291 | id == 291
291 | category_id == 16
291 | category_order == 13
291 | category_name == Gut Health
291 | category_color == #C47AC0
291 | slug == NLRP3-IBD
291 | title == Can This Gene Influence Your Risk of Gut Inflammation? (NLRP3)
291 | meta_description == NLP3 is a pro-inflammatory protein that has been associated with ulcerative colitis and celiac disease. Learn more here.
291 | summary == <p style="text-align:justify"><strong>NLRP3 is the sensor component of the NLRP3 inflammasome, which causes inflammation by producing cytokines. Certain variants have been associated with an increased incidence of ulcerative colitis and celiac disease. Read below to learn more.</strong></p>
291 | overall_score_text == Your Gut Inflammation Score (based on NLRP3)
291 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/NLRP3--Gut-inflammation.jpg
291 | author_id == 12
291 | author_name == Carlos Tello
291 | author_title == PhD
291 | author_order == 55
291 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/CarlosTello.webp
291 | author_intro == <p><strong>Carlos received his PhD and MS from the Universidad de Sevilla.</strong></p>    <p>Carlos spent 9 years in the laboratory investigating mineral transport in plants. He then started working as a freelancer, mainly in science writing, editing, and consulting. Carlos is passionate about learning the mechanisms behind biological processes and communicating science to both academic and non-academic audiences. He strongly believes that scientific literacy is crucial to maintain a healthy lifestyle and avoid falling for scams.</p>
291 | author_social_media_name == linkedin
291 | author_social_media_icon == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/social-icon/linkedin.png
291 | author_social_order == 1
291 | author_social_link == https://www.linkedin.com/in/carlos-tello-lacal-b946b4a7/
291 | reviewer == None
291 | medical_reviewer_id == 11
291 | medical_reviewer_name == Puya Yazdi
291 | medical_reviewer_title == MD
291 | publish_date == 2020
291 | publish_date == 8
291 | publish_date == 27
291 | avg_rating == 5.0
291 | tags_id == 195
291 | tags_name == Crohn's Disease
291 | tags_id == 194
291 | tags_name == Gut Health
291 | tags_id == 308
291 | tags_name == Gut Inflammation
291 | tags_id == 73
291 | tags_name == IBD
291 | tags_id == 650
291 | tags_name == NLRP3 Gene
291 | tags_id == 29
291 | tags_name == ULK4 Gene
291 | permissions_favorite == False
291 | permissions_rate == False
291 | content_article == <p><em><span style="font-weight: 400;">This article is for informational purposes only. None of the information here should be taken as medical advice. If you suspect you may have digestive issues, seek medical help immediately. </span></em><em><span style="font-weight: 400;">Keep in mind that these results are based on association studies, which are correlative and aren&rsquo;t necessarily causative. In addition, any single genetic variant will typically contribute only a small proportion to the overall risk of the condition, and non-genetic factors play a large role in developing a condition as well. Therefore, just because you have one of these genotypes does not necessarily mean you are at increased risk of developing this condition!</span></em></p> <h2><strong>The <em>NLRP3 </em>Gene In Inflammatory Conditions</strong></h2> <p><a href="../../../gene/NLRP3/"><em><span style="font-weight: 400;">NLRP3</span></em></a> <span style="font-weight: 400;">is the sensor component of the NLRP3 inflammasome. Once this complex has been activated in response to pathogens and other damage-associated signals, its effector protein CASP1 produces the inflammatory cytokines </span><a href="http://selfhacked.com/blog/interleukin-1/"><span style="font-weight: 400;">IL-1&beta;</span></a><span style="font-weight: 400;"> and </span><a href="http://www.selfdecode.com/gene/IL18/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">IL-18</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163918/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">When it comes to inflammatory conditions, the NLRP3 inflammasome is a double-edged sword. On the one hand, its overactivation causes widespread inflammation and autoimmune conditions. On the other hand, a reduced immune response to foreign antigens may cause chronic inflammation [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026862/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">NLRP3 is the sensor component of a protein complex that produces inflammatory cytokines.</span></p> <h2><strong><em>NLRP3 </em>Variants &amp; Gut Inflammation</strong></h2> <p><span style="font-weight: 400;">The &lsquo;GG&rsquo; genotype of </span><a href="../../../snp/rs10754558/"><span style="font-weight: 400;">rs10754558</span></a><span style="font-weight: 400;"> is approximately 2.5 times more common among people with ulcerative colitis, while &lsquo;CG&rsquo; is protective. Interestingly, this variant has also been associated with severe food allergies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29102545/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25297810/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19767079/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Two other minor variants, &lsquo;C&rsquo; at </span><a href="../../../snp/rs3806265/"><span style="font-weight: 400;">rs3806265</span></a><span style="font-weight: 400;"> and &lsquo;T&rsquo; at rs4925648, were also associated with an increased incidence of Crohn&rsquo;s disease in the same British study. Conversely, the minor &lsquo;A&rsquo; variant at rs3738447 was protective [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20403135/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In the case of the&nbsp; </span><a href="../../../snp/rs10733113/"><span style="font-weight: 400;">rs10733113</span></a><span style="font-weight: 400;">, </span><a href="../../../snp/rs4353135/"><span style="font-weight: 400;">rs4353135</span></a><span style="font-weight: 400;">, and rs4266924 polymorphisms, the major variants&nbsp; (&lsquo;G&rsquo;, &lsquo;T&rsquo;, and &lsquo;A&rsquo;, respectively) were the ones associated with Crohn&rsquo;s disease in a Canadian study [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728932/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Some of the variants associated with </span><a href="https://selfhacked.com/blog/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections/"><span style="font-weight: 400;">IBD</span></a><span style="font-weight: 400;"> increase </span><em><span style="font-weight: 400;">NLRP3 </span></em><span style="font-weight: 400;">expression and activity, while others&nbsp; reduce it [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19767079/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20403135/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889178/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26033552/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24295199/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Several </span><em><span style="font-weight: 400;">NLRP3 </span></em><span style="font-weight: 400;">variants, often increasing its activity, have been associated with a higher incidence of Crohn&rsquo;s disease and ulcerative colitis.</span></span></p> <h2><strong>Your NLRP3 Results for Gut Inflammation</strong></h2> <p>*8993053452486152*</p> <p>&nbsp;</p> <h3><strong>SNP Summary and Table</strong></h3> <p><strong>NLRP3 rs10754558&nbsp;</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with gut issues</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with ulcerative colitis</span></li> </ul> <p><strong>NLRP3 rs3806265</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Not associated with gut issues</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with Crohn&rsquo;s disease</span></li> </ul> <p><strong>NLRP3 rs10733113</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Associated with Crohn&rsquo;s disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Not associated with gut issues</span></li> </ul> <p><strong>NLRP3 rs4353135</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with Crohn&rsquo;s disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with gut issues</span></li> </ul> <p>&nbsp;</p> <p>*8032791809021982*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Reduce Gut Inflammation</strong></h2> <p><em><span style="font-weight: 400;">You may try the complementary approaches listed below if you and your doctor determine that they could be appropriate for you. Discuss the strategies listed here with your doctor. Remember that none of them should ever be done in place of what your doctor recommends or prescribes.</span></em></p> <p>*7768852320121151*</p> <p>&nbsp;</p> <h3><strong>Diet</strong></h3> <h4><strong>Resistant Starch/Butyrate</strong></h4> <p><span style="font-weight: 400;">In animal studies, </span><a href="https://selfhacked.com/blog/butyrate-health-benefits/"><span style="font-weight: 400;">butyrate</span></a><span style="font-weight: 400;"> protected the gut by blocking NLRP3 activation, which reduced inflammation and preserved gut barrier function [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30138914/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31347703/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">So far, butyrate&rsquo;s potential benefits have been better studied in ulcerative colitis than in Crohn&rsquo;s disease. However, in one study of 13 people with Crohn&rsquo;s disease, a type of IBD, butyrate supplements improved 69% of cases, with symptoms completely disappearing in 54% (seven participants) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299284/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12769445"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16225487"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/8943981"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10795763"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Butyrate is available as a supplement; dietary factors also affect how much butyrate is produced by your gut bacteria. The best foods to increase butyrate production are those with plenty of resistant starches&mdash;starch that you can&rsquo;t digest, but that the gut flora can. Baked potatoes and green bananas are two good sources of resistant starch [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299284/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.eurekalert.org/pub_releases/2013-04/fi-rsc042513.php"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627159/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Diets rich in resistant starch increase butyrate production by the gut bacteria. This compound can improve IBD by reducing inflammation and preserving gut barrier function, in part through its inhibitory effects on NLRP3 activation.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Probiotics</strong></h4> <p><span style="font-weight: 400;">In animal studies, supplementation with </span><a href="http://selfhacked.com/blog/l-rhamnosus/"><em><span style="font-weight: 400;">Lactobacillus rhamnosus</span></em></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/l-johnsonii/"><em><span style="font-weight: 400;">L. johnsonii</span></em></a><span style="font-weight: 400;">, and Enterococcus faecium improved intestinal damage and inflammation caused by drugs and bacterial infections, in part by reducing </span><em><span style="font-weight: 400;">NLRP3 </span></em><span style="font-weight: 400;">expression [</span><a href="https://pubmed.ncbi.nlm.nih.gov/32229117/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32823867/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28872975/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895498/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">People with IBD often have impaired </span><a href="https://www.selfhacked.com/blog/gut-bacteria-microbiome/"><span style="font-weight: 400;">gut microbiome</span></a><span style="font-weight: 400;">, which may worsen their disease. </span><a href="https://selfhacked.com/blog/probiotics-good-bacteria/"><span style="font-weight: 400;">Probiotic</span></a><span style="font-weight: 400;"> strains have been studied in people with Crohn&rsquo;s disease, including </span><em><span style="font-weight: 400;">Lactobacillus rhamnosus</span></em><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/l-casei/"><em><span style="font-weight: 400;">Lactobacillus casei</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/b-breve/"><em><span style="font-weight: 400;">Bifidobacterium breve</span></em></a><span style="font-weight: 400;">, </span><a href="https://selfhacked.com/blog/b-longum/"><em><span style="font-weight: 400;">Bifidobacterium longum</span></em></a><span style="font-weight: 400;">, and </span><a href="https://selfhacked.com/blog/s-boulardii/"><em><span style="font-weight: 400;">Saccharomyces </span></em></a><a href="http://selfhacked.com/blog/s-boulardii/"><em><span style="font-weight: 400;">boulardii</span></em></a><span style="font-weight: 400;">. Of these, the first four showed some promise for people with active Crohn&rsquo;s disease, while </span><a href="http://selfhacked.com/blog/s-boulardii/"><em><span style="font-weight: 400;">S. boulardii</span></em></a><span style="font-weight: 400;"> and </span><a href="http://selfhacked.com/blog/l-rhamnosus/"><em><span style="font-weight: 400;">L. rhamnosus</span></em></a> <span style="font-weight: 400;">may be helpful for keeping the disease at bay in patients in remission [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155344/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In a meta-analysis, a blended</span><a href="https://selfhacked.com/blog/probiotics-gut-health/"> <span style="font-weight: 400;">probiotic</span></a><span style="font-weight: 400;"> containing</span> <a href="https://selfhacked.com/blog/l-plantarum/"><em><span style="font-weight: 400;">Lactobacillus</span></em></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/b-longum/"><em><span style="font-weight: 400;">Bifidobacterium</span></em></a><span style="font-weight: 400;"> strains increased remission rates by 1.7x in ulcerative colitis patients. These strains were beneficial in different trials with ulcerative colitis patients [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24280877"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15507864"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15984978"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19174792"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">People with IBD often have an impaired gut microbiome, which can be corrected by taking probiotics. In animal studies, different probiotic strains improved intestinal damage and inflammation, and reduced </span><em><span style="font-weight: 400;">NLRP3 </span></em><span style="font-weight: 400;">expression.</span></span></p> <h4><strong>Curcumin</strong></h4> <p><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">Curcumin</span></a><span style="font-weight: 400;"> is the active ingredient of turmeric with potent anti-inflammatory effects, which it mainly exerts by reducing </span><em><span style="font-weight: 400;">NLRP3 </span></em><span style="font-weight: 400;">expression and activation. In mice with colitis, it relieved the symptoms through this mechanism [</span><a href="https://pubmed.ncbi.nlm.nih.gov/32464325/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29549176/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30396035/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Multiple clinical trials have produced promising results for curcumin in IBD, and further research is currently underway [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29957091"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514688/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153885/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Curcumin is the main active ingredient of turmeric, which shows promise in IBD therapy. It mainly exerts its anti-inflammatory effects by reducing NLRP3 activity.</span></p> <h4><strong>Korean Red Ginseng</strong></h4> <p><span style="font-weight: 400;">Ginseng&rsquo;s active compound </span><a href="https://www.selfhacked.com/blog/ginseng/"><span style="font-weight: 400;">ginsenoside</span></a><span style="font-weight: 400;"> Rg3 suppresses NLRP3 activation. In mice with colitis, it preserved gut barrier function and relieved the symptoms through this mechanism [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31914640/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32521491/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">The active compounds of ginseng reduced inflammation and promoted tissue regeneration in the guts of mice and rats with colitis [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293438/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30212750/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/32468636/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Korean red ginseng improves colitis and preserves gut barrier function, in part by blocking NLRP3 activation.</span></p>
291 | content_snp_table_8993053452486152_key == 8993053452486152
291 | content_snp_table_8993053452486152_blur == True
291 | content_snp_table_8993053452486152_hidden == False
291 | content_learn_more_8032791809021982_key == 8032791809021982
291 | content_learn_more_8032791809021982_blur == True
291 | content_learn_more_8032791809021982_hidden == False
291 | content_learn_more_8032791809021982_text == Based on the variants we looked at, your NLRP3 gene is associated with an increased risk of ulcerative colitis and celiac disease. However, this doesn't necessarily reflect your overall risk of gut inflammation, just one gene related to it. Including resistant starch in your diet may help. Keep scrolling to find out more.
291 | content_recommendation_7768852320121151_key == 7768852320121151
291 | content_recommendation_7768852320121151_blur == True
291 | content_recommendation_7768852320121151_hidden == False
rsIDs = rs3806265,rs10754558,rs3738447,rs4266924,rs4925648,rs4353135,rs10733113
rsStatus = rs3806265,NLRP3,chr1,247423034,T,A,C,G,37,0,Normal
rsStatus = rs10754558,NLRP3,chr1,247448734,G,C,T,,5,27,HET
rsStatus = rs3738447,NLRP3,chr1,247425658,G,A,,,35,0,Normal
rsStatus = rs4266924,OR2B11,chr1,247453832,G,A,C,,7,21,HET
rsStatus = rs4925648,NLRP3,chr1,247417266,C,T,,,31,0,Normal
rsStatus = rs4353135,OR2B11,chr1,247453734,G,C,T,,30,0,Normal
rsStatus = rs10733113,OR2B11,chr1,247459055,A,C,G,T,29,0,Normal
