312 | id == 312
312 | category_id == 19
312 | category_order == 16
312 | category_name == Pain
312 | category_color == #C47AC0
312 | slug == MYT1L-pain
312 | title == A Connection Between Cognitive Disability and Chronic Pain (MYT1L)
312 | meta_description == The MYT1L gene is important for the correct development of nerve cells. What is its role in chronic pain? Read on to find out.
312 | summary == <p><strong>The <em>MYT1L </em>gene is important for the correct development of nerve cells. What is its role in chronic pain disorders like fibromyalgia? Read on to find out.</strong></p>
312 | overall_score_text == Chronic Pain Score (Based on MYT1L)
312 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/MYT1L-Chronic-Pain.jpg
312 | author_id == 1
312 | author_name == Jasmine Foster
312 | author_title == BSc, BEd
312 | author_order == 36
312 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
312 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
312 | reviewer == None
312 | medical_reviewer_id == 11
312 | medical_reviewer_name == Puya Yazdi
312 | medical_reviewer_title == MD
312 | publish_date == 2020
312 | publish_date == 9
312 | publish_date == 7
312 | avg_rating == 5.0
312 | tags_id == 596
312 | tags_name == Chronic Pain
312 | tags_id == 207
312 | tags_name == Exercise
312 | tags_id == 7
312 | tags_name == Fibromyalgia
312 | tags_id == 679
312 | tags_name == Manganese
312 | tags_id == 678
312 | tags_name == MYT1L Gene
312 | tags_id == 26
312 | tags_name == Neurogenesis
312 | tags_id == 71
312 | tags_name == Pain
312 | tags_id == 341
312 | tags_name == Zinc
312 | tags_id == 414
312 | tags_name == Zinc Fingers
312 | permissions_favorite == False
312 | permissions_rate == False
312 | content_article == <h2><span style="font-weight: 400;">Summary</span></h2> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">MYT1L</span></em><span style="font-weight: 400;"> gene encodes a protein that controls other genes in the nerves and brain.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Certain </span><em><span style="font-weight: 400;">MYT1L </span></em><span style="font-weight: 400;">variants have been associated with chronic pain.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Lifestyle, diet, and supplement choices that support correct </span><em><span style="font-weight: 400;">MYT1L</span></em><span style="font-weight: 400;"> function may help reduce pain sensitivity.</span></li> </ul> <h2><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">MYT1L </span></em><span style="font-weight: 400;">Gene in Chronic Pain</span></h2> <ul> <li style="font-weight: 400;"><em><span style="font-weight: 400;">MYT1L </span></em><span style="font-weight: 400;">(</span><a href="https://selfhacked.com/blog/myelin/"><span style="font-weight: 400;">myelin</span></a><span style="font-weight: 400;"> transcription factor 1 like gene) encodes a protein that controls the expression of other genes in nerves and the brain [</span><a href="https://ghr.nlm.nih.gov/gene/MYT1L"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><em><span style="font-weight: 400;">MYT1L</span></em><span style="font-weight: 400;"> is best known for its association with cognitive disabilities and autism spectrum disorders [</span><a href="https://ghr.nlm.nih.gov/gene/MYT1L"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Variants in </span><em><span style="font-weight: 400;">MYT1L</span></em><span style="font-weight: 400;"> have also been associated with chronic pain disorders, including fibromyalgia [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322092/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/24582949/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">When MYT1L isn&rsquo;t working correctly, nerves may become overly sensitive to pain signals [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597252/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h2><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">MYT1L </span></em><span style="font-weight: 400;">Results for Chronic Pain</span></h2> <p>*9522080822970911*</p> <p><strong>MYT1L </strong><a href="https://selfdecode.com/snp/rs3748989/"><strong>rs3748989</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Not associated with chronic pain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with chronic bodily pain</span></li> </ul> <p><strong>MYT1L </strong><a href="https://selfdecode.com/snp/rs6759706/"><strong>rs6759706</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Not associated with chronic pain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Associated with chronic bodily pain</span></li> </ul> <p><strong>MYT1L </strong><a href="https://selfdecode.com/snp/rs11127292/"><strong>rs11127292</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = associated with relatively higher odds of fibromyalgia (chronic pain disorder)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = associated with relatively lower odds of fibromyalgia </span></li> </ul> <p>*9881828047212062*</p> <h2><span style="font-weight: 400;">Recommendations for Reducing Pain</span></h2> <p>*2874399725596988*</p> <h3><span style="font-weight: 400;">Lifestyle</span></h3> <h4><span style="font-weight: 400;">Physical Fitness</span></h4> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">According to a study of mice prone to chronic pain, </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">physical activity</span></a><span style="font-weight: 400;"> increased </span><em><span style="font-weight: 400;">MYT1L</span></em><span style="font-weight: 400;"> expression and reduced pain sensitivity [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987254/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">In 37,000 chronic pain patients, physical activity reduced the intensity of reported pain and improved quality of life [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469540/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The same large review found that chronic pain patients who don&rsquo;t regularly exercise report feeling more pain than those who do [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469540/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">For some people, starting a new or more intense exercise program temporarily increases soreness and muscle pain. However, this short-term soreness goes away after a few days or weeks [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469540/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">In both humans and animals, physical fitness reduces chronic pain. Increased </span><em><span style="font-weight: 400;">MYT1L</span></em><span style="font-weight: 400;"> expression may help explain this effect.</span></span></p> <h3><span style="font-weight: 400;">Manganese Sufficiency</span></h3> <ul> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/manganese/"><span style="font-weight: 400;">Manganese</span></a><span style="font-weight: 400;"> exposure increased </span><em><span style="font-weight: 400;">MYT1L </span></em><span style="font-weight: 400;">expression in human cells and in lab rats [</span><a href="https://www.sciencedirect.com/science/article/abs/pii/S0161813X06002555?via%3Dihub"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145856"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Manganese is known to be essential for the health and correct function of nerve cells [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525788/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Chronic exposure to manganese can be toxic and may even increase pain sensitivity, so it&rsquo;s important to talk to your doctor before supplementing [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583632/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The best dietary sources of manganese include shellfish, nuts, and brown rice [</span><a href="https://ods.od.nih.gov/factsheets/Manganese-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h3><span style="font-weight: 400;">Zinc Sufficiency</span></h3> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">MYT1L is a member of the &ldquo;zinc finger&rdquo; family of proteins and requires </span><a href="https://selfhacked.com/blog/literally-everything-wanted-know-zinc-backed-science/"><span style="font-weight: 400;">zinc</span></a><span style="font-weight: 400;"> to function correctly [</span><a href="https://ghr.nlm.nih.gov/gene/MYT1L"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Zinc may interact with nerve cells and reduce the feeling of pain through multiple mechanisms [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494785/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Zinc is widely available as a supplement. It is also abundant in shellfish, beef, and nuts [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494785/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Manganese and zinc appear to be essential for the correct function of MYT1L in nerve cells.</span></p>
312 | content_snp_table_9522080822970911_key == 9522080822970911
312 | content_snp_table_9522080822970911_blur == True
312 | content_snp_table_9522080822970911_hidden == False
312 | content_learn_more_9881828047212062_key == 9881828047212062
312 | content_learn_more_9881828047212062_blur == True
312 | content_learn_more_9881828047212062_hidden == False
312 | content_learn_more_9881828047212062_text == Based on the variants we looked at, your MYT1L gene is somewhat associated with abnormal nerve development. However, this doesn't necessarily reflect your overall risk of chronic pain, just one gene related to it. Exercise, manganese, and zinc may help. Keep reading to learn more.
312 | content_recommendation_2874399725596988_key == 2874399725596988
312 | content_recommendation_2874399725596988_blur == True
312 | content_recommendation_2874399725596988_hidden == False
rsIDs = rs6759706,rs3748989,rs11127292
rsStatus = rs6759706,NCOA1,chr2,24662016,G,C,T,,23,0,Normal
rsStatus = rs3748989,MYT1L,chr2,1943196,C,T,,,31,0,Normal
rsStatus = rs11127292,MYT1L,chr2,2026171,C,T,,,25,0,Normal
