303 | id == 303
303 | category_id == 19
303 | category_order == 16
303 | category_name == Pain
303 | category_color == #C47AC0
303 | slug == magi1-pain-headache
303 | title == A Surprising Genetic Link to Headaches (MAGI1)
303 | meta_description == The MAGI1 gene helps stimulate the nerves, but it may also contribute to pain. Click to learn about its role in headaches.
303 | summary == <p style="text-align:justify"><strong>What do nerve growth, headaches, and chili pepper have in common? Read this post about the <em>MAGI1</em> gene to discover a surprising link to headaches and get personalized tips!</strong></p>
303 | overall_score_text == Your Headache Score (Based on MAGI1 Gene)
303 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/MAGI1-Headaches.jpg
303 | author_id == 9
303 | author_name == Aleksa Ristic
303 | author_title == MS (Pharmacy)
303 | author_order == 45
303 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
303 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
303 | reviewer == None
303 | medical_reviewer_id == 11
303 | medical_reviewer_name == Puya Yazdi
303 | medical_reviewer_title == MD
303 | publish_date == 2020
303 | publish_date == 9
303 | publish_date == 2
303 | avg_rating == 5.0
303 | tags_id == 600
303 | tags_name == Capsaicin
303 | tags_id == 596
303 | tags_name == Chronic Pain
303 | tags_id == 69
303 | tags_name == Headache
303 | tags_id == 676
303 | tags_name == MAGI1 gene
303 | tags_id == 31
303 | tags_name == Migraine
303 | tags_id == 224
303 | tags_name == Nervous System
303 | tags_id == 675
303 | tags_name == NGF
303 | permissions_favorite == False
303 | permissions_rate == False
303 | content_article == <h2><strong>Summary</strong></h2> <ul> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The MAGI1 gene may boost nerve growth factor (NGF).</span></li> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">High NGF levels correlate with headaches and chronic pain.</span></li> <li style="font-weight: 400;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">One gene variant may increase </span><em><span style="font-weight: 400;">MAGI1</span></em><span style="font-weight: 400;"> expression.</span></span></li> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">One supplement can relieve headaches by targeting this variant.</span></li> </ul> <h2><strong>The Role of the </strong><strong><em>MAGI1</em></strong><strong> Gene in Headache</strong></h2> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">The MAGI1 gene enables the functions of nerve growth factor (NGF) [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/23769981/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">NGF supports nerve growth and development, but high levels have been associated with headache and chronic pain [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442742/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11445643/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17611164/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">More MAGI1 = more NGF = potentially higher risk of headaches</span></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The MAGI1 gene may boost nerve growth factor, which plays a role in headaches and chronic pain.</span></p> <h2><strong>Your </strong><strong><em>MAGI1</em></strong><strong> Results for Headaches</strong></h2> <p>*8337133423244489*</p> <p><strong><em>MAGI1</em></strong> <a href="../../../snp/rs1495452/"><strong>rs1495452</strong></a><strong>:</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with higher odds of cluster headaches</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - not associated with cluster headaches</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele likely increases </span><em><span style="font-weight: 400;">MAGI1</span></em><span style="font-weight: 400;"> expression, leading to higher levels of nerve growth factor.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">This variant may also correlate with migraines [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*8980226843852712*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Relieve Headaches</strong></h2> <p>*1787727334964697*</p> <h3><strong>Capsaicin</strong></h3> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Capsaicin, the active ingredient in chili peppers, may suppress nerve growth factor [</span><a href="https://pubmed.ncbi.nlm.nih.gov/6185853/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Topical creams and patches with 8% capsaicin may be as effective as oral painkillers against different types of chronic pain [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464756/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23707278/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956009/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/21753727/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28365034/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Inhaled capsaicin may reduce the number and severity of cluster headache attacks [</span><a href="https://pubmed.ncbi.nlm.nih.gov/2520386/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/7708405/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/8495452/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Capsaicin may relieve cluster headaches by targeting your MAGI1 gene variant.</span></p>
303 | content_snp_table_8337133423244489_key == 8337133423244489
303 | content_snp_table_8337133423244489_blur == True
303 | content_snp_table_8337133423244489_hidden == False
303 | content_learn_more_8980226843852712_key == 8980226843852712
303 | content_learn_more_8980226843852712_blur == True
303 | content_learn_more_8980226843852712_hidden == False
303 | content_learn_more_8980226843852712_text == Based on the variant we looked at, your MAGI1 gene is associated with slightly higher odds of headaches. However, this doesn't necessarily reflect your overall risk of headaches, just one gene related to it. Consider trying topical or inhaled capsaicin to relieve headaches. Keep reading to learn more.
303 | content_recommendation_1787727334964697_key == 1787727334964697
303 | content_recommendation_1787727334964697_blur == True
303 | content_recommendation_1787727334964697_hidden == False
rsIDs = rs1495452
rsStatus = rs1495452,MAGI1,chr3,65848401,G,A,C,,33,0,Normal
