310 | id == 310
310 | category_id == 19
310 | category_order == 16
310 | category_name == Pain
310 | category_color == #C47AC0
310 | slug == CYP3A4-painkillers
310 | title == Can Your Genes Influence How You Respond To Pain Medication? (CYP3A4)
310 | meta_description == CYP3A4 gene variants may be affecting your response to painkillers. Read on to find out more!
310 | summary == <p style="text-align:justify"><strong><em>CYP3A4</em> variants may influence your response to painkillers. Read on to find out the impact these variants may be having on you and what you can do to reduce it!&nbsp;</strong></p>
310 | overall_score_text == Your Painkiller Response Score (based on CYP3A4 gene)
310 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/CYP3A4-Resp.-to-Painkillers.jpg
310 | author_id == 13
310 | author_name == Lewis Cuthbertson
310 | author_title == PhD
310 | author_order == 12
310 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Lewis_SelfDecode.jpg
310 | author_intro == <p><strong>Lewis completed his PhD in Molecular Microbiology at Northumbria University (UK).</strong></p>    <p>Lewis spent several years researching the biodiversity of bacterial communities in the Arctic and Antarctic, whilst also performing research for a DNA sequencing service, where he was involved in several health based microbiome studies. This gave him an insight into how the highly diverse and invisible to the naked eye portion of human health, can potentially impact an individual&rsquo;s quality of life, driving his desire to help others understand their own complex health needs through the most current scientific research.<br />  &nbsp;</p>
310 | reviewer == None
310 | medical_reviewer_id == 11
310 | medical_reviewer_name == Puya Yazdi
310 | medical_reviewer_title == MD
310 | publish_date == 2020
310 | publish_date == 9
310 | publish_date == 5
310 | avg_rating == 5.0
310 | tags_id == 685
310 | tags_name == CYP3A4
310 | tags_id == 598
310 | tags_name == Opioids
310 | tags_id == 71
310 | tags_name == Pain
310 | tags_id == 639
310 | tags_name == Painkiller
310 | tags_id == 652
310 | tags_name == Response to Opioids
310 | tags_id == 653
310 | tags_name == Response to Painkillers
310 | permissions_favorite == False
310 | permissions_rate == False
310 | content_article == <h2><span style="font-weight: 400;">Summary</span></h2> <ul> <li style="font-weight: 400;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">The </span><a href="https://selfhacked.com/blog/cyp3a4/"><em><span style="font-weight: 400;">CYP3A4</span></em></a> <span style="font-weight: 400;">gene encodes for </span><a href="https://selfhacked.com/blog/cyp-enzymes-interact-supplements-related-genes/"><span style="font-weight: 400;">Cytochrome P450</span></a><span style="font-weight: 400;"> 3A4 enzymes.</span></span></li> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">These enzymes assist in removing pain drugs from the body.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Genetic variants are associated with poorer response to pain medication.</span></li> </ul> <h2><em><span style="font-weight: 400;">CYP3A4</span></em><span style="font-weight: 400;"> and Response to Painkillers</span></h2> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">The CYP3A4 (Cytochrome P450 family 3 subfamily A member 4) gene encodes Cytochrome P450 3A4 enzymes, which are responsible for the removal of painkillers from the body [</span><a href="https://www.painphysicianjournal.com/linkout?issn=&amp;vol=18&amp;page=131"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Variants of the CYP3A4 gene are associated with increased enzyme production, and therefore faster painkiller elimination [</span><a href="https://www.painphysicianjournal.com/linkout?issn=&amp;vol=18&amp;page=131"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Faster elimination of painkillers, reduces their overall duration and effectiveness.</span></li> </ul> <h2><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">CYP3A4</span></em><span style="font-weight: 400;"> Results for Response to Painkillers</span></h2> <h3>*3938719189081798*</h3> <h3><span style="font-weight: 400;">SNP Table and Summary</span></h3> <p><span style="font-weight: 400;">[</span><strong>CYP3A4</strong><span style="font-weight: 400;">] rs28371759</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; =&nbsp; Poorer response to painkillers. Increased enzyme levels [</span><a href="https://www.painphysicianjournal.com/linkout?issn=&amp;vol=18&amp;page=131"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Normal response to painkillers</span></li> </ul> <p><span style="font-weight: 400;">[</span><strong>CYP3A4</strong><span style="font-weight: 400;">] rs776746</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; =&nbsp; Less medication required for pain relief [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932617/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Normal response to painkillers</span></li> </ul> <p><span style="font-weight: 400;">[</span><strong>CYP3A4</strong><span style="font-weight: 400;">] rs15524</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; =&nbsp; Less medication required for pain relief [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932617/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Normal response to painkillers</span></li> </ul> <p><span style="font-weight: 400;">[</span><strong>CYP3A4</strong><span style="font-weight: 400;">] rs12248560</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; =&nbsp; Poorer response to painkillers. Increased enzyme levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932617/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Normal response to painkillers</span></li> </ul> <p><span style="font-weight: 400;">[</span><strong>CYP3A4</strong><span style="font-weight: 400;">] rs2242480</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; =&nbsp; Less medication required for pain relief [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25794200/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.painphysicianjournal.com/linkout?issn=&amp;vol=18&amp;page=131"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Normal response to painkillers</span></li> </ul> <p><span style="font-weight: 400;">[</span><strong>CYP3A4</strong><span style="font-weight: 400;">] rs3758581</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; =&nbsp; Poorer response to painkillers. Increased enzyme levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20233192/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Normal response to painkillers</span></li> </ul> <p><span style="font-weight: 400;">[</span><strong>CYP3A4</strong><span style="font-weight: 400;">] rs17885098</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; =&nbsp; Poorer response to painkillers. Increased enzyme levels [</span><a href="https://pubmed.ncbi.nlm.nih.gov/20233192/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Normal response to painkillers</span></li> </ul> <p><strong>*7406062546128638*</strong></p> <h2><span style="font-weight: 400;">Recommendations for Improving Response to Painkillers</span></h2> <p><strong>*5720611044020907*</strong></p> <h3><span style="font-weight: 400;">Lifestyle</span></h3> <h4><span style="font-weight: 400;">Apply cold</span></h4> <ul> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/12-reasons-embrace-cold/"><span style="font-weight: 400;">Cold</span></a><span style="font-weight: 400;"> exposure (e.g., with ice packs) is commonly used to reduce swelling and </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> after traumatic injuries.&nbsp;</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">It may also help reduce the pain and need for </span><a href="http://selfhacked.com/blog/why-the-ice-bucket-challenge-is-so-popular-it-functions-like-heroin/"><span style="font-weight: 400;">opioid</span></a><span style="font-weight: 400;"> medication after surgical procedures such as knee replacement and jaw or cruciate ligament reconstruction [</span><a href="https://pubmed.ncbi.nlm.nih.gov/21505324/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781860/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22972114/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22626630/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15915833/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24713365/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/15809948/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30798949/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h3><span style="font-weight: 400;">Diet</span></h3> <h4><span style="font-weight: 400;">Spicy Food</span></h4> <ul> <li style="font-weight: 400;"><a href="http://selfhacked.com/blog/capsaicin/"><span style="font-weight: 400;">Capsaicin</span></a><span style="font-weight: 400;">, the chemical that makes cayenne and chili taste spicy, increases </span><a href="https://selfhacked.com/blog/endorphins/"><span style="font-weight: 400;">endorphin</span></a><span style="font-weight: 400;"> release and activates opioid receptors [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462993/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273101/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Capsaicin may reduce the impact of variants by increasing/maintaining higher natural opioid levels (endorphins), thus slightly reducing the impact of the body removing opioid medications too fast.</span></li> </ul> <h3><span style="font-weight: 400;">Supplements</span></h3> <h4><span style="font-weight: 400;">Magnesium</span></h4> <ul> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/21-proven-science-based-reasons-magnesium-amazing-including-drawbacks/"><span style="font-weight: 400;">Magnesium</span></a><span style="font-weight: 400;"> amplifies the painkilling effect of morphine. in conditions of sustained pain. It also stimulates a compound that activates opioid receptors and releases endorphins [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11873038"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/19519724"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The best sources of magnesium are supplements, nuts, leafy greens, and whole grains [</span><a href="https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Magnesium may be required for opioid receptor signalling. This may reduce the impact of variants by promoting higher overall levels of natural opioids.</span></li> </ul>
310 | content_snp_table_3938719189081798_key == 3938719189081798
310 | content_snp_table_3938719189081798_blur == True
310 | content_snp_table_3938719189081798_hidden == False
310 | content_learn_more_7406062546128638_key == 7406062546128638
310 | content_learn_more_7406062546128638_blur == True
310 | content_learn_more_7406062546128638_hidden == False
310 | content_learn_more_7406062546128638_text == Based on the variants we looked at, your CYP3A4 gene makes you somewhat more likely to develop a poorer response to painkillers. However, this doesn't necessarily reflect your overall risk of poor painkiller response; it’s just one gene related to it. Keep scrolling to find out more.
310 | content_recommendation_5720611044020907_key == 5720611044020907
310 | content_recommendation_5720611044020907_blur == True
310 | content_recommendation_5720611044020907_hidden == False
rsIDs = rs12248560,rs15524,rs2242480,rs28371759,rs776746,rs3758581,rs17885098
rsStatus = rs12248560,CYP2C19,chr10,94761900,C,A,T,,37,0,Normal
rsStatus = rs15524,CYP3A5,chr7,99648291,A,G,,,27,0,Normal
rsStatus = rs2242480,CYP3A4,chr7,99763843,C,T,,,27,0,Normal
rsStatus = rs28371759,CYP3A4,chr7,99764003,A,G,,,31,0,Normal
rsStatus = rs776746,CYP3A5,chr7,99672916,T,C,,,10,25,HET
rsStatus = rs3758581,CYP2C19,chr10,94842866,A,C,G,,41,0,Normal
rsStatus = rs17885098,CYP2C19,chr10,94762804,C,T,,,7,21,HET
