304 | id == 304
304 | category_id == 19
304 | category_order == 16
304 | category_name == Pain
304 | category_color == #C47AC0
304 | slug == HTR2A-serotonin-pain
304 | title == How Does Serotonin Impact Chronic Pain? (HTR2A)
304 | meta_description == The HTR2A gene enables the function of a natural painkiller, serotonin. Uncover the link between this gene and chronic pain.
304 | summary == <p style="text-align:justify"><strong>Serotonin helps reduce pain, but its effects depend on different genetic factors. Read this post to learn how the <em>HTR2A</em> gene influences serotonin functions and chronic pain susceptibility.</strong></p>
304 | overall_score_text == Your Chronic Pain Score (Based on HTR2A Gene)
304 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/HTR2A-Chronic-Pain.jpg
304 | author_id == 9
304 | author_name == Aleksa Ristic
304 | author_title == MS (Pharmacy)
304 | author_order == 45
304 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
304 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
304 | reviewer == None
304 | medical_reviewer_id == 11
304 | medical_reviewer_name == Puya Yazdi
304 | medical_reviewer_title == MD
304 | publish_date == 2020
304 | publish_date == 9
304 | publish_date == 2
304 | avg_rating == 5.0
304 | tags_id == 673
304 | tags_name == 5-HT2A receptor
304 | tags_id == 646
304 | tags_name == Acupuncture
304 | tags_id == 621
304 | tags_name == Cannabis
304 | tags_id == 596
304 | tags_name == Chronic Pain
304 | tags_id == 672
304 | tags_name == HTR2A gene
304 | tags_id == 309
304 | tags_name == Serotonin
304 | permissions_favorite == False
304 | permissions_rate == False
304 | content_article == <h2><strong>Summary</strong></h2> <ul> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The HTR2A gene encodes a serotonin receptor, 5-HT2A. Activation of this receptor may protect against certain chronic pain types.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Variants in this gene may reduce the number of 5-HT2A receptors and impair serotonin signaling, contributing to chronic pain.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Specific supplements and lifestyle modifications may relieve pain by targeting your gene variants.</span></li> </ul> <p>&nbsp;</p> <h2><strong>The </strong><strong><em>HTR2A</em></strong><strong> Gene and Serotonin in Chronic Pain</strong></h2> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">The HTR2A gene encodes a </span><a href="https://www.selfhacked.com/blog/how-to-increase-serotonin"><span style="font-weight: 400;">serotonin</span></a><span style="font-weight: 400;"> receptor, 5-HT2A [</span><a href="https://ghr.nlm.nih.gov/gene/HTR2A"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">This receptor has conflicting effects on </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;">: it may protect against certain chronic pain types but contribute to headaches [</span><a href="https://link.springer.com/article/10.1134/S1819712411020085"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18656400/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11028827/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11870006/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/5ht2a-receptors-a-root-cause-of-anxiety-fatigue-sleep-problems-and-cirs/"><span style="font-weight: 400;">Read this post</span></a><span style="font-weight: 400;"> to learn more about the 5-HT2A receptor roles in mental health, </span><a href="https://selfhacked.com/blog/health-benefits-sleep/"><span style="font-weight: 400;">sleep</span></a><span style="font-weight: 400;">, cognition, etc.&nbsp;</span></li> </ul> <h2><strong>Your </strong><strong><em>HTR2A</em></strong><strong> Results for Chronic Pain</strong></h2> <p>*8931083459987617*</p> <p><strong>Primary SNPs:</strong></p> <p><strong><em>HTR2A</em></strong> <a href="../../../snp/rs6313/"><strong>rs6313</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:&nbsp;</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with chronic pain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with increased odds of chronic pain</span></li> </ul> <p><strong><em>HTR2A</em></strong> <a href="../../../snp/rs6311/"><strong>rs6311</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with chronic pain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with increased odds of chronic pain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele may influence serotonin signaling via the 5-HT2A receptor and contribute to chronic pain [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21325954/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888666/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><span style="font-weight: 400;">These variants have been associated with different types of chronic pain, including hip and low back pain [<a href="https://pubmed.ncbi.nlm.nih.gov/25826379/">R</a>, <a href="http://www.nealelab.is/uk-biobank/">R</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190934/">R</a>].</span></p> <p><strong>Other important SNPs:</strong></p> <p><span style="font-weight: 400;"><strong><em>HTR2A </em></strong><a href="../../../snp/rs12584920/" target="_blank" rel="noopener">rs12584920</a> [<a href="https://pubmed.ncbi.nlm.nih.gov/21305503/" target="_blank" rel="noopener">R</a>]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with chronic pain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with increased odds of chronic pain</span></li> </ul> <p><span style="font-weight: 400;"><strong><em>HTR2A </em></strong><a href="../../../snp/rs17289394/" target="_blank" rel="noopener">rs17289394</a> [<a href="https://pubmed.ncbi.nlm.nih.gov/21305503/" target="_blank" rel="noopener">R</a>]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with chronic pain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with increased odds of chronic pain</span></li> </ul> <p>*8830911955495038*</p> <p><em><span style="font-weight: 400;"><strong>Important notes:</strong> the effects of these variants on receptor activity are still under investigation. Additionally, 5-HT2A receptor activation has shown conflicting effects on pain perception, depending on different factors. The bottom line is that impaired serotonin signaling via these receptors plays a major role in chronic pain.</span></em></p> <h2><strong>Recommendations to Reduce Chronic Pain</strong></h2> <p>*7519214139496524*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Acupuncture</strong></h4> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">According to decent clinical evidence, </span><a href="https://selfhacked.com/blog/acupuncture-benefits-mechanisms-risks/"><span style="font-weight: 400;">acupuncture</span></a><span style="font-weight: 400;"> may help with different types of chronic pain [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036643/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26896946"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Acupuncture relieves pain partly by balancing serotonin levels and targeting the 5-HT2A receptors [</span><a href="https://www.sciencedirect.com/science/article/abs/pii/S187638201630124X"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29220534/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h3><strong>Supplements</strong></h3> <h4><strong>Cannabis</strong></h4> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Different cannabis preparations may reduce chronic pain from </span><a href="https://selfhacked.com/blog/causes-symptoms-diagnosis-risk-factors-of-multiple-sclerosis/"><span style="font-weight: 400;">multiple sclerosis</span></a><span style="font-weight: 400;">, nerve damage, medical procedures, inflammation, and more [</span><a href="https://www.mstrust.org.uk/a-z/sativex-nabiximols"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26362106?dopt=Abstract"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27286745?dopt=Abstract"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/49-ways-increase-natural-cannabinoids-without-smoking-pot-including-ways-decrease-cannabinoids/"><span style="font-weight: 400;">Cannabinoids</span></a><span style="font-weight: 400;"> can balance serotonin levels via 5-HT2A receptors [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552103/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277878/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Products containing similar </span><a href="https://selfhacked.com/blog/cannabidiol-cbd/"><span style="font-weight: 400;">CBD</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/tetrahydrocannabinol-thc/"><span style="font-weight: 400;">THC</span></a><span style="font-weight: 400;"> amounts have shown the strongest painkiller effects [</span><a href="https://www.mstrust.org.uk/a-z/sativex-nabiximols"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.bayer.ca/omr/online/sativex-pm-en.pdf"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27286745?dopt=Abstract"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">THC is psychoactive, and it&rsquo;s forbidden in many countries. If you want to avoid it, choose CBD oil instead.</span></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cannabis may counteract your gene variant and help with different types of chronic pain.</span></p>
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304 | content_learn_more_8830911955495038_text == Based on the variants we looked at, your HTR2A gene is associated with slightly higher odds of chronic pain. However, this doesn't necessarily reflect your overall risk of chronic pain, just one gene related to it. Consider trying acupuncture, and follow other gene-based tips to relieve headaches. Keep reading to learn more.
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rsIDs = rs12584920,rs6311,rs6313,rs17289394
rsStatus = rs12584920,HTR2A,chr13,46890902,G,C,T,,36,0,Normal
rsStatus = rs6311,HTR2A,chr13,46897343,C,A,T,,35,0,Normal
rsStatus = rs6313,HTR2A,chr13,46895805,G,A,C,,25,0,Normal
rsStatus = rs17289394,HTR2A,chr13,46899085,G,A,,,17,3,HET
