290 | id == 290
290 | category_id == 16
290 | category_order == 13
290 | category_name == Gut Health
290 | category_color == #C47AC0
290 | slug == CD209-gut
290 | title == Can This Gene Influence Your Risk of Gut Inflammation? (CD209)
290 | meta_description == CD209 is an immune system protein that has been associated with ulcerative colitis and celiac disease. Learn more here.
290 | summary == <p style="text-align:justify"><strong>CD209 is an immune system protein that recognizes harmful bacteria and activates the immune response. A variant has been associated with an increased incidence of ulcerative colitis and celiac disease in people otherwise not predisposed to these conditions. Read below to learn more.</strong></p>
290 | overall_score_text == Your Gut Inflammation Score (based on CD209)
290 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CD209--Gut-inflammation.jpg
290 | author_id == 12
290 | author_name == Carlos Tello
290 | author_title == PhD
290 | author_order == 55
290 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/CarlosTello.webp
290 | author_intro == <p><strong>Carlos received his PhD and MS from the Universidad de Sevilla.</strong></p>    <p>Carlos spent 9 years in the laboratory investigating mineral transport in plants. He then started working as a freelancer, mainly in science writing, editing, and consulting. Carlos is passionate about learning the mechanisms behind biological processes and communicating science to both academic and non-academic audiences. He strongly believes that scientific literacy is crucial to maintain a healthy lifestyle and avoid falling for scams.</p>
290 | author_social_media_name == linkedin
290 | author_social_media_icon == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/social-icon/linkedin.png
290 | author_social_order == 1
290 | author_social_link == https://www.linkedin.com/in/carlos-tello-lacal-b946b4a7/
290 | reviewer == None
290 | medical_reviewer_id == 11
290 | medical_reviewer_name == Puya Yazdi
290 | medical_reviewer_title == MD
290 | publish_date == 2020
290 | publish_date == 8
290 | publish_date == 27
290 | avg_rating == 5.0
290 | tags_id == 518
290 | tags_name == CD209 Gene
290 | tags_id == 213
290 | tags_name == Celiac Disease
290 | tags_id == 648
290 | tags_name == Dendritic Cells
290 | tags_id == 194
290 | tags_name == Gut Health
290 | tags_id == 308
290 | tags_name == Gut Inflammation
290 | tags_id == 649
290 | tags_name == Macrophages
290 | tags_id == 196
290 | tags_name == Ulcerative Colitis
290 | permissions_favorite == False
290 | permissions_rate == False
290 | content_article == <p><em><span style="font-weight: 400;">This article is for informational purposes only. None of the information here should be taken as medical advice. If you have gut inflammation symptoms, seek medical help immediately. </span></em><em><span style="font-weight: 400;">Keep in mind that these results are based on association studies, which are correlative and aren&rsquo;t necessarily causative. In addition, any single genetic variant will typically contribute only a small proportion to the overall risk of the condition, and non-genetic factors play a large role in developing a condition as well. Therefore, just because you have one of these genotypes does not necessarily mean you are at increased risk of developing this condition!</span></em></p> <h2><strong>The <em>CD209 </em>Gene In the Immune Response</strong></h2> <p><a href="../../../gene/cd209/"><em><span style="font-weight: 400;">CD209</span></em></a> <span style="font-weight: 400;">encodes a type of protein called a &lsquo;C-lectin&rsquo;, meaning it can bind to some carbohydrates. CD209 recognizes molecules on the surface of some bacteria and activates immune responses [</span><a href="https://ghr.nlm.nih.gov/gene/CD209"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126011/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12574325/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">This protein is found on the surface of two immune cell types [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16978536/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Macrophages: upon recognition by CD209, these cells engulf and &lsquo;eat&rsquo; bacteria.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Dendritic cells: binding of the bacteria to CD209 promotes the migration of these cells to inflammation sites, where they stimulate the development of immature T cells.</span></li> </ul> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">CD209 is an immune system protein that recognizes bacteria and activates the immune response.</span></p> <h2><strong><em>CD209</em> Variants &amp; Gut Inflammation</strong></h2> <p><span style="font-weight: 400;">Rather than causing gut issues, the minor &lsquo;G&rsquo; allele at </span><a href="../../../snp/rs4804803/"><span style="font-weight: 400;">rs4804803</span></a><span style="font-weight: 400;"> suppresses the protective effects of certain </span><em><span style="font-weight: 400;">HLA </span></em><span style="font-weight: 400;">variants.</span></p> <p><span style="font-weight: 400;">For instance, this polymorphism isn&rsquo;t associated with </span><a href="https://selfhacked.com/blog/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections/"><span style="font-weight: 400;">IBD</span></a><span style="font-weight: 400;"> but increased susceptibility to </span><a href="https://selfhacked.com/blog/ulcerative-colitis/"><span style="font-weight: 400;">ulcerative colitis</span></a><span style="font-weight: 400;"> in carriers of a protective variant at </span><a href="../../../chemical/hla-dr3-antigen/"><em><span style="font-weight: 400;">HLA-DR3</span></em></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241584/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">Similarly, this variant wasn&rsquo;t associated with celiac disease but increased susceptibility in people not carrying the risk variant at </span><a href="../../../gene/hla-dq/"><em><span style="font-weight: 400;">HLA-DQ2</span></em></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087754/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Because this variant reduces gene expression, the lower immune response may increase the persistence of harmful bacteria in the gut and cause chronic inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096904/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Interestingly, CD209 could bind to carbohydrate-bound proteins from peanuts, soy, tree nuts, egg, and milk in test tubes, and activated dendritic cells. This suggests a role for this protein in food allergies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26948687/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">An underactive </span><em><span style="font-weight: 400;">CD209 </span></em><span style="font-weight: 400;">variant increases the risk of ulcerative colitis and celiac disease in people otherwise not susceptible to these conditions. Preliminary research suggests a role for this protein in food allergies.</span></span></p> <h2><strong>Your <em>CD209</em> Results for Gut Inflammation</strong></h2> <p>*5126389789887804*</p> <p>&nbsp;</p> <h3><span style="font-weight: 400;">SNP Summary and Table</span></h3> <p><strong>CD209 rs4804803</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with gut issues</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Increases the risk of ulcerative colitis and celiac disease in people otherwise not predisposed to these conditions</span></li> </ul> <p>&nbsp;</p> <p>*8337201442790954*</p> <p>&nbsp;</p> <h2><strong>Recommendations To Reduce Gut Inflammation</strong></h2> <p><em><span style="font-weight: 400;">You may try the complementary approaches listed below if you and your doctor determine that they could be appropriate for you. Discuss the strategies listed here with your doctor. Remember that none of them should ever be done in place of what your doctor recommends or prescribes.</span></em></p> <p>*8337201442790954*</p> <p>&nbsp;</p> <h3><strong>Korean Red Ginseng</strong></h3> <p><span style="font-weight: 400;">Korean red </span><a href="https://selfhacked.com/blog/ginseng/"><span style="font-weight: 400;">ginseng</span></a><span style="font-weight: 400;"> contains polysaccharides that can bind to C-type lectin receptors like CD209 and boost the immune response. This plant is also rich in antiinflammatory chemicals called </span><a href="https://www.selfhacked.com/blog/ginseng/"><span style="font-weight: 400;">ginsenosides</span></a><span style="font-weight: 400;"> and responsible for many of its effects [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223067/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260618"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The active compounds of ginseng reduced inflammation and promoted tissue regeneration in the guts of mice and rats with colitis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293438/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30212750/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32468636/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Korean red ginseng may bind to CD209, boost the immune response, and suppress gut inflammation.</span></p>
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290 | content_learn_more_8537905492934028_text == Based on the variants we looked at, your CD209 gene is associated with an increased risk of ulcerative colitis and celiac disease. However, this doesn't necessarily reflect your overall risk of gut inflammation, just one gene related to it. Korean red ginseng may help. Keep scrolling to find out more.
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rsIDs = rs4804803
rsStatus = rs4804803,CD209,chr19,7747847,A,G,,,40,0,Normal
