297 | id == 297
297 | category_id == 19
297 | category_order == 16
297 | category_name == Pain
297 | category_color == #C47AC0
297 | slug == ADRB1-pain-sensitivity
297 | title == A Gene That Influences Sensitivity to Pain (ADRB1)
297 | meta_description == Variants of ADRB1 can alter pain sensitivity. Click to learn more.
297 | summary == <p style="text-align:justify"><strong>The <em>ADRB1</em> gene encodes ADRB1, a receptor that can alter responses to pain. Variants of <em>ADRB1</em> have been associated with increased pain sensitivity. Scroll&nbsp;to learn more.</strong></p>
297 | overall_score_text == Your Pain Sensitivity Score (based on ADRB1 Gene)
297 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ADRB1--Pain-Pain-Sensitivity.jpg
297 | author_id == 14
297 | author_name == Shany Lahan
297 | author_title == MS (Neuroscience)
297 | author_order == 5
297 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Shany.webp
297 | author_intro == <p>Shany received her MSc in Neuroscience from Western University.</p>    <p>Prior to joining SelfDecode, Shany conducted research related to Alzheimer&rsquo;s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode&nbsp;with a mission to help others optimize their health and wellbeing &ndash; as well as help them understand the science behind it all.</p>
297 | reviewer == None
297 | medical_reviewer_id == 11
297 | medical_reviewer_name == Puya Yazdi
297 | medical_reviewer_title == MD
297 | publish_date == 2020
297 | publish_date == 8
297 | publish_date == 31
297 | avg_rating == 5.0
297 | tags_id == 664
297 | tags_name == ADRB1 Gene
297 | tags_id == 52
297 | tags_name == Norepinephrine
297 | tags_id == 598
297 | tags_name == Opioids
297 | tags_id == 601
297 | tags_name == Pain Sensitivity
297 | tags_id == 653
297 | tags_name == Response to Painkillers
297 | permissions_favorite == False
297 | permissions_rate == False
297 | content_article == <h2 style="text-align: justify;"><strong>Summary</strong></h2> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">ADRB1 </span></em><span style="font-weight: 400;">gene</span><span style="font-weight: 400;"> codes for the receptor ADRB1.</span></span></li> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Activation of ADRB1 by the neurotransmitter norepinephrine induces pain.</span></li> <li style="font-weight: 400;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">ADRB1 and opioid-induced pain relief are interconnected.&nbsp;</span></span></li> <li style="font-weight: 400;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">A variant of </span><em><span style="font-weight: 400;">ADRB1 </span></em><span style="font-weight: 400;">can increase sensitivity to cold-induced pain. Supplements may reduce sensitivity, function, or the amount of ADRB1 produced, thus decreasing pain.</span></span></li> <li style="font-weight: 400;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">A variant of </span><em><span style="font-weight: 400;">ADRB1 </span></em><span style="font-weight: 400;">can enhance the metabolism of painkillers in the liver, which can decrease the effectiveness of painkillers. Lifestyle changes can increase natural painkillers in the body, thus counteracting the enhanced metabolism of painkillers in the liver.</span></span></li> </ul> <h2 style="text-align: justify;"><strong><em>ADRB1&nbsp;</em></strong></h2> <p style="text-align: justify;"><strong>The </strong><a href="../../../gene/adrb1/"><strong><em>ADRB1 </em></strong><strong>gene</strong></a><strong> codes for the beta-1 adrenergic receptor (ADRB1). </strong><a href="https://selfhacked.com/blog/norepinephrine-stress-hormone/"><strong>Norepinephrine</strong></a><strong> is a neurotransmitter that binds to and activates ADRB1.&nbsp;</strong></p> <p style="text-align: justify;"><strong>ADRB1 has been shown to be involved in pain;</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">An animal study found that rats given esmolol (a heart medication) experienced a reduced pain response to a toxic substance. Esmolol can physically block norepinephrine from binding to ADRB1 [</span><a href="https://pubmed.ncbi.nlm.nih.gov/11212051/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></li> </ul> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">Women that were prescribed esmolol required less opioids to reduce pain experienced after surgery, </span><strong>suggesting that ADRB1 and opioid-induced pain relief are interconnected</strong><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15377583/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23257656/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h2 style="text-align: justify;"><strong>Your <em>ADRB1 </em>Results for Pain Sensitivity</strong></h2> <p style="text-align: justify;">*3670074482419417*</p> <h3 style="text-align: justify;"><strong>SNP Summary and Table</strong></h3> <p style="text-align: justify;"><strong><em>ADRB1 </em></strong><a href="../../../snp/rs1801252/"><strong>rs1801252</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Increased sensitivity to cold-induced pain in men</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with sensitivity to cold-induced pain</span></li> </ul> <p style="text-align: justify;"><strong><em>ADRB1 </em></strong><a href="../../../snp/rs1801253/"><strong>rs1801253</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with sensitivity to painkillers&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Decreased sensitivity to painkillers in women</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">rs1801253-G might enhance the metabolism of painkillers in the liver [</span><a href="https://pubmed.ncbi.nlm.nih.gov/23257656/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p style="text-align: justify;">*7495676894536853*</p> <h2 style="text-align: left;"><strong>Recommendations to Improve Pain Sensitivity&nbsp;</strong></h2> <p style="text-align: justify;">*5983785710099343*</p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Exercise</strong></h4> <p style="text-align: justify;"><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">Exercise</span></a><span style="font-weight: 400;"> can increase the amount of natural opioids (</span><a href="https://selfhacked.com/blog/endorphins/"><span style="font-weight: 400;">endorphins</span></a><span style="font-weight: 400;">) that the body makes [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104618/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></p> <ul style="text-align: justify;"> <li style="text-align: justify;"><span style="font-weight: 400;">Endorphins can be produced in response to pain and in turn, can decrease the body&rsquo;s pain response [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104618/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]. </span></li> <li style="text-align: justify;">Endorphins might counteract the increased painkiller metabolism associated with rs1801253-G.</li> </ul> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Exercise releases endorphins (natural opioids), which may counteract increased painkiller metabolism.</span></p> <h3 style="text-align: justify;"><strong>Supplements</strong></h3> <h4 style="text-align: justify;"><span style="font-weight: 400;"><a href="https://selfhacked.com/blog/benefits-yohimbine/" target="_blank" rel="noopener"><strong>Yohimbine</strong></a>&nbsp;</span><span style="font-weight: 400;">&nbsp;</span></h4> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">Is an active compound derived from the bark of an African tree;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Was found to enhance adaptation to pain and therefore, reduce pain sensitivity, in a study of 20 healthy participants [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28627793/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">];</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Combined with an antidepressant, significantly reduced sensitivity and function of beta adrenergic receptors after 4 days [</span><a href="https://pubmed.ncbi.nlm.nih.gov/2868116/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">];</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Is not FDA-approved and has a number of associated side effects; therefore, it&rsquo;s important to consult with your doctor before supplementing with yohimbine.</span></li> </ul> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Yohimbine may reduce sensitivity and function of beta adrenergic receptors, thus reducing pain sensitivity.</span></p> <h4 style="text-align: justify;"><a href="https://selfhacked.com/blog/literally-everything-wanted-know-zinc-backed-science/" target="_blank" rel="noopener"><strong>Zinc</strong></a></h4> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">Is an essential nutrient that has been shown to decrease the amount of ADRB1 produced [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26446862/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/27185063/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">];&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">In the form of zinc sulfate, was found to significantly reduce cramping pain associated with menstruation in a study of 150 high school students [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24559600/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">];</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Can also be found in various foods, including oysters, red meat, poultry, and beans [</span><a href="https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p style="text-align: justify;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Zinc may decrease the amount of ADRB1 produced, thus reducing pain.&nbsp;</span></p>
297 | content_snp_table_3670074482419417_key == 3670074482419417
297 | content_snp_table_3670074482419417_blur == True
297 | content_snp_table_3670074482419417_hidden == False
297 | content_learn_more_7495676894536853_key == 7495676894536853
297 | content_learn_more_7495676894536853_blur == True
297 | content_learn_more_7495676894536853_hidden == False
297 | content_learn_more_7495676894536853_text == Based on the variants we looked at, your ADRB1 gene is associated with somewhat increased sensitivity to pain. However, this doesn't necessarily reflect your overall risk of pain sensitivity; it’s just one gene related to it. Exercise, yohimbine supplements, and zinc supplements may help. Keep scrolling to find out more.
297 | content_recommendation_5983785710099343_key == 5983785710099343
297 | content_recommendation_5983785710099343_blur == True
297 | content_recommendation_5983785710099343_hidden == False
rsIDs = rs1801252,rs1801253
rsStatus = rs1801252,ADRB1,chr10,114044277,A,G,,,25,0,Normal
rsStatus = rs1801253,ADRB1,chr10,114045297,G,A,C,,26,0,Normal
