296 | id == 296
296 | category_id == 19
296 | category_order == 16
296 | category_name == Pain
296 | category_color == #C47AC0
296 | slug == FAAH-cannabinoids-pain
296 | title == How Cannabinoids Influence Pain Sensitivity (FAAH)
296 | meta_description == The FAAH gene influences our cannabinoid system. Click to learn about its link with pain sensitivity and check your variants.
296 | summary == <p><strong>Did you know that cannabinoids play a crucial role in pain perception? Read this post to learn the link between the <em>FAAH</em> gene, cannabinoid system, and pain sensitivity.</strong></p>
296 | overall_score_text == Your Pain Sensitivity Score (Based on FAAH Gene)
296 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/FAAH--Pain-Pain-Sensitivity-Pain-Tolerance.jpg
296 | author_id == 9
296 | author_name == Aleksa Ristic
296 | author_title == MS (Pharmacy)
296 | author_order == 45
296 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
296 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
296 | reviewer == None
296 | medical_reviewer_id == 11
296 | medical_reviewer_name == Puya Yazdi
296 | medical_reviewer_title == MD
296 | publish_date == 2020
296 | publish_date == 8
296 | publish_date == 30
296 | avg_rating == 5.0
296 | tags_id == 660
296 | tags_name == Anandamide
296 | tags_id == 662
296 | tags_name == CBD
296 | tags_id == 60
296 | tags_name == Endocannabinoid System
296 | tags_id == 370
296 | tags_name == FAAH Gene
296 | tags_id == 601
296 | tags_name == Pain Sensitivity
296 | tags_id == 663
296 | tags_name == Palmitoylethanolamide
296 | tags_id == 50
296 | tags_name == Stress
296 | permissions_favorite == False
296 | permissions_rate == False
296 | content_article == <h2><strong>Summary</strong></h2> <ul> <li style="font-weight: 400;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">FAAH</span></em><span style="font-weight: 400;"> gene encodes an enzyme that breaks down anandamide, a cannabinoid with painkiller effects.</span></span></li> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Less FAAH = more anandamide = less pain.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Different gene variants can influence pain sensitivity by changing the FAAH enzyme levels.</span></li> <li style="font-weight: 400;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Specific lifestyle changes and supplements may help relieve pain by targeting <em>FAAH</em> gene variants</span></li> </ul> <h2><strong>The <em>FAAH</em> Gene in Pain Perception</strong></h2> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">The </span><a href="http://selfhacked.com/blog/the-bliss-gene-faah-snps-rs324420/"><em><span style="font-weight: 400;">FAAH</span></em></a><span style="font-weight: 400;"> gene encodes an enzyme that breaks down the main internal </span><a href="https://selfhacked.com/blog/49-ways-increase-natural-cannabinoids-without-smoking-pot-including-ways-decrease-cannabinoids/"><span style="font-weight: 400;">cannabinoid</span></a><span style="font-weight: 400;">, anandamide [</span><a href="https://ghr.nlm.nih.gov/gene/FAAH"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Anandamide can reduce </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;">; less FAAH means more anandamide and lower pain sensitivity, and vice versa [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260554/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Some supplements and potential drugs reduce pain by blocking the FAAH enzyme [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429331/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882713/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><a href="https://selfhack.com/blog/the-bliss-gene-faah-snps-rs324420/"><span style="font-weight: 400;">Read this post</span></a><span style="font-weight: 400;"> to learn more about the impact of </span><em><span style="font-weight: 400;">FAAH</span></em><span style="font-weight: 400;"> on mental health, obesity, etc.</span></p> <h2><strong>Your <em>FAAH</em> Results for Pain Sensitivity</strong></h2> <p>*7619404057227661*</p> <p><strong>Primary SNP:</strong></p> <p><strong><em>FAAH</em></strong> <a href="../../../snp/rs324420/"><strong>rs324420</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/26808012/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with lower pain sensitivity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with relatively higher pain sensitivity, compared with &lsquo;A&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele reduces FAAH production and activity; less FAAH=more anandamide=less pain [</span><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123078/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830932/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>Other Important SNPs:</strong></p> <p><strong><em>FAAH</em></strong> <a href="../../../snp/rs3766246/"><strong>rs3766246</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/26808012/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with lower pain sensitivity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with relatively higher pain sensitivity, compared with &lsquo;A&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">This variant also has a weak association with painkiller use for postoperative pain</span></li> </ul> <p><strong><em>FAAH</em></strong> <a href="../../../snp/rs932816/"><strong>rs932816</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564596/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with lower pain sensitivity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with relatively higher pain sensitivity, compared with &lsquo;A&rsquo;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">This variant has also been associated with low back pain [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671913/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*1848312509778429*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Reduce Pain</strong></h2> <p>*1181932123050799*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Avoid Stress</strong></h4> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Chronic </span><a href="https://selfhacked.com/blog/63-factors-raising-stress-cortisol-level-backed-science/"><span style="font-weight: 400;">stress</span></a><span style="font-weight: 400;"> is closely associated with chronic pain [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546756/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27772562/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Stress can enhance</span><em><span style="font-weight: 400;"> FAAH</span></em><span style="font-weight: 400;"> gene expression and enzyme activity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348185/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25083571/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Many strategies to relieve pain&mdash;such as physiotherapy,&nbsp; </span><a href="https://selfhacked.com/blog/acupuncture-benefits-mechanisms-risks/"><span style="font-weight: 400;">acupuncture</span></a><span style="font-weight: 400;">, massage, and </span><a href="https://selfhacked.com/blog/health-benefits-yoga/"><span style="font-weight: 400;">yoga</span></a><span style="font-weight: 400;">&mdash;partly work by reducing stress [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11783835"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26896946"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/16827629/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805350/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Avoiding stress and practicing your favorite relaxation techniques may help reduce pain by targeting your <em>FAAH</em> variants.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Palmitoylethanolamide (PEA)</strong></h4> <ul> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/palmitoylethanolamide-pea/"><span style="font-weight: 400;">Palmitoylethanolamide</span></a><span style="font-weight: 400;"> (PEA) can reduce </span><em><span style="font-weight: 400;">FAAH</span></em><span style="font-weight: 400;"> gene expression [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429331/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">PEA can relieve pain from nerve damage, fibromyalgia, dental interventions, joint dislocation, and more [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22845893/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26815246/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676767/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22558609/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996286/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631430/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h4><strong>CBD Oil</strong></h4> <ul> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/cannabidiol-cbd/"><span style="font-weight: 400;">CBD</span></a><span style="font-weight: 400;">, the active ingredient in cannabis and hemp, can inhibit the FAAH enzyme [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573017/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28120232/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">CBD oil may reduce pain from </span><a href="https://selfhacked.com/blog/causes-symptoms-diagnosis-risk-factors-of-multiple-sclerosis/"><span style="font-weight: 400;">multiple sclerosis</span></a><span style="font-weight: 400;"> and some medical procedures [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/28457055"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/29579828"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12617376"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The research for many other pain types is underway [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27757048/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12617376/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><a href="https://selfhacked.com/blog/can-cbd-oil-relieve-pain/"><span style="font-weight: 400;">Read this post</span></a><span style="font-weight: 400;"> to learn more about the potential of CBD oil to relieve pain.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Palmitoylethanolamide (PEA) and CBD oil may counteract your gene variants and help relieve pain.</span></p>
296 | content_snp_table_7619404057227661_key == 7619404057227661
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296 | content_learn_more_1848312509778429_text == Based on the variants we looked at, your FAAH gene is associated with relatively higher pain sensitivity. However, this doesn't necessarily reflect your overall pain sensitivity, just one gene related to it. Avoid stress and consider taking specific supplements to relieve pain. Keep reading to learn more.
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rsIDs = rs932816,rs3766246,rs324420
rsStatus = rs932816,FAAH,chr1,46394077,G,A,,,25,0,Normal
rsStatus = rs3766246,FAAH,chr1,46399999,A,C,G,T,35,0,Normal
rsStatus = rs324420,FAAH,chr1,46405089,C,A,,,20,13,HET
