302 | id == 302
302 | category_id == 19
302 | category_order == 16
302 | category_name == Pain
302 | category_color == #C47AC0
302 | slug == MRVI1-pain
302 | title == How Blood Flow to the Brain Affects Headaches & Migraines (MRVI1)
302 | meta_description == MRVI1 plays a role in controlling blood flow to the brain through nitric oxide. What is its role in headaches and migraines?
302 | summary == <p><strong>MRVI1 plays a role in controlling blood flow to the brain through nitric oxide. What is its role in headaches and migraines? Read on to find out.</strong></p>
302 | overall_score_text == Headache Score (Based on MRVI1)
302 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/MRVI1-Headaches.jpg
302 | author_id == 1
302 | author_name == Jasmine Foster
302 | author_title == BSc, BEd
302 | author_order == 36
302 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
302 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
302 | reviewer == None
302 | medical_reviewer_id == 11
302 | medical_reviewer_name == Puya Yazdi
302 | medical_reviewer_title == MD
302 | publish_date == 2020
302 | publish_date == 9
302 | publish_date == 1
302 | avg_rating == 5.0
302 | tags_id == 372
302 | tags_name == Blood vessels
302 | tags_id == 69
302 | tags_name == Headache
302 | tags_id == 31
302 | tags_name == Migraine
302 | tags_id == 556
302 | tags_name == Nitric Oxide
302 | tags_id == 71
302 | tags_name == Pain
302 | tags_id == 674
302 | tags_name == Vasodilation
302 | permissions_favorite == False
302 | permissions_rate == False
302 | content_article == <ul> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The MRVI1 protein appears to play a role in the contraction and dilation (shrinking and widening) of blood vessels in the brain.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Variations in the MRVI1 gene have been associated with headaches, migraines, and some types of chronic pain.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Careful lifestyle, diet, and supplement choices can help you regulate blood flow to the brain and prevent headaches.</span></li> </ul> <h2><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">MRVI1 </span></em><span style="font-weight: 400;">Gene in Headaches &amp; Migraines</span></h2> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">MRVI1</span></em><span style="font-weight: 400;"> gene encodes a protein called murine retrovirus integration site 1 homolog, which is a long way of saying that it is very similar to a mouse gene that binds to some types of viruses [</span><a href="https://www.ncbi.nlm.nih.gov/gene/10335"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><em><span style="font-weight: 400;">MRVI1 </span></em><span style="font-weight: 400;">is also called </span><em><span style="font-weight: 400;">IRAG </span></em><span style="font-weight: 400;">or </span><em><span style="font-weight: 400;">IRAG1 </span></em><span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/gene/10335"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><em><span style="font-weight: 400;">MRVI1</span></em><span style="font-weight: 400;"> is also believed to protect against certain types of cancer by preventing the growth of tumor cells [</span><a href="https://www.ncbi.nlm.nih.gov/gene/10335"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">In humans, </span><em><span style="font-weight: 400;">MRVI1</span></em><span style="font-weight: 400;"> appears to help regulate the contraction of blood vessels and the release of nitric oxide [</span><a href="https://europepmc.org/article/med/27322543"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/35004606"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Some people&rsquo;s headaches and migraines may be caused by abnormal widening of the blood vessels feeding the brain [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088188/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">In keeping with its connection to blood flow in the brain, </span><em><span style="font-weight: 400;">MRVI1</span></em><span style="font-weight: 400;"> variants may also be linked to strokes [</span><a href="https://europepmc.org/article/med/29531354"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h2><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">MRVI1 </span></em><span style="font-weight: 400;">Results for Headaches</span></h2> <p>*3383990764635560*</p> <p><strong>MRVI1 </strong><a href="../../../snp/rs4909945/"><strong>rs4909945</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with headaches, migraines, or chronic pain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with higher rates of headaches and migraines [</span><a href="https://pubmed.ncbi.nlm.nih.gov/29397368/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>MRVI1 </strong><a href="../../../snp/rs4910165/"><strong>rs4910165</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with headaches, migraines, or chronic pain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Possibly protective against headaches and migraines [</span><a href="https://europepmc.org/article/med/29397368"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://europepmc.org/article/med/27322543"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p>*4405428947062537*</p> <h2><span style="font-weight: 400;">Recommendations for Preventing Headaches</span></h2> <p>*4525360001268852*</p> <h3><span style="font-weight: 400;">Diet</span></h3> <h4><span style="font-weight: 400;">Magnesium &amp; Vitamin B6</span></h4> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">MRVI1 appears to be involved in the widening of blood vessels through nitric oxide, a mechanism implicated in headaches and migraines [</span><a href="https://europepmc.org/article/med/27322543"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/35004606"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Magnesium and vitamin B6 are required for the healthy regulation of nitric oxide and blood flow in the brain. People with migraines are often deficient in one or both nutrients [</span><a href="http://www.ncbi.nlm.nih.gov/pubmed/22426836"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/14584010"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Magnesium is abundant in spinach, nuts, and legumes [</span><a href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Vitamin B6 is abundant in organ meats, legumes, fish, and potatoes [</span><a href="https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Magnesium and vitamin B6 are required to regulate nitric oxide and blood flow to the brain and may counteract the effects of detrimental </span><em><span style="font-weight: 400;">MRVI1</span></em><span style="font-weight: 400;"> variants.</span></span></p> <h3><span style="font-weight: 400;">Supplements</span></h3> <h4><span style="font-weight: 400;">Caffeine</span></h4> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">MRVI1 appears to be involved in the widening of blood vessels through nitric oxide, a mechanism implicated in headaches and migraines [</span><a href="https://europepmc.org/article/med/27322543"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.nature.com/articles/35004606"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/caffeine-benefits/"><span style="font-weight: 400;">Caffeine</span></a><span style="font-weight: 400;"> may inhibit nitric oxide production and constrict the blood vessels in the brain [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1746303/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748160/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Caffeine is a part of different FDA-approved drugs for migraine and tension headaches [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10524663/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/14756851/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452084/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484257/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256978/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/12917936/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170908/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">As a painkiller, caffeine is more effective in combination with other painkillers than on its own [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485506/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20624245/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485702/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11999141/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Caffeine may counteract the effects of detrimental </span><em><span style="font-weight: 400;">MRVI1</span></em><span style="font-weight: 400;"> variants by reducing nitric oxide production and constricting blood vessels in the brain.</span></span></p>
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302 | content_learn_more_4405428947062537_text == Based on the variants we looked at, your MRVI1 gene is somewhat associated with abnormal blood flow to the brain. However, this doesn't necessarily reflect your overall risk of headaches or migraines, just one gene related to it. Magnesium, vitamin B6, and caffeine may help. Keep reading to learn more.
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rsIDs = rs4909945,rs4910165
rsStatus = rs4909945,IRAG1,chr11,10652192,T,A,C,,35,0,Normal
rsStatus = rs4910165,IRAG1,chr11,10652497,C,G,,,7,25,HET
