308 | id == 308
308 | category_id == 19
308 | category_order == 16
308 | category_name == Pain
308 | category_color == #C47AC0
308 | slug == SERPINA6-Chronic-Pain
308 | title == Can This Gene Cause Chronic Pain? (SERPINA6)
308 | meta_description == SERPINA6 variants may increase your susceptibility to chronic pain. Read on to find out more!
308 | summary == <p style="text-align:justify"><strong>Variants of the <em>SERPINA6</em> gene may make you more susceptible to chronic pain. Read on to find out how these variants may be influencing your own chronic pain risk!</strong></p>
308 | overall_score_text == Chronic Pain Score (based on SERPINA6)
308 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/SERPINA6-Chronic-Pain.jpg
308 | author_id == 13
308 | author_name == Lewis Cuthbertson
308 | author_title == PhD
308 | author_order == 12
308 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Lewis_SelfDecode.jpg
308 | author_intro == <p><strong>Lewis completed his PhD in Molecular Microbiology at Northumbria University (UK).</strong></p>    <p>Lewis spent several years researching the biodiversity of bacterial communities in the Arctic and Antarctic, whilst also performing research for a DNA sequencing service, where he was involved in several health based microbiome studies. This gave him an insight into how the highly diverse and invisible to the naked eye portion of human health, can potentially impact an individual&rsquo;s quality of life, driving his desire to help others understand their own complex health needs through the most current scientific research.<br />  &nbsp;</p>
308 | reviewer == None
308 | medical_reviewer_id == 11
308 | medical_reviewer_name == Puya Yazdi
308 | medical_reviewer_title == MD
308 | publish_date == 2020
308 | publish_date == 9
308 | publish_date == 5
308 | avg_rating == 5.0
308 | tags_id == 596
308 | tags_name == Chronic Pain
308 | tags_id == 416
308 | tags_name == Cortisol
308 | tags_id == 7
308 | tags_name == Fibromyalgia
308 | tags_id == 69
308 | tags_name == Headache
308 | tags_id == 71
308 | tags_name == Pain
308 | tags_id == 683
308 | tags_name == SERPINA6
308 | permissions_favorite == False
308 | permissions_rate == False
308 | content_article == <h2><span style="font-weight: 400;">Summary</span></h2> <ul> <li style="font-weight: 400;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Genetic Variants may alter </span><em><span style="font-weight: 400;">SERPINA6</span></em><span style="font-weight: 400;"> gene production resulting in less cortisol-binding </span><a href="https://www.selfhacked.com/blog/globulin-test-high-and-low-levels-normal-range/"><span style="font-weight: 400;">globulin</span></a><span style="font-weight: 400;">.</span></span></li> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Lower cortisol-binding globulin may elongate the body&rsquo;s inflammatory response, leading to chronic pain.</span></li> </ul> <h2><span style="font-weight: 400;">SERPINA6, the </span><a href="http://selfhacked.com/blog/reasons-cortisol-low-high/"><span style="font-weight: 400;">HPA axis</span></a><span style="font-weight: 400;"> and Chronic pain</span></h2> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">The </span><a href="../../../gene/serpina6/"><em><span style="font-weight: 400;">SERPINA6</span></em></a> <span style="font-weight: 400;">gene encodes a protein known as corticosteroid-binding </span><a href="https://www.selfhacked.com/blog/globulin-test-high-and-low-levels-normal-range/"><span style="font-weight: 400;">globulin</span></a><span style="font-weight: 400;">, which is responsible for transporting </span><a href="https://selfhacked.com/blog/need-know-cortisol-health-effects/"><span style="font-weight: 400;">cortisol</span></a><span style="font-weight: 400;">, an anti inflammatory hormone [</span><a href="https://ghr.nlm.nih.gov/gene/SERPINA6"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">When </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> is felt, the body releases cortisol. Once sufficient cortisol has been released, the brain senses this and reduces the inflammatory response.&nbsp;</span></li> <li style="font-weight: 400;"><em><span style="font-weight: 400;">SERPINA6 </span></em><span style="font-weight: 400;">variants have been associated with chronic pain. They have also been associated with lower levels of cortisol-binding globulin [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927682/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927682/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200236/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Lower cortisol-binding globulin may cause the pain response to last longer as a result of </span><a href="http://selfhacked.com/blog/reasons-cortisol-low-high/"><span style="font-weight: 400;">HPA axis</span></a><span style="font-weight: 400;"> overactivity, leading to chronic musculoskeletal or </span><a href="https://selfhacked.com/blog/natural-treatment-migraines/"><span style="font-weight: 400;">head pain</span></a><span style="font-weight: 400;"> through inflammation [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28453590/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h2><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">SERPINA6</span></em><span style="font-weight: 400;"> Results for Chronic Pain</span></h2> <p><strong>*1975130801113487*</strong></p> <h3><span style="font-weight: 400;">SNP Summary and Table</span></h3> <p><strong>[</strong><strong><em>SERPINA6</em></strong><strong>] rs941601</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = increased number of pain sites [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927682/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = no change to number of pain sites [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927682/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>[</strong><strong><em>SERPINA6</em></strong><strong>] rs746530</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = increased number of pain sites [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927682/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = no change to number of pain sites [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927682/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>[</strong><strong><em>SERPINA6</em></strong><strong>] rs28929474</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = associated with chronic </span><a href="https://selfhacked.com/blog/natural-treatment-migraines/"><span style="font-weight: 400;">headache</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = not associated with chronic headache [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>[</strong><strong><em>SERPINA6</em></strong><strong>] rs11629171</strong></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = associated with fibromyalgia [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = not associated with fibromyalgia [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>*8133538499533577*</strong></p> <h2><span style="font-weight: 400;">Recommendations to Reduce Chronic Pain</span></h2> <p><strong>*6157902886508007*</strong></p> <h3><span style="font-weight: 400;">Supplements</span></h3> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">A traditional chinese medicine known as GSZD, or GuiZhi-ShaoYao-ZhiMu decoction, may have anti-inflammatory effects towards the </span><em><span style="font-weight: 400;">SERPINA6 </span></em><span style="font-weight: 400;">gene.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The herbal ingredients are similar to those found in known therapeutic drugs [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898408/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28609129/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h3><span style="font-weight: 400;">Lifestyle</span></h3> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Make sure to maintain a good posture whilst moving. Poor posture has been associated with decreased Corticosteroid-binding globulin levels in a study of rodents [</span><a href="https://pubmed.ncbi.nlm.nih.gov/8146213/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul>
308 | content_snp_table_1975130801113487_key == 1975130801113487
308 | content_snp_table_1975130801113487_blur == True
308 | content_snp_table_1975130801113487_hidden == False
308 | content_learn_more_8133538499533577_key == 8133538499533577
308 | content_learn_more_8133538499533577_blur == True
308 | content_learn_more_8133538499533577_hidden == False
308 | content_learn_more_8133538499533577_text == Based on the variants we looked at, your SERPINA6 gene is associated with an increased risk of chronic pain. However, this doesn't necessarily reflect your overall chronic pain risk — just one gene related to it. Read on to find out more.
308 | content_recommendation_6157902886508007_key == 6157902886508007
308 | content_recommendation_6157902886508007_blur == True
308 | content_recommendation_6157902886508007_hidden == False
rsIDs = rs11629171,rs941601,rs28929474,rs746530
rsStatus = rs11629171,SERPINA6,chr14,94307113,C,A,G,T,20,0,Normal
rsStatus = rs941601,SERPINA6,chr14,94305204,C,T,,,14,10,HET
rsStatus = rs28929474,SERPINA1,chr14,94378610,C,G,T,,9,0,Normal
rsStatus = rs746530,,chr14,94330956,A,C,G,T,15,0,Normal
