313 | id == 313
313 | category_id == 19
313 | category_order == 16
313 | category_name == Pain
313 | category_color == #C47AC0
313 | slug == TNF-chronic-pain
313 | title == The TNF-alpha Gene & Pain
313 | meta_description == TNF is associated with your response to chronic pain. Click here to get some gene-based diet and lifestyle tips!
313 | summary == <p style="text-align:justify"><strong>The TNF gene produces the protein TNF-alpha and is involved in inflammation. Variants in this gene may impact whether or not you have chronic pain, as well as how severe the pain is. Read on to learn some strategies for reducing your TNF-alpha levels!</strong></p>
313 | overall_score_text == Your Response to Chronic Pain (Based on TNF)
313 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/TNF_post_image.jfif
313 | author_id == 15
313 | author_name == John Williams
313 | author_title == B.Sc
313 | author_order == 3987
313 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/sinan_pic.png
313 | author_intro == <p>John received his BSc from the University of Toronto.&nbsp;John has spent the last several years teaching high school science and math to English-language learners, which has forced him to learn how to simplify difficult concepts as much as possible. He has also worked in two different research labs and has experience as a student intern working and studying under doctors in hospitals and clinics to help diagnose and treat patients, interpret lab results and fill out mountains of paperwork.</p>
313 | reviewer_id == 10
313 | reviewer_name == Biljana Novkovic
313 | reviewer_title == PhD
313 | medical_reviewer_id == 11
313 | medical_reviewer_name == Puya Yazdi
313 | medical_reviewer_title == MD
313 | publish_date == 2020
313 | publish_date == 9
313 | publish_date == 7
313 | avg_rating == 5.0
313 | tags_id == 596
313 | tags_name == Chronic Pain
313 | tags_id == 24
313 | tags_name == Inflammation
313 | tags_id == 235
313 | tags_name == TNF-alpha
313 | tags_id == 234
313 | tags_name == TNF gene
313 | permissions_favorite == False
313 | permissions_rate == False
313 | content_article == <h2 style="text-align: justify;">What Is TNF-alpha?</h2> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400; background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">TNF-alpha is a cytokine, a kind of protein that sends messages between cells. It plays a role in inflammation &mdash; a process that causes an area of your body to feel hot, red, swollen and painful.</span></li> <li style="font-weight: 400;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">TNF-alpha causes the nerve cells responsible for pain to fire more often [</span><a href="http://cebp.aacrjournals.org/content/16/12/2745.long"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://cebp.aacrjournals.org/lookup/external-ref?access_num=9450372&amp;link_type=MED&amp;atom=%2Fcebp%2F16%2F12%2F2745.atom"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://cebp.aacrjournals.org/content/16/12/2745.long"><span style="font-weight: 400;">R]</span></a></span></li> <li style="font-weight: 400;"><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The relatively uncommon &lsquo;A&rsquo; allele in SNP <a href="https://selfdecode.com/snp/rs1800629/"><strong>rs1800629</strong></a> is associated with an increased risk of chronic pain [<a href="https://pubmed.ncbi.nlm.nih.gov/27131251/">R</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/28610765/">R</a>, <a href="https://www.degruyter.com/view/journals/sjpain/12/1/article-p1.xml">R</a>, <a href="https://www.sciencedirect.com/science/article/abs/pii/S1043466612008149?via%3Dihub">R</a>]. This is because the &lsquo;A&rsquo; allele results in more TNF-alpha being produced [<a href="https://pubmed.ncbi.nlm.nih.gov/15217507/">R</a>, <a href="https://cebp.aacrjournals.org/content/16/12/2745.long">R</a>].</span></li> </ul> <h2 style="text-align: justify;">Your TNF-a Genotype</h2> <p style="text-align: justify;"><strong>*5836649603129895*</strong></p> <p style="text-align: justify;"><strong>Primary SNP:</strong></p> <p style="text-align: justify;"><strong><em>TNF</em></strong> <a href="https://selfdecode.com/snp/rs1800629/"><strong>rs1800629</strong></a></p> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = increased levels of TNF-alpha; associated with increased chronic pain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = normal levels of TNF-alpha; no association with chronic pain</span></li> </ul> <p style="text-align: justify;"><span style="font-weight: 400;">The problematic &lsquo;A&rsquo; allele is not very common; it occurs in only 9% of the population. The &lsquo;A&rsquo; allele is most common in European and African populations, but even in these populations 75-80% of individuals only have the normal &lsquo;G&rsquo; allele.</span></p> <p style="text-align: justify;"><strong>*7662223890176738*</strong></p> <h2 style="text-align: justify;"><strong>Recommendations to Reduce TNF-alpha Levels</strong></h2> <p style="text-align: justify;"><strong>*2868578806746718*</strong></p> <h3 style="text-align: justify;"><strong>Lifestyle</strong></h3> <h4 style="text-align: justify;"><strong>Weight Loss and Exercise</strong></h4> <ul style="text-align: justify;"> <li style="font-weight: 400;"><span style="font-weight: 400;">Both obesity [</span><a href="http://www.ncbi.nlm.nih.gov/pubmed/17505154"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">] and a lack of exercise [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15772055"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">,</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320801/"> <span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">] are associated with increased TNF-alpha levels. Therefore, losing weight can be beneficial in reducing chronic pain as there is less TNF-alpha around to cause inflammation.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">A scientific review found that most studies note a 10 to 50% reduction in chronic back pain intensity following a moderate amount of exercise [</span><a href="https://pubmed.ncbi.nlm.nih.gov/14749199/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h3 style="text-align: justify;"><strong>Supplements&nbsp;</strong></h3> <h4 style="text-align: justify;"><strong>Fish Oil (Omega-3)</strong></h4> <ul style="text-align: justify;"> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/fish-oil-top-22-science-based-health-benefits-of-fish-oil/"><span style="font-weight: 400;">Omega-3 fatty acids</span></a><span style="font-weight: 400;"> found in fish oil have been found to reduce TNF-alpha levels [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772138/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">] in children of Type 2 diabetics and in patients with metabolic syndrome [</span><a href="https://pubmed.ncbi.nlm.nih.gov/30519766/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;">Patients with higher levels of omega-3 fatty acids were found to have less arthritis-related knee pain [<a href="https://pubmed.ncbi.nlm.nih.gov/28542024/">R</a>].</li> </ul> <p style="text-align: justify;">&nbsp;</p>
313 | content_snp_table_5836649603129895_key == 5836649603129895
313 | content_snp_table_5836649603129895_blur == True
313 | content_snp_table_5836649603129895_hidden == False
313 | content_learn_more_7662223890176738_key == 7662223890176738
313 | content_learn_more_7662223890176738_blur == True
313 | content_learn_more_7662223890176738_hidden == False
313 | content_learn_more_7662223890176738_text == Your TNF variants are associated with slightly higher chronic pain likelihood and severity. However, this doesn't necessarily reflect your overall risk of chronic pain — just one gene related to it. Read on for gene-based tips.
313 | content_recommendation_2868578806746718_key == 2868578806746718
313 | content_recommendation_2868578806746718_blur == True
313 | content_recommendation_2868578806746718_hidden == False
rsIDs = rs1800629
rsStatus = rs1800629,TNF,chr6,31575254,G,A,,,9,0,Normal
