314 | id == 314
314 | category_id == 20
314 | category_order == 17
314 | category_name == Attention
314 | category_color == #C47AC0
314 | slug == MTHFR-folate-attention
314 | title == The Link Between Folate Metabolism and Attention (MTHFR)
314 | meta_description == The MTHFR gene is crucial for folate metabolism. Click to learn about its link with attention disorders.
314 | summary == <p style="text-align:justify"><strong>The MTHFR gene helps produce a crucial enzyme in folate metabolism. Read on to learn the link between this gene, your diet &amp; attention disorders.</strong></p>
314 | overall_score_text == Your Attention Score (Based on MTHFR Gene)
314 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/MTHFR-Attention.jpg
314 | author_id == 9
314 | author_name == Aleksa Ristic
314 | author_title == MS (Pharmacy)
314 | author_order == 45
314 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Aleksa.jpg
314 | author_intro == <p><strong>Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.</strong>&nbsp;&nbsp;</p>    <p>Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions&mdash;writing and health&mdash;and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.</p>
314 | reviewer == None
314 | medical_reviewer_id == 11
314 | medical_reviewer_name == Puya Yazdi
314 | medical_reviewer_title == MD
314 | publish_date == 2020
314 | publish_date == 9
314 | publish_date == 8
314 | avg_rating == 5.0
314 | tags_id == 30
314 | tags_name == ADHD
314 | tags_id == 56
314 | tags_name == Attention
314 | tags_id == 13
314 | tags_name == Cognition
314 | tags_id == 100
314 | tags_name == Folate
314 | tags_id == 151
314 | tags_name == Homocysteine
314 | tags_id == 36
314 | tags_name == MTHFR Gene
314 | tags_id == 294
314 | tags_name == Vitamin B12
314 | permissions_favorite == False
314 | permissions_rate == False
314 | content_article == <h2><strong>Summary</strong></h2> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>The MTHFR gene enables folate metabolism and homocysteine removal, helping to prevent attention disorders.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>Different gene variants reduce MTHFR activity and correlate with attention disorders such as ADHD.</strong></span><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><strong>Specific foods and supplements may help you maintain optimal attention by targeting your gene variants.</strong></span></p> <h2><strong>The Link Between MTHFR &amp; Attention</strong></h2> <p><span style="font-weight: 400;">The </span><a href="../../article/lectin-sensitive-genes-mthfr-15"><span style="font-weight: 400;">MTHFR</span></a><span style="font-weight: 400;"> gene codes for a crucial enzyme in </span><a href="https://selfhacked.com/blog/16-proven-benefits-vitamin-b9-folate-folic-acid/"><span style="font-weight: 400;">folate</span></a><span style="font-weight: 400;"> metabolism [</span><a href="https://ghr.nlm.nih.gov/gene/MTHFR"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Increased MTHFR activity helps remove </span><a href="https://selfhacked.com/blog/optimal-homocysteine-levels-increase-decrease/"><span style="font-weight: 400;">homocysteine</span></a><span style="font-weight: 400;">, which can adversely affect cognition and attention [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836397/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15497469/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167178/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Folate deficiency and elevated homocysteine correlate with attention disorders such as ADHD [</span><a href="https://pubmed.ncbi.nlm.nih.gov/31496704/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153567/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">The MTHFR gene enables folate metabolism and homocysteine removal, which helps prevent attention disorders.</span></p> <h2><strong>Your MTHFR Results for Attention</strong></h2> <p>*1655879950036674*</p> <p><strong>Primary SNP:</strong></p> <p><strong>MTHFR </strong><a href="../../../snp/rs1801131/"><strong>rs1801131</strong></a> <span style="font-weight: 400;">[</span><a href="https://pubmed.ncbi.nlm.nih.gov/29407547/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084051/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/18154909/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li><span style="font-weight: 400;">&lsquo;G&rsquo; - associated with attention disorders such as ADHD</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; - not associated with attention disorders</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;G&rsquo; allele reduces MTHFR activity and impairs folate metabolism, contributing to elevated homocysteine [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11395038/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Some studies failed to confirm the link between this SNP and attention disorders [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/11395038/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30053573/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p><strong>Other important SNPs:</strong></p> <p><strong>MTHFR </strong><a href="../../../snp/rs2274976/"><strong>rs2274976</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084051/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span><strong>:</strong></p> <ul> <li><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with impaired attention &amp; cognition</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; - not associated with attention disorders</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The effect of this variant was significant only in patients deficient in folate and vitamin B12.</span></li> </ul> <p><strong>MTHFR </strong><a href="../../../snp/rs4846049/"><strong>rs4846049</strong></a> <span style="font-weight: 400;">[</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515551/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li><span style="font-weight: 400;">&lsquo;T&rsquo; - associated with attention disorders such as ADHD</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; - not associated with attention disorders</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The &lsquo;T&rsquo; allele reduces MTHFR activity and impairs folate metabolism, contributing to elevated homocysteine [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22647417/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <p>*3232227461753829*</p> <p>&nbsp;</p> <h2><strong>Recommendations to Improve Attention</strong></h2> <p>*1537935439004709*</p> <h3><strong>Diet and Supplements</strong></h3> <h4><strong>Folate</strong></h4> <p><span style="font-weight: 400;">People with attention disorders are more likely to lack dietary </span><a href="https://selfhacked.com/blog/16-proven-benefits-vitamin-b9-folate-folic-acid/"><span style="font-weight: 400;">folate</span></a><span style="font-weight: 400;"> [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153567/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30267523/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Folate deficiency contributes to the negative effects of MTHFR variants [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084051/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Folate supplementation may reduce the side effects of ADHD drug treatment [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776000/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Get enough folate from beef liver, leafy greens, whole grains, and fortified foods; consider taking a supplement if deficient [</span><a href="https://ods.od.nih.gov/factsheets/Folate-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Optimal folate intake may help prevent attention disorders by targeting your gene variants.</span></p> <h4><strong>Vitamin B12</strong></h4> <p><span style="font-weight: 400;">Attention disorders such as ADHD correlate with </span><a href="https://selfhacked.com/blog/vitamin-b12/"><span style="font-weight: 400;">vitamin B12</span></a><span style="font-weight: 400;"> deficiency [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689552/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370427/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/30267523/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">MTHFR variants have a stronger effect on attention when vitamin B12 status is low [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084051/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Get enough of this vitamin from animal foods, especially organ meats [</span><a href="https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">If you can&rsquo;t maintain optimal B12 levels with diet, consider taking a supplement.</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;">Get enough vitamin B12 to lessen the impact of your gene variants on attention.</span></p>
314 | content_snp_table_1655879950036674_key == 1655879950036674
314 | content_snp_table_1655879950036674_blur == True
314 | content_snp_table_1655879950036674_hidden == False
314 | content_learn_more_3232227461753829_key == 3232227461753829
314 | content_learn_more_3232227461753829_blur == True
314 | content_learn_more_3232227461753829_hidden == False
314 | content_learn_more_3232227461753829_text == Based on the variants we looked at, your MTHFR gene is associated with slightly higher odds of attention disorders. However, this doesn't necessarily reflect your overall risk of attention disorders, just one gene related to it. Dietary folate and vitamin B12 may help you maintain optimal attention by targeting your gene variants. Keep scrolling to find out more.
314 | content_recommendation_1537935439004709_key == 1537935439004709
314 | content_recommendation_1537935439004709_blur == True
314 | content_recommendation_1537935439004709_hidden == False
rsIDs = rs1801131,rs2274976,rs4846049
rsStatus = rs1801131,MTHFR,chr1,11794419,T,G,,,24,15,HET
rsStatus = rs2274976,MTHFR,chr1,11790870,C,T,,,38,0,Normal
rsStatus = rs4846049,MTHFR,chr1,11790308,T,A,G,,32,0,Normal
