300 | id == 300
300 | category_id == 19
300 | category_order == 16
300 | category_name == Pain
300 | category_color == #C47AC0
300 | slug == HTR2A-serotonin-headache
300 | title == The Link Between Serotonin Receptors and Headaches (HTR2A)
300 | meta_description == The HTR2A gene encodes a serotonin receptor, 5-HT2A. Click to learn about its link with headaches.
300 | summary == <p style="text-align:justify"><strong>High serotonin can be your friend or foe&mdash;depending on your genes! Read this post to learn the link between the HTR2A gene, serotonin, and headaches.</strong></p>
300 | overall_score_text == Your Headache Score (Based on HTR2A Gene)
300 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/HTR2A-Headaches.jpg
300 | author_id == 9
300 | author_name == Aleksa Ristic
300 | author_title == MS (Pharmacy)
300 | author_order == 45
300 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
300 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
300 | reviewer == None
300 | medical_reviewer_id == 11
300 | medical_reviewer_name == Puya Yazdi
300 | medical_reviewer_title == MD
300 | publish_date == 2020
300 | publish_date == 9
300 | publish_date == 1
300 | avg_rating == 5.0
300 | tags_id == 673
300 | tags_name == 5-HT2A receptor
300 | tags_id == 646
300 | tags_name == Acupuncture
300 | tags_id == 69
300 | tags_name == Headache
300 | tags_id == 672
300 | tags_name == HTR2A gene
300 | tags_id == 92
300 | tags_name == Magnesium
300 | tags_id == 31
300 | tags_name == Migraine
300 | tags_id == 71
300 | tags_name == Pain
300 | tags_id == 309
300 | tags_name == Serotonin
300 | permissions_favorite == False
300 | permissions_rate == False
300 | content_article == <h2><strong>Summary</strong></h2> <ul> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The HTR2A gene encodes a serotonin receptor, 5-HT2A; activation of this receptor may trigger headaches.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Two variants in this gene may <span style="font-weight: 400;">affect the activity of 5-HT2A receptors</span>; they have been associated with higher odds of headache.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Specific supplements and lifestyle modifications may relieve headaches by targeting your gene variants.</span></li> </ul> <h2><strong>The HTR2A Gene, Serotonin &amp; Headaches</strong></h2> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Impairment in </span><a href="https://www.selfhacked.com/blog/how-to-increase-serotonin"><span style="font-weight: 400;">serotonin</span></a><span style="font-weight: 400;"> secretion plays a significant role in </span><a href="https://selfhacked.com/blog/natural-treatment-migraines/"><span style="font-weight: 400;">headache</span></a><span style="font-weight: 400;"> development, especially migraines [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/17970989/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/2475821/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The HTR2A gene encodes a serotonin receptor, 5-HT2A. Activation of this receptor may cause sudden changes in </span><a href="https://selfhacked.com/blog/15-ways-improve-brain-circulation/"><span style="font-weight: 400;">brain circulation</span></a><span style="font-weight: 400;"> and trigger headaches [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117050/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://link.springer.com/article/10.1134/S1819712411020085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18656400/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/5ht2a-receptors-a-root-cause-of-anxiety-fatigue-sleep-problems-and-cirs/"><span style="font-weight: 400;">Read this post</span></a><span style="font-weight: 400;"> to learn more about the 5-HT2A receptor roles in mental health, </span><a href="https://selfhacked.com/blog/health-benefits-sleep/"><span style="font-weight: 400;">sleep</span></a><span style="font-weight: 400;">, cognition, and more.&nbsp;</span></li> </ul> <h2><strong>Your <em>HTR2A</em> Results for Headaches</strong></h2> <p>*5780202468157896*</p> <p><strong>Primary SNPs:</strong></p> <p><strong><em>HTR2A</em></strong> <a href="../../../snp/rs6313/"><strong>rs6313</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:&nbsp;</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with increased odds of headaches</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - not associated with headaches</span></li> </ul> <p><strong><em>HTR2A</em></strong> <a href="../../../snp/rs6311/"><strong>rs6311</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - associated with increased odds of headaches</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - not associated with headaches</span></li> </ul> <p><em><span style="font-weight: 400;"><strong>Important notes:</strong> the effects of these variants on gene expression and receptor activity are still under investigation. Additionally, 5-HT2A receptor activation has shown conflicting effects on pain signaling, depending on different factors. The bottom line is that impaired serotonin signaling via these receptors plays a major role in headaches.</span></em></p> <p>*1268835898171816*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Relieve Headaches</strong></h2> <p>*6909831117537266*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Acupuncture</strong></h4> <ul> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/acupuncture-benefits-mechanisms-risks/"><span style="font-weight: 400;">Acupuncture</span></a><span style="font-weight: 400;"> is an alternative treatment approach with promising results in managing headaches, especially migraines [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC381326/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977344/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Acupuncture may relieve headaches in part by targeting the 5-HT2A receptors [</span><a href="https://www.sciencedirect.com/science/article/abs/pii/S187638201630124X"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h3><strong>Supplements</strong></h3> <h4><strong>Magnesium</strong></h4> <ul> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/21-proven-science-based-reasons-magnesium-amazing-including-drawbacks/"><span style="font-weight: 400;">Magnesium</span></a><span style="font-weight: 400;"> deficiency can impair serotonin levels and blood flow in the brain, potentially contributing to migraines [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31691193/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21352223/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">People with migraines and other </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> disorders are often deficient in magnesium and may benefit from supplementation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22271372/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22426836/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">High-dose magnesium citrate (600 mg) is possibly effective for migraine prevention [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29131326/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h4><strong>Feverfew</strong></h4> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Folks have traditionally used </span><a href="https://selfhacked.com/blog/feverfew-benefits/"><span style="font-weight: 400;">feverfew</span></a><span style="font-weight: 400;"> for different pain types, including headaches. Clinical trials have confirmed its effectiveness for migraines [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23875764"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12230594"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/16232154"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/2899663"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Feverfew may help with chronic headaches by targeting the 5-HT2A receptor [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11603284"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Acupuncture, magnesium and feverfew may prevent and relieve headaches by targeting your gene variants.</span></p>
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300 | content_learn_more_1268835898171816_text == Based on the variants we looked at, your HTR2A gene is associated with slightly higher odds of headaches. However, this doesn't necessarily reflect your overall risk of headaches, just one gene related to it. Consider supplementing with magnesium, and follow other gene-based tips to relieve headaches. Keep reading to learn more.
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rsIDs = rs6311,rs6313
rsStatus = rs6311,HTR2A,chr13,46897343,C,A,T,,35,0,Normal
rsStatus = rs6313,HTR2A,chr13,46895805,G,A,C,,25,0,Normal
