307 | id == 307
307 | category_id == 19
307 | category_order == 16
307 | category_name == Pain
307 | category_color == #C47AC0
307 | slug == HTR1B-serotonin-pain
307 | title == Can You Relieve Pain Via Serotonin Receptors? (HTR1B)
307 | meta_description == The HTR1B gene helps produce the serotonin receptor, 5-HT1B. Click to learn about its role in chronic pain.
307 | summary == <p style="text-align:justify"><strong>Serotonin is crucial for chronic pain prevention, but certain gene variants may impair its function. Read this post to learn about the HTR1B gene and its role in pain perception.</strong></p>
307 | overall_score_text == Your Chronic Pain Score (Based on HTR1B Gene)
307 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/HTR1B-Chronic-Pain.jpg
307 | author_id == 9
307 | author_name == Aleksa Ristic
307 | author_title == MS (Pharmacy)
307 | author_order == 45
307 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
307 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
307 | reviewer == None
307 | medical_reviewer_id == 11
307 | medical_reviewer_name == Puya Yazdi
307 | medical_reviewer_title == MD
307 | publish_date == 2020
307 | publish_date == 9
307 | publish_date == 4
307 | avg_rating == 5.0
307 | tags_id == 682
307 | tags_name == 5-HT1B receptor
307 | tags_id == 646
307 | tags_name == Acupuncture
307 | tags_id == 510
307 | tags_name == Caffeine
307 | tags_id == 621
307 | tags_name == Cannabis
307 | tags_id == 596
307 | tags_name == Chronic Pain
307 | tags_id == 69
307 | tags_name == Headache
307 | tags_id == 681
307 | tags_name == HTR1B gene
307 | tags_id == 309
307 | tags_name == Serotonin
307 | permissions_favorite == False
307 | permissions_rate == False
307 | content_article == <h2><strong>Summary</strong></h2> <ul> <li style="font-weight: 400;"><strong><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The HTR1B gene helps produce the serotonin receptor, 5-HT1B, which may reduce pain.</span></strong></li> <li style="font-weight: 400;"><strong><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Variants in the HTR1B gene have been associated with chronic pain due to impaired 5-HT1B receptor activity.</span></strong></li> <li style="font-weight: 400;"><strong><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Specific supplements and alternative therapies may reduce pain by targeting HTR1B variants and improving 5-HT1B activity.</span></strong></li> </ul> <h2><strong>The HTR1B Gene in Pain Perception</strong></h2> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">The </span><a href="https://www.selfdecode.com/gene/htr1b/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><span style="font-weight: 400;">HTR1B</span></a><span style="font-weight: 400;"> gene helps produce the </span><a href="https://www.selfhacked.com/blog/how-to-increase-serotonin"><span style="font-weight: 400;">serotonin</span></a><span style="font-weight: 400;"> receptor, 5-HT1B [</span><a href="https://ghr.nlm.nih.gov/gene/HTR1B"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Activation of this receptor can relieve headaches and chronic </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> by shrinking the blood vessels and blocking pain signals [</span><a href="https://pubmed.ncbi.nlm.nih.gov/26168890/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23452061"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://jamanetwork.com/journals/jamaneurology/fullarticle/782346"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Some drugs for migraines activate 5-HT1B receptors in the brain [</span><a href="https://pubmed.ncbi.nlm.nih.gov/15349864/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h2><strong>Your HTR1B Results for Chronic Pain</strong></h2> <p>*6903997610058148*&nbsp;</p> <p><strong>Primary SNPs:</strong></p> <p><strong>HTR1B </strong><a href="../../../snp/rs6296/"><strong>rs6296</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.leelabsg.org/resources"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with chronic pain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with higher odds of chronic pain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">This SNP may also correlate with pain intensity during migraine attacks [</span><a href="https://pubmed.ncbi.nlm.nih.gov/17417740/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><strong>HTR1B </strong><a href="../../../snp/rs130060/"><strong>rs130060</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with chronic pain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher odds of chronic pain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">This SNP may also correlate with opioid painkiller use.</span></li> </ul> <p><strong>Other important SNPs:</strong></p> <p><strong>HTR1B </strong><a href="../../../snp/rs11568817/"><strong>rs11568817</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with chronic pain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with higher odds of chronic pain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;C&rsquo; allele may increase the activity of 5-HT1B receptors [</span><a href="https://pubmed.ncbi.nlm.nih.gov/22005095/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><strong>HTR1B </strong><a href="../../../snp/rs130058/"><strong>rs130058</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - not associated with chronic pain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with higher odds of chronic pain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">This SNP may also correlate with opioid painkiller use [</span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><span style="font-weight: 400;">The impact of these variants on 5-HT1B receptor activity is complex and depends on different factors. Bottom line: </span><strong>impaired 5-HT1B function is generally associated with chronic pain and headaches.</strong></p> <p>*4907046925387293*</p> <h2><strong>Recommendations to Reduce Pain</strong></h2> <p>*2722092571345957*&nbsp;</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Acupuncture</strong></h4> <ul> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/acupuncture-benefits-mechanisms-risks/"><span style="font-weight: 400;">Acupuncture</span></a><span style="font-weight: 400;"> may help with different chronic pain types, including headaches, nerve pain, and low back pain [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036643/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26896946"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15838072"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">It helps balance serotonin levels and may increase the activity of 5-HT1B receptors [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625224/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/26502543/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h3><strong>Supplements</strong></h3> <h4><strong>Caffeine</strong></h4> <ul> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/caffeine-benefits/"><span style="font-weight: 400;">Caffeine</span></a><span style="font-weight: 400;"> is effective for </span><a href="https://selfhacked.com/blog/natural-treatment-migraines/"><span style="font-weight: 400;">headache</span></a><span style="font-weight: 400;"> and migraine episode treatment [</span><a href="https://pubmed.ncbi.nlm.nih.gov/10524663/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/14756851/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3452084/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484257/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256978/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">It enables 5-HT1B receptors to shrink blood vessels and thus relieve pain [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572141/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Keep in mind that long-term caffeine consumption, especially in higher doses, can actually cause or worsen headaches [</span><a href="https://pubmed.ncbi.nlm.nih.gov/18625110/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Caffeine may relieve headaches by targeting your gene variants, but it may not be suitable for long-term pain prevention.</span></p> <h4><strong>Cannabis</strong></h4> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Cannabis may reduce chronic pain from </span><a href="https://selfhacked.com/blog/causes-symptoms-diagnosis-risk-factors-of-multiple-sclerosis/"><span style="font-weight: 400;">multiple sclerosis</span></a><span style="font-weight: 400;">, nerve damage, medical procedures, inflammation, and more [</span><a href="https://www.mstrust.org.uk/a-z/sativex-nabiximols"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/26362106?dopt=Abstract"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27286745?dopt=Abstract"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/49-ways-increase-natural-cannabinoids-without-smoking-pot-including-ways-decrease-cannabinoids/"><span style="font-weight: 400;">Cannabinoids</span></a><span style="font-weight: 400;"> can boost serotonin levels and reduce pain via 5-HT1B receptors, among others [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771033/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277878/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Products containing similar </span><a href="https://selfhacked.com/blog/cannabidiol-cbd/"><span style="font-weight: 400;">CBD</span></a><span style="font-weight: 400;"> and </span><a href="https://selfhacked.com/blog/tetrahydrocannabinol-thc/"><span style="font-weight: 400;">THC</span></a><span style="font-weight: 400;"> amounts have shown the strongest painkiller effects [</span><a href="https://www.mstrust.org.uk/a-z/sativex-nabiximols"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.bayer.ca/omr/online/sativex-pm-en.pdf"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/27286745?dopt=Abstract"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">THC is psychoactive, and it&rsquo;s forbidden in many countries. If you want to avoid it, choose CBD oil instead.</span></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Cannabis or CBD oil can help with different types of chronic pain by counteracting your HTR1B variants.</span></p>
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307 | content_learn_more_4907046925387293_text == Based on the variants we looked at, your HTR1B gene is associated with slightly higher odds of chronic pain. However, this doesn't necessarily reflect your overall risk of chronic pain, just one gene related to it. Caffeine may relieve pain by targeting your gene variants. Keep reading to learn more.
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rsIDs = rs11568817,rs130060,rs130058,rs6296
rsStatus = rs11568817,HTR1B,chr6,77463665,A,C,,,27,0,Normal
rsStatus = rs130060,HTR1B,chr6,77463033,A,C,G,,36,0,Normal
rsStatus = rs130058,HTR1B,chr6,77463564,T,A,C,G,28,0,Normal
rsStatus = rs6296,HTR1B,chr6,77462543,C,G,,,18,12,HET
