301 | id == 301
301 | category_id == 16
301 | category_order == 13
301 | category_name == Gut Health
301 | category_color == #C47AC0
301 | slug == FOXO3-gut
301 | title == Can This Gene Influence Your Risk of Gut Inflammation (FOXO3)?
301 | meta_description == FOXO3 reduces gut inflammation and has been associated with milder Crohn’s disease symptoms. Find out more here.
301 | summary == <p style="text-align:justify"><strong>The FOXO3 gene encodes a protein that regulates the expression of other genes. By lowering the levels of inflammatory cytokines, it helps reduce gut inflammation. A variant with increased activity has been associated with milder symptoms of Crohn&rsquo;s disease. Read on to find out.</strong></p>
301 | overall_score_text == Your Gut Inflammation Score (Based on FOXO3)
301 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/FOXO3--Gut-Inflammation.jpg
301 | author_id == 12
301 | author_name == Carlos Tello
301 | author_title == PhD
301 | author_order == 55
301 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/CarlosTello.webp
301 | author_intro == <p><strong>Carlos received his PhD and MS from the Universidad de Sevilla.</strong></p>    <p>Carlos spent 9 years in the laboratory investigating mineral transport in plants. He then started working as a freelancer, mainly in science writing, editing, and consulting. Carlos is passionate about learning the mechanisms behind biological processes and communicating science to both academic and non-academic audiences. He strongly believes that scientific literacy is crucial to maintain a healthy lifestyle and avoid falling for scams.</p>
301 | author_social_media_name == linkedin
301 | author_social_media_icon == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/social-icon/linkedin.png
301 | author_social_order == 1
301 | author_social_link == https://www.linkedin.com/in/carlos-tello-lacal-b946b4a7/
301 | reviewer == None
301 | medical_reviewer_id == 11
301 | medical_reviewer_name == Puya Yazdi
301 | medical_reviewer_title == MD
301 | publish_date == 2020
301 | publish_date == 9
301 | publish_date == 1
301 | avg_rating == 5.0
301 | tags_id == 195
301 | tags_name == Crohn's Disease
301 | tags_id == 96
301 | tags_name == Cytokines
301 | tags_id == 330
301 | tags_name == Food Intolerance
301 | tags_id == 102
301 | tags_name == FOXO3 Gene
301 | tags_id == 194
301 | tags_name == Gut Health
301 | tags_id == 308
301 | tags_name == Gut Inflammation
301 | permissions_favorite == False
301 | permissions_rate == False
301 | content_article == <h2><strong>Summary</strong></h2> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">The </span><a href="../../../gene/foxo3/"><em><span style="font-weight: 400;">FOXO3</span></em></a> <span style="font-weight: 400;">gene codes for a protein that regulates the expression of other genes.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Cytokines can cause inflammation in the gut. FOXO3 reduces the severity of gut inflammation by lowering cytokine levels.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">A </span><em><span style="font-weight: 400;">FOXO3 </span></em><span style="font-weight: 400;">variant increasing its production is associated with milder symptoms of Crohn&rsquo;s disease.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Specific lifestyle, dietary, and supplement choices may increase FOXO3 activity and reduce gut inflammation.</span></li> </ul> <h2><strong>The FOXO3 Gene &amp; Gut Inflammation</strong></h2> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">FOXO3 </span></em><span style="font-weight: 400;">gene encodes a protein that regulates the expression of other genes and has been implicated in immune function, DNA repair, and tumor suppression [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783344/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572328/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819984/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Cytokines are proteins that stimulate the immune response and the development of T cells in response to harmful microbes [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19132917/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712214/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">FOXO3 activity reduces the levels of the inflammatory cytokines </span><a href="../../article/tnf-longevity-86"><span style="font-weight: 400;">TNF</span></a><a href="http://selfhacked.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/"><span style="font-weight: 400;">-alpha</span></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/interleukin-1/"><span style="font-weight: 400;">IL-1&beta;</span></a><span style="font-weight: 400;">, </span><a href="http://selfhacked.com/blog/interleukin-6/"><span style="font-weight: 400;">IL-6</span></a><span style="font-weight: 400;">, and </span><a href="http://selfhacked.com/blog/il-8/"><span style="font-weight: 400;">IL-8</span></a><span style="font-weight: 400;">, while increasing the anti-inflammatory cytokine </span><a href="http://selfhacked.com/blog/il-10/"><span style="font-weight: 400;">IL-10</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091631/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790457/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">People with ulcerative colitis have lower FOXO3 levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736898/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">In mice, the lack of FOXO3 causes more severe gut inflammation and higher rates of inflammation-related colon cancer [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048782/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790457"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091631/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360252/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></li> <li style="font-weight: 400;"><a href="../../article/longevity-foxo3-32/"><span style="font-weight: 400;">Read this post</span></a><span style="font-weight: 400;"> to learn more about the </span><em><span style="font-weight: 400;">FOXO3 </span></em><span style="font-weight: 400;">gene and its association with longevity.</span></li> </ul> <h2><strong>Your FOXO3 Results for Gut Inflammation</strong></h2> <p>*7754602413117961*</p> <p>&nbsp;</p> <h3><strong>SNP Summary and Table</strong></h3> <p><strong>FOXO3 rs12212067</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Normal severity of Crohn&rsquo;s disease</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Milder severity of Crohn&rsquo;s disease</span></li> </ul> <p>&nbsp;</p> <p>*8128123900683528*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Reduce Gut Inflammation</strong></h2> <p>*2544361495425442*</p> <p>&nbsp;</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Exercise</strong></h4> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Moderate physical activity changes the composition of the gut flora by increasing beneficial species [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667627/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467063/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Physical </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;"> helps prevent IBD, but some people with active disease may be unable to adjust their physical activity. Staying physically fit by exercising regularly is essential as a means of prevention [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743119/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660805/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022156/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Interestingly, exercise increases FOXO3 levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303382/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395188/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Physical activity improves the gut microbiota, helps prevent IBD, and increases FOXO3 activity. Moderate, regular exercise may produce the best results.</span></p> <h3><strong>Diet</strong></h3> <h4><strong>Avoiding Food Triggers &amp; Including Beneficial Foods</strong></h4> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">In a study of people with Crohn&rsquo;s disease, carriers of the &lsquo;G&rsquo; variant often experienced worsened symptoms after eating wasabi, tomatoes (especially raw), mustard, and </span><a href="https://selfhacked.com/blog/scientifically-proven-health-benefits-of-ginger/"><span style="font-weight: 400;">ginger</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26226934/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">In the same study, people with this variant often benefited from eating sweet potatoes, Jerusalem artichokes, green beans, beefsteak, and peas [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26226934/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">In carriers of the &lsquo;G&rsquo; variant, food such as wasabi, tomatoes, mustard, and ginger may worsen Crohn&rsquo;s disease symptoms while sweet potatoes, Jerusalem artichokes, green beans, beefsteak, and peas may be beneficial.</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Curcumin</strong></h4> <p><a href="https://selfhacked.com/blog/curcumin-cures-top-15-scientifically-proven-health-benefits-with-references/"><span style="font-weight: 400;">Curcumin</span></a><span style="font-weight: 400;"> is the active component of the Indian spice turmeric.</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Curcumin inhibits multiple proteins involved in the immune response [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18370854/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Preliminary research in animals and cells suggests that curcumin shows promise in the treatment of IBD [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29957091/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">In the above-described study on people with Crohn&rsquo;s disease, carriers of the &lsquo;G&rsquo; variant often reported benefits from eating curry dishes with turmeric [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26226934/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Curcumin may help with IBD by reducing inflammation. Carriers of the &lsquo;G&rsquo; variant suffering from Crohn&rsquo;s disease may especially benefit from curcumin-rich curry dishes.</span></p>
301 | content_snp_table_8128123900683528_key == 8128123900683528
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301 | content_snp_table_8128123900683528_hidden == False
301 | content_learn_more_7754602413117961_key == 7754602413117961
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301 | content_learn_more_7754602413117961_text == Based on the variants we looked at, your FOXO3 gene makes you likely to experience more severe symptoms of Crohn’s disease. Engaging in regular, moderate physical exercise, avoiding food triggers, and supplementing with curcumin may help. Keep scrolling to find out more.
301 | content_recommendation_2544361495425442_key == 2544361495425442
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rsIDs = rs12212067
rsStatus = rs12212067,FOXO3,chr6,108659993,T,G,,,27,0,Normal
