288 | id == 288
288 | category_id == 19
288 | category_order == 16
288 | category_name == Pain
288 | category_color == #C47AC0
288 | slug == LRP1-pain
288 | title == Do People With Migraines Have Difficulty Clearing Beta Amyloid? (LRP1)
288 | meta_description == The LRP1 protein helps clear cellular debris and protects brain cells from damage. Can it also protect you from migraines?
288 | summary == <p><strong>The LRP1 protein helps clear cellular debris and protects brain cells from damage. Can it also protect you from migraines? Find out here.</strong></p>
288 | overall_score_text == Migraine Score (based on LRP1)
288 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/LRP1--Pain-Headaches-Migraine.jpg
288 | author_id == 1
288 | author_name == Jasmine Foster
288 | author_title == BSc, BEd
288 | author_order == 36
288 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
288 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
288 | reviewer == None
288 | medical_reviewer_id == 11
288 | medical_reviewer_name == Puya Yazdi
288 | medical_reviewer_title == MD
288 | publish_date == 2020
288 | publish_date == 8
288 | publish_date == 26
288 | avg_rating == 5.0
288 | tags_id == 510
288 | tags_name == Caffeine
288 | tags_id == 69
288 | tags_name == Headache
288 | tags_id == 643
288 | tags_name == LRP1 Gene
288 | tags_id == 92
288 | tags_name == Magnesium
288 | tags_id == 31
288 | tags_name == Migraine
288 | tags_id == 71
288 | tags_name == Pain
288 | permissions_favorite == False
288 | permissions_rate == False
288 | content_article == <p><em><span style="font-weight: 400;">If you have persistent or unexplained pain, it is important to discuss these concerns with your doctor. The information in this post is presented for educational purposes only, and should not be used to replace standard medical care.</span></em></p> <h2><span style="font-weight: 400;">What is LRP1?</span></h2> <p><span style="font-weight: 400;">The </span><a href="../../../gene/lrp1/"><em><span style="font-weight: 400;">LRP1</span></em></a> <span style="font-weight: 400;">gene encodes a cholesterol receptor called LDL related receptor protein 1 (LRP1) [</span><a href="https://ghr.nlm.nih.gov/gene/LRP1"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The LRP1 protein helps balance fats and clear out cellular waste products. It is essential for effectively disposing of beta-amyloid, a protein that builds up dangerously in the brains of people with Alzheimer&rsquo;s disease [</span><a href="https://ghr.nlm.nih.gov/gene/LRP1"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">LRP1 also appears to be important for keeping the arteries and veins healthy and strong [</span><a href="https://www.ahajournals.org/doi/10.1161/ATVBAHA.118.311882"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">LRP1</span></em><span style="font-weight: 400;"> gene is physically nearby to the </span><a href="../../../gene/stat6/"><em><span style="font-weight: 400;">STAT6</span></em></a><span style="font-weight: 400;"> gene, and some of the genetic associations with one gene will carry over to the other [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331903/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h2><span style="font-weight: 400;">LRP1 Variants &amp; Migraine</span></h2> <p><span style="font-weight: 400;">Three variants of </span><em><span style="font-weight: 400;">LRP1</span></em><span style="font-weight: 400;"> have been associated with migraines: </span><a href="../../../snp/rs11172113/"><span style="font-weight: 400;">rs11172113</span></a><span style="font-weight: 400;">, </span><a href="../../../snp/rs4559/"><span style="font-weight: 400;">rs4559</span></a><span style="font-weight: 400;">, and </span><a href="http://selfdecode.com/snp/rs113953523/"><span style="font-weight: 400;">rs113953523</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125402/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041123/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The &lsquo;T&rsquo; allele of rs11172113 has been associated with increased incidence of migraines compared to the relatively protective &lsquo;C&rsquo; allele. The link between this allele and migraines is highly significant and has been repeated in at least nine studies [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125402/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031047/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898025/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Another variant, rs4559, is linked to two genes: </span><em><span style="font-weight: 400;">LRP1 </span></em><span style="font-weight: 400;">and the nearby </span><em><span style="font-weight: 400;">STAT6</span></em><span style="font-weight: 400;">. The &lsquo;T&rsquo; allele here is more common in people with migraines; however, both the &lsquo;C&rsquo; and &lsquo;T&rsquo; alleles are very common, and the link here may be weaker than at other variants [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041123/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Finally, the rare &lsquo;A&rsquo; allele at rs113953523 has been strongly linked to migraines. Less than 1% of all people worldwide (2.2% of Europeans) have a copy of this allele [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041123/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">LRP1 helps clear out cellular waste, including beta amyloid from the brain. At least three variants of the </span><em><span style="font-weight: 400;">LRP1</span></em><span style="font-weight: 400;"> gene have been associated with migraines.</span></span></p> <h2><span style="font-weight: 400;">Your LRP1 Results for Migraine</span></h2> <p>*6183058756397564*</p> <h3><span style="font-weight: 400;">SNP Summary and Table</span></h3> <p><strong>LRP1 rs11172113</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with migraine</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Possibly protective against migraines</span></li> </ul> <p><strong>LRP1 rs4559</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with increased incidence of migraines</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with migraine</span></li> </ul> <p><strong>LRP1 rs113953523</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with migraine</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with increased incidence of migraines</span></li> </ul> <p>*2760164847985458*</p> <h2><span style="font-weight: 400;">Recommendations for Preventing Migraine</span></h2> <p>*1146420179717819*</p> <h3><span style="font-weight: 400;">Diet</span></h3> <h4><span style="font-weight: 400;">Coffee</span></h4> <p><span style="font-weight: 400;">A combination of caffeine and rifampicin has been found to increase the expression of </span><em><span style="font-weight: 400;">LRP1</span></em><span style="font-weight: 400;"> in the brain. This combination may have a protective effect against Alzheimer&rsquo;s disease, encouraging the clearance of amyloid beta proteins; amyloid beta may also have a connection to migraine with aura [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902015/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.028170"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">It is unclear whether caffeine alone might also increase </span><em><span style="font-weight: 400;">LRP1</span></em><span style="font-weight: 400;"> expression or whether the combination with rifampicin is required. We strongly recommend against taking medications like rifampicin without a prescription from a doctor [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902015/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Caffeine is a part of different FDA-approved drugs for migraine and tension headaches, along with Tylenol, aspirin, sumatriptan, diclofenac, and others [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10524663/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/14756851/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452084/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484257/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256978/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12917936/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170908/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In 2 clinical trials on almost 350 people, caffeine (both oral and intravenous) helped prevent postoperative headaches [</span><a href="https://pubmed.ncbi.nlm.nih.gov/7497559/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/9212763/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Ironically, headache is one of the most common symptoms of caffeine withdrawal, which can be a limitation for its long-term use [</span><a href="https://www.ncbi.nlm.nih.gov/books/NBK430790/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">A combination including caffeine increases </span><em><span style="font-weight: 400;">LRP1 </span></em><span style="font-weight: 400;">expression and improves the clearance of amyloid beta in brain cells.</span></span></p> <h4><span style="font-weight: 400;">Astaxanthin-Rich Foods</span></h4> <p><span style="font-weight: 400;">Astaxanthin is a red pigment found in some fish, seafood, and algae. It is responsible for the red color of trout, salmon, shrimp, and crabs, among others [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917265/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">This pigment has been found to increase the expression of </span><em><span style="font-weight: 400;">LRP1</span></em><span style="font-weight: 400;"> and thereby protect brain cells from inflammatory damage in a laboratory setting [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642485/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">While astaxanthin&rsquo;s effects on migraine, specifically, are unknown, it has been studied for its ability to suppress pain [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117702/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://clinicaltrials.gov/ct2/show/NCT03664466"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330488/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Astaxanthin is also a fairly strong anti-inflammatory compound and may help reduce the sensation of pain in that way [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680436/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Astaxanthin, a red pigment found in fish, seafood, and algae, increases the expression of </span><em><span style="font-weight: 400;">LRP1</span></em><span style="font-weight: 400;"> in brain cells and has been studied for its ability to suppress pain.</span></span></p> <h3><span style="font-weight: 400;">Supplements</span></h3> <h4><span style="font-weight: 400;">Magnesium</span></h4> <p><span style="font-weight: 400;">Magnesium is the fourth most abundant mineral found in our body. It is essential to all living cells and vital for numerous physiological functions [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592895/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775240/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Sufficient magnesium is required for beta amyloid to be cleared from the brain. Researchers believe that magnesium promotes the clearance of beta amyloid by increasing the expression of </span><em><span style="font-weight: 400;">LRP1</span></em><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29383689/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Magnesium stores may be unusually low in patients with migraine and other pain disorders. Some doctors may recommend magnesium supplements to reduce pain by correcting this deficiency [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22271372/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22426836/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Otherwise, the richest dietary sources of magnesium include spinach, nuts, and legumes. Most people get enough magnesium from their food [</span><a href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Magnesium appears to be required for LRP1 to clear beta amyloid from the brain, and magnesium deficiency is common in migraine.</span></p>
288 | content_snp_table_6183058756397564_key == 6183058756397564
288 | content_snp_table_6183058756397564_blur == True
288 | content_snp_table_6183058756397564_hidden == False
288 | content_learn_more_2760164847985458_key == 2760164847985458
288 | content_learn_more_2760164847985458_blur == True
288 | content_learn_more_2760164847985458_hidden == False
288 | content_learn_more_2760164847985458_text == Based on the variants we looked at, your LRP1 gene is associated with somewhat reduced beta amyloid clearance. However, this doesn't necessarily reflect your overall risk of migraine, just one gene related to it. Caffeine, astaxanthin, and magnesium may help. Keep scrolling to find out more.
288 | content_recommendation_1146420179717819_key == 1146420179717819
288 | content_recommendation_1146420179717819_blur == True
288 | content_recommendation_1146420179717819_hidden == False
rsIDs = rs113953523,rs11172113,rs4559
rsStatus = rs113953523,LRP1,chr12,57146051,G,A,,,24,10,HET
rsStatus = rs11172113,LRP1,chr12,57133500,T,C,G,,27,0,Normal
rsStatus = rs4559,NAB2,chr12,57095865,C,T,,,16,13,HET
