/"><span style="font-weight: 400;">rs2651899</span></a><span style="font-weight: 400;">, has shown a robust association with migraine, especially in European descendants. People with the &ldquo;C&rdquo; allele have, on average, 10% higher rates of migraines [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125402/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041123/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24021092/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">On the positive side, these people respond better to drug treatment for migraine attacks [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26502740/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The same SNP has been associated with obesity, confirming the genetic link between migraine and obesity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025268/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Another </span><em><span style="font-weight: 400;">PRDM16</span></em><span style="font-weight: 400;"> variant, </span><a href="../../../snp/rs12135062/"><span style="font-weight: 400;">rs12135062</span></a><span style="font-weight: 400;">-T, has been associated with 11% higher migraine rates in European populations [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331903/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Two <em>PRDM16</em> variants, rs2651899-C and&nbsp; rs12135062-T, have shown a robust association with migraines, especially in European populations.</span></p> <p>&nbsp;</p> <h2><strong>Your <em>PRDM16</em> Results for Migraine</strong></h2> <p>*3220645616917159*</p> <h3><strong>SNP Summary</strong></h3> <p><strong>Primary SNPs:</strong></p> <p><strong><em>PRDM16</em></strong> <a href="../../../snp/rs2651899/"><strong>rs2651899</strong></a><strong>&nbsp;</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = associated with higher migraine rates</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = not associated with migraine</span></li> </ul> <p><strong><em>PRDM16</em></strong> <a href="../../../snp/rs2651899/"><strong>rs2651899</strong></a><strong>&nbsp;</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = associated with higher migraine rates</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = not associated with migraine</span></li> </ul> <p>*1493292229239769*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Prevent Migraine</strong></h2> <p><em><span style="font-weight: 400;">You may try the complementary approaches listed below if you and your doctor determine that they could be appropriate for you. Remember that none of them should be done in place of what your doctor recommends or prescribes.</span></em></p> <p>*6024630320098541*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Exercise &amp; Weight Control</strong></h4> <p><span style="font-weight: 400;">As mentioned, </span><em><span style="font-weight: 400;">PRDM16</span></em><span style="font-weight: 400;"> variants may be one of the links between obesity and migraine. According to a study of nearly 22,000 subjects, migraine is significantly more common in people with total or abdominal obesity [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19496830/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Increased physical activity is essential for weight control and may also help prevent migraines. The lack of </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> correlates with a 21% and 50% higher risk of migraines in adolescents and adults, respectively. However, intense workout can trigger attacks in some individuals, so it's essential to keep it in moderation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975621/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Exercise regularly to keep your weight in check and reduce the impact of your <em>PRDM16</em> gene on migraine development.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Coenzyme Q10</strong></h4> <p><a href="https://selfhacked.com/blog/coenzyme-q10-ubiquinol/"><span style="font-weight: 400;">Coenzyme Q10</span></a><span style="font-weight: 400;"> is crucial for energy production and antioxidant defense [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178961/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. Supplementation with coenzyme Q10 boosted antioxidant enzymes in multiple clinical trials [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21388622"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11914748"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17644511"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The levels of coenzyme Q10 are often lower in people who experience migraines [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17355497"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. In different studies, supplementation with 100&ndash;300 mg/day reduced the duration, frequency, and severity of migraines [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21586650"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11972582"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15728298"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17355497"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Coenzyme Q10 may be particularly beneficial for people with </span><em><span style="font-weight: 400;">PRDM16 </span></em><span style="font-weight: 400;">variants, given this gene's role in oxidative stress response.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Coenzyme Q10 supplementation may boost antioxidant defense and help prevent migraines.</span></p> <h4><strong>Curcumin</strong></h4> <p><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">Curcumin</span></a><span style="font-weight: 400;">, the active ingredient of turmeric, is another compound with potent antioxidant activity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664031/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A combination of curcumin and coenzyme Q10 helped prevent migraines in 100 young adults [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31241007/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. When combined with </span><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">fish oil</span></a><span style="font-weight: 400;">, curcumin significantly reduced the frequency and severity of migraine attacks in 74 patients [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30760195/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Despite the promising results, stronger clinical evidence is needed to support the effectiveness of curcumin for migraine prevention.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Curcumin supplementation may lessen the impact of your <em>PRDM16</em> variants on oxidative stress and migraine development.</span></p>
284 | content_snp_table_3220645616917159_key == 3220645616917159
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284 | content_snp_table_3220645616917159_hidden == False
284 | content_learn_more_1493292229239769_key == 1493292229239769
284 | content_learn_more_1493292229239769_blur == True
284 | content_learn_more_1493292229239769_hidden == False
284 | content_learn_more_1493292229239769_text == Based on the variants we looked at, your PRDM16 gene is associated with slightly higher rates of migraine. However, this doesn't necessarily reflect your overall risk of migraine, just one gene related to it. Maintain a healthy weight and follow other gene-based tips to prevent migraine. Keep reading to learn more.
284 | content_recommendation_6024630320098541_key == 6024630320098541
284 | content_recommendation_6024630320098541_blur == True
284 | content_recommendation_6024630320098541_hidden == False
rsIDs = rs12135062,rs2651899
rsStatus = rs12135062,PRDM16,chr1,3186748,G,A,C,T,46,0,Normal
rsStatus = rs2651899,PRDM16,chr1,3167148,T,A,C,G,39,0,Normal
