293 | id == 293
293 | category_id == 19
293 | category_order == 16
293 | category_name == Pain
293 | category_color == #C47AC0
293 | slug == SCN10A-pain-sensitivity
293 | title == A Crucial Gene in Pain Perception (SCN10A)
293 | meta_description == The SCN10A gene plays a crucial role in pain perception. Click to learn how variants in this gene influence pain sensitivity.
293 | summary == <p><strong>The <em>SCN10A</em> gene encodes a crucial protein for pain perception. Read this post to learn how variants in this gene influence pain sensitivity.</strong></p>
293 | overall_score_text == Your Pain Sensitivity Score (Based on SCN10A Gene)
293 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/SCN10A--Pain-Pain-Sensitivity.jpg
293 | author_id == 9
293 | author_name == Aleksa Ristic
293 | author_title == MS (Pharmacy)
293 | author_order == 45
293 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
293 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
293 | reviewer == None
293 | medical_reviewer_id == 11
293 | medical_reviewer_name == Puya Yazdi
293 | medical_reviewer_title == MD
293 | publish_date == 2020
293 | publish_date == 8
293 | publish_date == 28
293 | avg_rating == 5.0
293 | tags_id == 656
293 | tags_name == Clove
293 | tags_id == 134
293 | tags_name == Heart Disease
293 | tags_id == 647
293 | tags_name == Menthol
293 | tags_id == 655
293 | tags_name == NaV1.8 channel
293 | tags_id == 71
293 | tags_name == Pain
293 | tags_id == 601
293 | tags_name == Pain Sensitivity
293 | tags_id == 654
293 | tags_name == SCN10A gene
293 | permissions_favorite == False
293 | permissions_rate == False
293 | content_article == <p><strong><em><span style="font-weight: 400;">If you have persistent or unexplained pain, it is important to discuss these concerns with your doctor. The information in this post is presented for educational purposes only, and should not be used to replace standard medical care.</span></em></strong></p> <h2><strong>The <em>SCN10A</em> Gene in Pain Signaling</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../../gene/scn10a/"><em><span style="font-weight: 400;">SCN10A</span></em></a><span style="font-weight: 400;"> gene encodes one part of a sodium channel, </span><strong>NaV1.8</strong><span style="font-weight: 400;">,</span> <span style="font-weight: 400;">which enables nerves to conduct pain signals. At the same time, this channel helps maintain a normal heart rhythm [</span><a href="https://ghr.nlm.nih.gov/gene/SCN10A"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Not surprisingly, changes in </span><em><span style="font-weight: 400;">SCN10A </span></em><span style="font-weight: 400;">expression can impact pain sensitivity. Mutations that enhance this gene's function are present in some people with chronic nerve pain [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016210/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511073/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>How <em>SCN10A</em> Variants Influence Pain Sensitivity</strong></h3> <p><span style="font-weight: 400;">A team of Chinese researchers has identified two SNPs, </span><a href="../../../snp/rs6795970/"><span style="font-weight: 400;">rs6795970</span></a><span style="font-weight: 400;"> and </span><a href="../../../snp/rs6801957/"><span style="font-weight: 400;">rs6801957</span></a><span style="font-weight: 400;">, associated with sensitivity to mechanical pain. Their minor alleles seem to reduce the NaV1.8 channel&rsquo;s activity, resulting in lower pain sensitivity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011395/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858611/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">So far, the research on pain sensitivity is limited to Chinese people, and it&rsquo;s not sure whether the </span><em><span style="font-weight: 400;">SCN10A</span></em><span style="font-weight: 400;"> variants would have the same effects in other populations.</span></p> <p><span style="font-weight: 400;">Rs6795970 may also play a role in &ldquo;</span><em><span style="font-weight: 400;">hypoalgesic IBD</span></em><span style="font-weight: 400;">," a form of IBD in which the patients don't feel abdominal pain [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277464/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In line with the roles of </span><em><span style="font-weight: 400;">SCN10A</span></em><span style="font-weight: 400;">, different SNPs in this gene correlate with heart function and related disorders [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23872634/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/21076409/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Two <em>SCN10A </em>variants, rs6795970 and rs6801957, have been associated with lower sensitivity to mechanical pain. So far, the research is limited to Chinese people.</span></p> <p>&nbsp;</p> <h2><strong>Your <em>SCN10A</em> Results for Pain Sensitivity</strong></h2> <p>*4963227085897506*</p> <h3><strong>SNP Summary</strong></h3> <p><strong>Primary SNPs:</strong></p> <p><strong><em>SNC10A</em></strong> <a href="../../../snp/rs6795970/"><strong>rs6795970</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = not associated with pain sensitivity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = associated with reduced pain sensitivity</span></li> </ul> <p><strong><em>SNC10A</em></strong> <a href="../../../snp/rs6801957/"><strong>rs6801957</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = not associated with pain sensitivity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = associated with reduced pain sensitivity</span></li> </ul> <p>*9548140232290421*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Reduce Pain</strong></h2> <p><strong><em><span style="font-weight: 400;">You may try the complementary approaches listed below if you and your doctor determine that they could be appropriate for you. Remember that none of them should be done in place of what your doctor recommends or prescribes.</span></em></strong></p> <p>*6714319236873754*</p> <h3><strong>Supplements</strong></h3> <h4><strong>Peppermint Oil/Menthol</strong></h4> <p>Menthol is an age-old ingredient in countless topical painkillers. It produces a cooling sensation by activating the TRPM8 receptors, but it can also reduce pain by blocking the NaV1.8 channels [<a href="https://pubmed.ncbi.nlm.nih.gov/22172548/" target="_blank" rel="noopener">R</a>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/22951274/" target="_blank" rel="noopener">R</a>].</p> <p>One review yielded 31 reports supporting the use of topical menthol for pain relief [<a href="https://pubmed.ncbi.nlm.nih.gov/29524352/" target="_blank" rel="noopener">R</a>].</p> <p>Menthol is the active ingredient of&nbsp;<a href="https://selfhacked.com/blog/peppermint-oil-benefits-uses-side-effects/" target="_blank" rel="noopener">peppermint oil</a>, which successfully relieved headaches in two clinical trials of 73 people [<a href="https://pubmed.ncbi.nlm.nih.gov/7954745/" target="_blank" rel="noopener">R</a>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/8805113/" target="_blank" rel="noopener">R</a>].</p> <p><span>Rubbing a 10% peppermint oil solution is one of the standard treatments for tension headaches in Europe [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27106030/"><span>R</span></a><span>].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Topical menthol and peppermint oil are time-tested natural painkillers. They reduce pain in part by blocking the NaV1.8 channels.</span></p> <h4><strong>Clove</strong></h4> <p><span style="font-weight: 400;">Eugenol, the active ingredient in clove, acts as a local anesthetic by blocking the NaV1.7 and NaV1.8 channels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19376653/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648112/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">In 73 healthy volunteers, a topical gel with clove essential oil applied on the mouth was as effective anesthetic as lidocaine [</span><a href="https://pubmed.ncbi.nlm.nih.gov/16530911/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. Similarly, a topical gel with clove and papaya prevented the pain caused by injection in a trial of 60 children [</span><a href="https://pubmed.ncbi.nlm.nih.gov/32611866/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <p><span style="font-weight: 400;">Multi-ingredient formulations with the essential oils of clove and other herbs reduced pain from ear infections and muscle strain in two small studies [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23274083/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25553684/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Clove is a natural local anesthetic that may lessen the impact of your <em>SCN10A</em> gene.</span></p>
293 | content_snp_table_4963227085897506_key == 4963227085897506
293 | content_snp_table_4963227085897506_blur == True
293 | content_snp_table_4963227085897506_hidden == False
293 | content_learn_more_9548140232290421_key == 9548140232290421
293 | content_learn_more_9548140232290421_blur == True
293 | content_learn_more_9548140232290421_hidden == False
293 | content_learn_more_9548140232290421_text == Based on the variants we looked at, your SCN9A gene is associated with average pain sensitivity. However, this doesn't necessarily reflect your overall pain sensitivity, just one gene related to it. If you experience pain, topical remedies with menthol and clove may be your best gene-based options. Keep reading to learn more.
293 | content_recommendation_6714319236873754_key == 6714319236873754
293 | content_recommendation_6714319236873754_blur == True
293 | content_recommendation_6714319236873754_hidden == False
rsIDs = rs6795970,rs6801957
rsStatus = rs6795970,SCN10A,chr3,38725184,A,G,T,,21,12,HET
rsStatus = rs6801957,SCN10A,chr3,38725824,T,A,C,G,45,0,Normal
