295 | id == 295
295 | category_id == 19
295 | category_order == 16
295 | category_name == Pain
295 | category_color == #C47AC0
295 | slug == MTDH-Migraines-Headaches
295 | title == Can This Gene Increase Your Risk Of Cluster Headaches And Migraines? (MTDH)
295 | meta_description == A MTDH variant may increase your risk of migraines and headaches. Read on to find out more!
295 | summary == <p><strong>Variants of the MTDH gene may make you more susceptible to migraines and headaches. Read on to find out how these variants may be influencing your own migraine risk!</strong></p>
295 | overall_score_text == Head Pain Score (based on MTDH)
295 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/MTDH--Pain-Cluster-Headaches.jpg
295 | author_id == 13
295 | author_name == Lewis Cuthbertson
295 | author_title == PhD
295 | author_order == 12
295 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Lewis_SelfDecode.jpg
295 | author_intro == <p><strong>Lewis completed his PhD in Molecular Microbiology at Northumbria University (UK).</strong></p>    <p>Lewis spent several years researching the biodiversity of bacterial communities in the Arctic and Antarctic, whilst also performing research for a DNA sequencing service, where he was involved in several health based microbiome studies. This gave him an insight into how the highly diverse and invisible to the naked eye portion of human health, can potentially impact an individual&rsquo;s quality of life, driving his desire to help others understand their own complex health needs through the most current scientific research.<br />  &nbsp;</p>
295 | reviewer == None
295 | medical_reviewer_id == 11
295 | medical_reviewer_name == Puya Yazdi
295 | medical_reviewer_title == MD
295 | publish_date == 2020
295 | publish_date == 8
295 | publish_date == 29
295 | avg_rating == 5.0
295 | tags_id == 659
295 | tags_name == Glutamate
295 | tags_id == 69
295 | tags_name == Headache
295 | tags_id == 31
295 | tags_name == Migraine
295 | tags_id == 657
295 | tags_name == MTDH
295 | tags_id == 71
295 | tags_name == Pain
295 | permissions_favorite == False
295 | permissions_rate == False
295 | content_article == <p><em><span style="font-weight: 400;">If you have persistent or unexplained pain, it is important to discuss these concerns with your doctor. The information in this post is presented for educational purposes only, and should not be used to replace standard medical care.</span></em></p> <h2><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">MTDH </span></em><span style="font-weight: 400;">gene and head pain</span></h2> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">The </span><a href="../../../gene/mtdh/"><em><span style="font-weight: 400;">MTDH</span></em></a> <span style="font-weight: 400;">gene encodes for a protein known as metadherin. Metadherin has been associated with reducing GLUT1 transporter protein levels. GLUT1 transporter proteins are the primary glutamate transporters of the brain [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20802479/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Glutamate is an excitatory neurotransmitter which has been suggested as a </span><a href="https://selfhacked.com/blog/migraines-and-headaches-causes-and-solutions/"><span style="font-weight: 400;">migraine</span></a><span style="font-weight: 400;"> active molecule. Higher </span><a href="https://selfhacked.com/blog/glutamate/"><span style="font-weight: 400;">glutamate</span></a><span style="font-weight: 400;"> levels have been observed in migraine patients [</span><a href="https://www.sciencedirect.com/science/article/abs/pii/S0306452209003303?via%3Dihub"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://link.springer.com/article/10.1007/s13311-018-0616-5"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17495624/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <ul> <li style="font-weight: 400;"><em><span style="font-weight: 400;">MTDH </span></em><span style="font-weight: 400;">gene variants may impact GLUT1 transporter levels, which could cause excessive glutamate buildup. This may increase migraine and </span><a href="https://selfhacked.com/blog/natural-treatment-migraines/"><span style="font-weight: 400;">headache</span></a><span style="font-weight: 400;"> risk, however the evidence for this proposed mechanism is indirect and further research is required to confirm the link [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755538/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20802479/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h2><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">MTDH</span></em><span style="font-weight: 400;"> Results for Head Pain</span></h2> <p><strong>*7316088671259529*</strong></p> <h3><span style="font-weight: 400;">SNP Summary and Table</span></h3> <p><strong>[</strong><strong><em>MTDH</em></strong><strong>] </strong><a href="../../../snp/rs1835740/"><strong>rs1835740</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;TT&rsquo; = associated with an increased risk of cluster headaches and migraines. Higher MTDH production [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755538/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20802479/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;CT&rsquo; = associated with an increased risk of cluster headaches and migraines. Higher MTDH production [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755538/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20802479/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;CC&rsquo; = not associated with head pain.</span></li> </ul> <p><strong>*9659067197458993*</strong></p> <h2><strong>Recommendations to reduce your risk of head pain</strong></h2> <p><strong>*4372743412949609*</strong></p> <h3><span style="font-weight: 400;">Diet</span></h3> <p><span style="font-weight: 400;">A </span><a href="https://selfhacked.com/blog/ketogenic-diet-ketosis-health-benefits-physiology-genetics/"><span style="font-weight: 400;">ketogenic diet</span></a><span style="font-weight: 400;"> is thought to reduce risk of migraine. It has been proposed that the diet may increase the availability of glutamate for conversion to GABA, by reducing glutamate&rsquo;s metabolism to aspartate [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28527061/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/books/NBK499830/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722878/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A ketogenic diet primarily consists of high-fats, moderate-proteins, and very-low-carbohydrates. The dietary macronutrients are divided into approximately 55% to 60% fat, 30% to 35% protein and 5% to 10% carbohydrates. Specifically, in a 2000 kcal per day diet, carbohydrates amount up to 20 to 50 g per day [</span><a href="https://www.ncbi.nlm.nih.gov/books/NBK499830/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Also avoid eating the food additive MSG, as this is essentially pure glutamate. A human study found that eating MSG was associated with headaches amongst other symptoms. This could be especially double-down for risk variant carriers, as it has been hypothesised that MSG may further stimulate glutamate receptors. If you do happen to consume MSG, consider eating ginger, as this has been shown to reduce the toxic effects of MSG [</span><a href="https://www.sciencedirect.com/science/article/abs/pii/S0091674997800085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19579948/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/19454881/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><span style="font-weight: 400;">Supplements</span></h3> <p><span style="font-weight: 400;">The following supplements may help with migraines and promoting healthy glutamate levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19454881/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://pubmed.ncbi.nlm.nih.gov/18705538/"><span style="font-weight: 400;"> R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/9484373/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/21-proven-science-based-reasons-magnesium-amazing-including-drawbacks/"><span style="font-weight: 400;">Magnesium</span></a><span style="font-weight: 400;"> - Magnesium is thought to block NMDA receptors. In the presence of glutamate, NMDA receptors normally promote excitatory neurotransmission.</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/riboflavin/"><span>Riboflavin</span></a><span> - Riboflavin reduces the release of glutamate into the brain, which in turn may reduce glutamate toxicity.</span></li> </ul>
295 | content_snp_table_7316088671259529_key == 7316088671259529
295 | content_snp_table_7316088671259529_blur == True
295 | content_snp_table_7316088671259529_hidden == False
295 | content_learn_more_9659067197458993_key == 9659067197458993
295 | content_learn_more_9659067197458993_blur == True
295 | content_learn_more_9659067197458993_hidden == False
295 | content_learn_more_9659067197458993_text == Based on the variant we looked at, your MTDH gene may be associated with risk of developing migraines and headaches. However, this doesn't necessarily reflect your overall head pain risk — just one gene related to it. Read on to find out more.
295 | content_recommendation_4372743412949609_key == 4372743412949609
295 | content_recommendation_4372743412949609_blur == True
295 | content_recommendation_4372743412949609_hidden == False
rsIDs = rs1835740
rsStatus = rs1835740,LOC101927066,chr8,97154685,T,C,,,4,22,HET
