311 | id == 311
311 | category_id == 19
311 | category_order == 16
311 | category_name == Pain
311 | category_color == #C47AC0
311 | slug == ABCB1-opioids-painkillers
311 | title == A Gene-Based Response to Painkillers (ABCB1)
311 | meta_description == The ABCB1 gene prevents opioids from entering the brain and interacts with pain treatment. Click to learn more.
311 | summary == <p style="text-align:justify"><strong>The ABCB1 gene encodes a protein that prevents opioids from entering the brain. Read on to learn how variants in this gene can impact opioid levels &amp; pain management.</strong></p>
311 | overall_score_text == Your Response to Painkillers (Based on ABCB1 Gene)
311 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/ABCB1-MDR1-Resp.-to-Painkillers.jpg
311 | author_id == 9
311 | author_name == Aleksa Ristic
311 | author_title == MS (Pharmacy)
311 | author_order == 45
311 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
311 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
311 | reviewer == None
311 | medical_reviewer_id == 11
311 | medical_reviewer_name == Puya Yazdi
311 | medical_reviewer_title == MD
311 | publish_date == 2020
311 | publish_date == 9
311 | publish_date == 6
311 | avg_rating == 5.0
311 | tags_id == 77
311 | tags_name == ABCB1 Gene
311 | tags_id == 600
311 | tags_name == Capsaicin
311 | tags_id == 598
311 | tags_name == Opioids
311 | tags_id == 71
311 | tags_name == Pain
311 | tags_id == 640
311 | tags_name == Painkillers
311 | tags_id == 686
311 | tags_name == P-glycoprotein
311 | tags_id == 687
311 | tags_name == Physiotherapy
311 | permissions_favorite == False
311 | permissions_rate == False
311 | content_article == <h2><strong>Summary</strong></h2> <p><strong><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The ABCB1 (MDR1) gene codes for P-glycoprotein, which prevents opioid painkillers from entering the brain.&nbsp;</span></strong><strong><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Certain variants can enhance the function of this gene and reduce opioids in the brain. People with these variants may require higher doses of opioid painkillers.</span></strong><strong><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Lifestyle changes and supplements may counteract ABCB1 variants and relieve pain by boosting internal opioids.</span></strong></p> <p>&nbsp;</p> <h2><strong>The ABCB1 Gene and Response to Painkillers</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../../gene/abcb1/"><span style="font-weight: 400;">ABCB1</span></a><span style="font-weight: 400;"> gene (also known as </span><a href="../../../gene/mdr1/"><span style="font-weight: 400;">MDR1</span></a><span style="font-weight: 400;">) codes for P-glycoprotein, which prevents drugs and other foreign substances from entering the brain [</span><a href="https://ghr.nlm.nih.gov/gene/ABCB1"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23896815/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">This gene&rsquo;s activity may prevent painkillers, especially opioids, from reaching the target site and thus reduce their effectiveness [</span><a href="https://www.painphysicianjournal.com/linkout?issn=&amp;vol=18&amp;page=131"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/31269327/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><strong>More active ABCB1 = less opioids in the brain = higher painkiller doses required.</strong></p> <h2><strong>Your ABCB1 Results for Response to Painkillers</strong></h2> <p>*5953761545408771*</p> <p><strong>Primary SNPs</strong><span style="font-weight: 400;">:</span></p> <p><strong><em>ABCB1</em></strong> <a href="../../../snp/rs1128503/"><strong>rs1128503</strong></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2599947/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with response to opioids</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with a poor response to opioids (higher doses required)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele enhances the ABCB1 gene function and reduces opioid levels in the brain.</span></li> </ul> <p><strong><em>ABCB1</em></strong> <a href="../../../snp/rs1045642/"><strong>rs1045642</strong></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/24703092/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with a good response to opioid painkillers</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - associated with a poor response to opioid painkillers (higher doses required)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;A&rsquo; allele enhances the ABCB1 gene function and reduces opioid levels in the brain.</span></li> </ul> <p><strong>Other Important SNPs:</strong></p> <p><strong><em>ABCB1</em></strong> <a href="../../../snp/rs3213619/"><strong>rs3213619</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2599947/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; - not associated with response to opioids</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with a poor response to opioids (higher doses required)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele enhances the ABCB1 gene function and reduces opioid levels in the brain.</span></li> </ul> <p>*5081982272159369*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Reduce Pain</strong></h2> <p>*5858396764543117*</p> <h3><strong>Lifestyle</strong></h3> <h4><strong>Physiotherapy</strong></h4> <p><span style="font-weight: 400;">Physiotherapy&mdash;including <a href="https://selfhacked.com/blog/massage-health-benefits/" target="_blank" rel="noopener">massage</a>, <a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/" target="_blank" rel="noopener">exercise</a>, and corrective movements&mdash; may counteract your gene variants by boosting <a href="https://selfhacked.com/blog/why-the-ice-bucket-challenge-is-so-popular-it-functions-like-heroin/" target="_blank" rel="noopener">endorphins</a>, your internal opioids [</span><a href="https://pubmed.ncbi.nlm.nih.gov/2526775/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/17483960/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Physiotherapy is effective against different types of chronic pain [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/24846036"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15062718"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/29173797/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28619390/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h4><strong>Cold Application</strong></h4> <p><span style="font-weight: 400;">Short-term <a href="https://selfhacked.com/blog/12-reasons-embrace-cold/" target="_blank" rel="noopener">cold exposure</a> may relieve pain by increasing internal opioids [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033575/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Cold application may help with headaches, nerve pain, joint pain, and more [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781860/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/22972114/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/3941818/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/3243707/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <h3><strong>Supplements</strong></h3> <h4><strong>Capsaicin</strong></h4> <p><span style="font-weight: 400;"><a href="https://selfhacked.com/blog/capsaicin/" target="_blank" rel="noopener">Capsaicin</a> can boost beta-endorphin, our primary internal opioid [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12506417/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/8925284/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Creams and patches with topical capsaicin may help with joint pain, low back pain, nerve pain, and more [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267943/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/11765591/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/14581111/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464756/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/23707278/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><a href="https://selfhacked.com/blog/23-ways-to-combat-pain-naturally-by-increasing-your-opioids/"><span style="font-weight: 400;">Read this post</span></a><span style="font-weight: 400;"> to discover more potential ways to reduce pain by stimulating your opioid system.</span></p>
311 | content_snp_table_5953761545408771_key == 5953761545408771
311 | content_snp_table_5953761545408771_blur == True
311 | content_snp_table_5953761545408771_hidden == False
311 | content_learn_more_5081982272159369_key == 5081982272159369
311 | content_learn_more_5081982272159369_blur == True
311 | content_learn_more_5081982272159369_hidden == False
311 | content_learn_more_5081982272159369_text == Based on the variants we looked at, your ABCB1 gene is associated with slightly reduced sensitivity to painkillers and lower opioid levels. However, this doesn't necessarily reflect your overall risk of abnormal opioid response, just one gene related to it. Cold application and capsaicin may relieve pain by targeting your gene variants. Keep scrolling to find out more.
311 | content_recommendation_5858396764543117_key == 5858396764543117
311 | content_recommendation_5858396764543117_blur == True
311 | content_recommendation_5858396764543117_hidden == False
rsIDs = rs1045642,rs3213619,rs1128503
rsStatus = rs1045642,ABCB1,chr7,87509329,A,C,G,T,38,0,Normal
rsStatus = rs3213619,ABCB1,chr7,87600877,A,G,,,40,0,Normal
rsStatus = rs1128503,ABCB1,chr7,87550285,A,G,,,18,15,HET
