315 | id == 315
315 | category_id == 19
315 | category_order == 16
315 | category_name == Pain
315 | category_color == #C47AC0
315 | slug == FKBP5-pain
315 | title == Could This Gene Affect the Relationship Between Stress and Pain? (FKBP5)
315 | meta_description == FKBP5 is an immune system protein that may regulate the body's response to stress. What is its link to chronic pain?
315 | summary == <p><strong><em>FKBP5 </em>is an immune system protein that may regulate the body&#39;s response to stress. What is its link to chronic pain? Read on to find out.</strong></p>
315 | overall_score_text == Chronic Pain Score (Based on FKBP5)
315 | image == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/background/FKBP5-Chronic-Pain.jpg
315 | author_id == 1
315 | author_name == Jasmine Foster
315 | author_title == BSc, BEd
315 | author_order == 36
315 | author_photo == https://sd-selfdecode-assets-prod.s3.amazonaws.com/blog/author-photo/Jasmine.jpg
315 | author_intro == <p><strong>Jasmine received her BS from McGill University and her BEd from Vancouver Island University.</strong></p>    <p>Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.</p>
315 | reviewer == None
315 | medical_reviewer_id == 11
315 | medical_reviewer_name == Puya Yazdi
315 | medical_reviewer_title == MD
315 | publish_date == 2020
315 | publish_date == 9
315 | publish_date == 8
315 | avg_rating == 5.0
315 | tags_id == 596
315 | tags_name == Chronic Pain
315 | tags_id == 688
315 | tags_name == FKBP5 Gene
315 | tags_id == 71
315 | tags_name == Pain
315 | tags_id == 50
315 | tags_name == Stress
315 | tags_id == 232
315 | tags_name == Vitamin D
315 | permissions_favorite == False
315 | permissions_rate == False
315 | content_article == <h2><span style="font-weight: 400;">Summary</span></h2> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">FKBP5 </span></em><span style="font-weight: 400;">gene encodes a protein that regulates many cellular processes and is believed to affect the stress response.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Certain </span><em><span style="font-weight: 400;">FKBP5 </span></em><span style="font-weight: 400;">variants have been associated with chronic back </span><a href="https://selfhacked.com/blog/pain-management/"><span style="font-weight: 400;">pain</span></a><span style="font-weight: 400;"> and nerve pain.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Lifestyle, diet, and supplement choices that reduce FKBP5 activity may help manage chronic pain.</span></li> </ul> <h2><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">FKBP5 </span></em><span style="font-weight: 400;">Gene in Chronic Pain</span></h2> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">The </span><em><span style="font-weight: 400;">FKBP5 </span></em><span style="font-weight: 400;">gene encodes FKBP prolyl isomerase 5, an immune system protein that helps regulate many basic cellular processes [</span><a href="https://ghr.nlm.nih.gov/gene/FKBP5"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Higher than normal FKBP5 activity is believed to reduce the body&rsquo;s ability to recover from stressful events [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19560279/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359276/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">High FKBP5 activity has been associated with stress-related psychiatric disorders like major </span><a href="https://selfhacked.com/blog/natural-treatments-depression/"><span style="font-weight: 400;">depression</span></a><span style="font-weight: 400;">, bipolar disorder, and </span><a href="https://selfhacked.com/blog/ptsd-causes-treatments/"><span style="font-weight: 400;">PTSD</span></a><span style="font-weight: 400;"> [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19560279/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Variants that increase </span><em><span style="font-weight: 400;">FKBP5 </span></em><span style="font-weight: 400;">have also been associated with chronic pain disorders, including chronic back pain and nerve pain (neuralgia) [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359276/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.leelabsg.org/resources"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></li> </ul> <h3><span style="font-weight: 400;">Specific Associations</span></h3> <p><span style="font-weight: 400;">Variants in the </span><em><span style="font-weight: 400;">FKBP5</span></em><span style="font-weight: 400;"> gene have been associated with specific types of pain and pain disorders, including:</span></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">Back pain [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.leelabsg.org/resources"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Post-traumatic chronic muscle pain [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158694/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955812/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699900/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Nerve pain [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.leelabsg.org/resources"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Headaches [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Chest pain [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.leelabsg.org/resources"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Neck and shoulder pain [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Increased use of painkillers [</span><a href="https://pubmed.ncbi.nlm.nih.gov/25826379/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="http://www.nealelab.is/uk-biobank/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]</span></li> </ul> <h2><span style="font-weight: 400;">Your </span><em><span style="font-weight: 400;">FKBP5 </span></em><span style="font-weight: 400;">Results for Chronic Pain</span></h2> <p>*9975160418390174*</p> <p><strong>FKBP5 </strong><a href="../../../snp/rs3800373/"><strong>rs3800373</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with chronic back pain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Possibly protective against chronic back pain</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The minor &lsquo;C&rsquo; allele may alter FKBP5 activity, possibly leading to reduced susceptibility to chronic pain.</span></li> </ul> <p><strong>FKBP5 </strong><a href="../../../snp/rs1360780/"><strong>rs1360780</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;C&rsquo; = Associated with chronic nerve pain (neuralgia)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;T&rsquo; = Possibly protective against neuralgia</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The minor &lsquo;T&rsquo; allele may alter FKBP5 activity, possibly leading to reduced susceptibility to chronic pain.</span></li> </ul> <p><strong>FKBP5 </strong><a href="../../../snp/rs9394314/"><strong>rs9394314</strong></a></p> <ul> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;A&rsquo; = Associated with chronic nerve pain (neuralgia)</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">&lsquo;G&rsquo; = Possibly protective against neuralgia</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">The minor &lsquo;G&rsquo; allele may alter FKBP5 activity, possibly leading to reduced susceptibility to chronic pain.</span></li> </ul> <p>*4715831021272421*</p> <h2><span style="font-weight: 400;">Recommendations for Reducing Pain</span></h2> <p>*6974002928797159*</p> <h3><span style="font-weight: 400;">Vitamin D</span></h3> <p><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/"><span style="font-weight: 400;">Vitamin D</span></a><span style="font-weight: 400;"> has been found to significantly decrease </span><em><span style="font-weight: 400;">FKBP5</span></em><span style="font-weight: 400;"> expression in human cells [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27220430/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">A meta-analysis of 19 clinical trials found that taking vitamin D supplements for 1-24 months reduced the intensity of chronic pain. However, the final follow-up pain score was similar in the vitamin D and placebo groups [</span><a href="https://pubmed.ncbi.nlm.nih.gov/27676659/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Vitamin D levels can be increased in many ways, including [</span><a href="https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">]:</span></p> <ul> <li style="font-weight: 400;"><a href="https://selfhacked.com/blog/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun/"><span style="font-weight: 400;">Sun exposure</span></a><span style="font-weight: 400;">. When exposed to the sun, your skin transforms a type of </span><a href="https://www.selfhacked.com/blog/cholesterol/"><span style="font-weight: 400;">cholesterol</span></a><span style="font-weight: 400;"> into vitamin D.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Fatty fish. Salmon, tuna, mackerel, and fish liver oils are among the only dietary sources of vitamin D.</span></li> <li style="font-weight: 400;"><span style="font-weight: 400;">Supplements. People who don&rsquo;t get enough vitamin D from the sun or from their diets may be recommended to take a supplement.</span></li> </ul> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">Vitamin D, which can be sourced through sun exposure, supplements, or fatty fish, decreases </span><em><span style="font-weight: 400;">FKBP5</span></em><span style="font-weight: 400;"> expression in human cells.</span></span></p> <h3><span style="font-weight: 400;">Stress Management</span></h3> <p><span style="font-weight: 400;">Elevated FKBP5 may reduce the body&rsquo;s ability to respond to and recover from stress. As such, it is especially important to practice stress management if you have detrimental </span><em><span style="font-weight: 400;">FKBP5</span></em><span style="font-weight: 400;"> variants [</span><a href="https://pubmed.ncbi.nlm.nih.gov/19560279/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359276/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Psychological therapies may also help manage chronic pain [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/10954644"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/12071487"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://www.ncbi.nlm.nih.gov/pubmed/22115492"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Cognitive behavioral therapy improved the overall quality of life in some individuals with chronic pain, with modest effectiveness [</span><a href="https://www.ncbi.nlm.nih.gov/pubmed/15599126"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="font-weight: 400;">Long-term commitment to practicing </span><a href="https://selfhacked.com/blog/health-benefits-yoga/"><span style="font-weight: 400;">yoga</span></a><span style="font-weight: 400;">, a form of stress-relieving </span><a href="https://selfhacked.com/blog/top-14-proven-health-benefits-exercise-references-mechanisms/"><span style="font-weight: 400;">exercise</span></a><span style="font-weight: 400;">, has been found to reduce back pain in some people. Chronic back pain patients who practiced yoga at least once a week for two years reported feeling less pain than those who did not practice [</span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805350/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">, </span><a href="https://pubmed.ncbi.nlm.nih.gov/28192789/"><span style="font-weight: 400;">R</span></a><span style="font-weight: 400;">].</span></p> <p><span style="background-color: #e8ebfc; border-left: 2px solid #4569fa; display: block; padding: 20px;"><span style="font-weight: 400;">High FKBP5 may limit the body&rsquo;s ability to recover from stress, so it&rsquo;s important to manage stress if you have detrimental </span><em><span style="font-weight: 400;">FKBP5 </span></em><span style="font-weight: 400;">variants.</span></span></p>
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315 | content_learn_more_4715831021272421_text == Based on the variants we looked at, your FKBP5 gene is somewhat associated with an abnormal stress response. However, this doesn't necessarily reflect your overall risk of chronic pain, just one gene related to it. Multiple sources of vitamin D and stress-busting hobbies may help. Keep reading to learn more.
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rsIDs = rs9394314,rs3800373,rs1360780
rsStatus = rs9394314,FKBP5,chr6,35715282,G,A,,,12,20,HET
rsStatus = rs3800373,FKBP5,chr6,35574699,C,A,G,,16,11,HET
rsStatus = rs1360780,FKBP5,chr6,35639794,T,A,C,,28,0,Normal
