287 | id == 287
287 | category_id == 19
287 | category_order == 16
287 | category_name == Pain
287 | category_color == #C47AC0
287 | slug == CREB1-painkiller-sensitivity
287 | title == A Gene That Alters Painkiller Sensitivity (CREB1)
287 | meta_description == A variant of the CREB1 gene has been associated with an increased painkiller dosage requirement. Click here to learn more.
287 | summary == <p style="text-align:justify"><strong>The <em>CREB1</em> gene has been associated with differing sensitivity to painkillers. One variant may require you to increase doses of painkillers you take, in order to reduce pain. Read more to learn about this variant.</strong></p>
287 | overall_score_text == Your Painkiller Sensitivity Score (Based on CREB1 Gene)
287 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CREB1--Pain-Resp-to-Painkillers.jpg
287 | author_id == 14
287 | author_name == Shany Lahan
287 | author_title == MS (Neuroscience)
287 | author_order == 5
287 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
287 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
287 | reviewer == None
287 | medical_reviewer_id == 11
287 | medical_reviewer_name == Puya Yazdi
287 | medical_reviewer_title == MD
287 | publish_date == 2020
287 | publish_date == 8
287 | publish_date == 25
287 | avg_rating == 5.0
287 | tags_id == 638
287 | tags_name == CREB1 Gene
287 | tags_id == 641
287 | tags_name == Drug Abuse
287 | tags_id == 642
287 | tags_name == Drug Dependence
287 | tags_id == 598
287 | tags_name == Opioids
287 | tags_id == 640
287 | tags_name == Painkillers
287 | permissions_favorite == False
287 | permissions_rate == False
287 | content_article == <h2 style="text-align: justify;"><strong><em>CREB1</em></strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">The </span><a href="../../../gene/creb1/"><em><span style="font-weight: 400;">CREB1 </span></em><span style="font-weight: 400;">gene</span></a><span style="font-weight: 400;"> codes for CREB1, an important regulator of other genes and their expression. CREB1 has been associated with the strengthening of communication between cells of the brain (neurons), an important step in memory formation and consolidation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22583753/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">CREB1 has also been associated with the body&rsquo;s response to painkillers, such as opioids.&nbsp;&nbsp;&nbsp;</span></p> <h2 style="text-align: justify;"><strong><em>CREB1 </em>Variants &amp; Pain</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">rs2952768-C is a variant of </span><em><span style="font-weight: 400;">CREB1 </span></em><span style="font-weight: 400;">that has been associated with decreased sensitivity to painkillers. Individuals with this variant require a higher dose of painkillers than individuals that carry the rs2952768-T variant, to reduce symptoms of acute and chronic pain&nbsp;[<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873034/">R</a>]. </span></p> <p style="text-align: justify;"><span style="font-weight: 400;">rs2952768-C has been associated with an increased expression of </span><em><span style="font-weight: 400;">CREB1</span></em><span style="font-weight: 400;">. It has been suggested that increased levels of CREB1 may increase the expression of pain-related genes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873034/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/9856954/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15464123/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15661627/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Interestingly, rs2952768-C has also been associated with decreased drug abuse or dependence, a likely byproduct of decreased sensitivity to opioid exposure [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873034/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">Specifically, this variant has been linked to decreased euphoria or pleasure (reward) in response to opioids. As carriers of this variant do not experience a strong reward response to opioids, they are less likely to use such drugs in the future, and are therefore at lower risk of drug abuse or dependence. In fact, drug abusers are less likely to carry the &lsquo;CC&rsquo; genotype at rs2952768, in comparison to healthy controls [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873034/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The <em>CREB1 </em>gene codes for a protein that regulates the expression of other genes. The rs2952768-C variant is associated with increased <em>CREB1 </em>gene expression, which may result in increased expression of pain-related genes and subsequent decreased sensitivity to painkillers.&nbsp;</span></p> <h2 style="text-align: justify;"><strong>Your CREB1 Results for Sensitivity to Painkillers</strong></h2> <p style="text-align: justify;">*9374846350602544*</p> <h3 style="text-align: justify;"><strong>SNP Summary and Table</strong></h3> <p style="text-align: justify;"><strong>Primary SNP: </strong><strong><em>CREB1 </em></strong><a href="../../../snp/rs2952768/"><strong>rs2952768</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Decreased sensitivity to painkillers.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Normal sensitivity to painkillers.</span></li> </ul> <p style="text-align: justify;">*7946722747135504*</p> <h2 style="text-align: justify;"><strong>Recommendations for Improving Painkiller Sensitivity</strong></h2> <p style="text-align: justify;"><span style="font-weight: 400;">Although increased expression of </span><em><span style="font-weight: 400;">CREB1 </span></em><span style="font-weight: 400;">is associated with decreased sensitivity to painkillers, lowering its expression may be detrimental to memory formation and consolidation, as well as may increase the risk of drug abuse and dependence.&nbsp;</span></p> <p style="text-align: justify;"><span style="font-weight: 400;">It is therefore not a good idea to try and decrease the expression of </span><em><span style="font-weight: 400;">CREB1</span></em><span style="font-weight: 400;">, despite the potential need for rs2952768-C carriers to increase their painkiller dosage when they are experiencing acute or chronic pain-related symptoms. </span></p>
287 | content_snp_table_9374846350602544_key == 9374846350602544
287 | content_snp_table_9374846350602544_blur == True
287 | content_snp_table_9374846350602544_hidden == False
287 | content_learn_more_7946722747135504_key == 7946722747135504
287 | content_learn_more_7946722747135504_blur == True
287 | content_learn_more_7946722747135504_hidden == False
287 | content_learn_more_7946722747135504_text == N/A
rsIDs = rs2952768
rsStatus = rs2952768,,chr2,207629510,T,A,C,G,24,0,Normal
