309 | id == 309
309 | category_id == 19
309 | category_order == 16
309 | category_name == Pain
309 | category_color == #C47AC0
309 | slug == UGT2B7-painkillers
309 | title == How To Improve Your Response To Painkillers (UGT2B7)
309 | meta_description == UGT2B7 gene variants may be affecting your response to painkillers. Read on to find out more!
309 | summary == <p style="text-align:justify"><strong>UGT2B7 variants may influence your response to painkillers. Read on to find out the impact these variants may be having on you and what you can do to reduce it!&nbsp;</strong></p>
309 | overall_score_text == Your Painkiller Response Score (based on UGT2B7 gene)
309 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/UGT2B7-Resp.-to-Painkillers.jpg
309 | author_id == 13
309 | author_name == Lewis Cuthbertson
309 | author_title == PhD
309 | author_order == 12
309 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Lewis_SelfDecode.jpg
309 | author_intro == <p><strong>Lewis completed his PhD in Molecular Microbiology at Northumbria University (UK).</strong></p>    <p>Lewis spent several years researching the biodiversity of bacterial communities in the Arctic and Antarctic, whilst also performing research for a DNA sequencing service, where he was involved in several health based microbiome studies. This gave him an insight into how the highly diverse and invisible to the naked eye portion of human health, can potentially impact an individual&rsquo;s quality of life, driving his desire to help others understand their own complex health needs through the most current scientific research.<br />  &nbsp;</p>
309 | reviewer == None
309 | medical_reviewer_id == 11
309 | medical_reviewer_name == Puya Yazdi
309 | medical_reviewer_title == MD
309 | publish_date == 2020
309 | publish_date == 9
309 | publish_date == 5
309 | avg_rating == 5.0
309 | tags_id == 598
309 | tags_name == Opioids
309 | tags_id == 71
309 | tags_name == Pain
309 | tags_id == 640
309 | tags_name == Painkillers
309 | tags_id == 652
309 | tags_name == Response to Opioids
309 | tags_id == 684
309 | tags_name == UGT2B7
309 | permissions_favorite == False
309 | permissions_rate == False
309 | content_article == <h2><span style="font-weight: 400;">Summary</span></h2> <ul> <li style="font-weight: 400;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><a href="https://www.selfdecode.com/gene/UGT2B7/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002"><em><span style="font-weight: 400;">UGT2B7</span></em></a> <span style="font-weight: 400;">gene encodes UDP-glucuronosyltransferase enzymes.</span></span></li> <li style="font-weight: 400;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">These enzymes facilitate the removal of analgesic medicines such as morphine from the body [</span><a href="https://www.fsipp.org/pdf/Role-GeneticTestingPainMedicine.pdf"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/20842532/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></span></li> <li style="font-weight: 400;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Gene variants are associated with less pain relief [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20842532/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></span></li> </ul> <h2><span style="font-weight: 400;">UGT2B7 and Response to Painkillers</span></h2> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">The UGT2B7 (UDP-Glucuronosyltransferase-2B7) gene encodes UDP-glucuronosyltransferase 2B7 enzymes, which are responsible for the removal of painkillers from the body.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Variants of the UGT2B7 gene are associated with increased enzyme production, and therefore faster painkiller elimination [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31269327/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.tandfonline.com/doi/full/10.3109/15563650.2011.635147"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Faster elimination of painkillers, reduces their duration and overall effectiveness.</span></li> </ul> <h2><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">UGT2B7</span></em><span style="font-weight: 400;"> Results for Response to Painkillers</span></h2> <h3>*1216889488942847*</h3> <h3><span style="font-weight: 400;">SNP Table and Summary</span></h3> <p><span style="font-weight: 400;">[</span><strong>UGT2B7</strong><span style="font-weight: 400;">] rs7438135</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Less effective </span><a href="http://selfhacked.com/blog/why-the-ice-bucket-challenge-is-so-popular-it-functions-like-heroin/"><span style="font-weight: 400;">opioids</span></a><span style="font-weight: 400;"> (higher tolerance to high doses) &amp; more adverse side-effects from opioid treatment [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31269327/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31874497/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Normal response to opioids</span></li> </ul> <p><span style="font-weight: 400;">[</span><strong>UGT2B7</strong><span style="font-weight: 400;">] rs776746</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Poorer response to opioids [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31269327/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Normal response to opioids</span></li> </ul> <p><span style="font-weight: 400;">[</span><strong>UGT2B7</strong><span style="font-weight: 400;">] rs7439366</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Poorer response to opioids (morphine, oxycontin) [</span><a href="https://www.researchgate.net/publication/336514545_Roles_of_UGT2B7_C802T_gene_polymorphism_on_the_efficacy_of_morphine_treatment_on_cancer_pain_among_the_Chinese_han_population"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29502154/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Improved response to opioids (fentanyl) [</span><a href="https://pubmed.ncbi.nlm.nih.gov/28256933/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <p><strong>*3438689322758783*</strong></p> <h2><span style="font-weight: 400;">Recommendations for Improving Response to Painkillers</span></h2> <p><strong>*8388529575184356*</strong></p> <h3><span style="font-weight: 400;">Lifestyle</span></h3> <h4><span style="font-weight: 400;">Apply cold</span></h4> <ul> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/12-reasons-embrace-cold/"><span style="font-weight: 400;">Cold</span></a><span style="font-weight: 400;"> exposure (e.g., with ice packs) is commonly used to reduce swelling and </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> after traumatic injuries.&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">It may also help reduce the pain and need for opioid medication after surgical procedures such as knee replacement and jaw or cruciate ligament reconstruction [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21505324/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781860/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22972114/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22626630/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15915833/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24713365/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15809948/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30798949/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h3><span style="font-weight: 400;">Diet</span></h3> <h4><span style="font-weight: 400;">Spicy Food</span></h4> <ul> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/capsaicin/"><span style="font-weight: 400;">Capsaicin</span></a><span style="font-weight: 400;">, the chemical that makes cayenne and chili taste spicy, increases endorphin release and activates opioid receptors [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462993/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273101/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Capsaicin may reduce the impact of variants by increasing/maintaining higher natural opioid levels (endorphins), thus slightly reducing the impact of the body removing opioid medications too fast.</span></li> </ul> <h3><span style="font-weight: 400;">Supplements</span></h3> <h4><span style="font-weight: 400;">Magnesium</span></h4> <ul> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/21-proven-science-based-reasons-magnesium-amazing-including-drawbacks/"><span style="font-weight: 400;">Magnesium</span></a><span style="font-weight: 400;"> amplifies the painkilling effect of morphine. in conditions of sustained pain. It also stimulates a compound that activates opioid receptors and releases endorphins [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11873038"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19519724"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The best sources of magnesium are supplements, nuts, leafy greens, and whole grains [</span><a href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Magnesium may be required for opioid receptor signalling. This may reduce the impact of variants by promoting higher overall levels of natural opioids.</span></li> </ul>
309 | content_snp_table_1216889488942847_key == 1216889488942847
309 | content_snp_table_1216889488942847_blur == True
309 | content_snp_table_1216889488942847_hidden == False
309 | content_learn_more_3438689322758783_key == 3438689322758783
309 | content_learn_more_3438689322758783_blur == True
309 | content_learn_more_3438689322758783_hidden == False
309 | content_learn_more_3438689322758783_text == Based on the variants we looked at, your UGT2B7 gene makes you somewhat more likely to develop a poorer response to painkillers. However, this doesn't necessarily reflect your overall risk of poor painkiller response; it’s just one gene related to it. Keep scrolling to find out more.
309 | content_recommendation_8388529575184356_key == 8388529575184356
309 | content_recommendation_8388529575184356_blur == True
309 | content_recommendation_8388529575184356_hidden == False
rsIDs = rs776746,rs7439366,rs7438135
rsStatus = rs776746,CYP3A5,chr7,99672916,T,C,,,10,25,HET
rsStatus = rs7439366,UGT2B7,chr4,69098620,T,C,,,18,0,Normal
