306 | id == 306
306 | category_id == 19
306 | category_order == 16
306 | category_name == Pain
306 | category_color == #C47AC0
306 | slug == PHACTR1-Headache-Migraine
306 | title == Could This Gene Influence Your Risk Of Headaches and Migraines? (PHACTR1)
306 | meta_description == A PHACTR1 variant may influence your risk of headaches and migraines. Read on to find out more!
306 | summary == <p style="text-align:justify"><strong>Variants of the PHACTR1 gene may influence your susceptibility to headaches and migraines. Read on to find out how these variants may be influencing your own risk!</strong></p>
306 | overall_score_text == Your Headache Score (based on PHACTR1)
306 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/PHACTR1--Pain-Headaches-Migraine.jpg
306 | author_id == 13
306 | author_name == Lewis Cuthbertson
306 | author_title == PhD
306 | author_order == 12
306 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Lewis_SelfDecode.jpg
306 | author_intro == <p><strong>Lewis completed his PhD in Molecular Microbiology at Northumbria University (UK).</strong></p>    <p>Lewis spent several years researching the biodiversity of bacterial communities in the Arctic and Antarctic, whilst also performing research for a DNA sequencing service, where he was involved in several health based microbiome studies. This gave him an insight into how the highly diverse and invisible to the naked eye portion of human health, can potentially impact an individual&rsquo;s quality of life, driving his desire to help others understand their own complex health needs through the most current scientific research.<br />  &nbsp;</p>
306 | reviewer == None
306 | medical_reviewer_id == 11
306 | medical_reviewer_name == Puya Yazdi
306 | medical_reviewer_title == MD
306 | publish_date == 2020
306 | publish_date == 9
306 | publish_date == 3
306 | avg_rating == 5.0
306 | tags_id == 69
306 | tags_name == Headache
306 | tags_id == 31
306 | tags_name == Migraine
306 | tags_id == 556
306 | tags_name == Nitric Oxide
306 | tags_id == 71
306 | tags_name == Pain
306 | tags_id == 680
306 | tags_name == PHACTR1
306 | permissions_favorite == False
306 | permissions_rate == False
306 | content_article == <h2 style="text-align: justify;"><span style="font-weight: 400;">Summary</span></h2> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Genetic Variants may alter <em>PHACTR1</em> gene production resulting in higher PP1 activity</span></li> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Higher PP1 activity reduces NOS3 enzyme activity leading to decreased nitric oxide</span></li> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Reduced nitric oxide may decrease nitric oxide associated migraines.</span></li> </ul> <h2 style="text-align: justify;"><span style="font-weight: 400;">The PHACTR1 gene, nitric oxide, and head pain</span></h2> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">The </span><a href="../../../gene/phactr1/"><em><span style="font-weight: 400;">PHACTR1</span></em></a> <span style="font-weight: 400;">gene encodes PHACTR1 proteins, which inhibit PP1 activity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC406487/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Variants may lower protein levels, which may increase PP1 activity. Increased PP1 activity reduces NOS3 enzymes [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25995042/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC406487/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997489/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682334/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ahajournals.org/doi/10.1161/circ.114.suppl_18.II_38-a"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">NOS3 produces nitric oxide, which at high levels may trigger migraines through </span><a href="https://selfhacked.com/blog/oxidative-stress-101/"><span style="font-weight: 400;">oxidative stress</span></a><span style="font-weight: 400;">. Reduced NOS3 therefore may lower nitric oxide associated migraines [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/14521592"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081524/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935643/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935643/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28984313/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h2 style="text-align: justify;"><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">PHACTR1</span></em><span style="font-weight: 400;"> Results for Migraines</span></h2> <p style="text-align: justify;"><strong>*2277645881940926*</strong></p> <h3 style="text-align: justify;"><span style="font-weight: 400;">SNP Summary and Table</span></h3> <p style="text-align: justify;"><strong>[</strong><strong><em>PHACTR1</em></strong><strong>] rs9349379</strong></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;GG&rsquo; = Associated with reduced risk of migraine without aura. Not associated with risk of headache, associated with lower PHACTR1 protein expression [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331903/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898025/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380465/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;AG&rsquo; = Associated with reduced risk of migraine without aura Not associated with increased risk of headaches. Associated with lower PHACTR1 protein expression [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331903/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898025/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380465/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;AA&rsquo; = Not associated with risk of migraine. Associated with increased risk of headaches [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331903/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898025/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380465/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p style="text-align: justify;"><strong>*5303023412998641*</strong></p> <h2 style="text-align: justify;"><span style="font-weight: 400;">Recommendations to Reduce Headache Risk</span></h2> <p style="text-align: justify;"><strong>*8645843708845475*</strong></p> <h3 style="text-align: justify;"><span style="font-weight: 400;">Supplements and Diet</span></h3> <h4 style="text-align: justify;"><span style="font-weight: 400;">Magnesium</span></h4> <ul style="text-align: justify;"> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/21-proven-science-based-reasons-magnesium-amazing-including-drawbacks/"><span style="font-weight: 400;">Magnesium</span></a><span style="font-weight: 400;"> deficiency may cause migraines. Magnesium removes nitric oxide [</span><a href="http://www.ncbi.nlm.nih.gov/pubmed/22426836"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Spinach, nuts, and legumes contain magnesium and it is also available as a supplement [</span><a href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h4 style="text-align: justify;"><span style="font-weight: 400;">Vitamin B6</span></h4> <ul style="text-align: justify;"> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/vitamin-b6/"><span style="font-weight: 400;">Vitamin B6</span></a><span style="font-weight: 400;"> modulates nitric oxide and deficiency may cause migraines.&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Organ meats, legumes, fish, and potatoes contain vitamin B6. It is also available as a supplement [</span><a href="https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.ncbi.nlm.nih.gov/pubmed/14584010"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h4 style="text-align: justify;"><span style="font-weight: 400;">Feverfew</span></h4> <ul> <li style="font-weight: 400; text-align: justify;"><span style="font-weight: 400;">Feverfew extracts have been found to inhibit the production of nitric oxide in cell studies and reduce migraine symptoms [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21928368/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul>
306 | content_snp_table_2277645881940926_key == 2277645881940926
306 | content_snp_table_2277645881940926_blur == True
306 | content_snp_table_2277645881940926_hidden == False
306 | content_learn_more_5303023412998641_key == 5303023412998641
306 | content_learn_more_5303023412998641_blur == True
306 | content_learn_more_5303023412998641_hidden == False
306 | content_learn_more_5303023412998641_text == Based on the variant we looked at, your PHACTR1 gene is associated with an increased risk of headaches and a reduced risk of migraine. However, this doesn't necessarily reflect your overall headache and migraine risk — just one gene related to it. Read on to find out more.
306 | content_recommendation_8645843708845475_key == 8645843708845475
306 | content_recommendation_8645843708845475_blur == True
306 | content_recommendation_8645843708845475_hidden == False
rsIDs = rs9349379
rsStatus = rs9349379,PHACTR1,chr6,12903725,A,C,G,T,31,0,Normal
